Click here to switch to the map view.

The map label for this gene is apt

Identifier: 157369377

GI number: 157369377

Start: 1248204

End: 1248800

Strand: Direct

Name: apt

Synonym: Spro_1134

Alternate gene names: 157369377

Gene position: 1248204-1248800 (Clockwise)

Preceding gene: 157369376

Following gene: 157369378

Centisome position: 22.91

GC content: 57.12

Gene sequence:

>597_bases
ATGACCTGCGCGCAAGTCATCAGGCAGTTTTATCAGGCAACAATTATGACCGCTACTGCGCAGCAGCTTCAGTTTATTAA
AGACAGTATCAAAACCATCCCGGATTACCCTAAGCCGGGCATACTGTTCCGTGACGTCACCAGCCTGCTGGAAAATCCGC
TGGCCTACGCCGCCAGCATTGAATTGCTGGTTGAGCGTTTCCGCGAAGCGGGCGTCACCAAAGTGGTTGGCACCGAAGCG
CGCGGCTTCCTGTTTGGCGCCCCGGTTGCGTTGGCGCTGGGCGTGGGTTTTGTACCGGTGCGCAAACCGGGCAAGCTGCC
GCGTGCCACCCTCAGCGAAAGCTATGAGCTGGAATACGGCACTGACAAGTTGGAAATCCACACCGATGCTATCAGCGCCG
GTGATAAAGTGCTGGTGGTGGACGATCTGCTGGCAACCGGCGGCACCATCGAAGCCACAGCAAAACTGATCCGCCGTCTG
GGTGGTGAAGTGACCGACGCCGCCTTCATTATCAATCTGCCGGATCTCGGCGGTGAAGCGCGTTTAAACACCCTGGGTAT
TGAATGCTACAGCCTGGTCAACTTCTCCGGCCACTGA

Upstream 100 bases:

>100_bases
TTGTTGACCTGCCACAACAAAAACAGCGCTGATCGCACACCGTCGGTTGCATTTGTCCGCCAGTTTGCATAAATTTGACC
GTTTTCGTGTGCGGGTTAAG

Downstream 100 bases:

>100_bases
TCTGCATTACCACAACGGCCTCGCGGATCGCCGCGGGGCTGTGTTAGCATGACCCTCCAGATTACTCGACTTTTCCGGTA
TTAATGAGCTATCAGGTTCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MTCAQVIRQFYQATIMTATAQQLQFIKDSIKTIPDYPKPGILFRDVTSLLENPLAYAASIELLVERFREAGVTKVVGTEA
RGFLFGAPVALALGVGFVPVRKPGKLPRATLSESYELEYGTDKLEIHTDAISAGDKVLVVDDLLATGGTIEATAKLIRRL
GGEVTDAAFIINLPDLGGEARLNTLGIECYSLVNFSGH

Sequences:

>Translated_198_residues
MTCAQVIRQFYQATIMTATAQQLQFIKDSIKTIPDYPKPGILFRDVTSLLENPLAYAASIELLVERFREAGVTKVVGTEA
RGFLFGAPVALALGVGFVPVRKPGKLPRATLSESYELEYGTDKLEIHTDAISAGDKVLVVDDLLATGGTIEATAKLIRRL
GGEVTDAAFIINLPDLGGEARLNTLGIECYSLVNFSGH
>Mature_197_residues
TCAQVIRQFYQATIMTATAQQLQFIKDSIKTIPDYPKPGILFRDVTSLLENPLAYAASIELLVERFREAGVTKVVGTEAR
GFLFGAPVALALGVGFVPVRKPGKLPRATLSESYELEYGTDKLEIHTDAISAGDKVLVVDDLLATGGTIEATAKLIRRLG
GEVTDAAFIINLPDLGGEARLNTLGIECYSLVNFSGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=177, Percent_Identity=41.2429378531073, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=45.7364341085271, Blast_Score=121, Evalue=4e-28,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=81.4207650273224, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=46.5408805031447, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=181, Percent_Identity=40.8839779005525, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=172, Percent_Identity=36.046511627907, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136334, Length=180, Percent_Identity=40.5555555555556, Blast_Score=133, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SERP5 (A8GAU8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477366.1
- ProteinModelPortal:   A8GAU8
- SMR:   A8GAU8
- STRING:   A8GAU8
- GeneID:   5607386
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1134
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   SPRO399741:SPRO_1134-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 21330; Mature: 21199

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCAQVIRQFYQATIMTATAQQLQFIKDSIKTIPDYPKPGILFRDVTSLLENPLAYAASI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHH
ELLVERFREAGVTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRATLSESYELEYG
HHHHHHHHHCCCEEEECCCCCCEEEHHHHHHHHCCCCEECCCCCCCCCHHHCCCEEEEEC
TDKLEIHTDAISAGDKVLVVDDLLATGGTIEATAKLIRRLGGEVTDAAFIINLPDLGGEA
CCEEEEEECHHCCCCEEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
RLNTLGIECYSLVNFSGH
EEHHHHHHHHEEECCCCC
>Mature Secondary Structure 
TCAQVIRQFYQATIMTATAQQLQFIKDSIKTIPDYPKPGILFRDVTSLLENPLAYAASI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHH
ELLVERFREAGVTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRATLSESYELEYG
HHHHHHHHHCCCEEEECCCCCCEEEHHHHHHHHCCCCEECCCCCCCCCHHHCCCEEEEEC
TDKLEIHTDAISAGDKVLVVDDLLATGGTIEATAKLIRRLGGEVTDAAFIINLPDLGGEA
CCEEEEEECHHCCCCEEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
RLNTLGIECYSLVNFSGH
EEHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA