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The map label for this gene is patB [H]

Identifier: 157371029

GI number: 157371029

Start: 3067465

End: 3068616

Strand: Direct

Name: patB [H]

Synonym: Spro_2789

Alternate gene names: 157371029

Gene position: 3067465-3068616 (Clockwise)

Preceding gene: 157371027

Following gene: 157371031

Centisome position: 56.3

GC content: 57.47

Gene sequence:

>1152_bases
ATGGCATTCAATTTTGATCAATGGGTAGACCGTAGTCACAGTGACAGCGTTAAGTGGGATAAATATCGCGACCGCGACAT
TATTCCACTCTGGGTCGCTGATACCGACTTCCCGTCACCGCCGGCCGTCATCGACGCATTACAGCAGCGCGTAGCCCACG
CGGTGTTCGGCTACAGTCATCCCTCACCCGAACTTATTGAGGTTTTTACCCGCCGCATGCTGGAACGTTACGGCTGGCGA
ATCAACCCCGAATGGCTGATTTTCCTGCCCGGTCTGGTTTGCGGTCTTAATTTATGCGTGCGTGCCTTTACCGCCGAAGG
AGAAGGCACCCTGGCACCGTCACCCATTTATCCCCCGTTTCGCAAAGCGGCGAAATTCGCCGGACGCACCCAGTTGCCGG
TGCCGTTGACGCTGCGCGACCGTCGCTGGCTGTTGGATTTCAGCGCCATTACCGGGCAGCTCAGCGGCAAAGAGAAACTA
CTGTTGTTGTGCAACCCGCAAAATCCGGGCGGTACGGTTTATCGCCGGCAGGAGTTACTGGAGCATCATGAGTTTGCCCT
GGCCCATGAGCTGACAGTCTGTTCGGACGAAATTCATTGCGACCTGCTGCTTGAGCCCGGCTGTGAGCACATCCCCTTTG
CCACCTTGAATGAAGATGCGGCCCAGCGCAGTATCACGCTGATGTCGCCGTCAAAAACCTTCAACATTGCCGGTCTTGGC
GCCTCGATGGCGATTGTTCCCAACCCGCAGTTACGTCAGAAGCTGGCCCGTGCTCGCAGCGGCATCGTGCCAGAGGTGGA
CGTACTGGCGCTGGTTGCCGCCCAGGCCGCCTACCAGCATGGCCAAGACTGGCTGGACGCGCTGTTGGTTTATCTGCGCG
CCAACCGTGATTTGGTGACCGAGCGTATTAATGCCATGCCCGGACTGTTGCTGCAGCCCATCGAAGCCACTTATCTGGCC
TGGATCGACTGCAGTCAACTGGCAGTCGATAACCCGCACGCCTTTTTTGAACAGGCTGGCGTCGGGTTAAGTCCGGGGCT
GGATTTTGGCAACCGCCATTTCGTCCGTCTAAATTTCGGTTGTCGGAGTGAACTGCTGAGTCAGGCGCTGGATCGCATGA
TGCTGGCGACCCAGGCGCTGATGCCAAATTAG

Upstream 100 bases:

>100_bases
GTCACCCCCAGATGACGGCTAACCTGCGACGGCAATTGTTAATTTTTCGATTTATCTCTTAGGCTGATAAAGAGCTATCA
ACCTATACAGGGTAGTAACT

Downstream 100 bases:

>100_bases
GCTTGCTCGCTGGCGACGATTTCCCGGATGGAATAAGGATGAAATTTGATAGTCACAGTCCCATCGGTGATCGCCAGCGT
CGGATTAGGCAAACGTTCGC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MAFNFDQWVDRSHSDSVKWDKYRDRDIIPLWVADTDFPSPPAVIDALQQRVAHAVFGYSHPSPELIEVFTRRMLERYGWR
INPEWLIFLPGLVCGLNLCVRAFTAEGEGTLAPSPIYPPFRKAAKFAGRTQLPVPLTLRDRRWLLDFSAITGQLSGKEKL
LLLCNPQNPGGTVYRRQELLEHHEFALAHELTVCSDEIHCDLLLEPGCEHIPFATLNEDAAQRSITLMSPSKTFNIAGLG
ASMAIVPNPQLRQKLARARSGIVPEVDVLALVAAQAAYQHGQDWLDALLVYLRANRDLVTERINAMPGLLLQPIEATYLA
WIDCSQLAVDNPHAFFEQAGVGLSPGLDFGNRHFVRLNFGCRSELLSQALDRMMLATQALMPN

Sequences:

>Translated_383_residues
MAFNFDQWVDRSHSDSVKWDKYRDRDIIPLWVADTDFPSPPAVIDALQQRVAHAVFGYSHPSPELIEVFTRRMLERYGWR
INPEWLIFLPGLVCGLNLCVRAFTAEGEGTLAPSPIYPPFRKAAKFAGRTQLPVPLTLRDRRWLLDFSAITGQLSGKEKL
LLLCNPQNPGGTVYRRQELLEHHEFALAHELTVCSDEIHCDLLLEPGCEHIPFATLNEDAAQRSITLMSPSKTFNIAGLG
ASMAIVPNPQLRQKLARARSGIVPEVDVLALVAAQAAYQHGQDWLDALLVYLRANRDLVTERINAMPGLLLQPIEATYLA
WIDCSQLAVDNPHAFFEQAGVGLSPGLDFGNRHFVRLNFGCRSELLSQALDRMMLATQALMPN
>Mature_382_residues
AFNFDQWVDRSHSDSVKWDKYRDRDIIPLWVADTDFPSPPAVIDALQQRVAHAVFGYSHPSPELIEVFTRRMLERYGWRI
NPEWLIFLPGLVCGLNLCVRAFTAEGEGTLAPSPIYPPFRKAAKFAGRTQLPVPLTLRDRRWLLDFSAITGQLSGKEKLL
LLCNPQNPGGTVYRRQELLEHHEFALAHELTVCSDEIHCDLLLEPGCEHIPFATLNEDAAQRSITLMSPSKTFNIAGLGA
SMAIVPNPQLRQKLARARSGIVPEVDVLALVAAQAAYQHGQDWLDALLVYLRANRDLVTERINAMPGLLLQPIEATYLAW
IDCSQLAVDNPHAFFEQAGVGLSPGLDFGNRHFVRLNFGCRSELLSQALDRMMLATQALMPN

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=225, Percent_Identity=27.5555555555556, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI56713254, Length=225, Percent_Identity=27.5555555555556, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI95147551, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI169881279, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787909, Length=394, Percent_Identity=34.010152284264, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1788627, Length=228, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788722, Length=380, Percent_Identity=23.9473684210526, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786816, Length=349, Percent_Identity=22.0630372492837, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=227, Percent_Identity=25.5506607929515, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=227, Percent_Identity=25.5506607929515, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17567369, Length=261, Percent_Identity=24.5210727969349, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=361, Percent_Identity=20.4986149584488, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573069, Length=205, Percent_Identity=27.3170731707317, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646114, Length=205, Percent_Identity=27.3170731707317, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573067, Length=205, Percent_Identity=27.3170731707317, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573065, Length=205, Percent_Identity=27.3170731707317, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42916; Mature: 42785

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNFDQWVDRSHSDSVKWDKYRDRDIIPLWVADTDFPSPPAVIDALQQRVAHAVFGYSH
CCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
PSPELIEVFTRRMLERYGWRINPEWLIFLPGLVCGLNLCVRAFTAEGEGTLAPSPIYPPF
CCHHHHHHHHHHHHHHHCCEECCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
RKAAKFAGRTQLPVPLTLRDRRWLLDFSAITGQLSGKEKLLLLCNPQNPGGTVYRRQELL
HHHHHHCCCCCCCCCEEECCCEEEEEHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
EHHEFALAHELTVCSDEIHCDLLLEPGCEHIPFATLNEDAAQRSITLMSPSKTFNIAGLG
HHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEEECCCCEEEEEECC
ASMAIVPNPQLRQKLARARSGIVPEVDVLALVAAQAAYQHGQDWLDALLVYLRANRDLVT
CEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
ERINAMPGLLLQPIEATYLAWIDCSQLAVDNPHAFFEQAGVGLSPGLDFGNRHFVRLNFG
HHHHHCCCHHHCCCCHHEEEEECHHHHCCCCCHHHHHHCCCCCCCCCCCCCEEEEEEECC
CRSELLSQALDRMMLATQALMPN
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFNFDQWVDRSHSDSVKWDKYRDRDIIPLWVADTDFPSPPAVIDALQQRVAHAVFGYSH
CCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
PSPELIEVFTRRMLERYGWRINPEWLIFLPGLVCGLNLCVRAFTAEGEGTLAPSPIYPPF
CCHHHHHHHHHHHHHHHCCEECCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
RKAAKFAGRTQLPVPLTLRDRRWLLDFSAITGQLSGKEKLLLLCNPQNPGGTVYRRQELL
HHHHHHCCCCCCCCCEEECCCEEEEEHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
EHHEFALAHELTVCSDEIHCDLLLEPGCEHIPFATLNEDAAQRSITLMSPSKTFNIAGLG
HHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEEECCCCEEEEEECC
ASMAIVPNPQLRQKLARARSGIVPEVDVLALVAAQAAYQHGQDWLDALLVYLRANRDLVT
CEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHH
ERINAMPGLLLQPIEATYLAWIDCSQLAVDNPHAFFEQAGVGLSPGLDFGNRHFVRLNFG
HHHHHCCCHHHCCCCHHEEEEECHHHHCCCCCHHHHHHCCCCCCCCCCCCCEEEEEEECC
CRSELLSQALDRMMLATQALMPN
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]