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The map label for this gene is gmhB [H]

Identifier: 157371987

GI number: 157371987

Start: 4149465

End: 4150070

Strand: Reverse

Name: gmhB [H]

Synonym: Spro_3752

Alternate gene names: 157371987

Gene position: 4150070-4149465 (Counterclockwise)

Preceding gene: 157371994

Following gene: 157371986

Centisome position: 76.16

GC content: 51.49

Gene sequence:

>606_bases
ATGCGATACTGTCGGCGTTTTCAGGCCCTCAGGAGCAAACCGGTGACACAAAGCGTTCCAGCAATTTTCCTCGATCGTGA
TGGCACGATTAATGTCGATCATGGCTACGTTCATGAAATCGATAATTTCCATTTTATAGATGGCGTGATTGACGCCTGTC
GCGAACTCAAAAAGATGGGCTTTGCTCTGGTATTGGTGACCAACCAGTCCGGCATCGCGCGCGGCATGTTCAGCGAAGAC
CAATTTATGTACCTGACCGAGTGGATGGACTGGTCGCTGGCCGATCGCGATGTTGACCTGGACGGTATCTATTTCTGTCC
ACATCATCCTGATGCAGTAGTAGAAGAGTTCCGTCAGGTGTGCGACTGCCGTAAACCTCAGCCGGGCATGTTGTTGCAGG
CGCAGCAGGAATTGAACATTGATATGGCTGCTTCTTATATGGTTGGCGATAAACCGGAAGATATGCAGGCAGCAATAGCG
GCAGGTGTCGGGACTAAAGTGCTGGTGCGTACCGGCAAACCTGTCACTGAGCAAGGTGAGAAACTGGCGGATTGGGTGAT
AAACAGCCTGGCAGACCTGCCGGAAGCCATCAAAAAGCGGGTTTAG

Upstream 100 bases:

>100_bases
ACCCTGGCGTGGACCAAGGTATGAGTCAGATGTTAAGGCGTCTAGACGTCCAAGTCAACGATCAACGCTGTTCTCTGCCG
TTCTCAGTGCCGGGTAAAAC

Downstream 100 bases:

>100_bases
TAGGCGTTGTGCATGAATAGTGAGCGGTCAGATAAAAAGTGAATATAAACCCTTGTCATTCTGAACCAGCTCCCTATAAT
GCGCCTCCATCGACACGGAA

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MRYCRRFQALRSKPVTQSVPAIFLDRDGTINVDHGYVHEIDNFHFIDGVIDACRELKKMGFALVLVTNQSGIARGMFSED
QFMYLTEWMDWSLADRDVDLDGIYFCPHHPDAVVEEFRQVCDCRKPQPGMLLQAQQELNIDMAASYMVGDKPEDMQAAIA
AGVGTKVLVRTGKPVTEQGEKLADWVINSLADLPEAIKKRV

Sequences:

>Translated_201_residues
MRYCRRFQALRSKPVTQSVPAIFLDRDGTINVDHGYVHEIDNFHFIDGVIDACRELKKMGFALVLVTNQSGIARGMFSED
QFMYLTEWMDWSLADRDVDLDGIYFCPHHPDAVVEEFRQVCDCRKPQPGMLLQAQQELNIDMAASYMVGDKPEDMQAAIA
AGVGTKVLVRTGKPVTEQGEKLADWVINSLADLPEAIKKRV
>Mature_201_residues
MRYCRRFQALRSKPVTQSVPAIFLDRDGTINVDHGYVHEIDNFHFIDGVIDACRELKKMGFALVLVTNQSGIARGMFSED
QFMYLTEWMDWSLADRDVDLDGIYFCPHHPDAVVEEFRQVCDCRKPQPGMLLQAQQELNIDMAASYMVGDKPEDMQAAIA
AGVGTKVLVRTGKPVTEQGEKLADWVINSLADLPEAIKKRV

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=186, Percent_Identity=82.258064516129, Blast_Score=323, Evalue=4e-90,
Organism=Escherichia coli, GI87082027, Length=149, Percent_Identity=32.2147651006711, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: 3.1.1.-

Molecular weight: Translated: 22710; Mature: 22710

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYCRRFQALRSKPVTQSVPAIFLDRDGTINVDHGYVHEIDNFHFIDGVIDACRELKKMG
CCHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCC
FALVLVTNQSGIARGMFSEDQFMYLTEWMDWSLADRDVDLDGIYFCPHHPDAVVEEFRQV
EEEEEEECCCCCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
CDCRKPQPGMLLQAQQELNIDMAASYMVGDKPEDMQAAIAAGVGTKVLVRTGKPVTEQGE
HCCCCCCCCCEEEHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHH
KLADWVINSLADLPEAIKKRV
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYCRRFQALRSKPVTQSVPAIFLDRDGTINVDHGYVHEIDNFHFIDGVIDACRELKKMG
CCHHHHHHHHHCCCCCCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCC
FALVLVTNQSGIARGMFSEDQFMYLTEWMDWSLADRDVDLDGIYFCPHHPDAVVEEFRQV
EEEEEEECCCCCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
CDCRKPQPGMLLQAQQELNIDMAASYMVGDKPEDMQAAIAAGVGTKVLVRTGKPVTEQGE
HCCCCCCCCCEEEHHHHCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHH
KLADWVINSLADLPEAIKKRV
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430; 12101286 [H]