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The map label for this gene is exuR [H]

Identifier: 157372556

GI number: 157372556

Start: 4794730

End: 4795506

Strand: Direct

Name: exuR [H]

Synonym: Spro_4323

Alternate gene names: 157372556

Gene position: 4794730-4795506 (Clockwise)

Preceding gene: 157372555

Following gene: 157372557

Centisome position: 88.0

GC content: 54.44

Gene sequence:

>777_bases
ATGGAATTCACTGAAACCAGACGCCTGTATCAGCAGCTGGCCGCCGAACTAAAGCAGCGTATTGAAAGCGGCCGGTATCC
GGTGGGCGATAAACTGCCGGCCGAACGCTACATTGCCGAAGAGATGAACGTCAGCCGCACCGTCGTGCGGGAGGCGATCA
TCATGCTGGAAGTGGAAGGCTACGTTGACGTGCGCAAAGGCTCCGGGATCCATGTGATGTCCAACCAGCAGAAAAACCTG
GTGATTCCGGGCGACAGCATCGAGTTTGCCACCGCCGGGCCATTTGAACTGCTGCAGGCGCGCCAACTGATTGAAAGCAA
CATTGCCGAATTCGCCGCTACCCAGGTCACCAAACAGGACATCGTTCTGTTGATGGAGATCCAGGAACAGGCACGTAAGG
AAGATCGCTTCCGCGACTCGCAGTGGGATCTGAAATTCCACGTTCAGGTCGCGCTGGCCACTCAGAACACTGCGATGGCC
ACCATCGTGGAAAAAATGTGGGTACAGCGCGTGAATAACCCCTATTGGATCAAGCTGCATGAGCATATTGACGACCGCTC
GATCGCCAGCTGGTGTGACGACCACGATCAGATCCTCAAGGCATTGATACGTAAAGATCCTTACGCCGCCAAACTGGCCA
TGTGGCAGCATCTGGAAAATACCAAGCAGATGCTGTTCAACGCCACCAGCGACGATTTTGAATATAATGCCGACCGCTAT
CTGTTCGCCGATAACCCGGTAGTTCATCTGGACGGCGTGGCCGCAGAAAATAAATAG

Upstream 100 bases:

>100_bases
GCGTGCCGGGCGCGCCCTCCCGGCCACTGGTAGCTCAGCAGGATAAGTGGTATAACAAATCCATGGTTACGCGCCCCTCC
CTACCCTAAGAGCATTCACT

Downstream 100 bases:

>100_bases
CGCGAGCAGTCAAAAACCGTAGCGTTATGTCAGGTATTGTAAAATCCGCTGAATCGATGCCTGAACGGCAATTTGCCGTG
TAGTATTTCACCGCTGGCAA

Product: DNA-binding transcriptional repressor ExuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MEFTETRRLYQQLAAELKQRIESGRYPVGDKLPAERYIAEEMNVSRTVVREAIIMLEVEGYVDVRKGSGIHVMSNQQKNL
VIPGDSIEFATAGPFELLQARQLIESNIAEFAATQVTKQDIVLLMEIQEQARKEDRFRDSQWDLKFHVQVALATQNTAMA
TIVEKMWVQRVNNPYWIKLHEHIDDRSIASWCDDHDQILKALIRKDPYAAKLAMWQHLENTKQMLFNATSDDFEYNADRY
LFADNPVVHLDGVAAENK

Sequences:

>Translated_258_residues
MEFTETRRLYQQLAAELKQRIESGRYPVGDKLPAERYIAEEMNVSRTVVREAIIMLEVEGYVDVRKGSGIHVMSNQQKNL
VIPGDSIEFATAGPFELLQARQLIESNIAEFAATQVTKQDIVLLMEIQEQARKEDRFRDSQWDLKFHVQVALATQNTAMA
TIVEKMWVQRVNNPYWIKLHEHIDDRSIASWCDDHDQILKALIRKDPYAAKLAMWQHLENTKQMLFNATSDDFEYNADRY
LFADNPVVHLDGVAAENK
>Mature_258_residues
MEFTETRRLYQQLAAELKQRIESGRYPVGDKLPAERYIAEEMNVSRTVVREAIIMLEVEGYVDVRKGSGIHVMSNQQKNL
VIPGDSIEFATAGPFELLQARQLIESNIAEFAATQVTKQDIVLLMEIQEQARKEDRFRDSQWDLKFHVQVALATQNTAMA
TIVEKMWVQRVNNPYWIKLHEHIDDRSIASWCDDHDQILKALIRKDPYAAKLAMWQHLENTKQMLFNATSDDFEYNADRY
LFADNPVVHLDGVAAENK

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082208, Length=258, Percent_Identity=77.9069767441861, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI1790780, Length=256, Percent_Identity=47.265625, Blast_Score=213, Evalue=7e-57,
Organism=Escherichia coli, GI1790032, Length=221, Percent_Identity=26.6968325791855, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789353, Length=252, Percent_Identity=23.8095238095238, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786303, Length=218, Percent_Identity=27.0642201834862, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29855; Mature: 29855

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTETRRLYQQLAAELKQRIESGRYPVGDKLPAERYIAEEMNVSRTVVREAIIMLEVEG
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHEEEECC
YVDVRKGSGIHVMSNQQKNLVIPGDSIEFATAGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVLLMEIQEQARKEDRFRDSQWDLKFHVQVALATQNTAMATIVEKMWVQRVNNPYWIKLH
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEE
EHIDDRSIASWCDDHDQILKALIRKDPYAAKLAMWQHLENTKQMLFNATSDDFEYNADRY
CCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LFADNPVVHLDGVAAENK
EEECCCEEEECCCCCCCC
>Mature Secondary Structure
MEFTETRRLYQQLAAELKQRIESGRYPVGDKLPAERYIAEEMNVSRTVVREAIIMLEVEG
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHEEEECC
YVDVRKGSGIHVMSNQQKNLVIPGDSIEFATAGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVLLMEIQEQARKEDRFRDSQWDLKFHVQVALATQNTAMATIVEKMWVQRVNNPYWIKLH
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEE
EHIDDRSIASWCDDHDQILKALIRKDPYAAKLAMWQHLENTKQMLFNATSDDFEYNADRY
CCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
LFADNPVVHLDGVAAENK
EEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA