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The map label for this gene is lpxD [H]

Identifier: 157372015

GI number: 157372015

Start: 4178671

End: 4179693

Strand: Reverse

Name: lpxD [H]

Synonym: Spro_3780

Alternate gene names: 157372015

Gene position: 4179693-4178671 (Counterclockwise)

Preceding gene: 157372016

Following gene: 157372014

Centisome position: 76.71

GC content: 54.06

Gene sequence:

>1023_bases
ATGCCTTCAATTCGACTGGCTGATCTAGCGCAGCAGTTGGATGCACAATTGCACGGTGATGGCGATCTCGTCATCACCGG
CATTGCTTCTATGCATTCGGCACAGGCTGGCCAAATCACGTTTTTGTCAAACAGCCGCTATCAAGAGCAGCTGGCTTCCT
GCCAGGCAAGCGCAGTAGTGCTTACCGAGGCGGATTTACCACACTGTCGTTCTGCGGCGCTGGTGGTTAAAAATCCTTAC
CTGACTTACGCGCGCATGGCGCAACTGATGGATACCACGCCGTCCCCGGCTCAGGATATCGCTCCAAGCGCGGTTATCTC
ACCTGAAGCCACTCTGGGTCAGCATGTTGCCATTGGTGCCAATGCGGTGATCGAGTCGGGCGCAGTGCTTGGCGATAACG
TGGTTATCGGCCCTGGCTGCTTCATCGGCAAACGTGCACGCATTGGCGCGGGTACGCGTCTGTGGGCGAACGTAACGATT
TATCATGAAGTCGAGATCGGCCAACGCTGCCTGATCCAATCAGGTACTGTGATTGGTGCTGATGGTTTCGGCTATGCCAA
CGAACGTGGTGAGTGGATAAAAATTCCTCAGTTGGGCACGGTAATTATCGGCGATCGCGTCGAGATTGGCGCTTGCACCA
CCATTGACCGCGGCGCGCTGGATAACACCCAGATCGGGAATGGTGTTATCATCGACAACCAATGCCAGATTGCACATAAC
GTGGTGATTGGCGACAATACTGCCGTTGCCGGCGGTGTTATCATGGCGGGCAGCCTGAAAATCGGCCGCTACTGCCAGAT
CGGCGGAGCCAGCGTGATCAACGGTCACATGGAGATCGCCGACAAGGTTGTTGTCACCGGAATGGGAATGGTTATGCGAC
CAATCACCGAACCTGGGGTATACTCTTCGGGCATTCCGTTACAACCCAACAAAGTTTGGCGTAAAACCGCTGCGTTGGTG
ATGAATATCGATGAGATTAGCAAGCGCTTAAAAGCTGTCGAACGAAAAGTCGGAAAAGACTAA

Upstream 100 bases:

>100_bases
AAAGAAGGCTACGACGTAGTTATCGATGCTAACGCTGTTGCCTACGCAGGGACTTCTAAAGACATCACTGCTGACGTGCT
GAAACAGGTTAAATAACAAC

Downstream 100 bases:

>100_bases
TCACTACCGCCCGCCTCGCTGGGTACAAAACGAAACGCGTTGGTCATGAGACCAAAAGCGCAAAGAGTTGTTAATTTGCG
GCCTGCATGACTTCCTCCTT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MPSIRLADLAQQLDAQLHGDGDLVITGIASMHSAQAGQITFLSNSRYQEQLASCQASAVVLTEADLPHCRSAALVVKNPY
LTYARMAQLMDTTPSPAQDIAPSAVISPEATLGQHVAIGANAVIESGAVLGDNVVIGPGCFIGKRARIGAGTRLWANVTI
YHEVEIGQRCLIQSGTVIGADGFGYANERGEWIKIPQLGTVIIGDRVEIGACTTIDRGALDNTQIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLKIGRYCQIGGASVINGHMEIADKVVVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALV
MNIDEISKRLKAVERKVGKD

Sequences:

>Translated_340_residues
MPSIRLADLAQQLDAQLHGDGDLVITGIASMHSAQAGQITFLSNSRYQEQLASCQASAVVLTEADLPHCRSAALVVKNPY
LTYARMAQLMDTTPSPAQDIAPSAVISPEATLGQHVAIGANAVIESGAVLGDNVVIGPGCFIGKRARIGAGTRLWANVTI
YHEVEIGQRCLIQSGTVIGADGFGYANERGEWIKIPQLGTVIIGDRVEIGACTTIDRGALDNTQIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLKIGRYCQIGGASVINGHMEIADKVVVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALV
MNIDEISKRLKAVERKVGKD
>Mature_339_residues
PSIRLADLAQQLDAQLHGDGDLVITGIASMHSAQAGQITFLSNSRYQEQLASCQASAVVLTEADLPHCRSAALVVKNPYL
TYARMAQLMDTTPSPAQDIAPSAVISPEATLGQHVAIGANAVIESGAVLGDNVVIGPGCFIGKRARIGAGTRLWANVTIY
HEVEIGQRCLIQSGTVIGADGFGYANERGEWIKIPQLGTVIIGDRVEIGACTTIDRGALDNTQIGNGVIIDNQCQIAHNV
VIGDNTAVAGGVIMAGSLKIGRYCQIGGASVINGHMEIADKVVVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALVM
NIDEISKRLKAVERKVGKD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=339, Percent_Identity=82.3008849557522, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1786378, Length=191, Percent_Identity=28.7958115183246, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35773; Mature: 35641

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIRLADLAQQLDAQLHGDGDLVITGIASMHSAQAGQITFLSNSRYQEQLASCQASAVV
CCCCHHHHHHHHHHHEECCCCCEEEEEEHHHCCCCCCEEEEEECCHHHHHHHCCCCCEEE
LTEADLPHCRSAALVVKNPYLTYARMAQLMDTTPSPAQDIAPSAVISPEATLGQHVAIGA
EEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCEEECCCCCCCCEEEECC
NAVIESGAVLGDNVVIGPGCFIGKRARIGAGTRLWANVTIYHEVEIGQRCLIQSGTVIGA
HHHHHCCCEECCCEEECCCCEECCCCCCCCCCEEEEEEEEEEEECCCCEEEEECCCEEEC
DGFGYANERGEWIKIPQLGTVIIGDRVEIGACTTIDRGALDNTQIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCEEEECCCEEECEECCCCCCCCCCCCCCCEEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLKIGRYCQIGGASVINGHMEIADKVVVTGMGMVMRPITEPGV
EEECCCCEEECCEEEECCEEECCEEECCCCEEECCHHHHHHHHHHHCCCHHCCCCCCCCC
YSSGIPLQPNKVWRKTAALVMNIDEISKRLKAVERKVGKD
CCCCCCCCCHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PSIRLADLAQQLDAQLHGDGDLVITGIASMHSAQAGQITFLSNSRYQEQLASCQASAVV
CCCHHHHHHHHHHHEECCCCCEEEEEEHHHCCCCCCEEEEEECCHHHHHHHCCCCCEEE
LTEADLPHCRSAALVVKNPYLTYARMAQLMDTTPSPAQDIAPSAVISPEATLGQHVAIGA
EEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCEEECCCCCCCCEEEECC
NAVIESGAVLGDNVVIGPGCFIGKRARIGAGTRLWANVTIYHEVEIGQRCLIQSGTVIGA
HHHHHCCCEECCCEEECCCCEECCCCCCCCCCEEEEEEEEEEEECCCCEEEEECCCEEEC
DGFGYANERGEWIKIPQLGTVIIGDRVEIGACTTIDRGALDNTQIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCEEEECCCEEECEECCCCCCCCCCCCCCCEEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLKIGRYCQIGGASVINGHMEIADKVVVTGMGMVMRPITEPGV
EEECCCCEEECCEEEECCEEECCEEECCCCEEECCHHHHHHHHHHHCCCHHCCCCCCCCC
YSSGIPLQPNKVWRKTAALVMNIDEISKRLKAVERKVGKD
CCCCCCCCCHHHHHHHHHHEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8293817 [H]