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The map label for this gene is pcaR [H]

Identifier: 157371276

GI number: 157371276

Start: 3345422

End: 3346255

Strand: Reverse

Name: pcaR [H]

Synonym: Spro_3036

Alternate gene names: 157371276

Gene position: 3346255-3345422 (Counterclockwise)

Preceding gene: 157371284

Following gene: 157371272

Centisome position: 61.41

GC content: 57.91

Gene sequence:

>834_bases
ATGAGTGATGCGTCGGAGTCTGGTGCTGGAGAACTGCGTCGGTTGCAGGAAATCGGGGAGTTAAGCAACGATCAATATAA
GGGTGACCCCAATTTTATGGCGTCGTTGGCCAGGGGACTGGAGGTGCTGCAGGCCTTCCAGCCGCAGTATTCACAAATGT
CGGTTTCTGAAATCAGCCAAATTACCGGTATCCCTCGTGCGGCGGTGCGGCGTTGCCTGTACACCCTGCGTGCGTTGGGA
TTTGTGCATTGCCCTGACGGCCGCCATTACCGGCTGCTGCCGCGGGTGCTGACCATCGGGCACGCCTATCTTTCTTCTTC
CGAACTGGCGAAAGCGGCGCAGAACTCGCTGGACTACCTCAGTAAGCTGCTGAATGAATCCTGCTCGGTGGCAACGCTGG
ACGGTGACAATATCCTGTATATCGCCCGCGCTTCGGTGAAGCGTATTATGACAATCGATTTGGGGCGCGGCAGCCGCCTG
CCGGCCTATGCGACTTCGATGGGACTGGTCTTGCTCAGTTCGCTGGATGAAGAACAGTTGGACGATTATCTGTCGCGGGT
CAGTTTCGAACCGCTGACCGAATTCACCGTGACCAGCGCCGAGCAACTGCGTGAACAGTTGGCTAAAGTGCGTCGGCAAG
GCTATGCCATCAACGATCAACAGTTGGAAATTGGTCTGCGTTCGATCGCGGTGCCGATGCATTCCCGCAAGGGCGGCGTA
GTCGCGGCGATGAACGTGGGCGTCAACGCTTCACAAATTTCGTCGGCGGAACTGCGTGAGCGGGTGCTGCCACAGCTGCA
ACGCACGGCGATGGAGCTGGCGCTGCTGCTGTAG

Upstream 100 bases:

>100_bases
CGACAAGTGCGAATATCAGCGTATTGTGCGATTATCGAAACATTAGTCCTTTGGTGATCAATTCTGTGATACGGATAACT
ATATTGAGTCGGAGGTCAGG

Downstream 100 bases:

>100_bases
CTCGCGGTTGGATGAGCACCGCTAAATGGTCATCGGCTGTTTCTCATTGCCGATGGCCAGCGGCGGCAAGGGGGACCAAC
AGCAGGCTCAACCGGCTGGT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSDASESGAGELRRLQEIGELSNDQYKGDPNFMASLARGLEVLQAFQPQYSQMSVSEISQITGIPRAAVRRCLYTLRALG
FVHCPDGRHYRLLPRVLTIGHAYLSSSELAKAAQNSLDYLSKLLNESCSVATLDGDNILYIARASVKRIMTIDLGRGSRL
PAYATSMGLVLLSSLDEEQLDDYLSRVSFEPLTEFTVTSAEQLREQLAKVRRQGYAINDQQLEIGLRSIAVPMHSRKGGV
VAAMNVGVNASQISSAELRERVLPQLQRTAMELALLL

Sequences:

>Translated_277_residues
MSDASESGAGELRRLQEIGELSNDQYKGDPNFMASLARGLEVLQAFQPQYSQMSVSEISQITGIPRAAVRRCLYTLRALG
FVHCPDGRHYRLLPRVLTIGHAYLSSSELAKAAQNSLDYLSKLLNESCSVATLDGDNILYIARASVKRIMTIDLGRGSRL
PAYATSMGLVLLSSLDEEQLDDYLSRVSFEPLTEFTVTSAEQLREQLAKVRRQGYAINDQQLEIGLRSIAVPMHSRKGGV
VAAMNVGVNASQISSAELRERVLPQLQRTAMELALLL
>Mature_276_residues
SDASESGAGELRRLQEIGELSNDQYKGDPNFMASLARGLEVLQAFQPQYSQMSVSEISQITGIPRAAVRRCLYTLRALGF
VHCPDGRHYRLLPRVLTIGHAYLSSSELAKAAQNSLDYLSKLLNESCSVATLDGDNILYIARASVKRIMTIDLGRGSRLP
AYATSMGLVLLSSLDEEQLDDYLSRVSFEPLTEFTVTSAEQLREQLAKVRRQGYAINDQQLEIGLRSIAVPMHSRKGGVV
AAMNVGVNASQISSAELRERVLPQLQRTAMELALLL

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=245, Percent_Identity=30.2040816326531, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788131, Length=243, Percent_Identity=30.0411522633745, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI87082359, Length=229, Percent_Identity=26.6375545851528, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786715, Length=222, Percent_Identity=27.4774774774775, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789999, Length=263, Percent_Identity=23.9543726235741, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI145693096, Length=229, Percent_Identity=27.9475982532751, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788581, Length=215, Percent_Identity=24.1860465116279, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30490; Mature: 30359

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDASESGAGELRRLQEIGELSNDQYKGDPNFMASLARGLEVLQAFQPQYSQMSVSEISQ
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ITGIPRAAVRRCLYTLRALGFVHCPDGRHYRLLPRVLTIGHAYLSSSELAKAAQNSLDYL
HCCCCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLLNESCSVATLDGDNILYIARASVKRIMTIDLGRGSRLPAYATSMGLVLLSSLDEEQL
HHHHCCCCCEEEECCCCEEEEEHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHH
DDYLSRVSFEPLTEFTVTSAEQLREQLAKVRRQGYAINDQQLEIGLRSIAVPMHSRKGGV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCE
VAAMNVGVNASQISSAELRERVLPQLQRTAMELALLL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDASESGAGELRRLQEIGELSNDQYKGDPNFMASLARGLEVLQAFQPQYSQMSVSEISQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ITGIPRAAVRRCLYTLRALGFVHCPDGRHYRLLPRVLTIGHAYLSSSELAKAAQNSLDYL
HCCCCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLLNESCSVATLDGDNILYIARASVKRIMTIDLGRGSRLPAYATSMGLVLLSSLDEEQL
HHHHCCCCCEEEECCCCEEEEEHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHH
DDYLSRVSFEPLTEFTVTSAEQLREQLAKVRRQGYAINDQQLEIGLRSIAVPMHSRKGGV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCE
VAAMNVGVNASQISSAELRERVLPQLQRTAMELALLL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]