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The map label for this gene is nuoC [H]

Identifier: 157371543

GI number: 157371543

Start: 3660474

End: 3662270

Strand: Reverse

Name: nuoC [H]

Synonym: Spro_3306

Alternate gene names: 157371543

Gene position: 3662270-3660474 (Counterclockwise)

Preceding gene: 157371544

Following gene: 157371542

Centisome position: 67.21

GC content: 56.54

Gene sequence:

>1797_bases
ATGACAGATTCAACGACGCACGACGCATTGCCGGCCTGGCAAACCAGAGATCACCTTGACGACCCGGTGATTGGCGAACT
GCGCAACCGTTTTGGGCCGGAAGCCTTTACTGTTCAGCCCACCCGTACCGGAATGCCCGTGGTATGGGTCAAACCTGACC
AGTTACTGGAAGTAATGACGTTTTTGAGAAAACAGCCGAAGCCTTACGTCATGCTGTTCGATCTGCATGGCGTGGACGAG
CGTCTTCGCACCCACCGCGACGGTTTGCCGGCTGCGGATTTTTCTGTTTTCTATCATCTGATTTCTATCGAACGCAACCG
CGACATCATGCTGAAAGTGGCGCTGTCTGAAAAAGACCTGCACGTGCCCACAGCGACCAAGGTTTTCCCTAATGCCAACT
GGTATGAGCGTGAAACCTGGGAAATGTTCGGTATTACCTTCGACGGCCACCCGCACCTGTCGCGCATCATGATGCCGCAA
ACCTGGGAAGGCCACCCGCTGCGTAAAGACTACCCGGCACGCGCCACCGAGTTCGATCCCTTTGTGTTGACCAAACAGAA
AGAAGATCTGGAAATGGAAGCGCTGACCTTCAAACCGGAAGACTGGGGCATGAAGCGCGGCACCGAGAACGAGGACTTCA
TGTTCCTTAACCTCGGCCCGAACCACCCGTCTGCGCACGGTGCATTCCGTATCATTCTGCAGCTGGATGGCGAAGAGATT
GTCGACTGCGTACCGGATATCGGTTACCACCACCGTGGCGCCGAGAAGATGGGCGAGCGTCAGTCCTGGCACAGCTACAT
TCCGTACACCGACCGTATCGAGTACCTCGGCGGCTGCGTGAACGAAATGCCTTACGTGCTGGCGGTTGAGAAACTGGCCG
GTATCAAGGTGCCGGATCGCGTTGATACCATCCGCGTGATGCTGTCCGAACTGTTCCGTATCAACAGCCACCTGCTGTAC
ATCAGTACGTTCATTCAGGACGTCGGCGCCATGACCCCGGTGTTCTTCGCCTTTACCGACCGTCAGAAAATCTACGATCT
GGTTGAAGCGATTACCGGTTTCCGTATGCACCCGGCCTGGTTCCGTATTGGCGGTGTCGCACACGACCTGCCGCGCGGTT
GGGACCGTCTGTTGCGCGAGTTCCTTGAGTGGATGCCAAAACGTCTGGATTCCTACGTCAAGGCTGCGTTGAAGAACAGC
ATCCTGAAGGGCCGTTCCGTCGGCGTGGCATCCTACAATGCTAAAGAAGCGTTGGAGTGGGGCGTCACTGGTGCAGGCCT
GCGCGCCACCGGTATCGAGTTCGATGTGCGTAAATGGCGTCCGTATTCCGGCTATGAGAATTTCGACTTCGAAGTTCCGG
TCGGTGACGGCAACAGCGACTGCTACACCCGCGTAATGCTGAAGGTGGAAGAGCTGCGTCAGAGCCTGCGCATTCTCGAA
CAGTGCCTGAACAACATGCCGGAAGGCCCGTTCAAGGCCGATCACCCGCTGACCACGCCGCCGCCGAAAGAGCGCACGCT
GCAGCACATTGAAACGCTGATCACCCACTTCCTGCAGGTTTCCTGGGGCCCGGTGATGCCAGCCAACGAATCATTCCAGA
TGATTGAAGCCACAAAAGGGATCAACAGCTACTACCTGACCAGCGACGGCAGCACCATGAGCTATCGCACCCGGGTACGT
ACGCCAAGCTTTGCGCACCTGCAGCAAATCCCAGCGGTAATCCGTGGCAGCCTGGTCTCCGACCTGATCGTCTATCTGGG
TAGTATCGATTTTGTAATGTCAGATGTGGACCGCTAA

Upstream 100 bases:

>100_bases
TTTAAGACGTTCATTTAACGTCCATCTTAGTGCGCTATTGGTTAACACAGCGAAAAGTGAACTTGCGGCGAAATAACCCT
TCAGTGTGGTGAAAAAAATT

Downstream 100 bases:

>100_bases
CTATGCATGATCAAAAAGACAATCACGCGAATAACCAAGCGCTTGAACCTATCAATGCGGCCGCTCCCCAGAGCGGCGTT
GATGCATTTGAGCTGAGTGC

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MTDSTTHDALPAWQTRDHLDDPVIGELRNRFGPEAFTVQPTRTGMPVVWVKPDQLLEVMTFLRKQPKPYVMLFDLHGVDE
RLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSEKDLHVPTATKVFPNANWYERETWEMFGITFDGHPHLSRIMMPQ
TWEGHPLRKDYPARATEFDPFVLTKQKEDLEMEALTFKPEDWGMKRGTENEDFMFLNLGPNHPSAHGAFRIILQLDGEEI
VDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIKVPDRVDTIRVMLSELFRINSHLLY
ISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYVKAALKNS
ILKGRSVGVASYNAKEALEWGVTGAGLRATGIEFDVRKWRPYSGYENFDFEVPVGDGNSDCYTRVMLKVEELRQSLRILE
QCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRVR
TPSFAHLQQIPAVIRGSLVSDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_598_residues
MTDSTTHDALPAWQTRDHLDDPVIGELRNRFGPEAFTVQPTRTGMPVVWVKPDQLLEVMTFLRKQPKPYVMLFDLHGVDE
RLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSEKDLHVPTATKVFPNANWYERETWEMFGITFDGHPHLSRIMMPQ
TWEGHPLRKDYPARATEFDPFVLTKQKEDLEMEALTFKPEDWGMKRGTENEDFMFLNLGPNHPSAHGAFRIILQLDGEEI
VDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIKVPDRVDTIRVMLSELFRINSHLLY
ISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYVKAALKNS
ILKGRSVGVASYNAKEALEWGVTGAGLRATGIEFDVRKWRPYSGYENFDFEVPVGDGNSDCYTRVMLKVEELRQSLRILE
QCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRVR
TPSFAHLQQIPAVIRGSLVSDLIVYLGSIDFVMSDVDR
>Mature_597_residues
TDSTTHDALPAWQTRDHLDDPVIGELRNRFGPEAFTVQPTRTGMPVVWVKPDQLLEVMTFLRKQPKPYVMLFDLHGVDER
LRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSEKDLHVPTATKVFPNANWYERETWEMFGITFDGHPHLSRIMMPQT
WEGHPLRKDYPARATEFDPFVLTKQKEDLEMEALTFKPEDWGMKRGTENEDFMFLNLGPNHPSAHGAFRIILQLDGEEIV
DCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIKVPDRVDTIRVMLSELFRINSHLLYI
STFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYVKAALKNSI
LKGRSVGVASYNAKEALEWGVTGAGLRATGIEFDVRKWRPYSGYENFDFEVPVGDGNSDCYTRVMLKVEELRQSLRILEQ
CLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRVRT
PSFAHLQQIPAVIRGSLVSDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=40.7310704960835, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=40.4825737265416, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI4758788, Length=126, Percent_Identity=40.4761904761905, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI145693162, Length=598, Percent_Identity=91.304347826087, Blast_Score=1141, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=563, Percent_Identity=26.2877442273535, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1788832, Length=595, Percent_Identity=26.5546218487395, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17555284, Length=428, Percent_Identity=40.1869158878505, Blast_Score=334, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI17568379, Length=428, Percent_Identity=39.2523364485981, Blast_Score=332, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI71990788, Length=124, Percent_Identity=32.258064516129, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563621, Length=124, Percent_Identity=32.258064516129, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=39.3229166666667, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24638644, Length=383, Percent_Identity=40.4699738903394, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24656494, Length=126, Percent_Identity=36.5079365079365, Blast_Score=83, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68762; Mature: 68630

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTTHDALPAWQTRDHLDDPVIGELRNRFGPEAFTVQPTRTGMPVVWVKPDQLLEVMT
CCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCEEECCCCCCCCEEEECHHHHHHHHH
FLRKQPKPYVMLFDLHGVDERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSEKDL
HHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHEECCCCEEEEEEECCCCC
HVPTATKVFPNANWYERETWEMFGITFDGHPHLSRIMMPQTWEGHPLRKDYPARATEFDP
CCCCCCEECCCCCCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
FVLTKQKEDLEMEALTFKPEDWGMKRGTENEDFMFLNLGPNHPSAHGAFRIILQLDGEEI
EEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHH
VDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIKVPDR
HHHHCCCCCCCCCHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCH
VDTIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAW
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCHH
FRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYVKAALKNSILKGRSVGVASYNAKEALEW
HEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHH
GVTGAGLRATGIEFDVRKWRPYSGYENFDFEVPVGDGNSDCYTRVMLKVEELRQSLRILE
CCCCCCCEECCCEEEHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKG
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCC
INSYYLTSDGSTMSYRTRVRTPSFAHLQQIPAVIRGSLVSDLIVYLGSIDFVMSDVDR
CCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
TDSTTHDALPAWQTRDHLDDPVIGELRNRFGPEAFTVQPTRTGMPVVWVKPDQLLEVMT
CCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCEEECCCCCCCCEEEECHHHHHHHHH
FLRKQPKPYVMLFDLHGVDERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSEKDL
HHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHEECCCCEEEEEEECCCCC
HVPTATKVFPNANWYERETWEMFGITFDGHPHLSRIMMPQTWEGHPLRKDYPARATEFDP
CCCCCCEECCCCCCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
FVLTKQKEDLEMEALTFKPEDWGMKRGTENEDFMFLNLGPNHPSAHGAFRIILQLDGEEI
EEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHH
VDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIKVPDR
HHHHCCCCCCCCCHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCH
VDTIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAW
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCHH
FRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYVKAALKNSILKGRSVGVASYNAKEALEW
HEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHH
GVTGAGLRATGIEFDVRKWRPYSGYENFDFEVPVGDGNSDCYTRVMLKVEELRQSLRILE
CCCCCCCEECCCEEEHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKG
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCC
INSYYLTSDGSTMSYRTRVRTPSFAHLQQIPAVIRGSLVSDLIVYLGSIDFVMSDVDR
CCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA