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The map label for this gene is dsdC [H]

Identifier: 157370691

GI number: 157370691

Start: 2684098

End: 2685033

Strand: Direct

Name: dsdC [H]

Synonym: Spro_2451

Alternate gene names: 157370691

Gene position: 2684098-2685033 (Clockwise)

Preceding gene: 157370689

Following gene: 157370693

Centisome position: 49.26

GC content: 52.56

Gene sequence:

>936_bases
ATGACGGTAAATCTAACGGGGCCACATCGCTCACTGAATGGTTGGCAGTTATCGCGGTTATTTACCTTTGAAGTGGCTGC
GCGGCATGAGTCTTTCGCCATGGCGGCCGATGAGCTTTCTGTCAGCCCCAGCGCCGTCAGCCATAATATTAACCAGCTTG
AAGCCAATCTGGGTATCCAGCTGTTTGTTCGCTCTCACCGTAAGGTGGAACTCACGACCGAAGGCAAACGGGTTTTTTGG
GCGCTAAAATCTTCACTTGGCACCCTGAATCAGGAGATTCTGGATATCAAGAATCAGGCGCTATCAGGTTCATTAACAAT
TTACTCCCGCCCCTCCATTGCTCAGTGCTGGATCGTGCCGGCGTTGGCGGATTTCTCACGCCGATACCCCGCCATTAATC
TGACCATTCTGACCGGCAATGAATATGTGAACTTCCAACGCGCCGGCATTGATCTGGCGGTTTACTTTGACGCCACCCCG
TCATCGCAGCTTCATTATCAATACCTGATGGATGAAGCGATCATCCCGGTATGCAGCCCGGAGTACGCCAGTCAATTTGA
GCTGGCCAACTTTCCCGGCAACCTCTCCCACTGCACCCTGCTCCACGATCGACAAGCCTGGAGCTATGATTCCGGTACCG
ATGAGTGGCACAGTTGGGCTCAGCATTTCGGTATCAATCTGGATACCTCTCCGGGTATAGGTTTTGATCGTTCCGATTTG
GCCGTTACGGCAGCCATCAATCATGTTGGCGTGGCTATGGGCCGCAAACGGTTGATCCACAAACGGCTTAACTCTGGTGA
ACTGGTGGCACCATTCCCGAAAATGGAGCTGAAATGTGACCAGCACTACTATGTATCGACACTTTCCGACCGCCAGTGGC
CGAAGATTGACGCCTTCATTGCTTGGTTAAAAGCCCTGGGGGAACAACCGGCGTAA

Upstream 100 bases:

>100_bases
GACTTACGCCAAAAAATGGTGCAGTTTAGCGACATGGGTCAACTTTACTCACCAAGCTGGTGTGTAAATCGCAGATATTT
TTAAATTTTCTGGGGGGATT

Downstream 100 bases:

>100_bases
GCACCGATTCCCCAGAGAAATGCGCATTGAGATTGTCGAGTACCAACTGCACCGTTGCCGCTATCGCCTCCGGGGAACGC
CCGGCGATATGCGGCGTTAG

Product: DNA-binding transcriptional regulator DsdC

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTVNLTGPHRSLNGWQLSRLFTFEVAARHESFAMAADELSVSPSAVSHNINQLEANLGIQLFVRSHRKVELTTEGKRVFW
ALKSSLGTLNQEILDIKNQALSGSLTIYSRPSIAQCWIVPALADFSRRYPAINLTILTGNEYVNFQRAGIDLAVYFDATP
SSQLHYQYLMDEAIIPVCSPEYASQFELANFPGNLSHCTLLHDRQAWSYDSGTDEWHSWAQHFGINLDTSPGIGFDRSDL
AVTAAINHVGVAMGRKRLIHKRLNSGELVAPFPKMELKCDQHYYVSTLSDRQWPKIDAFIAWLKALGEQPA

Sequences:

>Translated_311_residues
MTVNLTGPHRSLNGWQLSRLFTFEVAARHESFAMAADELSVSPSAVSHNINQLEANLGIQLFVRSHRKVELTTEGKRVFW
ALKSSLGTLNQEILDIKNQALSGSLTIYSRPSIAQCWIVPALADFSRRYPAINLTILTGNEYVNFQRAGIDLAVYFDATP
SSQLHYQYLMDEAIIPVCSPEYASQFELANFPGNLSHCTLLHDRQAWSYDSGTDEWHSWAQHFGINLDTSPGIGFDRSDL
AVTAAINHVGVAMGRKRLIHKRLNSGELVAPFPKMELKCDQHYYVSTLSDRQWPKIDAFIAWLKALGEQPA
>Mature_310_residues
TVNLTGPHRSLNGWQLSRLFTFEVAARHESFAMAADELSVSPSAVSHNINQLEANLGIQLFVRSHRKVELTTEGKRVFWA
LKSSLGTLNQEILDIKNQALSGSLTIYSRPSIAQCWIVPALADFSRRYPAINLTILTGNEYVNFQRAGIDLAVYFDATPS
SQLHYQYLMDEAIIPVCSPEYASQFELANFPGNLSHCTLLHDRQAWSYDSGTDEWHSWAQHFGINLDTSPGIGFDRSDLA
VTAAINHVGVAMGRKRLIHKRLNSGELVAPFPKMELKCDQHYYVSTLSDRQWPKIDAFIAWLKALGEQPA

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=295, Percent_Identity=76.6101694915254, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1789173, Length=296, Percent_Identity=32.0945945945946, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786448, Length=292, Percent_Identity=32.5342465753425, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787128, Length=261, Percent_Identity=28.3524904214559, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786401, Length=277, Percent_Identity=24.9097472924188, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=24.3986254295533, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87081978, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788748, Length=178, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI157672245, Length=165, Percent_Identity=33.9393939393939, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790262, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789639, Length=187, Percent_Identity=24.5989304812834, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693105, Length=172, Percent_Identity=25.5813953488372, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34879; Mature: 34748

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNLTGPHRSLNGWQLSRLFTFEVAARHESFAMAADELSVSPSAVSHNINQLEANLGIQ
CEEECCCCCCCCCCEEEEEEEEEEEHHCCCHHEEEHHHCCCCHHHHHCCHHHHHHCCCEE
LFVRSHRKVELTTEGKRVFWALKSSLGTLNQEILDIKNQALSGSLTIYSRPSIAQCWIVP
EEEECCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEHH
ALADFSRRYPAINLTILTGNEYVNFQRAGIDLAVYFDATPSSQLHYQYLMDEAIIPVCSP
HHHHHHHCCCEEEEEEEECCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCC
EYASQFELANFPGNLSHCTLLHDRQAWSYDSGTDEWHSWAQHFGINLDTSPGIGFDRSDL
HHHCCEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCE
AVTAAINHVGVAMGRKRLIHKRLNSGELVAPFPKMELKCDQHYYVSTLSDRQWPKIDAFI
EEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCEEEEEECCCCCCCHHHHHH
AWLKALGEQPA
HHHHHHCCCCC
>Mature Secondary Structure 
TVNLTGPHRSLNGWQLSRLFTFEVAARHESFAMAADELSVSPSAVSHNINQLEANLGIQ
EEECCCCCCCCCCEEEEEEEEEEEHHCCCHHEEEHHHCCCCHHHHHCCHHHHHHCCCEE
LFVRSHRKVELTTEGKRVFWALKSSLGTLNQEILDIKNQALSGSLTIYSRPSIAQCWIVP
EEEECCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEHH
ALADFSRRYPAINLTILTGNEYVNFQRAGIDLAVYFDATPSSQLHYQYLMDEAIIPVCSP
HHHHHHHCCCEEEEEEEECCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCC
EYASQFELANFPGNLSHCTLLHDRQAWSYDSGTDEWHSWAQHFGINLDTSPGIGFDRSDL
HHHCCEEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCE
AVTAAINHVGVAMGRKRLIHKRLNSGELVAPFPKMELKCDQHYYVSTLSDRQWPKIDAFI
EEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEECCEEEEEECCCCCCCHHHHHH
AWLKALGEQPA
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]