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The map label for this gene is degS [H]

Identifier: 157372586

GI number: 157372586

Start: 4825377

End: 4826435

Strand: Direct

Name: degS [H]

Synonym: Spro_4353

Alternate gene names: 157372586

Gene position: 4825377-4826435 (Clockwise)

Preceding gene: 157372585

Following gene: 157372594

Centisome position: 88.56

GC content: 55.9

Gene sequence:

>1059_bases
ATGTTTGCTAAGCTCTTGCGTTCCGTCGTTATTGGTTTAATCGTTGCCGGCCTGCTGCTGGTTGCACTGCCCGTGCTACG
TTCTTCCAATGCTCTGTTCGCAGAAAAACATGACAGTACTCTTGACGAAACACCGGTCAGCTACAACAAAGCAGTGCGCC
GCGCCGCGCCCGCCGTGGTGAATATCTACAACCGCAATATGAACGGTTCCGCCAACATACTCTCTCTGGGATCTGGCGTG
ATCATGAACGAGCGCGGTTATATCCTGACTAATCGCCACGTGATCAAGGATGCACAACAAATTACCGTGGTGGTGCAGGA
CGGCCGCCGTTACGAAGCATTGTTAGTCGGTTCTGACGGTTTGACCGATCTGGCGGTGCTGAAAATTGATCCGGGCAACC
TGCCGGTGATCCCGATAAACACGGCTCGCACCGCGCACGTAGGTGACGTAGTACTGGCGATCGGCAACCCCTTCAATCTC
GGTCAGACCGTCACTCAGGGGATCCTCAGCGCTACCGGCCGCATCAGTATGAGCACCACCGGTCGCCAAACCTTCCTGCA
GACCGATGCCTCGATTAACCGCGGCAACTCGGGCGGCGCGCTGGTCAACTCGCTGGGCGAGCTAATCGGCATCAATACCC
TGACCTACGATAAAATCACCGATGGGGAAACGCCGGAAGGTTTGGGCTTCGCCATTCCTATCGAGCTGGCCACCAAGATT
ATGGACAAGCTGATCCGCGACGGCCGCGTCATCCGCGGTTATTTCGGTATTCAGGGTAAAGAGATTATCCCCCTGCGTTC
GTCCAATTCCGGCATCGATCGCCTGCAGGGCATTATCGTGACCGAAATTACGCCGAACGGGCCGGCTGGTAACGCCGGGT
TCCATATCAACGACGTGATCATCAACGTCGACAACAAACCGGCGATTTCGGTGCTGGAGACCATGGACCAGGTGGCGGAG
ATCCGCCCAGGCACTGAAATTCCGGTGATTGTGTTGCGCGAAGGCAAACGCATCACCTTGAAGATGACCGTGGGCGAATT
CCCGGAAGACACCAATTAA

Upstream 100 bases:

>100_bases
TTAATCGGTAATTTGTTTAAAAACCGGGCCCGGTGACATACTGCGCCCGGTATTCTCATGCTATCCTCCGTGTATCTTTC
ATCTCACGTACTAAAACTCC

Downstream 100 bases:

>100_bases
AAAGGGCCCGGCAACGCCGAGCCCTCCAATACTGCATTGCGCCGGGGCATCACCCCGGCATCCAACAGATTACTCGCCTT
TCACACGCTCGATATTTGCA

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MFAKLLRSVVIGLIVAGLLLVALPVLRSSNALFAEKHDSTLDETPVSYNKAVRRAAPAVVNIYNRNMNGSANILSLGSGV
IMNERGYILTNRHVIKDAQQITVVVQDGRRYEALLVGSDGLTDLAVLKIDPGNLPVIPINTARTAHVGDVVLAIGNPFNL
GQTVTQGILSATGRISMSTTGRQTFLQTDASINRGNSGGALVNSLGELIGINTLTYDKITDGETPEGLGFAIPIELATKI
MDKLIRDGRVIRGYFGIQGKEIIPLRSSNSGIDRLQGIIVTEITPNGPAGNAGFHINDVIINVDNKPAISVLETMDQVAE
IRPGTEIPVIVLREGKRITLKMTVGEFPEDTN

Sequences:

>Translated_352_residues
MFAKLLRSVVIGLIVAGLLLVALPVLRSSNALFAEKHDSTLDETPVSYNKAVRRAAPAVVNIYNRNMNGSANILSLGSGV
IMNERGYILTNRHVIKDAQQITVVVQDGRRYEALLVGSDGLTDLAVLKIDPGNLPVIPINTARTAHVGDVVLAIGNPFNL
GQTVTQGILSATGRISMSTTGRQTFLQTDASINRGNSGGALVNSLGELIGINTLTYDKITDGETPEGLGFAIPIELATKI
MDKLIRDGRVIRGYFGIQGKEIIPLRSSNSGIDRLQGIIVTEITPNGPAGNAGFHINDVIINVDNKPAISVLETMDQVAE
IRPGTEIPVIVLREGKRITLKMTVGEFPEDTN
>Mature_352_residues
MFAKLLRSVVIGLIVAGLLLVALPVLRSSNALFAEKHDSTLDETPVSYNKAVRRAAPAVVNIYNRNMNGSANILSLGSGV
IMNERGYILTNRHVIKDAQQITVVVQDGRRYEALLVGSDGLTDLAVLKIDPGNLPVIPINTARTAHVGDVVLAIGNPFNL
GQTVTQGILSATGRISMSTTGRQTFLQTDASINRGNSGGALVNSLGELIGINTLTYDKITDGETPEGLGFAIPIELATKI
MDKLIRDGRVIRGYFGIQGKEIIPLRSSNSGIDRLQGIIVTEITPNGPAGNAGFHINDVIINVDNKPAISVLETMDQVAE
IRPGTEIPVIVLREGKRITLKMTVGEFPEDTN

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=303, Percent_Identity=37.6237623762376, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4506141, Length=287, Percent_Identity=36.5853658536585, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI24308541, Length=275, Percent_Identity=34.5454545454545, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI7019477, Length=316, Percent_Identity=31.3291139240506, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1789630, Length=353, Percent_Identity=70.5382436260623, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789629, Length=271, Percent_Identity=43.5424354243542, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1786356, Length=280, Percent_Identity=39.6428571428571, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24646839, Length=297, Percent_Identity=31.6498316498317, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 37619; Mature: 37619

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAKLLRSVVIGLIVAGLLLVALPVLRSSNALFAEKHDSTLDETPVSYNKAVRRAAPAVV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCEE
NIYNRNMNGSANILSLGSGVIMNERGYILTNRHVIKDAQQITVVVQDGRRYEALLVGSDG
EEEECCCCCCCCEEEECCCEEECCCCEEEECCHHHCCCEEEEEEEECCCEEEEEEECCCC
LTDLAVLKIDPGNLPVIPINTARTAHVGDVVLAIGNPFNLGQTVTQGILSATGRISMSTT
CCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCC
GRQTFLQTDASINRGNSGGALVNSLGELIGINTLTYDKITDGETPEGLGFAIPIELATKI
CCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEHHHHHHHH
MDKLIRDGRVIRGYFGIQGKEIIPLRSSNSGIDRLQGIIVTEITPNGPAGNAGFHINDVI
HHHHHHCCEEEEEEECCCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCCCEEEEEEE
INVDNKPAISVLETMDQVAEIRPGTEIPVIVLREGKRITLKMTVGEFPEDTN
EEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MFAKLLRSVVIGLIVAGLLLVALPVLRSSNALFAEKHDSTLDETPVSYNKAVRRAAPAVV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCEE
NIYNRNMNGSANILSLGSGVIMNERGYILTNRHVIKDAQQITVVVQDGRRYEALLVGSDG
EEEECCCCCCCCEEEECCCEEECCCCEEEECCHHHCCCEEEEEEEECCCEEEEEEECCCC
LTDLAVLKIDPGNLPVIPINTARTAHVGDVVLAIGNPFNLGQTVTQGILSATGRISMSTT
CCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCC
GRQTFLQTDASINRGNSGGALVNSLGELIGINTLTYDKITDGETPEGLGFAIPIELATKI
CCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEHHHHHHHH
MDKLIRDGRVIRGYFGIQGKEIIPLRSSNSGIDRLQGIIVTEITPNGPAGNAGFHINDVI
HHHHHHCCEEEEEEECCCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCCCEEEEEEE
INVDNKPAISVLETMDQVAEIRPGTEIPVIVLREGKRITLKMTVGEFPEDTN
EEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]