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The map label for this gene is trpC [H]

Identifier: 157370910

GI number: 157370910

Start: 2939904

End: 2941265

Strand: Direct

Name: trpC [H]

Synonym: Spro_2670

Alternate gene names: 157370910

Gene position: 2939904-2941265 (Clockwise)

Preceding gene: 157370909

Following gene: 157370911

Centisome position: 53.95

GC content: 56.46

Gene sequence:

>1362_bases
ATGCAGGAAACCGTGCTCAACAAGATTGTTCGTGACAAAGCGCAATGGGTCGCGGCACGACAGCAACAACAGCCACTGGC
CAGTTTTCAAAATGAAATCGTCCCGAGTGAACGCGGCTTTTACCACGCGTTAGAGGGAGCCAGAACGGCGTTTATTCTTG
AATGTAAAAAGGCATCCCCTTCCAAAGGGTTGATCCGCGAAAACTTCGATCCGGTAGAAATAGCTTCGGTCTACAAAGAT
TTTGCCTCGGCAATTTCGGTGCTGACAGACGAAAAATACTTCCAGGGCAGCTTCGATTTTCTGCCGCTGGTCAGCAAAAC
GGTGACACAGCCGGTGCTGTGCAAAGATTTCATTATCGACCCGTATCAGATCTATCTGGCGCGTTTCTATCAGGCCGATG
CCATCCTGCTGATGCTGTCGGTGGTTGACGACGAGCAATACCGCAAGTTAGCCGCAGTGGCCCATAGCCTGAACATGGGT
GTACTGACCGAAGTGATCAGCGAAGAAGAGCTGCAACGGGCCATTGCTCTGGAAGCGCGCGTGGTGGGCATCAATAACCG
TGACCTGCGCGACCTGAGTATCGATCTGGATCGCACCCGTCAGTTGGCGCCACGCGTGCCACACGGCGTGACGGTGATCA
GCGAGTCCGGCATCAACAATTACGGTCAGATCCGCGAATTGAGCCACTTTGCCAACGGTTTCCTGATTGGCAGCGCATTA
ATGTCGGAAACTGACCTGCGCGCTGCCGTACGCCGGGTGATACTGGGCGACAATAAAGTCTGCGGGCTGACCCGTCCACA
GGATGCTGCCGCGGCTTATCAGGCCGGTGCCGTCTACGGGGGTTTGATTTTTGTCGGGCGCTCGCCGCGCTATGTTGATA
TCAATCGTGCCCGCGAAGTGATTGCCGGTGCACCGCTAAAATACGTCGGCGTGTTCTGTGACGCGCAGGTAGAGACGGTA
GTACAGACCGTCGAGCGCCTGGGCCTGAAAGCGGTGCAACTGCACGGCGCTGAAGATCAAGCCTATATCACCGCCTTGCG
TGCCAAACTGCCGGCCGACTGCCAAATTTGGAAAGCGCTGAGCGTAAAAGACCATTTGCCAAAGCGCGATTTGCTGCACG
TTGACCGTTATCTACTGGATAACGGCGCGGGTGGTACCGGGCAGCGTTTCGACTGGTCGGTACTGCACGGCGAAAACCTG
GAGAACGTGATGCTGGCCGGTGGCCTGGGCGCGGATAACTGTGTTGACGCGGCCAAACTTGGCTGTGCCGGTCTGGACTT
TAACTCCGGCGTTGAGAGCCAGCCCGGCATTAAGGATCCTGCCCGCCTCGCAGCGGTGTTCCAGACCCTGCGCGCTTACT
GA

Upstream 100 bases:

>100_bases
GCATGAAGACCTGCGCCAAAATGCGCAGCAGGCACTGGACATGATTCACAGCGGGCAGGCTTACGAGCGTGTCACCGCAC
TGGCAGCAAGAGGATAAATG

Downstream 100 bases:

>100_bases
AGATCATTAACGGATAATAACGGGAACTATAATGACGCTGCTTAACCCCTACTTCGGCGAATTTGGTGGCCAATATGTGC
CGCAGATTCTGATGCCGGCC

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MQETVLNKIVRDKAQWVAARQQQQPLASFQNEIVPSERGFYHALEGARTAFILECKKASPSKGLIRENFDPVEIASVYKD
FASAISVLTDEKYFQGSFDFLPLVSKTVTQPVLCKDFIIDPYQIYLARFYQADAILLMLSVVDDEQYRKLAAVAHSLNMG
VLTEVISEEELQRAIALEARVVGINNRDLRDLSIDLDRTRQLAPRVPHGVTVISESGINNYGQIRELSHFANGFLIGSAL
MSETDLRAAVRRVILGDNKVCGLTRPQDAAAAYQAGAVYGGLIFVGRSPRYVDINRAREVIAGAPLKYVGVFCDAQVETV
VQTVERLGLKAVQLHGAEDQAYITALRAKLPADCQIWKALSVKDHLPKRDLLHVDRYLLDNGAGGTGQRFDWSVLHGENL
ENVMLAGGLGADNCVDAAKLGCAGLDFNSGVESQPGIKDPARLAAVFQTLRAY

Sequences:

>Translated_453_residues
MQETVLNKIVRDKAQWVAARQQQQPLASFQNEIVPSERGFYHALEGARTAFILECKKASPSKGLIRENFDPVEIASVYKD
FASAISVLTDEKYFQGSFDFLPLVSKTVTQPVLCKDFIIDPYQIYLARFYQADAILLMLSVVDDEQYRKLAAVAHSLNMG
VLTEVISEEELQRAIALEARVVGINNRDLRDLSIDLDRTRQLAPRVPHGVTVISESGINNYGQIRELSHFANGFLIGSAL
MSETDLRAAVRRVILGDNKVCGLTRPQDAAAAYQAGAVYGGLIFVGRSPRYVDINRAREVIAGAPLKYVGVFCDAQVETV
VQTVERLGLKAVQLHGAEDQAYITALRAKLPADCQIWKALSVKDHLPKRDLLHVDRYLLDNGAGGTGQRFDWSVLHGENL
ENVMLAGGLGADNCVDAAKLGCAGLDFNSGVESQPGIKDPARLAAVFQTLRAY
>Mature_453_residues
MQETVLNKIVRDKAQWVAARQQQQPLASFQNEIVPSERGFYHALEGARTAFILECKKASPSKGLIRENFDPVEIASVYKD
FASAISVLTDEKYFQGSFDFLPLVSKTVTQPVLCKDFIIDPYQIYLARFYQADAILLMLSVVDDEQYRKLAAVAHSLNMG
VLTEVISEEELQRAIALEARVVGINNRDLRDLSIDLDRTRQLAPRVPHGVTVISESGINNYGQIRELSHFANGFLIGSAL
MSETDLRAAVRRVILGDNKVCGLTRPQDAAAAYQAGAVYGGLIFVGRSPRYVDINRAREVIAGAPLKYVGVFCDAQVETV
VQTVERLGLKAVQLHGAEDQAYITALRAKLPADCQIWKALSVKDHLPKRDLLHVDRYLLDNGAGGTGQRFDWSVLHGENL
ENVMLAGGLGADNCVDAAKLGCAGLDFNSGVESQPGIKDPARLAAVFQTLRAY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=451, Percent_Identity=73.6141906873614, Blast_Score=687, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322638, Length=253, Percent_Identity=36.3636363636364, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320210, Length=217, Percent_Identity=34.1013824884793, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 49794; Mature: 49794

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETVLNKIVRDKAQWVAARQQQQPLASFQNEIVPSERGFYHALEGARTAFILECKKASP
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCC
SKGLIRENFDPVEIASVYKDFASAISVLTDEKYFQGSFDFLPLVSKTVTQPVLCKDFIID
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHCCCHHHHHHCCC
PYQIYLARFYQADAILLMLSVVDDEQYRKLAAVAHSLNMGVLTEVISEEELQRAIALEAR
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEE
VVGINNRDLRDLSIDLDRTRQLAPRVPHGVTVISESGINNYGQIRELSHFANGFLIGSAL
EEECCCCCCCEEEECHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHH
MSETDLRAAVRRVILGDNKVCGLTRPQDAAAAYQAGAVYGGLIFVGRSPRYVDINRAREV
HHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCEEEEEEEECCCCCEEEHHHHHHH
IAGAPLKYVGVFCDAQVETVVQTVERLGLKAVQLHGAEDQAYITALRAKLPADCQIWKAL
HHCCCHHHHHEECCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHC
SVKDHLPKRDLLHVDRYLLDNGAGGTGQRFDWSVLHGENLENVMLAGGLGADNCVDAAKL
CHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCHHHHHHHH
GCAGLDFNSGVESQPGIKDPARLAAVFQTLRAY
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQETVLNKIVRDKAQWVAARQQQQPLASFQNEIVPSERGFYHALEGARTAFILECKKASP
CCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCC
SKGLIRENFDPVEIASVYKDFASAISVLTDEKYFQGSFDFLPLVSKTVTQPVLCKDFIID
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHCCCHHHHHHCCC
PYQIYLARFYQADAILLMLSVVDDEQYRKLAAVAHSLNMGVLTEVISEEELQRAIALEAR
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEE
VVGINNRDLRDLSIDLDRTRQLAPRVPHGVTVISESGINNYGQIRELSHFANGFLIGSAL
EEECCCCCCCEEEECHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHH
MSETDLRAAVRRVILGDNKVCGLTRPQDAAAAYQAGAVYGGLIFVGRSPRYVDINRAREV
HHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCEEEEEEEECCCCCEEEHHHHHHH
IAGAPLKYVGVFCDAQVETVVQTVERLGLKAVQLHGAEDQAYITALRAKLPADCQIWKAL
HHCCCHHHHHEECCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHC
SVKDHLPKRDLLHVDRYLLDNGAGGTGQRFDWSVLHGENLENVMLAGGLGADNCVDAAKL
CHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCHHHHHHHH
GCAGLDFNSGVESQPGIKDPARLAAVFQTLRAY
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]