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The map label for this gene is dnaX [H]

Identifier: 157369378

GI number: 157369378

Start: 1248884

End: 1250836

Strand: Direct

Name: dnaX [H]

Synonym: Spro_1135

Alternate gene names: 157369378

Gene position: 1248884-1250836 (Clockwise)

Preceding gene: 157369377

Following gene: 157369379

Centisome position: 22.92

GC content: 59.4

Gene sequence:

>1953_bases
ATGAGCTATCAGGTTCTAGCCCGTAAGTGGCGCCCTCAAACGTTTGCAGATGTGGTCGGACAGGAACATGTCCTGACGGC
ACTGGCTAACGGCCTCTCGCTGGGGCGGATCCATCACGCCTATCTGTTCTCGGGTACGCGCGGCGTGGGTAAAACCACCA
TTGCGCGCCTGCTGGCCAAAGGCCTGAACTGTGAAACCGGCATCACCGCCACGCCGTGCGGTCAATGTGATAACTGCCGC
GAGATTGAGCAGGGGCGTTTTGTCGATCTGATCGAGATCGACGCCGCGTCCAGAACCAAGGTGGAAGATACCCGCGATCT
GCTGGATAACGTCCAGTACGCTCCCGCCCGTGGCCGCTTCAAGGTTTACCTGATTGACGAAGTGCACATGCTCTCGCGTC
ACAGCTTCAATGCGCTGTTGAAAACGCTGGAAGAGCCGCCTTCGCACGTCAAATTCCTGTTGGCAACCACCGACCCGCAA
AAGTTGCCGGTAACCATTTTGTCCCGCTGTCTGCAATTTCATCTGAAGGCGCTGGACGTCGATCAGATCCGCAGCCAGTT
GGAAACGGTGCTGCAGGCAGAGCAGATCACCAGCGATCAGCGTGCGTTGCAGCTATTGGCGCGTGCCGCCGATGGCAGCA
TGCGTGATGCACTGAGCCTCACTGACCAGGCGATTGCCATGGGACAGGGGCAGGTGACTACCGCCACCGTCAGCCAAATG
CTGGGCACGCTTGACGATGAACAGCCGCTGGCTATTCTCGAAGCGCTGGTCAGTGCCGATGGCGAAAAGGTGATGGCGCA
GGTCGCGCAGGCCGCTTCGCGCGGTGTCGATTGGGAAAATCTGCTGATCGAGACGCTGGCGTTGCTGCACCGTATTGCGA
TGGTGCAGTTGCTGCCGTCGGTGTTGGATAATCATTACGCCGCCATTGAACAGCGGCTGCGTGAGCTGGCGCGTACCTTG
CCGCCGACTGACGTACAGCTCTATTACCAAACGCTGTTGGTTGGCCGCAAAGAGCTGGCCTTTGCGCCGGATCGCCGCAT
GGGGGTTGAAATGACCCTGCTGCGCGCGCTGGCGTTTCATCCGAAGGCGATGATCCCCGAGCCGGTAGCCATGGTGCAGA
CTGCACCTGTGCAGATGGCTCAGCCGCAGGTTCAAGCGGCCCAGCCGCCACAGTTTCAGGACGCACCGCCGCCGTTAGGG
CAGGTTGCACCGCAGAACAATCAGCAAGCGAATTTACCGGATGCCACCGCGCAATTATTAAAGGCGCGTACCCAACTGCT
GAGGCAGCAGGGAGCATCCACAACAAAAAAGAGTGAACCGGCGGCGCCTGGAAAAGCGCGGCCGGCGAACTCGGCACTGG
AGCGATTGGCTTCCGTGACTGAGCGCAGCCAGCAGCGCCAGGCGGAAAAGATCGTGCAGGAAAAACCGGCCAAGCCGGAG
GCTTATCGCTGGCGTGCACTGACCGAGCCGGAGGCCGAACCGGAGCCGCTGGCTACGCCGAAAGCGTTGCGCACCGCGCT
CGAGCATGAGAAAACGCCCGAGCTGTCGGCCAAGCTGGTGGTTGAATCGCTGGAACGCGACGCCTGGGCGGCGGAAATCG
ATAAGCTTAAAATCCCAAAACTGGTGCAGCAACTGGCATTAAACGCGGTTAAACAACAGTTGGAACCCGGTAAGATTTGT
CTTCACCTGCGGTCGTCGCAGCGTCACCTGAATTCGCCTTCGGCGCAGAAGGTGCTGACCGATGCGCTCAGCGAGCTGTA
CGGTAGCCCGGTTGAGTTGACCGTGGTGGAAGACGATAATCCGGCGGAGCGGACTCCGCTGGAGTGGCGACAAGCCATTT
ATGAAGAAAAACTGGCGCAGGCGCGCCAGTCGATCGTTACGGATACCCATATTCAGACTTTGCGCCGTTTCTTCGACGCG
GACCTGGATGAAGAGAGTATTCGCCCCATTTAA

Upstream 100 bases:

>100_bases
ACTTCTCCGGCCACTGATCTGCATTACCACAACGGCCTCGCGGATCGCCGCGGGGCTGTGTTAGCATGACCCTCCAGATT
ACTCGACTTTTCCGGTATTA

Downstream 100 bases:

>100_bases
ACGCTGCGTAAAGTGCGCGGCCCTAGCGACGAGAGACGACTATGTTTGGTAAAGGCGGTCTGGGCAACCTGATGAAGCAA
GCCCAGCAAATGCAAGAAAA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTTIARLLAKGLNCETGITATPCGQCDNCR
EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPSHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVDQIRSQLETVLQAEQITSDQRALQLLARAADGSMRDALSLTDQAIAMGQGQVTTATVSQM
LGTLDDEQPLAILEALVSADGEKVMAQVAQAASRGVDWENLLIETLALLHRIAMVQLLPSVLDNHYAAIEQRLRELARTL
PPTDVQLYYQTLLVGRKELAFAPDRRMGVEMTLLRALAFHPKAMIPEPVAMVQTAPVQMAQPQVQAAQPPQFQDAPPPLG
QVAPQNNQQANLPDATAQLLKARTQLLRQQGASTTKKSEPAAPGKARPANSALERLASVTERSQQRQAEKIVQEKPAKPE
AYRWRALTEPEAEPEPLATPKALRTALEHEKTPELSAKLVVESLERDAWAAEIDKLKIPKLVQQLALNAVKQQLEPGKIC
LHLRSSQRHLNSPSAQKVLTDALSELYGSPVELTVVEDDNPAERTPLEWRQAIYEEKLAQARQSIVTDTHIQTLRRFFDA
DLDEESIRPI

Sequences:

>Translated_650_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTTIARLLAKGLNCETGITATPCGQCDNCR
EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPSHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVDQIRSQLETVLQAEQITSDQRALQLLARAADGSMRDALSLTDQAIAMGQGQVTTATVSQM
LGTLDDEQPLAILEALVSADGEKVMAQVAQAASRGVDWENLLIETLALLHRIAMVQLLPSVLDNHYAAIEQRLRELARTL
PPTDVQLYYQTLLVGRKELAFAPDRRMGVEMTLLRALAFHPKAMIPEPVAMVQTAPVQMAQPQVQAAQPPQFQDAPPPLG
QVAPQNNQQANLPDATAQLLKARTQLLRQQGASTTKKSEPAAPGKARPANSALERLASVTERSQQRQAEKIVQEKPAKPE
AYRWRALTEPEAEPEPLATPKALRTALEHEKTPELSAKLVVESLERDAWAAEIDKLKIPKLVQQLALNAVKQQLEPGKIC
LHLRSSQRHLNSPSAQKVLTDALSELYGSPVELTVVEDDNPAERTPLEWRQAIYEEKLAQARQSIVTDTHIQTLRRFFDA
DLDEESIRPI
>Mature_649_residues
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTTIARLLAKGLNCETGITATPCGQCDNCRE
IEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPSHVKFLLATTDPQK
LPVTILSRCLQFHLKALDVDQIRSQLETVLQAEQITSDQRALQLLARAADGSMRDALSLTDQAIAMGQGQVTTATVSQML
GTLDDEQPLAILEALVSADGEKVMAQVAQAASRGVDWENLLIETLALLHRIAMVQLLPSVLDNHYAAIEQRLRELARTLP
PTDVQLYYQTLLVGRKELAFAPDRRMGVEMTLLRALAFHPKAMIPEPVAMVQTAPVQMAQPQVQAAQPPQFQDAPPPLGQ
VAPQNNQQANLPDATAQLLKARTQLLRQQGASTTKKSEPAAPGKARPANSALERLASVTERSQQRQAEKIVQEKPAKPEA
YRWRALTEPEAEPEPLATPKALRTALEHEKTPELSAKLVVESLERDAWAAEIDKLKIPKLVQQLALNAVKQQLEPGKICL
HLRSSQRHLNSPSAQKVLTDALSELYGSPVELTVVEDDNPAERTPLEWRQAIYEEKLAQARQSIVTDTHIQTLRRFFDAD
LDEESIRPI

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=310, Percent_Identity=23.8709677419355, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI194306571, Length=311, Percent_Identity=23.1511254019293, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI194306567, Length=311, Percent_Identity=23.1511254019293, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1786676, Length=655, Percent_Identity=72.5190839694656, Blast_Score=920, Evalue=0.0,
Organism=Escherichia coli, GI1787341, Length=139, Percent_Identity=31.6546762589928, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=273, Percent_Identity=22.3443223443223, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=217, Percent_Identity=25.3456221198157, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=285, Percent_Identity=23.5087719298246, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921076, Length=320, Percent_Identity=27.8125, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17647857, Length=293, Percent_Identity=24.2320819112628, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI18859927, Length=269, Percent_Identity=24.1635687732342, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 72056; Mature: 71925

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTTIARLLAK
CCHHHHHHHCCCHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGQCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
CCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPSHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
DQIRSQLETVLQAEQITSDQRALQLLARAADGSMRDALSLTDQAIAMGQGQVTTATVSQM
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LGTLDDEQPLAILEALVSADGEKVMAQVAQAASRGVDWENLLIETLALLHRIAMVQLLPS
HHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLDNHYAAIEQRLRELARTLPPTDVQLYYQTLLVGRKELAFAPDRRMGVEMTLLRALAFH
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHC
PKAMIPEPVAMVQTAPVQMAQPQVQAAQPPQFQDAPPPLGQVAPQNNQQANLPDATAQLL
CCCCCCCCHHHHHHCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KARTQLLRQQGASTTKKSEPAAPGKARPANSALERLASVTERSQQRQAEKIVQEKPAKPE
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AYRWRALTEPEAEPEPLATPKALRTALEHEKTPELSAKLVVESLERDAWAAEIDKLKIPK
HHEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LVQQLALNAVKQQLEPGKICLHLRSSQRHLNSPSAQKVLTDALSELYGSPVELTVVEDDN
HHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCC
PAERTPLEWRQAIYEEKLAQARQSIVTDTHIQTLRRFFDADLDEESIRPI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTTIARLLAK
CHHHHHHHCCCHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGQCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
CCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPSHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
DQIRSQLETVLQAEQITSDQRALQLLARAADGSMRDALSLTDQAIAMGQGQVTTATVSQM
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LGTLDDEQPLAILEALVSADGEKVMAQVAQAASRGVDWENLLIETLALLHRIAMVQLLPS
HHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLDNHYAAIEQRLRELARTLPPTDVQLYYQTLLVGRKELAFAPDRRMGVEMTLLRALAFH
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHC
PKAMIPEPVAMVQTAPVQMAQPQVQAAQPPQFQDAPPPLGQVAPQNNQQANLPDATAQLL
CCCCCCCCHHHHHHCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KARTQLLRQQGASTTKKSEPAAPGKARPANSALERLASVTERSQQRQAEKIVQEKPAKPE
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AYRWRALTEPEAEPEPLATPKALRTALEHEKTPELSAKLVVESLERDAWAAEIDKLKIPK
HHEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
LVQQLALNAVKQQLEPGKICLHLRSSQRHLNSPSAQKVLTDALSELYGSPVELTVVEDDN
HHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCC
PAERTPLEWRQAIYEEKLAQARQSIVTDTHIQTLRRFFDADLDEESIRPI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]