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The map label for this gene is tyrB [H]

Identifier: 157371327

GI number: 157371327

Start: 3398346

End: 3399533

Strand: Reverse

Name: tyrB [H]

Synonym: Spro_3088

Alternate gene names: 157371327

Gene position: 3399533-3398346 (Counterclockwise)

Preceding gene: 157371328

Following gene: 157371326

Centisome position: 62.39

GC content: 57.58

Gene sequence:

>1188_bases
ATGTTTAATCACATTGGCCGTTCGGCGGCCGATCCTATTATGTCGTTGATGGAAGCTTATTTACGGGATGAAAATACGCA
GAAAGTTAATCTGGGTATTGGTCTTTATTACGATCAGCAAGGGCGGATCCCACTGATGCAAGCGGTTGAGGCCGCCGAGC
GGCAGTTGCTCGATCAGCGTCGCCCGCATGGATATCCGCCGATAGAAGGCTCGGCGCTGTTTGCCCAGCAGGTACAGACC
TTGTTGTTCGGTGAAGCGGCATCAGCGTCGATTAGCACGGTACAAACCGTTGGTGGTTCAGGTGCTCTGAAGCTGGCGGC
GGATTTTATCCATCACTACCTGTCCCGCCATGATATCTGGGTGTCAGATCCTACCTGGGCCAACCATTGGGCGATCTTCG
AGGGCGCCGGGCTGAAGGTACATACCTATCCGTATTTCGATGAGGCCAACGGCGGCCTGCGTTTTGACGCCATGCTCGAT
ACGTTGGACAGCCTGCCGGAAGGCAGCGTGGTGCTGTTGCACCCTTGCTGTCATAACCCGACCGGCACCGATCTCAGCCC
GGCGCAGTGGCGTGCCACGCTTGAGGTGGTGCAGCGCCGCCGCCTGCTGCCGTTGTTCGATATTGCCTATCAGGGCTTTG
GCGATAGTCTGGACGAGGATTGTTTTGCGCTGCGTGAGGCATTGAAAACCGACCTGGAATTTTTGGTCGCCAATTCGTTT
TCGAAAAACGTCGCGCTGTATGGCCAGCGGCTGGGGGGGCTTTCGGTCCGCTGCGCCAGTCCGGAGAGTGCGAACAACCT
CAAGGACGCGTTGAAAACCTTGATCCGCCGCAGCTATTCCTGCCCGCCGACTCACGGCAGCCAGATTGTGGAAACGCTGT
TGGCGGATGCCAACTTGCGCCAGCAGTGGGAAAGCGAACTGGCCGGCATGCGTCAACGTATCAAACAGATGCGTCAAACC
CTGGCTAACGGGCTGGAGCAGGGCGGTTCGCCGTTGGACTACCGGCGCATTCGCGACCAGAAAGGCATGTTCAGTTACAC
CGGATTGAACCCGCAGCAGCTCGAGCGGCTACGGCAAGATTACGCCATCTATCTGGTGGCGCCCGGCCGCATGTGTTTGC
CCGGCCTGAATCAAAACAATGTCGACTACGTGACTGCCGCCATCCTGGATGTCACCCGTACTGTGTGA

Upstream 100 bases:

>100_bases
CAGGCATGAAAATAGAAATAACCGTCACTGCTACTGCCTGAAAATAGATAACTATAATCCCCACCTGCAAATTCATTAAA
TAATGAATTAAGGAATCGCT

Downstream 100 bases:

>100_bases
ATAAGGTAGGACCGCCATGAAACAGATGAAAGGTTTTGAAGAAATTGCGCGGCGGCAGGGCGGGTTGAAGAAACAGCTCA
CCGCCGGGCAGATGACCATG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: TyrAT; Aromatic-amino-acid transaminase; Aspartate aminotransferase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MFNHIGRSAADPIMSLMEAYLRDENTQKVNLGIGLYYDQQGRIPLMQAVEAAERQLLDQRRPHGYPPIEGSALFAQQVQT
LLFGEAASASISTVQTVGGSGALKLAADFIHHYLSRHDIWVSDPTWANHWAIFEGAGLKVHTYPYFDEANGGLRFDAMLD
TLDSLPEGSVVLLHPCCHNPTGTDLSPAQWRATLEVVQRRRLLPLFDIAYQGFGDSLDEDCFALREALKTDLEFLVANSF
SKNVALYGQRLGGLSVRCASPESANNLKDALKTLIRRSYSCPPTHGSQIVETLLADANLRQQWESELAGMRQRIKQMRQT
LANGLEQGGSPLDYRRIRDQKGMFSYTGLNPQQLERLRQDYAIYLVAPGRMCLPGLNQNNVDYVTAAILDVTRTV

Sequences:

>Translated_395_residues
MFNHIGRSAADPIMSLMEAYLRDENTQKVNLGIGLYYDQQGRIPLMQAVEAAERQLLDQRRPHGYPPIEGSALFAQQVQT
LLFGEAASASISTVQTVGGSGALKLAADFIHHYLSRHDIWVSDPTWANHWAIFEGAGLKVHTYPYFDEANGGLRFDAMLD
TLDSLPEGSVVLLHPCCHNPTGTDLSPAQWRATLEVVQRRRLLPLFDIAYQGFGDSLDEDCFALREALKTDLEFLVANSF
SKNVALYGQRLGGLSVRCASPESANNLKDALKTLIRRSYSCPPTHGSQIVETLLADANLRQQWESELAGMRQRIKQMRQT
LANGLEQGGSPLDYRRIRDQKGMFSYTGLNPQQLERLRQDYAIYLVAPGRMCLPGLNQNNVDYVTAAILDVTRTV
>Mature_395_residues
MFNHIGRSAADPIMSLMEAYLRDENTQKVNLGIGLYYDQQGRIPLMQAVEAAERQLLDQRRPHGYPPIEGSALFAQQVQT
LLFGEAASASISTVQTVGGSGALKLAADFIHHYLSRHDIWVSDPTWANHWAIFEGAGLKVHTYPYFDEANGGLRFDAMLD
TLDSLPEGSVVLLHPCCHNPTGTDLSPAQWRATLEVVQRRRLLPLFDIAYQGFGDSLDEDCFALREALKTDLEFLVANSF
SKNVALYGQRLGGLSVRCASPESANNLKDALKTLIRRSYSCPPTHGSQIVETLLADANLRQQWESELAGMRQRIKQMRQT
LANGLEQGGSPLDYRRIRDQKGMFSYTGLNPQQLERLRQDYAIYLVAPGRMCLPGLNQNNVDYVTAAILDVTRTV

Specific function: catalyzes the formation of methionine from 2-keto-4- methylthiobutyrate (KMTB) primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) or glutamate as the amino donors. Histidine, leucine, asparagine, or arginine are also functional

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=399, Percent_Identity=38.0952380952381, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI4504067, Length=395, Percent_Identity=36.7088607594937, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=25.7217847769029, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1790488, Length=398, Percent_Identity=47.9899497487437, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1787159, Length=395, Percent_Identity=41.2658227848101, Blast_Score=333, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=37.5314861460957, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI25147133, Length=397, Percent_Identity=37.5314861460957, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17569539, Length=385, Percent_Identity=37.1428571428571, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17569537, Length=401, Percent_Identity=31.4214463840399, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17550384, Length=271, Percent_Identity=35.0553505535055, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25147136, Length=211, Percent_Identity=35.5450236966825, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323055, Length=407, Percent_Identity=37.8378378378378, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322743, Length=433, Percent_Identity=33.256351039261, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24580972, Length=399, Percent_Identity=36.5914786967419, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24580970, Length=399, Percent_Identity=36.5914786967419, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI19920542, Length=390, Percent_Identity=37.1794871794872, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI19922362, Length=397, Percent_Identity=37.7833753148615, Blast_Score=271, Evalue=5e-73,
Organism=Drosophila melanogaster, GI24654046, Length=397, Percent_Identity=37.7833753148615, Blast_Score=271, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.5; =2.6.1.57; =2.6.1.1 [H]

Molecular weight: Translated: 44029; Mature: 44029

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNHIGRSAADPIMSLMEAYLRDENTQKVNLGIGLYYDQQGRIPLMQAVEAAERQLLDQR
CCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
RPHGYPPIEGSALFAQQVQTLLFGEAASASISTVQTVGGSGALKLAADFIHHYLSRHDIW
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEE
VSDPTWANHWAIFEGAGLKVHTYPYFDEANGGLRFDAMLDTLDSLPEGSVVLLHPCCHNP
ECCCCCCCCEEEEECCCEEEEECCCEECCCCCEEHHHHHHHHHCCCCCCEEEEECCCCCC
TGTDLSPAQWRATLEVVQRRRLLPLFDIAYQGFGDSLDEDCFALREALKTDLEFLVANSF
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
SKNVALYGQRLGGLSVRCASPESANNLKDALKTLIRRSYSCPPTHGSQIVETLLADANLR
CCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHH
QQWESELAGMRQRIKQMRQTLANGLEQGGSPLDYRRIRDQKGMFSYTGLNPQQLERLRQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHC
YAIYLVAPGRMCLPGLNQNNVDYVTAAILDVTRTV
CEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFNHIGRSAADPIMSLMEAYLRDENTQKVNLGIGLYYDQQGRIPLMQAVEAAERQLLDQR
CCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
RPHGYPPIEGSALFAQQVQTLLFGEAASASISTVQTVGGSGALKLAADFIHHYLSRHDIW
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEE
VSDPTWANHWAIFEGAGLKVHTYPYFDEANGGLRFDAMLDTLDSLPEGSVVLLHPCCHNP
ECCCCCCCCEEEEECCCEEEEECCCEECCCCCEEHHHHHHHHHCCCCCCEEEEECCCCCC
TGTDLSPAQWRATLEVVQRRRLLPLFDIAYQGFGDSLDEDCFALREALKTDLEFLVANSF
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
SKNVALYGQRLGGLSVRCASPESANNLKDALKTLIRRSYSCPPTHGSQIVETLLADANLR
CCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHH
QQWESELAGMRQRIKQMRQTLANGLEQGGSPLDYRRIRDQKGMFSYTGLNPQQLERLRQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHC
YAIYLVAPGRMCLPGLNQNNVDYVTAAILDVTRTV
CEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10074065 [H]