Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 157368914

GI number: 157368914

Start: 735909

End: 736910

Strand: Reverse

Name: qor [C]

Synonym: Spro_0669

Alternate gene names: 157368914

Gene position: 736910-735909 (Counterclockwise)

Preceding gene: 157368916

Following gene: 157368910

Centisome position: 13.52

GC content: 56.79

Gene sequence:

>1002_bases
ATGTCGATTAAAGCCATTGCCGTAGACCCAAAAAACCCCGCCAACTTCATTGCAATCAGCCCGGAAAAACCCACCCCAGG
CCAGTACGATTTATTGGTTGAAGTCAAAGCGGTGTCGGTCAACCCGGTGGATACCAAGGTCCATGCCGGCCTGCAAAAAA
GTGGCCTGCAGCAGCCCCGTATTCTCGGTTGGGATGCCAGCGGTATCGTGGTCGAAGTGGGCAGCAGCGTCAGCGGTTTC
AAACCCGGTGATGAAGTCTGGTACGCCGGTGATATCACCCGCCCAGGCAGCAACACTACCCATCAGTTGATTGACTCACG
TATTACCGCCCATAAGCCGCAAAGTCTGAACTGGGCTGAAGCCGCCGCCATGCCGCTGACCGCCCTGACCGCCTGGGAAG
CGCTGTTCGAACACCTGAAGATTCAGGACGCCGCCCCCGGTAAAACCCTGTTGATTATCGGCGGTGCCGGTGGCGTAGGT
TCGCTGGCGATCCCGTTTGCCGCGCAGCGCAGCCAGGTGAAGGTGATTGCGACTGCATCACGCCCCGAGTCGGCGGCCTG
GTGCCGGGAGCGCGGTGCCGATCTGGTGGTGGACTACCGCGATCTGAAAGCGAATCTGGCGCAGCAGGGCATTGAGAATG
TGGATTATATTCTTTGCCTGAACGACACCGACGGGCACTGGAAAGCGATTTCCGATCTGATTGCGCCAATGGGCCATATC
TGTACCATCGTCGAAAATGCACAGCCGTTGGACCAAAATGCGCTGAAGTTGAAAAGTGCCGCTTTGCATTGGGAGTTGAT
GTTTACTCGCAGCATGTTCACCACGCCGGACATCGCCCAACAGGGTGAGATCCTCAAGCAAGTGGCGCAAATGCTGGATG
AAGGAAAACTGAGTACCACCCTGAGCGAAACCTTGCAGGGGTTGACGGTCGACACCCTGACCGCCGCGCATAAAAAACTG
CTCGACGGGCATATGCAGGGCAAACTGGTGATTGTTTACTGA

Upstream 100 bases:

>100_bases
ATTGTTCACCTCAAACGAACACTCAGTTAGTTATTGTCCATCTTATCATCAACTGCCAACAGGTCTACACTGAGGGTATT
CATTCGAAAGGAGCACAGTC

Downstream 100 bases:

>100_bases
TGGCAGACGGGGCGCAGCACGCTGCGCCCCGATGGCTTATACCGCCGCAACACCGAGCAGCCGACTGGCATCGGCCGCCA
GCAGTTGTTTTACCAGCTCG

Product: zinc-binding alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSIKAIAVDPKNPANFIAISPEKPTPGQYDLLVEVKAVSVNPVDTKVHAGLQKSGLQQPRILGWDASGIVVEVGSSVSGF
KPGDEVWYAGDITRPGSNTTHQLIDSRITAHKPQSLNWAEAAAMPLTALTAWEALFEHLKIQDAAPGKTLLIIGGAGGVG
SLAIPFAAQRSQVKVIATASRPESAAWCRERGADLVVDYRDLKANLAQQGIENVDYILCLNDTDGHWKAISDLIAPMGHI
CTIVENAQPLDQNALKLKSAALHWELMFTRSMFTTPDIAQQGEILKQVAQMLDEGKLSTTLSETLQGLTVDTLTAAHKKL
LDGHMQGKLVIVY

Sequences:

>Translated_333_residues
MSIKAIAVDPKNPANFIAISPEKPTPGQYDLLVEVKAVSVNPVDTKVHAGLQKSGLQQPRILGWDASGIVVEVGSSVSGF
KPGDEVWYAGDITRPGSNTTHQLIDSRITAHKPQSLNWAEAAAMPLTALTAWEALFEHLKIQDAAPGKTLLIIGGAGGVG
SLAIPFAAQRSQVKVIATASRPESAAWCRERGADLVVDYRDLKANLAQQGIENVDYILCLNDTDGHWKAISDLIAPMGHI
CTIVENAQPLDQNALKLKSAALHWELMFTRSMFTTPDIAQQGEILKQVAQMLDEGKLSTTLSETLQGLTVDTLTAAHKKL
LDGHMQGKLVIVY
>Mature_332_residues
SIKAIAVDPKNPANFIAISPEKPTPGQYDLLVEVKAVSVNPVDTKVHAGLQKSGLQQPRILGWDASGIVVEVGSSVSGFK
PGDEVWYAGDITRPGSNTTHQLIDSRITAHKPQSLNWAEAAAMPLTALTAWEALFEHLKIQDAAPGKTLLIIGGAGGVGS
LAIPFAAQRSQVKVIATASRPESAAWCRERGADLVVDYRDLKANLAQQGIENVDYILCLNDTDGHWKAISDLIAPMGHIC
TIVENAQPLDQNALKLKSAALHWELMFTRSMFTTPDIAQQGEILKQVAQMLDEGKLSTTLSETLQGLTVDTLTAAHKKLL
DGHMQGKLVIVY

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=330, Percent_Identity=29.0909090909091, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI90669511, Length=304, Percent_Identity=30.9210526315789, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI194239674, Length=195, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI13236495, Length=195, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI194239676, Length=179, Percent_Identity=29.0502793296089, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI24308257, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI18379349, Length=217, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI28557745, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790485, Length=176, Percent_Identity=32.9545454545455, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71987554, Length=346, Percent_Identity=28.3236994219653, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17507255, Length=238, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35823; Mature: 35692

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKAIAVDPKNPANFIAISPEKPTPGQYDLLVEVKAVSVNPVDTKVHAGLQKSGLQQPR
CCEEEEEECCCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHCCHHHCCCCCCC
ILGWDASGIVVEVGSSVSGFKPGDEVWYAGDITRPGSNTTHQLIDSRITAHKPQSLNWAE
EEEECCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
AAAMPLTALTAWEALFEHLKIQDAAPGKTLLIIGGAGGVGSLAIPFAAQRSQVKVIATAS
HHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCEEEEEEECC
RPESAAWCRERGADLVVDYRDLKANLAQQGIENVDYILCLNDTDGHWKAISDLIAPMGHI
CCCHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCHHHH
CTIVENAQPLDQNALKLKSAALHWELMFTRSMFTTPDIAQQGEILKQVAQMLDEGKLSTT
EEHCCCCCCCCCHHHHHHHHHEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHH
LSETLQGLTVDTLTAAHKKLLDGHMQGKLVIVY
HHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEC
>Mature Secondary Structure 
SIKAIAVDPKNPANFIAISPEKPTPGQYDLLVEVKAVSVNPVDTKVHAGLQKSGLQQPR
CEEEEEECCCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHCCHHHCCCCCCC
ILGWDASGIVVEVGSSVSGFKPGDEVWYAGDITRPGSNTTHQLIDSRITAHKPQSLNWAE
EEEECCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
AAAMPLTALTAWEALFEHLKIQDAAPGKTLLIIGGAGGVGSLAIPFAAQRSQVKVIATAS
HHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCEEEEEEECC
RPESAAWCRERGADLVVDYRDLKANLAQQGIENVDYILCLNDTDGHWKAISDLIAPMGHI
CCCHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCHHHH
CTIVENAQPLDQNALKLKSAALHWELMFTRSMFTTPDIAQQGEILKQVAQMLDEGKLSTT
EEHCCCCCCCCCHHHHHHHHHEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHH
LSETLQGLTVDTLTAAHKKLLDGHMQGKLVIVY
HHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]