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The map label for this gene is pcaR [H]

Identifier: 157370754

GI number: 157370754

Start: 2760714

End: 2761547

Strand: Direct

Name: pcaR [H]

Synonym: Spro_2514

Alternate gene names: 157370754

Gene position: 2760714-2761547 (Clockwise)

Preceding gene: 157370753

Following gene: 157370767

Centisome position: 50.67

GC content: 56.47

Gene sequence:

>834_bases
ATGACCAAAATCACCGACGGCGAAGAAATCACCGCGCCTGATAGTTTAGTGTCCGCCGCCAGCGGCGATCCCTTTAAGGG
CGACCCCAATTTTATGGCCTCGCTGGCCCGCGGCCTTGAGGTGATCCAGGCTTTTACTCCGCAGCGTCGTCTGATGTCGA
TTTCACAAATCAGCCAGAAAACCGGCATTCCACGCGCTGCGGTGCGTCGTTGCCTGTATACCCTGAACAAGCTGGGGTTT
GTTTACGCGCAGGACGGCAAAAACTTTGAGCTGCGCCCACGGATCCTGACGCTGGCCCATGCCTATCTCGGTGCCACGCC
GCTGGCGAAAGCCACCCAGCCGGTTCTGAAACACATCAGCCAGTTGTTGAATGAGTCCTGTTCTATCGCCACGCTGGACG
GCGACAATATTTTGTATATCGCCCGTGCCTCTGCCGAACGCATCATGACCATAGATCTGAACATCGGCAGCCGCCTGCCG
GCCTTCGCCACCTCTATGGGCCGGGTGCTGTTGAGCCATTTGCCGATTGATAAGCGTGAGGATTACCTGCAACGCATCAC
CCTGACGCGCTATACGCAATACACCCTGAGTTCGATTGATAAACTGCGTGAAGAACTGGATAAGGTTCGCGCTCAGGGTT
ACGCGATTAACGATCAGGAGTTGGAAATCGGTCTGCGATCCATCGCGGTACCGATTACCTCGGTCAACGGCGGCGTCACT
GCCGCGTTAAACGTTGGGGTGCAGGCCGGCCATGTCCCGCTGAGCGAACTGACCGAACGTATCCTGCCGATCCTGCTCGA
AGGCTCACAGGAACTTTCGCTACTAAACCACTAA

Upstream 100 bases:

>100_bases
ATCAACCGCCGGAAGATCAGGTTCGTCATATCCGTCAGTTGGCCGTAGTGGCCACCCTGCGCTATCTGGCGCTGTAAGCA
CTGCTCCCTGGGAGATTGTG

Downstream 100 bases:

>100_bases
ATCGATTGGCGTGCGTTGGCCAGGTACTTGGCCATTTCCGCCTCAGGCACCATGCCGCCACCGGTCGCCCACACCAGGTG
GGTGGCATTTTTCATTTGTT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MTKITDGEEITAPDSLVSAASGDPFKGDPNFMASLARGLEVIQAFTPQRRLMSISQISQKTGIPRAAVRRCLYTLNKLGF
VYAQDGKNFELRPRILTLAHAYLGATPLAKATQPVLKHISQLLNESCSIATLDGDNILYIARASAERIMTIDLNIGSRLP
AFATSMGRVLLSHLPIDKREDYLQRITLTRYTQYTLSSIDKLREELDKVRAQGYAINDQELEIGLRSIAVPITSVNGGVT
AALNVGVQAGHVPLSELTERILPILLEGSQELSLLNH

Sequences:

>Translated_277_residues
MTKITDGEEITAPDSLVSAASGDPFKGDPNFMASLARGLEVIQAFTPQRRLMSISQISQKTGIPRAAVRRCLYTLNKLGF
VYAQDGKNFELRPRILTLAHAYLGATPLAKATQPVLKHISQLLNESCSIATLDGDNILYIARASAERIMTIDLNIGSRLP
AFATSMGRVLLSHLPIDKREDYLQRITLTRYTQYTLSSIDKLREELDKVRAQGYAINDQELEIGLRSIAVPITSVNGGVT
AALNVGVQAGHVPLSELTERILPILLEGSQELSLLNH
>Mature_276_residues
TKITDGEEITAPDSLVSAASGDPFKGDPNFMASLARGLEVIQAFTPQRRLMSISQISQKTGIPRAAVRRCLYTLNKLGFV
YAQDGKNFELRPRILTLAHAYLGATPLAKATQPVLKHISQLLNESCSIATLDGDNILYIARASAERIMTIDLNIGSRLPA
FATSMGRVLLSHLPIDKREDYLQRITLTRYTQYTLSSIDKLREELDKVRAQGYAINDQELEIGLRSIAVPITSVNGGVTA
ALNVGVQAGHVPLSELTERILPILLEGSQELSLLNH

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=219, Percent_Identity=30.5936073059361, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786468, Length=229, Percent_Identity=27.5109170305677, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082359, Length=203, Percent_Identity=27.0935960591133, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786715, Length=243, Percent_Identity=25.5144032921811, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788581, Length=193, Percent_Identity=23.3160621761658, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789999, Length=253, Percent_Identity=21.7391304347826, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693096, Length=222, Percent_Identity=26.1261261261261, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30322; Mature: 30191

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKITDGEEITAPDSLVSAASGDPFKGDPNFMASLARGLEVIQAFTPQRRLMSISQISQK
CCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TGIPRAAVRRCLYTLNKLGFVYAQDGKNFELRPRILTLAHAYLGATPLAKATQPVLKHIS
CCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QLLNESCSIATLDGDNILYIARASAERIMTIDLNIGSRLPAFATSMGRVLLSHLPIDKRE
HHHCCCCCEEEECCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHH
DYLQRITLTRYTQYTLSSIDKLREELDKVRAQGYAINDQELEIGLRSIAVPITSVNGGVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEECCCCEE
AALNVGVQAGHVPLSELTERILPILLEGSQELSLLNH
EEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure 
TKITDGEEITAPDSLVSAASGDPFKGDPNFMASLARGLEVIQAFTPQRRLMSISQISQK
CCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TGIPRAAVRRCLYTLNKLGFVYAQDGKNFELRPRILTLAHAYLGATPLAKATQPVLKHIS
CCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QLLNESCSIATLDGDNILYIARASAERIMTIDLNIGSRLPAFATSMGRVLLSHLPIDKRE
HHHCCCCCEEEECCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHH
DYLQRITLTRYTQYTLSSIDKLREELDKVRAQGYAINDQELEIGLRSIAVPITSVNGGVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEECCCCEE
AALNVGVQAGHVPLSELTERILPILLEGSQELSLLNH
EEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]