Click here to switch to the map view.

The map label for this gene is parE [H]

Identifier: 157372496

GI number: 157372496

Start: 4726703

End: 4728598

Strand: Reverse

Name: parE [H]

Synonym: Spro_4263

Alternate gene names: 157372496

Gene position: 4728598-4726703 (Counterclockwise)

Preceding gene: 157372497

Following gene: 157372495

Centisome position: 86.78

GC content: 58.23

Gene sequence:

>1896_bases
ATGACTCAATCCAGCTATAACGCTGATGCCATTGAAGTACTCAGCGGTCTAGAACCAGTGCGCCGTCGTCCCGGCATGTA
TACCGACACGACGCGCCCCAATCACCTCGGCCAAGAGGTGATAGATAACAGCGTCGATGAAGCGTTGGCCGGTCACGCCA
AGCGCATCGACGTGATTCTGCACGCCGATCAGTCACTGGAAGTGATCGATGACGGCCGCGGCATGCCGGTGGATATCCAT
CCTGAAGAAGGCGTTCCTGCGGTTGAGTTGATCATGTGTCGTCTGCACGCGGGCGGTAAATTCTCCAATAAAAACTACCA
GTTCTCCGGCGGCCTGCACGGCGTGGGGATTTCGGTGGTTAACGCCCTGTCGACCCGGGTGGAAGTCAACGTCAAGCGCG
ATGGTAATGTCTACAGCATTGCCTTCGAAAACGGCGACAAGGTGCAGGATTTGGCGGTGACCGGCAGCTGCGGCAAACGC
AATACCGGCACCAGCATCCACTTCTGGCCTGACGAGAAGTTCTTCGACAGCCCACGTTTCTCGGTTTCGCGTCTCAGCCA
CCTGCTGAAAGCCAAAGCGGTACTCTGTCCAGGAGTAGAAATCTACTTCATCGACAAGCTGAACAATACCGAGCAACGCT
GGTGCTATCAGGACGGCCTGACCGATTACCTGATGGAAGCGGTTAACGGCCTGATTACCCTGCCGGAAGCGGCGTTTGTC
GGCAACTTTGCCGGTGACACCGAAGCGGTAGACTGGGCACTGCTGTGGCTGCCGGAAGGCGGTGAACTGCTGACCGAAAG
CTACGTGAACCTGATCCCGACCATGCAGGGCGGCACCCACGTTAACGGCCTGCGTCAGGGGTTGCTGGATGCGATGCGCG
AGTTCTGCGAATTCCGCAATATTCTGCCGCGCGGCGTGAAGCTTTCCGCTGAGGATATCTGGGACCGTTGCGCCTATGTG
CTGTCGGTGAAGATGCAGGATCCGCAGTTCGCCGGGCAGACCAAAGAGCGTCTGTCGTCGCGCCAGTGTGCAGCCTTCGT
CTCCGGCGTGGTGAAAGACGCCTTCAGCCTGTGGCTGAACCAGAACATACAGGCGGCGGAACAGCTGGCCGAGCTGGCTA
TTTCCAGCGCCCAGCGCCGTCTGCGTGCCGCCAAAAAAGTGGTGCGCAAGAAGCTGACCAGCGGTCCGGCGCTGCCGGGT
AAACTGGCCGACTGCACCTCGCAGGACCTGAACATGACCGAGTTGTTCCTGGTGGAAGGGGACTCGGCGGGCGGTTCAGC
CAAGCAGGCTCGCGATCGCGAATATCAGGCGATCATGCCGCTGAAAGGTAAAATCCTCAATACCTGGGAAGTGTCTTCGG
ACGAAGTGTTGGCTTCGCAGGAAGTGCACGACATCTCGGTGGCGATCGGTATTGATCCGGACAGCGAAGATCTCAGCCAA
TTGCGCTATGGCAAAATTTGTATCCTGGCGGATGCGGACTCAGACGGCCTGCACATTGCCACGCTGCTGTGCGCGCTGTT
TGTGCGCCACTTCCGTTCGCTGGTGAAGGGTGGTCACGTGTATGTGGCGATGCCGCCTCTGTACCGTATCGACCTCGGCA
AAGAGGTGTTCTATGCGCTGGATGAAGAAGAAAAGGCCGGCGTACTGGAACAGTTGAAGCGCAAAAAGGGCAAGCCTAAC
GTTCAGCGCTTTAAAGGGCTGGGTGAGATGAACCCGCCACAGCTGCGTGAAACCACGCTCGACCCCAATACCCGTCGTCT
GGTGCAGTTGACGGTGAGCGATGAAGACGTGGATCAGACGCTGGCGATGATGGACATGTTGCTGGCCAAGAAGCGTTCGG
AAGATCGCCGCAACTGGCTGCAGGACAAAGGCGATATGGCCGAGCTGTCTGCCTGA

Upstream 100 bases:

>100_bases
GTTTCGAGCACTACTTCCCCCAGATTGTGGATTTTTTAGGGCTCAACGCTGTCTGAGCAGGCGGTTCCGGTTCCTTCCTT
TAACCACGAAAAATTCAACG

Downstream 100 bases:

>100_bases
CAGACCAGGCGAAAGACTGACAGACCCGGCTTCCCCGCCGGGTCTTCTTCCCGCAGGGGGACCGCGTGCGGCACCCGACC
ACACTGGGCGGAATCCATGA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MTQSSYNADAIEVLSGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRIDVILHADQSLEVIDDGRGMPVDIH
PEEGVPAVELIMCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSTRVEVNVKRDGNVYSIAFENGDKVQDLAVTGSCGKR
NTGTSIHFWPDEKFFDSPRFSVSRLSHLLKAKAVLCPGVEIYFIDKLNNTEQRWCYQDGLTDYLMEAVNGLITLPEAAFV
GNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEFRNILPRGVKLSAEDIWDRCAYV
LSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNIQAAEQLAELAISSAQRRLRAAKKVVRKKLTSGPALPG
KLADCTSQDLNMTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
LRYGKICILADADSDGLHIATLLCALFVRHFRSLVKGGHVYVAMPPLYRIDLGKEVFYALDEEEKAGVLEQLKRKKGKPN
VQRFKGLGEMNPPQLRETTLDPNTRRLVQLTVSDEDVDQTLAMMDMLLAKKRSEDRRNWLQDKGDMAELSA

Sequences:

>Translated_631_residues
MTQSSYNADAIEVLSGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRIDVILHADQSLEVIDDGRGMPVDIH
PEEGVPAVELIMCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSTRVEVNVKRDGNVYSIAFENGDKVQDLAVTGSCGKR
NTGTSIHFWPDEKFFDSPRFSVSRLSHLLKAKAVLCPGVEIYFIDKLNNTEQRWCYQDGLTDYLMEAVNGLITLPEAAFV
GNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEFRNILPRGVKLSAEDIWDRCAYV
LSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNIQAAEQLAELAISSAQRRLRAAKKVVRKKLTSGPALPG
KLADCTSQDLNMTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
LRYGKICILADADSDGLHIATLLCALFVRHFRSLVKGGHVYVAMPPLYRIDLGKEVFYALDEEEKAGVLEQLKRKKGKPN
VQRFKGLGEMNPPQLRETTLDPNTRRLVQLTVSDEDVDQTLAMMDMLLAKKRSEDRRNWLQDKGDMAELSA
>Mature_630_residues
TQSSYNADAIEVLSGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRIDVILHADQSLEVIDDGRGMPVDIHP
EEGVPAVELIMCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSTRVEVNVKRDGNVYSIAFENGDKVQDLAVTGSCGKRN
TGTSIHFWPDEKFFDSPRFSVSRLSHLLKAKAVLCPGVEIYFIDKLNNTEQRWCYQDGLTDYLMEAVNGLITLPEAAFVG
NFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEFRNILPRGVKLSAEDIWDRCAYVL
SVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNIQAAEQLAELAISSAQRRLRAAKKVVRKKLTSGPALPGK
LADCTSQDLNMTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQL
RYGKICILADADSDGLHIATLLCALFVRHFRSLVKGGHVYVAMPPLYRIDLGKEVFYALDEEEKAGVLEQLKRKKGKPNV
QRFKGLGEMNPPQLRETTLDPNTRRLVQLTVSDEDVDQTLAMMDMLLAKKRSEDRRNWLQDKGDMAELSA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=581, Percent_Identity=26.5060240963855, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI19913406, Length=588, Percent_Identity=23.9795918367347, Blast_Score=115, Evalue=2e-25,
Organism=Escherichia coli, GI1789408, Length=629, Percent_Identity=91.7329093799682, Blast_Score=1207, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=551, Percent_Identity=41.016333938294, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=608, Percent_Identity=24.8355263157895, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17535065, Length=628, Percent_Identity=24.5222929936306, Blast_Score=113, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=260, Percent_Identity=26.5384615384615, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=695, Percent_Identity=24.0287769784173, Blast_Score=143, Evalue=7e-35,
Organism=Drosophila melanogaster, GI17136538, Length=585, Percent_Identity=23.9316239316239, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69868; Mature: 69737

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSSYNADAIEVLSGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRIDVIL
CCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
HADQSLEVIDDGRGMPVDIHPEEGVPAVELIMCRLHAGGKFSNKNYQFSGGLHGVGISVV
ECCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHH
NALSTRVEVNVKRDGNVYSIAFENGDKVQDLAVTGSCGKRNTGTSIHFWPDEKFFDSPRF
HHHHHEEEEEEECCCCEEEEEECCCCCEEEEEEECCCCCCCCCCEEEECCCCHHCCCCCH
SVSRLSHLLKAKAVLCPGVEIYFIDKLNNTEQRWCYQDGLTDYLMEAVNGLITLPEAAFV
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHCCEEECCCHHHH
GNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEFRN
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLN
CCCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNIQAAEQLAELAISSAQRRLRAAKKVVRKKLTSGPALPGKLADCTSQDLNMTELFLVEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEEEC
DSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
CCCCCCHHHHHCCCCEEECCCCCCEEEEEECCCCCHHHCCCCEEEEEEEECCCCHHHHHH
LRYGKICILADADSDGLHIATLLCALFVRHFRSLVKGGHVYVAMPPLYRIDLGKEVFYAL
HCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHEEE
DEEEKAGVLEQLKRKKGKPNVQRFKGLGEMNPPQLRETTLDPNTRRLVQLTVSDEDVDQT
CCHHHCCHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCHHHH
LAMMDMLLAKKRSEDRRNWLQDKGDMAELSA
HHHHHHHHHHHCCHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
TQSSYNADAIEVLSGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRIDVIL
CCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
HADQSLEVIDDGRGMPVDIHPEEGVPAVELIMCRLHAGGKFSNKNYQFSGGLHGVGISVV
ECCCCCEEEECCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHH
NALSTRVEVNVKRDGNVYSIAFENGDKVQDLAVTGSCGKRNTGTSIHFWPDEKFFDSPRF
HHHHHEEEEEEECCCCEEEEEECCCCCEEEEEEECCCCCCCCCCEEEECCCCHHCCCCCH
SVSRLSHLLKAKAVLCPGVEIYFIDKLNNTEQRWCYQDGLTDYLMEAVNGLITLPEAAFV
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHCCEEECCCHHHH
GNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEFRN
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLN
CCCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNIQAAEQLAELAISSAQRRLRAAKKVVRKKLTSGPALPGKLADCTSQDLNMTELFLVEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEEEC
DSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSEDLSQ
CCCCCCHHHHHCCCCEEECCCCCCEEEEEECCCCCHHHCCCCEEEEEEEECCCCHHHHHH
LRYGKICILADADSDGLHIATLLCALFVRHFRSLVKGGHVYVAMPPLYRIDLGKEVFYAL
HCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCHHHEEE
DEEEKAGVLEQLKRKKGKPNVQRFKGLGEMNPPQLRETTLDPNTRRLVQLTVSDEDVDQT
CCHHHCCHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHCCCCCCCEEEEEEEECCCCHHHH
LAMMDMLLAKKRSEDRRNWLQDKGDMAELSA
HHHHHHHHHHHCCHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2170028; 8388096; 9278503; 8227000; 8980775 [H]