Click here to switch to the map view.

The map label for this gene is tktA [H]

Identifier: 157372188

GI number: 157372188

Start: 4380502

End: 4382496

Strand: Reverse

Name: tktA [H]

Synonym: Spro_3954

Alternate gene names: 157372188

Gene position: 4382496-4380502 (Counterclockwise)

Preceding gene: 157372190

Following gene: 157372184

Centisome position: 80.43

GC content: 62.21

Gene sequence:

>1995_bases
ATGTCCTCTCGTAAAGAGCTTGCCAACGCCATCCGCGCACTCAGCATGGACGCCGTACAAAAAGCAAATTCCGGCCACCC
GGGTGCACCTATGGGCATGGCGGACATCGCCGAAGTCCTGTGGCGTGACTACCTGAACCACAACCCGACCAACCCGCACT
GGGCTGACCGTGACCGCTTCGTCCTCTCCAACGGCCATGGCTCCATGCTGATTTACAGCCTGTTGCACCTCACCGGCTAC
GACCTGCCGATGAGCGAGCTGGAAAACTTCCGCCAGCTGCACTCCAAAACCCCGGGCCACCCGGAATACGGCTACACCCC
GGGCGTGGAAACCACCACTGGCCCACTGGGTCAGGGCATCGCCAACGCCGTCGGTTTCGCCATTGCCGAACGCACCCTGG
GCGCGCAGTTCAACCGTCCGGGTCATGACATCGTCGACCACCACACCTACGCCTTTATGGGCGACGGCTGCATGATGGAA
GGCATCTCCCACGAAGTCTGTTCGCTGGCCGGTACCCTCAAGCTCGGCAAACTGACCGCGTTCTACGATGACAACGGCAT
CTCCATCGACGGTCACGTCGAAGGCTGGTTCACCGACAACACCGCCGAGCGCTTTGAAGCCTACGGCTGGCACGTGGTGC
GTCACGTTGACGGCCACAACCCGGACGCCATCAAGGCCGCCATTGAAGAAGCCCGCAAGGTCACCGACAAGCCGTCGCTG
CTGATGTGCAAAACCGTGATTGGTTTCGGCTCCCCGAACAAGGCCGGCACCCACGACGTGCACGGTGCTGCGCTGGGCGC
CGCCGAAGTGGCCGCCACCCGCGAAGCGCTGGGCTGGAAATACGCCGCCTTCGAAATCCCGCAGGACATCTATGCCCAGT
GGGATGCCAAAGAAGCCGGCAAGGCCAAAGAAGCGGCCTGGAACGACAAGTTCGCCGCCTACGCGAAAGCCTTCCCTGAA
CTGGCTGCCGAGTTCAAACGCCGTGTGAACGGTGAGCTGCCGGCCAACTGGAAAGCCGAAGCCAAAGCCTTCGTGGAAAA
ACTGCAGGCCAACCCGGCCAATATCGCCAGCCGCAAGGCCTCGCAGAACGCACTGGAAACCTTCGGCAAGGTGCTGCCGG
AATTCCTCGGCGGCTCCGCTGACCTGGCACCGAGCAACCTGACCATGTGGTCCGGCTCCAAGCCACTCAACGAAGACCTG
GCGGGTAACTACATCCACTACGGCGTGCGCGAGTTCGGCATGACCGCCATCACCAACGGCATCGCGCTGCACGGCGGCTT
CCTGCCGTACTCGGCGACCTTCCTGATGTTCGTGGAATACGCCCGTAATGCGGTGCGTATGGCGGCGCTGATGAAAATCC
GCAACGTGTTCGTTTACACCCATGACTCCATCGGTCTGGGCGAAGACGGCCCGACGCACCAGCCGGTTGAGCAAATGGCC
AGCCTGCGCGTGACCCCGAACATGAGCACCTGGCGTCCGTGTGACCAGGTGGAGTCGGCGGTAGCCTGGCAGTACGGCAT
CGAGCGCAACGACGGCCCGACCACGCTGATTTTCTCACGTCAGAACCTGACCCAGCAGCCGCGTACCGCAGAGCAACTGG
CCAACGTTTACCGTGGTGGTTATGTGCTGAAGGACTGCGCCGGGACGCCGGACGTCATTCTGATTGCCACCGGTTCGGAA
GTGGGTATCACCGTGGAAGCGGCAGACCAGCTGACTGCGGCCGGCCGTAAGGTGCGCGTGGTCTCCATGCCGTCTACCGA
CGCGTTCGACAAGCAGGATGCGGCCTACCGTGAATCCGTGCTGCCGGCGGCAGTGAGCGCACGCGTGGCGGTAGAAGCGG
GTATCGCGGACTACTGGTACAAGTATGTTGGCCTGAACGGCGCCATCGTGGGTATGACCACCTTTGGTGAGTCAGCCCCG
GCAGAGCAGCTGTTCAAAGAGTTTGGCTTCACCGTGGACAACGTGGTGGCCAAGGCGCAGGCACTGCTGAAATAA

Upstream 100 bases:

>100_bases
GTGAACTCGCTCTCATTTGGCATTAGGGATTGCCGTTTTAATGCTGAGTCTGAGAAAATAGAAAACTTGACTGATTTTTT
AATCCGACCTGGAGTAAAAC

Downstream 100 bases:

>100_bases
GCGGTCCTTCGCAAGCTGATAAAAAAACCGGTCATTGACCGGTTTTTTTTATTTTAGGCCATCGTCCCGGCGCGGCGCGG
TGCGCGCAACCGATCGTAAA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMME
GISHEVCSLAGTLKLGKLTAFYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAGKAKEAAWNDKFAAYAKAFPE
LAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKASQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDL
AGNYIHYGVREFGMTAITNGIALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRTAEQLANVYRGGYVLKDCAGTPDVILIATGSE
VGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESVLPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTTFGESAP
AEQLFKEFGFTVDNVVAKAQALLK

Sequences:

>Translated_664_residues
MSSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGY
DLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMME
GISHEVCSLAGTLKLGKLTAFYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAGKAKEAAWNDKFAAYAKAFPE
LAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKASQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDL
AGNYIHYGVREFGMTAITNGIALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRTAEQLANVYRGGYVLKDCAGTPDVILIATGSE
VGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESVLPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTTFGESAP
AEQLFKEFGFTVDNVVAKAQALLK
>Mature_663_residues
SSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRFVLSNGHGSMLIYSLLHLTGYD
LPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGIANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEG
ISHEVCSLAGTLKLGKLTAFYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSLL
MCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAGKAKEAAWNDKFAAYAKAFPEL
AAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKASQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDLA
GNYIHYGVREFGMTAITNGIALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMAS
LRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRTAEQLANVYRGGYVLKDCAGTPDVILIATGSEV
GITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESVLPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTTFGESAPA
EQLFKEFGFTVDNVVAKAQALLK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=693, Percent_Identity=26.2626262626263, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI4507521, Length=693, Percent_Identity=26.2626262626263, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI133778974, Length=680, Percent_Identity=25.4411764705882, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=84.7662141779789, Blast_Score=1190, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=73.071104387292, Blast_Score=1040, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=675, Percent_Identity=24, Blast_Score=146, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=48.2861400894188, Blast_Score=594, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=45.3869047619048, Blast_Score=559, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45551847, Length=693, Percent_Identity=26.6955266955267, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45550715, Length=693, Percent_Identity=26.6955266955267, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24645119, Length=659, Percent_Identity=26.1001517450683, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24666278, Length=687, Percent_Identity=24.1630276564774, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72099; Mature: 71968

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEGISHEVCSLAGTLKLGKLTA
HHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCCHHHHCCHHHHHHHHHHEEECCEEE
FYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
EECCCCEEECCCEEEEEECCHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAG
EEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCHHCC
KAKEAAWNDKFAAYAKAFPELAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKA
CHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDLAGNYIHYGVREFGMTAITNG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHCC
IALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHH
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRTAEQLANVYRGG
HEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCC
YVLKDCAGTPDVILIATGSEVGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESV
EEEECCCCCCCEEEEEECCCCEEEEECHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHH
LPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTTFGESAPAEQLFKEFGFTVDNVVAKAQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC
>Mature Secondary Structure 
SSRKELANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLNHNPTNPHWADRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLPMSELENFRQLHSKTPGHPEYGYTPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
ANAVGFAIAERTLGAQFNRPGHDIVDHHTYAFMGDGCMMEGISHEVCSLAGTLKLGKLTA
HHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCCHHHHCCHHHHHHHHHHEEECCEEE
FYDDNGISIDGHVEGWFTDNTAERFEAYGWHVVRHVDGHNPDAIKAAIEEARKVTDKPSL
EECCCCEEECCCEEEEEECCHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
LMCKTVIGFGSPNKAGTHDVHGAALGAAEVAATREALGWKYAAFEIPQDIYAQWDAKEAG
EEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCHHCC
KAKEAAWNDKFAAYAKAFPELAAEFKRRVNGELPANWKAEAKAFVEKLQANPANIASRKA
CHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
SQNALETFGKVLPEFLGGSADLAPSNLTMWSGSKPLNEDLAGNYIHYGVREFGMTAITNG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHCC
IALHGGFLPYSATFLMFVEYARNAVRMAALMKIRNVFVYTHDSIGLGEDGPTHQPVEQMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHH
SLRVTPNMSTWRPCDQVESAVAWQYGIERNDGPTTLIFSRQNLTQQPRTAEQLANVYRGG
HEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCC
YVLKDCAGTPDVILIATGSEVGITVEAADQLTAAGRKVRVVSMPSTDAFDKQDAAYRESV
EEEECCCCCCCEEEEEECCCCEEEEECHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHH
LPAAVSARVAVEAGIADYWYKYVGLNGAIVGMTTFGESAPAEQLFKEFGFTVDNVVAKAQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
ALLK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]