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The map label for this gene is ipdC [H]

Identifier: 157371649

GI number: 157371649

Start: 3772794

End: 3774455

Strand: Reverse

Name: ipdC [H]

Synonym: Spro_3412

Alternate gene names: 157371649

Gene position: 3774455-3772794 (Counterclockwise)

Preceding gene: 157371652

Following gene: 157371647

Centisome position: 69.27

GC content: 58.48

Gene sequence:

>1662_bases
ATGAATACGACCTATAGAGTGGCTGATTACCTACTCGATCGTTTGGCTCAGATCGGCATCCGACATTTCTTTGGCGTGCC
GGGTGACTACAACCTGCAGTTTCTCGATCATGTCATCAGTCATCCGCAAATTACCTGGGTAGGCTGCGCTAATGAACTCA
ATGCTGCCTATGCCGCAGATGGTTACGCACGCTGTAAACCGGCCGCCGCTTTATTGACCACCTTTGGCGTGGGCGAACTG
AGCGCGCTCAACGGTATTGCCGGCAGCTACGCCGAATATCTGCCGGTGATCCACGTGGTGGGTGCGCCAACGTTACGCGC
GCAGCGGGCCGGTGATTTGTTGCACCATTCGCTGGGGGACGGTGACTTTGGCCACTTTGCCCGTATGGCGAAAGAGGTGA
CCGTCGCGCAGGCCAGCCTAACCCCCGACAACGCCGAGGCGGAAATCGACCGCCTGCTGACCATCGCGCTGTTTGAGCAC
CGCCCGGTCTATATAGTGTTACCCAGTGAGGTGGCGGAAGCACCGTTGGCATCCCGGCCTGCGCCGCTGGTGTTACGGCA
GGCGCATCTTTCCCAGGCGTCGCTGCAAGCTTTTATCGCCGCCGCGCGGCAAATGCTGTTACCGGCCAGGCGGGTTTCCC
TGCTGGCGGATTTTTTGGCGGAACGTTTTGGGGCGGAAAAAGTGCTGGAACAATGGATGAATGAGGTTGAGATACCGCAT
TCAACCATGCTGCTGGGCAAGAGTGTATTGGATGAAACCCATGCCTGCTTTACCGGCACTTACGCCGGTGCCGCCAGCGA
TCCACAGGTGAAGCAACTGATTGAAGGGGCCGATGTGGTGATTAACGTCGGCGTGCGCTTTACCGATACCATTACCGCCG
GTTTCAGCCATCATCTGCCTGCGGAAAAATGCATTGATCTTCAGCCGTTTGAAGCACGGGTAGGGCAGCAGGTATTTAGC
CAAATCCCGCTGCGTGATGCGGTAATAGCACTGCACCAGTTGACGCTATCGTTGGCAAAACAATGGCCAGTACCGGCCAT
TAAACGCCCGACGTTGCCCGATCCGAACGGCAGCGGCCTGGATCAGCACGGTTTTTGGCAACAGATACAGGACTTTCTGC
GCCCGGGCGATATTTTGATCGCCGAACAGGGCACCGCCTGCTTTGGTGCTGCGGCTCTTGGCCTGCCGCAAGGCTGCCGG
TTTATCGTCCAGTCGCTGTGGGGCTCTATCGGTTACACCCTGCCGGCGGCGTTCGGTGCACAAACGGCGGAGCCGGATCG
GCGGGTGGTGTTGCTGATCGGCGATGGTTCGGCTCAGCTCACGGCGCAGGAACTGGGTTCGATGCTGCGTGATGGACAAA
AGCCGGTGATCTTCCTGCTCAATAATGAGGGGTATACCGTTGAACGGGCCATTCACGGCCCGCAACAGCGTTACAACGAC
ATCGCCCAGTGGAACTGGACGCAGTTACCGCAGGCGCTGGCGGGCGAGCATCAGGTGAAAACGCTGCGGGTCGCCGATCC
GCAGCAGTTGCGTCAGGCGCTGAAAGAAGTTGGCGACAGCCCACAACTGGCCTTTGTGGAAGTGATGCTGCCGAAGATGG
ATATTCCCGAACTGCTCGATAGCGTTTCACGCGCCATTCACTCGCGTAACGCGGCCGCCTGA

Upstream 100 bases:

>100_bases
ACGCTGGGTTGCCAGTCGTTTTTTATACACAAAGCTCGAAATTCATACCACATCTTCGATACTTAATACTGACAATCTCA
AGTGTTGGCAGGTGATGATC

Downstream 100 bases:

>100_bases
TCCGCTGCGTTCTCCAGCAGGCGTTCCAGTAACCAATACCCCGCCGGCCCCGGCGGGGTCAGTTTCGACCATACCGCATC
CACTGAAATCAGCTTCGGCC

Product: thiamine pyrophosphate binding domain-containing protein

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MNTTYRVADYLLDRLAQIGIRHFFGVPGDYNLQFLDHVISHPQITWVGCANELNAAYAADGYARCKPAAALLTTFGVGEL
SALNGIAGSYAEYLPVIHVVGAPTLRAQRAGDLLHHSLGDGDFGHFARMAKEVTVAQASLTPDNAEAEIDRLLTIALFEH
RPVYIVLPSEVAEAPLASRPAPLVLRQAHLSQASLQAFIAAARQMLLPARRVSLLADFLAERFGAEKVLEQWMNEVEIPH
STMLLGKSVLDETHACFTGTYAGAASDPQVKQLIEGADVVINVGVRFTDTITAGFSHHLPAEKCIDLQPFEARVGQQVFS
QIPLRDAVIALHQLTLSLAKQWPVPAIKRPTLPDPNGSGLDQHGFWQQIQDFLRPGDILIAEQGTACFGAAALGLPQGCR
FIVQSLWGSIGYTLPAAFGAQTAEPDRRVVLLIGDGSAQLTAQELGSMLRDGQKPVIFLLNNEGYTVERAIHGPQQRYND
IAQWNWTQLPQALAGEHQVKTLRVADPQQLRQALKEVGDSPQLAFVEVMLPKMDIPELLDSVSRAIHSRNAAA

Sequences:

>Translated_553_residues
MNTTYRVADYLLDRLAQIGIRHFFGVPGDYNLQFLDHVISHPQITWVGCANELNAAYAADGYARCKPAAALLTTFGVGEL
SALNGIAGSYAEYLPVIHVVGAPTLRAQRAGDLLHHSLGDGDFGHFARMAKEVTVAQASLTPDNAEAEIDRLLTIALFEH
RPVYIVLPSEVAEAPLASRPAPLVLRQAHLSQASLQAFIAAARQMLLPARRVSLLADFLAERFGAEKVLEQWMNEVEIPH
STMLLGKSVLDETHACFTGTYAGAASDPQVKQLIEGADVVINVGVRFTDTITAGFSHHLPAEKCIDLQPFEARVGQQVFS
QIPLRDAVIALHQLTLSLAKQWPVPAIKRPTLPDPNGSGLDQHGFWQQIQDFLRPGDILIAEQGTACFGAAALGLPQGCR
FIVQSLWGSIGYTLPAAFGAQTAEPDRRVVLLIGDGSAQLTAQELGSMLRDGQKPVIFLLNNEGYTVERAIHGPQQRYND
IAQWNWTQLPQALAGEHQVKTLRVADPQQLRQALKEVGDSPQLAFVEVMLPKMDIPELLDSVSRAIHSRNAAA
>Mature_553_residues
MNTTYRVADYLLDRLAQIGIRHFFGVPGDYNLQFLDHVISHPQITWVGCANELNAAYAADGYARCKPAAALLTTFGVGEL
SALNGIAGSYAEYLPVIHVVGAPTLRAQRAGDLLHHSLGDGDFGHFARMAKEVTVAQASLTPDNAEAEIDRLLTIALFEH
RPVYIVLPSEVAEAPLASRPAPLVLRQAHLSQASLQAFIAAARQMLLPARRVSLLADFLAERFGAEKVLEQWMNEVEIPH
STMLLGKSVLDETHACFTGTYAGAASDPQVKQLIEGADVVINVGVRFTDTITAGFSHHLPAEKCIDLQPFEARVGQQVFS
QIPLRDAVIALHQLTLSLAKQWPVPAIKRPTLPDPNGSGLDQHGFWQQIQDFLRPGDILIAEQGTACFGAAALGLPQGCR
FIVQSLWGSIGYTLPAAFGAQTAEPDRRVVLLIGDGSAQLTAQELGSMLRDGQKPVIFLLNNEGYTVERAIHGPQQRYND
IAQWNWTQLPQALAGEHQVKTLRVADPQQLRQALKEVGDSPQLAFVEVMLPKMDIPELLDSVSRAIHSRNAAA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=495, Percent_Identity=24.2424242424242, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790104, Length=480, Percent_Identity=23.3333333333333, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=560, Percent_Identity=38.2142857142857, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323073, Length=561, Percent_Identity=37.2549019607843, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321524, Length=558, Percent_Identity=36.3799283154122, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6320123, Length=558, Percent_Identity=33.1541218637993, Blast_Score=310, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6320588, Length=602, Percent_Identity=31.3953488372093, Blast_Score=267, Evalue=2e-72,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 60180; Mature: 60180

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTYRVADYLLDRLAQIGIRHFFGVPGDYNLQFLDHVISHPQITWVGCANELNAAYAAD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCHHHCHHHHCC
GYARCKPAAALLTTFGVGELSALNGIAGSYAEYLPVIHVVGAPTLRAQRAGDLLHHSLGD
CHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
GDFGHFARMAKEVTVAQASLTPDNAEAEIDRLLTIALFEHRPVYIVLPSEVAEAPLASRP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCEEEEECCHHHCCCCCCCC
APLVLRQAHLSQASLQAFIAAARQMLLPARRVSLLADFLAERFGAEKVLEQWMNEVEIPH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCH
STMLLGKSVLDETHACFTGTYAGAASDPQVKQLIEGADVVINVGVRFTDTITAGFSHHLP
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCCEEEHHHHCCCCCCCC
AEKCIDLQPFEARVGQQVFSQIPLRDAVIALHQLTLSLAKQWPVPAIKRPTLPDPNGSGL
HHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DQHGFWQQIQDFLRPGDILIAEQGTACFGAAALGLPQGCRFIVQSLWGSIGYTLPAAFGA
CCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHCC
QTAEPDRRVVLLIGDGSAQLTAQELGSMLRDGQKPVIFLLNNEGYTVERAIHGPQQRYND
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEHHHCCHHHHHHH
IAQWNWTQLPQALAGEHQVKTLRVADPQQLRQALKEVGDSPQLAFVEVMLPKMDIPELLD
HHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHH
SVSRAIHSRNAAA
HHHHHHHHCCCCC
>Mature Secondary Structure
MNTTYRVADYLLDRLAQIGIRHFFGVPGDYNLQFLDHVISHPQITWVGCANELNAAYAAD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCHHHCHHHHCC
GYARCKPAAALLTTFGVGELSALNGIAGSYAEYLPVIHVVGAPTLRAQRAGDLLHHSLGD
CHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
GDFGHFARMAKEVTVAQASLTPDNAEAEIDRLLTIALFEHRPVYIVLPSEVAEAPLASRP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCEEEEECCHHHCCCCCCCC
APLVLRQAHLSQASLQAFIAAARQMLLPARRVSLLADFLAERFGAEKVLEQWMNEVEIPH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCH
STMLLGKSVLDETHACFTGTYAGAASDPQVKQLIEGADVVINVGVRFTDTITAGFSHHLP
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCCEEEHHHHCCCCCCCC
AEKCIDLQPFEARVGQQVFSQIPLRDAVIALHQLTLSLAKQWPVPAIKRPTLPDPNGSGL
HHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DQHGFWQQIQDFLRPGDILIAEQGTACFGAAALGLPQGCRFIVQSLWGSIGYTLPAAFGA
CCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHCC
QTAEPDRRVVLLIGDGSAQLTAQELGSMLRDGQKPVIFLLNNEGYTVERAIHGPQQRYND
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEHHHCCHHHHHHH
IAQWNWTQLPQALAGEHQVKTLRVADPQQLRQALKEVGDSPQLAFVEVMLPKMDIPELLD
HHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHH
SVSRAIHSRNAAA
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]