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The map label for this gene is treR [H]

Identifier: 157368781

GI number: 157368781

Start: 587957

End: 588904

Strand: Reverse

Name: treR [H]

Synonym: Spro_0534

Alternate gene names: 157368781

Gene position: 588904-587957 (Counterclockwise)

Preceding gene: 157368784

Following gene: 157368780

Centisome position: 10.81

GC content: 61.18

Gene sequence:

>948_bases
ATGCAAAACCGGCTGACCATCAAGGACATCGCACGCCTGAGCGGCGTAGGTAAATCCACCGTATCACGCGTGTTGAACAA
CGAAGGCAGCGTGAGCCCGCAGACCCGTGAACGGGTGGAAGCGGTGATCCGTCAGCAGGGGTTCACCCCGTCCAAGTCTG
CTCGCGCCATGCGCGGCCAGAGCGACAAAGTGGTCGGCATTATCGTTTCCCGTCTCGACTCTCCGTCTGAAAACCAGGCG
GTACGCACCATGTTGCCACTGCTGTATCAGCACGGCTTCGACCCGATCGTGATGGAAAGCCAGTTCGAGACCCGGCTGGT
GGAAGAGCATTTGCACGTTCTGCAACAGCGTAATGTCGACGGAGTGATCCTGTTCGGTTTCACCGGCCTGACGGCGGCCA
TGCTCAGCCCATGGCAGGATAAAATGGTGGTGCTGGCACGCGAATACGAGGGGTTTTCTTCGGTTTGCTACGACGACGAC
GGTGCCGTGCGGCTGCTGATGGAACGCCTGCAGCAACAGGGCCACCGGCATATCGGCTACCTGGGGGTGCAACTGTCGGA
TGCCACCACCGGTATGCGCCGCCACCAGGCCTATCTCGACGCCTGCCGGCAACAGCAGATTACCCCAAGCGTGGCGCTGG
GCGAACTGAGCTATCAGAGCGGCTTCCAACTGGCTGCCTCGGTCATCGATGCCCAGACTACCGCCCTGGTGTGCGCCTCC
GACACTATCGCCCTGGGTGCGATCAAATACCTGCAACAGCAGCATATTGCCCCGCTGCAAGTGTGCGGCATCGGCAACAC
GCCGCTGCTAAACTTCCTGTTCCCCGAAACCTTTTCGGTTGATCTGGGCTACGGCACGGCCGGGCTGCAGGCCGCGCAAC
AGCTGCTGGGCCAGCTCAGCGGCGAACAGGGCATCCGCCAGATCATCGTACCCAGCCAACTCGCCTAA

Upstream 100 bases:

>100_bases
GGATACAGCGCCAAGATCCGTTGCGGAAAATAGGCTATGCTGACGGGCATTCAGCGTAGGCCGCCAGTTTACGCCTTTTA
ACCTCAATGAAAATTAAACC

Downstream 100 bases:

>100_bases
CGGCGGTTAGTTGTTTATCCGCATACATTCCCCAGTCTGAAATCTCCTGTTGATGCTCACACCCAGTGAGCGTCAATTCA
TCGCTATTTTTGTGCCCGCC

Product: trehalose repressor

Products: NA

Alternate protein names: Trehalose operon repressor [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MQNRLTIKDIARLSGVGKSTVSRVLNNEGSVSPQTRERVEAVIRQQGFTPSKSARAMRGQSDKVVGIIVSRLDSPSENQA
VRTMLPLLYQHGFDPIVMESQFETRLVEEHLHVLQQRNVDGVILFGFTGLTAAMLSPWQDKMVVLAREYEGFSSVCYDDD
GAVRLLMERLQQQGHRHIGYLGVQLSDATTGMRRHQAYLDACRQQQITPSVALGELSYQSGFQLAASVIDAQTTALVCAS
DTIALGAIKYLQQQHIAPLQVCGIGNTPLLNFLFPETFSVDLGYGTAGLQAAQQLLGQLSGEQGIRQIIVPSQLA

Sequences:

>Translated_315_residues
MQNRLTIKDIARLSGVGKSTVSRVLNNEGSVSPQTRERVEAVIRQQGFTPSKSARAMRGQSDKVVGIIVSRLDSPSENQA
VRTMLPLLYQHGFDPIVMESQFETRLVEEHLHVLQQRNVDGVILFGFTGLTAAMLSPWQDKMVVLAREYEGFSSVCYDDD
GAVRLLMERLQQQGHRHIGYLGVQLSDATTGMRRHQAYLDACRQQQITPSVALGELSYQSGFQLAASVIDAQTTALVCAS
DTIALGAIKYLQQQHIAPLQVCGIGNTPLLNFLFPETFSVDLGYGTAGLQAAQQLLGQLSGEQGIRQIIVPSQLA
>Mature_315_residues
MQNRLTIKDIARLSGVGKSTVSRVLNNEGSVSPQTRERVEAVIRQQGFTPSKSARAMRGQSDKVVGIIVSRLDSPSENQA
VRTMLPLLYQHGFDPIVMESQFETRLVEEHLHVLQQRNVDGVILFGFTGLTAAMLSPWQDKMVVLAREYEGFSSVCYDDD
GAVRLLMERLQQQGHRHIGYLGVQLSDATTGMRRHQAYLDACRQQQITPSVALGELSYQSGFQLAASVIDAQTTALVCAS
DTIALGAIKYLQQQHIAPLQVCGIGNTPLLNFLFPETFSVDLGYGTAGLQAAQQLLGQLSGEQGIRQIIVPSQLA

Specific function: Repressor of the treBC operon. Binds trehalose 6- phosphate as an inducer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790689, Length=315, Percent_Identity=63.1746031746032, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1788474, Length=289, Percent_Identity=26.643598615917, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790369, Length=310, Percent_Identity=24.8387096774194, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787906, Length=264, Percent_Identity=27.2727272727273, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1789202, Length=272, Percent_Identity=28.6764705882353, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787580, Length=327, Percent_Identity=25.3822629969419, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI48994940, Length=318, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787948, Length=267, Percent_Identity=24.3445692883895, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786540, Length=312, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790194, Length=294, Percent_Identity=24.8299319727891, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790715, Length=321, Percent_Identity=23.98753894081, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786268, Length=211, Percent_Identity=26.5402843601896, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761
- InterPro:   IPR012771 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 34512; Mature: 34512

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRLTIKDIARLSGVGKSTVSRVLNNEGSVSPQTRERVEAVIRQQGFTPSKSARAMRGQ
CCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCC
SDKVVGIIVSRLDSPSENQAVRTMLPLLYQHGFDPIVMESQFETRLVEEHLHVLQQRNVD
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCC
GVILFGFTGLTAAMLSPWQDKMVVLAREYEGFSSVCYDDDGAVRLLMERLQQQGHRHIGY
EEEEECHHHHHHHHHCCCCHHEEEEEEHHCCCCCCEECCCHHHHHHHHHHHHCCCCEEEE
LGVQLSDATTGMRRHQAYLDACRQQQITPSVALGELSYQSGFQLAASVIDAQTTALVCAS
EEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHEEEECC
DTIALGAIKYLQQQHIAPLQVCGIGNTPLLNFLFPETFSVDLGYGTAGLQAAQQLLGQLS
CHHHHHHHHHHHHHCCCCEEEECCCCCCHHHEECCCCEEEECCCCHHHHHHHHHHHHHHC
GEQGIRQIIVPSQLA
CHHHHHHHCCCCCCC
>Mature Secondary Structure
MQNRLTIKDIARLSGVGKSTVSRVLNNEGSVSPQTRERVEAVIRQQGFTPSKSARAMRGQ
CCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCC
SDKVVGIIVSRLDSPSENQAVRTMLPLLYQHGFDPIVMESQFETRLVEEHLHVLQQRNVD
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCC
GVILFGFTGLTAAMLSPWQDKMVVLAREYEGFSSVCYDDDGAVRLLMERLQQQGHRHIGY
EEEEECHHHHHHHHHCCCCHHEEEEEEHHCCCCCCEECCCHHHHHHHHHHHHCCCCEEEE
LGVQLSDATTGMRRHQAYLDACRQQQITPSVALGELSYQSGFQLAASVIDAQTTALVCAS
EEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHEEEECC
DTIALGAIKYLQQQHIAPLQVCGIGNTPLLNFLFPETFSVDLGYGTAGLQAAQQLLGQLS
CHHHHHHHHHHHHHCCCCEEEECCCCCCHHHEECCCCEEEECCCCHHHHHHHHHHHHHHC
GEQGIRQIIVPSQLA
CHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9148912; 7610040; 9278503; 7608078; 9865945 [H]