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The map label for this gene is ptxR [H]

Identifier: 157371949

GI number: 157371949

Start: 4103906

End: 4104802

Strand: Reverse

Name: ptxR [H]

Synonym: Spro_3714

Alternate gene names: 157371949

Gene position: 4104802-4103906 (Counterclockwise)

Preceding gene: 157371952

Following gene: 157371947

Centisome position: 75.33

GC content: 60.42

Gene sequence:

>897_bases
ATGCTTAACCTGCAGCGTTTGGCGATCTTTGTGGCGGTGGTGGATGCGGGCAGCTTCACCGCCGCAGCGGTGGCATTGGG
GCAAACCAAGGCGGTGGTCAGTTTCAATGTCAAACAGTTGGAAAGCGAGTTGGGCGTCTCGTTGCTGGTGCGCAGCACCC
GGCGGTTGGCGTTGACCGATGCCGGTGAACGCTTTTATCAACGCTGTCTGCGGCTACTGCAAGACGCGGAGAATGTGCTG
GATGACGTGCGCCGCGATCACCACGGCCTGAGCGGGGTATTGCGTATCACCACCACGCCGGAGTACGGCGCACAGGTGGT
GGTACCGGCGCTGGCGGCATTTTCCCAGTTGCATCCGCGTTTGCGCATTCAGCATGTTTCTTCTTCTTATCATGCCGATT
TGATTTCGGAGCGCTTCGACGTGGCGATCCGGCTGGGGCAACTGGCGGACTCCAGTCATCACGCAGCGCGGCTCGACAGC
TTTGCCATCCTGCCGGTCGCCTCACCGGCGTATCTGGCCCGTCATCCTGTTGGCTCGCTGGCGCAACTGGCGCAGGCGCA
GTGGATTGCCCACAGCCGACTAAGTTCACCCTTAAACTGGCAGGTGATTACCCCAGAACGGCAGGCGGTGCTGTTCAAAG
TTGAAGATGCCGCCACACTGATGGGCGACAGTGCCGCCGCACTGCTGGCGTTTGCCCTGCACGGTGCCGGGGTGGCATTG
CTGCCAGAATGGCTGGTGCGGCCCGCCATTGCCGAAGGCAAGCTGTGCTCACTGCTGGCAGACCATCAATTCCCGATACA
AAGCATTTATGCACTGTATCCAAACACGCGTCACGTGCCGGAAAAGGTGCGGGCGTTTATTGACTTTCTGCGGGCGCGGG
TAGCCACGGGCGAATAA

Upstream 100 bases:

>100_bases
TCCGGTTGAAGGCCCGCAGTGTAGCGGGTGGGAAACTGCGGATAAATCGGCTGCGAACGATTACACTGTCAAAATAATTT
TGACAATAACGGGCAACACT

Downstream 100 bases:

>100_bases
ACGTCATTATGGCTTCCACTGTCTTCTGGTGTACCCATTCACGCTGAGTATTTGAGGAAGCGCATAACACCGCTGCGTCT
TTCTCCTCTGCGGCCAGAAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLNLQRLAIFVAVVDAGSFTAAAVALGQTKAVVSFNVKQLESELGVSLLVRSTRRLALTDAGERFYQRCLRLLQDAENVL
DDVRRDHHGLSGVLRITTTPEYGAQVVVPALAAFSQLHPRLRIQHVSSSYHADLISERFDVAIRLGQLADSSHHAARLDS
FAILPVASPAYLARHPVGSLAQLAQAQWIAHSRLSSPLNWQVITPERQAVLFKVEDAATLMGDSAAALLAFALHGAGVAL
LPEWLVRPAIAEGKLCSLLADHQFPIQSIYALYPNTRHVPEKVRAFIDFLRARVATGE

Sequences:

>Translated_298_residues
MLNLQRLAIFVAVVDAGSFTAAAVALGQTKAVVSFNVKQLESELGVSLLVRSTRRLALTDAGERFYQRCLRLLQDAENVL
DDVRRDHHGLSGVLRITTTPEYGAQVVVPALAAFSQLHPRLRIQHVSSSYHADLISERFDVAIRLGQLADSSHHAARLDS
FAILPVASPAYLARHPVGSLAQLAQAQWIAHSRLSSPLNWQVITPERQAVLFKVEDAATLMGDSAAALLAFALHGAGVAL
LPEWLVRPAIAEGKLCSLLADHQFPIQSIYALYPNTRHVPEKVRAFIDFLRARVATGE
>Mature_298_residues
MLNLQRLAIFVAVVDAGSFTAAAVALGQTKAVVSFNVKQLESELGVSLLVRSTRRLALTDAGERFYQRCLRLLQDAENVL
DDVRRDHHGLSGVLRITTTPEYGAQVVVPALAAFSQLHPRLRIQHVSSSYHADLISERFDVAIRLGQLADSSHHAARLDS
FAILPVASPAYLARHPVGSLAQLAQAQWIAHSRLSSPLNWQVITPERQAVLFKVEDAATLMGDSAAALLAFALHGAGVAL
LPEWLVRPAIAEGKLCSLLADHQFPIQSIYALYPNTRHVPEKVRAFIDFLRARVATGE

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=294, Percent_Identity=35.3741496598639, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=32.1917808219178, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1789440, Length=288, Percent_Identity=29.1666666666667, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787589, Length=293, Percent_Identity=31.0580204778157, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=28.9115646258503, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI87081978, Length=294, Percent_Identity=30.2721088435374, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787128, Length=303, Percent_Identity=25.7425742574257, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788706, Length=308, Percent_Identity=27.9220779220779, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788481, Length=293, Percent_Identity=26.6211604095563, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789173, Length=296, Percent_Identity=27.027027027027, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1786448, Length=310, Percent_Identity=26.1290322580645, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI157672245, Length=173, Percent_Identity=32.9479768786127, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786713, Length=267, Percent_Identity=25.0936329588015, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787601, Length=273, Percent_Identity=24.1758241758242, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788748, Length=120, Percent_Identity=34.1666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=262, Percent_Identity=27.8625954198473, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=126, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1788887, Length=151, Percent_Identity=34.4370860927152, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32526; Mature: 32526

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLQRLAIFVAVVDAGSFTAAAVALGQTKAVVSFNVKQLESELGVSLLVRSTRRLALTD
CCCHHHHHHHHHEECCCCHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHEEECH
AGERFYQRCLRLLQDAENVLDDVRRDHHGLSGVLRITTTPEYGAQVVVPALAAFSQLHPR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCH
LRIQHVSSSYHADLISERFDVAIRLGQLADSSHHAARLDSFAILPVASPAYLARHPVGSL
HEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCCHHHHHCCCHHH
AQLAQAQWIAHSRLSSPLNWQVITPERQAVLFKVEDAATLMGDSAAALLAFALHGAGVAL
HHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCHHHHHCCHHHHHHHHHHHCCCHHH
LPEWLVRPAIAEGKLCSLLADHQFPIQSIYALYPNTRHVPEKVRAFIDFLRARVATGE
HHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLNLQRLAIFVAVVDAGSFTAAAVALGQTKAVVSFNVKQLESELGVSLLVRSTRRLALTD
CCCHHHHHHHHHEECCCCHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHHHHHHHEEECH
AGERFYQRCLRLLQDAENVLDDVRRDHHGLSGVLRITTTPEYGAQVVVPALAAFSQLHPR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCH
LRIQHVSSSYHADLISERFDVAIRLGQLADSSHHAARLDSFAILPVASPAYLARHPVGSL
HEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCCHHHHHCCCHHH
AQLAQAQWIAHSRLSSPLNWQVITPERQAVLFKVEDAATLMGDSAAALLAFALHGAGVAL
HHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCHHHHHCCHHHHHHHHHHHCCCHHH
LPEWLVRPAIAEGKLCSLLADHQFPIQSIYALYPNTRHVPEKVRAFIDFLRARVATGE
HHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]