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The map label for this gene is folP [H]

Identifier: 157368731

GI number: 157368731

Start: 534184

End: 535017

Strand: Direct

Name: folP [H]

Synonym: Spro_0484

Alternate gene names: 157368731

Gene position: 534184-535017 (Clockwise)

Preceding gene: 157368730

Following gene: 157368732

Centisome position: 9.8

GC content: 56.83

Gene sequence:

>834_bases
ATGCAGTTAACCGTGCGAGACACGACTTTCGATCTTTCCCATCCGCGGGTGATGGGGATCCTCAACGTAACCCCGGATTC
TTTTTCTGACGGCGGCCAACACAACCAGCTAAATCAGGCGTTGTTGCATGCGCATGCCCTGATTTCGGCCGGTGCGACCA
TGATTGATGTGGGGGGCGAGTCGACCAGACCGGGAGCGGCAGAGGTTAGTGAAGACGAAGAGATCGCACGCGTAGTGCCC
GTGGTGGAAGCCATTGCCAGGCGTTTTGAAGTCTTTATCTCGGTGGATACCTCGAAAGCCGGGGTGATCCGCGAGTCGGC
TCAGGCCGGGGCGCATCTGATCAACGACGTTCGCTCGCTACAGGAGCCGGGCGCGCTGGCTGCCGCCGCGGAAAGCGGGC
TACCGGTGTGTCTGATGCATATGCAGGGTGAACCGCGCACCATGCAGCAGGCGCCGCACTATGATGACCTTATTGGTGAT
GTTAACGCCTTTTTCCAGCGACATATTGAACGCTGCAATGCCGCCGGGATTAAAAATCAGAAATTGCTGCTCGACCCAGG
ATTCGGTTTCGGTAAGAATTTAGCGCACAATTATCAGCTTCTGGCCAGATTGTCAGAGTTTCATCACTTCGGCCTGCCGT
TGTTGGTGGGGATGTCGCGTAAGTCGATGATTGGACAACTGCTGAACGTGCCCCCCGATCAGCGGGTCATCGGCAGCGTG
GCCTGTGCGGTGATTGCCGCCATGCAGGGCGCACAGATTGTCAGAGTGCATGACGTTAAAGAAACCGTCGAGGCGATGCG
TGTCGTCGAGGCAACACTTTCAGCTAAGGGATGA

Upstream 100 bases:

>100_bases
ACAAGTAACTTTGGCTGTGTAATAACATCGAACCCCGGCATGCCGGGGTTTTTTATTGTCCGGCGGGCAGTGAACCAGGC
AACAGTAAGGTGGATTAGTA

Downstream 100 bases:

>100_bases
TAGAGACATGAGTGAGCGCAAATATTTTGGTACCGACGGCATTCGTGGCAAGGTCGGCGATACTCCTATTACCCCGGAAT
TCGTTTTGAAGCTGGGCTGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MQLTVRDTTFDLSHPRVMGILNVTPDSFSDGGQHNQLNQALLHAHALISAGATMIDVGGESTRPGAAEVSEDEEIARVVP
VVEAIARRFEVFISVDTSKAGVIRESAQAGAHLINDVRSLQEPGALAAAAESGLPVCLMHMQGEPRTMQQAPHYDDLIGD
VNAFFQRHIERCNAAGIKNQKLLLDPGFGFGKNLAHNYQLLARLSEFHHFGLPLLVGMSRKSMIGQLLNVPPDQRVIGSV
ACAVIAAMQGAQIVRVHDVKETVEAMRVVEATLSAKG

Sequences:

>Translated_277_residues
MQLTVRDTTFDLSHPRVMGILNVTPDSFSDGGQHNQLNQALLHAHALISAGATMIDVGGESTRPGAAEVSEDEEIARVVP
VVEAIARRFEVFISVDTSKAGVIRESAQAGAHLINDVRSLQEPGALAAAAESGLPVCLMHMQGEPRTMQQAPHYDDLIGD
VNAFFQRHIERCNAAGIKNQKLLLDPGFGFGKNLAHNYQLLARLSEFHHFGLPLLVGMSRKSMIGQLLNVPPDQRVIGSV
ACAVIAAMQGAQIVRVHDVKETVEAMRVVEATLSAKG
>Mature_277_residues
MQLTVRDTTFDLSHPRVMGILNVTPDSFSDGGQHNQLNQALLHAHALISAGATMIDVGGESTRPGAAEVSEDEEIARVVP
VVEAIARRFEVFISVDTSKAGVIRESAQAGAHLINDVRSLQEPGALAAAAESGLPVCLMHMQGEPRTMQQAPHYDDLIGD
VNAFFQRHIERCNAAGIKNQKLLLDPGFGFGKNLAHNYQLLARLSEFHHFGLPLLVGMSRKSMIGQLLNVPPDQRVIGSV
ACAVIAAMQGAQIVRVHDVKETVEAMRVVEATLSAKG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=276, Percent_Identity=76.0869565217391, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324073, Length=315, Percent_Identity=30.7936507936508, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29793; Mature: 29793

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTVRDTTFDLSHPRVMGILNVTPDSFSDGGQHNQLNQALLHAHALISAGATMIDVGGE
CEEEEECCEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCC
STRPGAAEVSEDEEIARVVPVVEAIARRFEVFISVDTSKAGVIRESAQAGAHLINDVRSL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
QEPGALAAAAESGLPVCLMHMQGEPRTMQQAPHYDDLIGDVNAFFQRHIERCNAAGIKNQ
HCCCCHHHHHCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KLLLDPGFGFGKNLAHNYQLLARLSEFHHFGLPLLVGMSRKSMIGQLLNVPPDQRVIGSV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHH
ACAVIAAMQGAQIVRVHDVKETVEAMRVVEATLSAKG
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLTVRDTTFDLSHPRVMGILNVTPDSFSDGGQHNQLNQALLHAHALISAGATMIDVGGE
CEEEEECCEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCC
STRPGAAEVSEDEEIARVVPVVEAIARRFEVFISVDTSKAGVIRESAQAGAHLINDVRSL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
QEPGALAAAAESGLPVCLMHMQGEPRTMQQAPHYDDLIGDVNAFFQRHIERCNAAGIKNQ
HCCCCHHHHHCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KLLLDPGFGFGKNLAHNYQLLARLSEFHHFGLPLLVGMSRKSMIGQLLNVPPDQRVIGSV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHH
ACAVIAAMQGAQIVRVHDVKETVEAMRVVEATLSAKG
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]