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The map label for this gene is menB [H]

Identifier: 157371518

GI number: 157371518

Start: 3624364

End: 3625221

Strand: Reverse

Name: menB [H]

Synonym: Spro_3281

Alternate gene names: 157371518

Gene position: 3625221-3624364 (Counterclockwise)

Preceding gene: 157371519

Following gene: 157371517

Centisome position: 66.53

GC content: 57.58

Gene sequence:

>858_bases
ATGCTCTATCCAAATGAAGAACAGCTGTATGCCGCTATCGAATGGCAGGATTGCTCCGGTGATTTCGAAGATATTCTGTA
TCACAAGTCCAGCGACGGCATCGCTAAAATCACTATCAACCGTCCACAGGTACGTAATGCCTTCCGCCCGCACACGGTAA
AGGAGATGATTGAAGCGCTGTCCAATGCCCGTTACGACGACGGCATTGGCACCATTATCCTCACCGGTGCCGGTGACAAA
GCCTTCTGCTCCGGCGGCGATCAGAAAGTCCGCGGCGACTACGGCGGCTATCAGGATGACAGCGGTGTACATCACCTGAA
CGTGCTCGACTTCCAGCGCCAGATCCGTACCTGTCCGAAGCCGATAGTGGCGATGGTGGCTGGCTATTCAATCGGTGGCG
GCCACGTACTGCACATGATGTGTGACCTGACCATTGCGGCGGACAACGCTATTTTCGGCCAGACCGGCCCGAAAGTGGGC
TCTTTCGACGGCGGCTGGGGCGCTTCCTACATGGCGCGCATCGTGGGTCAGAAGAAGGCTCGCGAAATCTGGTTCCTGTG
TCGTCAGTATGACGCCGCTGCGGCTTTGGACATGGGCCTGGTCAATACCGTGGTGCCTTTGGCCGATCTGGAGAAAGAAA
CCGTGCGCTGGTGCCGCGAAATGCTGCAGAACAGCCCGATGGCGCTGCGCTGTCTGAAAGCGGCCCTGAACGCCGACTGT
GACGGTCAGGCCGGTCTGCAGGAGCTGGCGGGTAACGCCACCATGCTGTTCTACATGACTGACGAAGGCCAGGAAGGACG
CAACGCGTTTAACGAAAAGCGCCAGCCGGACTTCAGCAAATTCAAGCGTAACCCGTAA

Upstream 100 bases:

>100_bases
TCGTGCCGCAGGCCGGGCATAACTCGCACCTGGCCAATCCGCAGGCGTTCGCCGCCGAGCTGCGCAATTTTCTCGTTAAC
CCTGGTTAAAGGAACCGAAC

Downstream 100 bases:

>100_bases
TGAACACAACCCCCCGTAACGCGGCCCTTTACCGTTACAGCCTGCCAATGGACGCGGGCGTTGTGTTGCGCAATCAGCGG
CTAAAAACCCGCGATGGTTT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLYPNEEQLYAAIEWQDCSGDFEDILYHKSSDGIAKITINRPQVRNAFRPHTVKEMIEALSNARYDDGIGTIILTGAGDK
AFCSGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPIVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAAAALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP

Sequences:

>Translated_285_residues
MLYPNEEQLYAAIEWQDCSGDFEDILYHKSSDGIAKITINRPQVRNAFRPHTVKEMIEALSNARYDDGIGTIILTGAGDK
AFCSGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPIVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAAAALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP
>Mature_285_residues
MLYPNEEQLYAAIEWQDCSGDFEDILYHKSSDGIAKITINRPQVRNAFRPHTVKEMIEALSNARYDDGIGTIILTGAGDK
AFCSGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPKPIVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRQYDAAAALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=264, Percent_Identity=32.5757575757576, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=30.1204819277108, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI45643119, Length=215, Percent_Identity=30.2325581395349, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI260275230, Length=215, Percent_Identity=30.2325581395349, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI260274832, Length=220, Percent_Identity=30.4545454545455, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4502327, Length=259, Percent_Identity=28.1853281853282, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI213417737, Length=221, Percent_Identity=25.3393665158371, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI25453481, Length=254, Percent_Identity=24.8031496062992, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI51538573, Length=254, Percent_Identity=24.8031496062992, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI157694516, Length=221, Percent_Identity=25.3393665158371, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4757966, Length=254, Percent_Identity=24.8031496062992, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI51538581, Length=254, Percent_Identity=24.8031496062992, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI37594469, Length=156, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4757968, Length=254, Percent_Identity=25.1968503937008, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI49355787, Length=254, Percent_Identity=25.1968503937008, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI37594471, Length=156, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI70995211, Length=238, Percent_Identity=27.3109243697479, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=91.5789473684211, Blast_Score=553, Evalue=1e-159,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=30.3643724696356, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI221142681, Length=255, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082183, Length=255, Percent_Identity=27.4509803921569, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787660, Length=268, Percent_Identity=29.4776119402985, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=30.9803921568627, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=30.241935483871, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=206, Percent_Identity=29.6116504854369, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=26.1904761904762, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=25.3807106598985, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=27.6515151515151, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=215, Percent_Identity=27.4418604651163, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129971, Length=250, Percent_Identity=34, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653477, Length=250, Percent_Identity=34, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653139, Length=270, Percent_Identity=27.4074074074074, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=31.2169312169312, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24650670, Length=187, Percent_Identity=31.5508021390374, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31475; Mature: 31475

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPNEEQLYAAIEWQDCSGDFEDILYHKSSDGIAKITINRPQVRNAFRPHTVKEMIEAL
CCCCCCCCEEEEEEECCCCCCHHHHHEECCCCCEEEEEECCHHHHCCCCCHHHHHHHHHH
SNARYDDGIGTIILTGAGDKAFCSGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCCEEEEECCCCCCEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PIVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAAAALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MLYPNEEQLYAAIEWQDCSGDFEDILYHKSSDGIAKITINRPQVRNAFRPHTVKEMIEAL
CCCCCCCCEEEEEEECCCCCCHHHHHEECCCCCEEEEEECCHHHHCCCCCHHHHHHHHHH
SNARYDDGIGTIILTGAGDKAFCSGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCCEEEEECCCCCCEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PIVAMVAGYSIGGGHVLHMMCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYDAAAALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]