BacMap

Definition	Serratia proteamaculans 568 chromosome, complete genome.
Accession	NC_009832
Length	5,448,853

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The map label for this gene is hflB [H]

Identifier: 157368730

GI number: 157368730

Start: 532160

End: 534091

Strand: Direct

Name: hflB [H]

Synonym: Spro_0483

Alternate gene names: 157368730

Gene position: 532160-534091 (Clockwise)

Preceding gene: 157368729

Following gene: 157368731

Centisome position: 9.77

GC content: 54.76

Gene sequence:

>1932_bases
ATGGCGAAAAACCTAATTCTCTGGTTAGTCATCGCGGTAGTGTTGATGTCTGTATTCCAGAGCTTTGGGCCCAGCGAGTC
GAATGGCCGTAGGGTGGATTACTCTACCTTCATGTCCGAGCTGACCCAGGACCAGGTTCGCGAAGCGCGAATCAACGGAC
GTGAAATTAACGTTACCAAGAAAGACAGTAACAAATACACGACCTACATCCCTGTCAACGATCCGAAATTGCTGGATACG
TTGTTAACCAAGAATGTGAAAGTTGTTGGTGAGCCACCTGAAGAGCCGAGTTTACTGGCTTCTATCTTTATTTCGTGGTT
CCCAATGCTGTTGCTGATCGGGGTTTGGATCTTCTTCATGCGGCAGATGCAGGGCGGCGGCGGCAAGGGCGCGATGTCCT
TCGGCAAGAGCAAGGCCCGCATGTTGACGGAAGACCAGATCAAAACCACTTTTGCCGACGTTGCTGGTTGCGACGAAGCA
AAAGAAGAAGTGAGCGAACTGGTGGAATACCTGCGTGAGCCGAGCCGTTTCCAGAAGTTGGGCGGTAAGATCCCTAAAGG
CGTGCTGATGGTTGGCCCTCCAGGGACCGGTAAAACGCTGTTGGCGAAAGCTATCGCCGGCGAGGCAAAAGTGCCGTTCT
TCACCATTTCCGGTTCCGACTTCGTGGAAATGTTCGTGGGTGTTGGTGCATCTCGTGTGCGTGACATGTTCGAACAGGCC
AAGAAAGCGGCACCGTGCATCATCTTTATCGATGAAATCGACGCCGTCGGTCGCCAGCGTGGCGCCGGTCTGGGTGGCGG
TCACGATGAACGTGAGCAAACGCTGAACCAGATGCTGGTTGAAATGGACGGCTTTGAAGGCAACGAAGGCATTATCGTCA
TCGCTGCGACCAACCGTCCTGACGTACTTGACCCGGCATTGCTGCGTCCAGGCCGTTTCGACCGTCAGGTTGTTGTTGGT
CTGCCAGACGTACGTGGTCGTGAGCAGATCCTGAAAGTGCACTCCCGTCGCGTGCCTTTGGCACCGGATGTTGATGCTTC
AGTACTGGCGCGTGGTACACCGGGCTTCTCAGGTGCTGACCTGGCTAACCTGGTCAACGAAGCGGCACTGTTTGCTGCCC
GTGGCAACAAACGCGTTGTGTCGATGGTTGAGTTCGAAAAAGCCAAAGACAAGATCATGATGGGTGCGGAACGTCGCTCC
ATGGTGATGACCGAAGCGCAGAAAGAGTCGACCGCGTATCACGAAGCAGGCCACGCCATTATCGGCCGTCTGGTTCCTGA
GCACGATCCGGTACACAAGGTAACCATTATTCCTCGTGGCCGTGCGTTGGGGGTTACCTTCTTCCTGCCGGAAGGCGATG
CTATCAGCGCCAGCCGTCAGAAACTGGAGAGTCAAATCTCTACTCTGTACGGTGGCCGTCTGGCTGAAGAGATCATCTAC
GGGCCAGAGAAAGTCTCTACAGGTGCGTCGAACGACATTAAAGTGGCGACCTCGATTGCCCGCAACATGGTGACCCAATG
GGGCTTCTCCGAGAAGCTGGGGCCATTGCTGTATGCGGAAGAAGAGGGCGAAGTGTTCCTGGGCCGTTCCGTGGCCAAGG
CGAAACACATGTCGGACGAAACCGCGCGCATCATCGACCAGGAAGTTAAATCCCTGATCGAACGCAACTACATCCGTGCG
CGTGCGTTGTTGATGGAAAACATGGACATCCTGCATTCAATGAAGGATGCACTGATGAAGTATGAAACCATCGATGCGCC
TCAGATCGACGATCTGATGAACCGCAAAGACGTGCGTCCGCCAGCGGGTTGGGACGATGCGAGCAAAGGCAGCAACTCCG
ACAATGGCGGCACACCAAAAGCCCCAACGCCGGTAGATGAGCCACGCACGCCAAACCCAGGCAATACCATGTCTGAACAG
CTAGACAAGTAA

Upstream 100 bases:

>100_bases
GTTCGCGCGAAGTGTACATTGTAGCGACAGGGCGCAAGCTGTAGTACCCTAACGCTGTTTGTTAACACAGTTGTAATATG
AGGTTAATCCCTTGAGTGAC

Downstream 100 bases:

>100_bases
CTTTGGCTGTGTAATAACATCGAACCCCGGCATGCCGGGGTTTTTTATTGTCCGGCGGGCAGTGAACCAGGCAACAGTAA
GGTGGATTAGTAATGCAGTT

Product: ATP-dependent metalloprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 643; Mature: 642

Protein sequence:

>643_residues
MAKNLILWLVIAVVLMSVFQSFGPSESNGRRVDYSTFMSELTQDQVREARINGREINVTKKDSNKYTTYIPVNDPKLLDT
LLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEA
KEEVSELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVG
LPDVRGREQILKVHSRRVPLAPDVDASVLARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRS
MVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
GPEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETARIIDQEVKSLIERNYIRA
RALLMENMDILHSMKDALMKYETIDAPQIDDLMNRKDVRPPAGWDDASKGSNSDNGGTPKAPTPVDEPRTPNPGNTMSEQ
LDK

Sequences:

>Translated_643_residues
MAKNLILWLVIAVVLMSVFQSFGPSESNGRRVDYSTFMSELTQDQVREARINGREINVTKKDSNKYTTYIPVNDPKLLDT
LLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEA
KEEVSELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVG
LPDVRGREQILKVHSRRVPLAPDVDASVLARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRS
MVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
GPEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETARIIDQEVKSLIERNYIRA
RALLMENMDILHSMKDALMKYETIDAPQIDDLMNRKDVRPPAGWDDASKGSNSDNGGTPKAPTPVDEPRTPNPGNTMSEQ
LDK
>Mature_642_residues
AKNLILWLVIAVVLMSVFQSFGPSESNGRRVDYSTFMSELTQDQVREARINGREINVTKKDSNKYTTYIPVNDPKLLDTL
LTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAK
EEVSELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAK
KAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGL
PDVRGREQILKVHSRRVPLAPDVDASVLARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSM
VMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIYG
PEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETARIIDQEVKSLIERNYIRAR
ALLMENMDILHSMKDALMKYETIDAPQIDDLMNRKDVRPPAGWDDASKGSNSDNGGTPKAPTPVDEPRTPNPGNTMSEQL
DK

Specific function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins [H]

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase M41 family [H]

Homologues:

Organism=Homo sapiens, GI300192933, Length=525, Percent_Identity=44.952380952381, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI7657689, Length=449, Percent_Identity=49.6659242761693, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI21327685, Length=449, Percent_Identity=49.6659242761693, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI4507173, Length=471, Percent_Identity=41.1889596602972, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI4506209, Length=254, Percent_Identity=42.5196850393701, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI24497435, Length=262, Percent_Identity=41.6030534351145, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI6005942, Length=226, Percent_Identity=44.6902654867257, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI21361144, Length=228, Percent_Identity=45.6140350877193, Blast_Score=206, Evalue=7e-53,
Organism=Homo sapiens, GI24430151, Length=254, Percent_Identity=40.5511811023622, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI195539395, Length=253, Percent_Identity=40.7114624505929, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI89064750, Length=264, Percent_Identity=41.6666666666667, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI5729991, Length=264, Percent_Identity=41.6666666666667, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI24430155, Length=264, Percent_Identity=41.6666666666667, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI45643123, Length=280, Percent_Identity=38.5714285714286, Blast_Score=193, Evalue=5e-49,
Organism=Homo sapiens, GI45643125, Length=278, Percent_Identity=38.8489208633094, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI157671927, Length=237, Percent_Identity=40.084388185654, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI4505725, Length=213, Percent_Identity=42.2535211267606, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI40806173, Length=137, Percent_Identity=59.1240875912409, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI229577436, Length=246, Percent_Identity=39.8373983739837, Blast_Score=170, Evalue=5e-42,
Organism=Homo sapiens, GI194018488, Length=255, Percent_Identity=39.6078431372549, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI24497618, Length=231, Percent_Identity=39.8268398268398, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI153792536, Length=231, Percent_Identity=39.8268398268398, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI5901990, Length=233, Percent_Identity=40.343347639485, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI226371754, Length=234, Percent_Identity=39.7435897435897, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI14149767, Length=273, Percent_Identity=36.2637362637363, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI62177112, Length=273, Percent_Identity=36.2637362637363, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI156564401, Length=235, Percent_Identity=40, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI310125280, Length=235, Percent_Identity=39.5744680851064, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI310125282, Length=235, Percent_Identity=39.5744680851064, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI7019569, Length=248, Percent_Identity=37.0967741935484, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI11875211, Length=227, Percent_Identity=40.0881057268723, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI40806170, Length=227, Percent_Identity=40.0881057268723, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI31742536, Length=255, Percent_Identity=34.1176470588235, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI112789543, Length=255, Percent_Identity=34.1176470588235, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI17865802, Length=251, Percent_Identity=37.8486055776892, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI31377644, Length=238, Percent_Identity=35.2941176470588, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI64084766, Length=318, Percent_Identity=28.3018867924528, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI116292174, Length=249, Percent_Identity=30.5220883534137, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI75677353, Length=196, Percent_Identity=31.1224489795918, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI283436220, Length=207, Percent_Identity=29.4685990338164, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI283436222, Length=207, Percent_Identity=29.4685990338164, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI283436224, Length=206, Percent_Identity=29.6116504854369, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1789568, Length=641, Percent_Identity=94.0717628705148, Blast_Score=1244, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71994521, Length=468, Percent_Identity=48.7179487179487, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17554264, Length=484, Percent_Identity=44.4214876033058, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI115534323, Length=457, Percent_Identity=43.9824945295405, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17554786, Length=262, Percent_Identity=43.1297709923664, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17563248, Length=261, Percent_Identity=42.5287356321839, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17532375, Length=338, Percent_Identity=37.2781065088757, Blast_Score=219, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI25144278, Length=262, Percent_Identity=43.1297709923664, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25144281, Length=262, Percent_Identity=43.1297709923664, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71987364, Length=254, Percent_Identity=41.7322834645669, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71987372, Length=254, Percent_Identity=41.7322834645669, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17531535, Length=245, Percent_Identity=44.0816326530612, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17508701, Length=228, Percent_Identity=45.6140350877193, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17563250, Length=254, Percent_Identity=39.7637795275591, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17505546, Length=248, Percent_Identity=40.7258064516129, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17508053, Length=243, Percent_Identity=40.3292181069959, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17554784, Length=259, Percent_Identity=41.3127413127413, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25153574, Length=249, Percent_Identity=37.7510040160643, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17537217, Length=257, Percent_Identity=36.9649805447471, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI193209502, Length=225, Percent_Identity=39.5555555555556, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI193206114, Length=243, Percent_Identity=39.0946502057613, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI133931034, Length=243, Percent_Identity=39.0946502057613, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI193206116, Length=243, Percent_Identity=39.0946502057613, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17570397, Length=165, Percent_Identity=46.0606060606061, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32566590, Length=165, Percent_Identity=46.0606060606061, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI133901658, Length=212, Percent_Identity=40.5660377358491, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI133901662, Length=212, Percent_Identity=40.5660377358491, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25146157, Length=260, Percent_Identity=39.2307692307692, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562804, Length=230, Percent_Identity=37.3913043478261, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI86561515, Length=242, Percent_Identity=35.5371900826446, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32563584, Length=241, Percent_Identity=37.344398340249, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17508421, Length=241, Percent_Identity=37.344398340249, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17560432, Length=226, Percent_Identity=37.1681415929204, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541224, Length=263, Percent_Identity=34.2205323193916, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17541226, Length=263, Percent_Identity=34.2205323193916, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71990294, Length=198, Percent_Identity=31.3131313131313, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325281, Length=495, Percent_Identity=46.2626262626263, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6323736, Length=505, Percent_Identity=46.3366336633663, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6320854, Length=504, Percent_Identity=45.8333333333333, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322704, Length=261, Percent_Identity=42.5287356321839, Blast_Score=222, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320077, Length=260, Percent_Identity=42.3076923076923, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6321390, Length=254, Percent_Identity=41.3385826771654, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324691, Length=237, Percent_Identity=43.4599156118143, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324833, Length=253, Percent_Identity=41.897233201581, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320197, Length=245, Percent_Identity=38.7755102040816, Blast_Score=194, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6320602, Length=241, Percent_Identity=42.3236514522822, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6322994, Length=230, Percent_Identity=39.1304347826087, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324000, Length=240, Percent_Identity=41.6666666666667, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323429, Length=252, Percent_Identity=40.8730158730159, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321709, Length=256, Percent_Identity=38.671875, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6322651, Length=245, Percent_Identity=35.5102040816327, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319554, Length=213, Percent_Identity=39.4366197183099, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321465, Length=239, Percent_Identity=37.6569037656904, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325431, Length=226, Percent_Identity=38.0530973451327, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325183, Length=237, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6320887, Length=247, Percent_Identity=33.1983805668016, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6320583, Length=160, Percent_Identity=27.5, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24658770, Length=450, Percent_Identity=48.4444444444444, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24665814, Length=526, Percent_Identity=42.7756653992395, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI28574878, Length=528, Percent_Identity=42.8030303030303, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24639391, Length=450, Percent_Identity=44.2222222222222, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17137738, Length=254, Percent_Identity=43.7007874015748, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI161076486, Length=310, Percent_Identity=37.741935483871, Blast_Score=222, Evalue=7e-58,
Organism=Drosophila melanogaster, GI17137560, Length=310, Percent_Identity=37.741935483871, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI161076488, Length=310, Percent_Identity=37.741935483871, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI19920408, Length=262, Percent_Identity=41.6030534351145, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24651451, Length=262, Percent_Identity=42.3664122137405, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI45554047, Length=163, Percent_Identity=58.2822085889571, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24649446, Length=254, Percent_Identity=41.3385826771654, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24660075, Length=230, Percent_Identity=43.4782608695652, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281365776, Length=230, Percent_Identity=43.4782608695652, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45552965, Length=230, Percent_Identity=43.4782608695652, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24640100, Length=253, Percent_Identity=40.3162055335968, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI19921202, Length=243, Percent_Identity=41.9753086419753, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17738151, Length=242, Percent_Identity=42.5619834710744, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24652279, Length=272, Percent_Identity=37.8676470588235, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24663015, Length=253, Percent_Identity=41.1067193675889, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI18860063, Length=240, Percent_Identity=42.0833333333333, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281361487, Length=253, Percent_Identity=40.3162055335968, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24656825, Length=227, Percent_Identity=41.8502202643172, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24656820, Length=227, Percent_Identity=41.8502202643172, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI281363136, Length=235, Percent_Identity=39.1489361702128, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI78707192, Length=235, Percent_Identity=39.1489361702128, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355121, Length=232, Percent_Identity=37.0689655172414, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24644145, Length=233, Percent_Identity=39.0557939914163, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI20129529, Length=274, Percent_Identity=35.7664233576642, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI281360144, Length=228, Percent_Identity=37.280701754386, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360140, Length=228, Percent_Identity=37.280701754386, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360136, Length=228, Percent_Identity=37.280701754386, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24644411, Length=228, Percent_Identity=37.280701754386, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360142, Length=230, Percent_Identity=37.8260869565217, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21357333, Length=230, Percent_Identity=37.8260869565217, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360146, Length=230, Percent_Identity=37.8260869565217, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360138, Length=230, Percent_Identity=37.8260869565217, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18859657, Length=251, Percent_Identity=38.6454183266932, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI28573010, Length=214, Percent_Identity=41.1214953271028, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17864540, Length=214, Percent_Identity=41.1214953271028, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28571849, Length=238, Percent_Identity=40.3361344537815, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571847, Length=238, Percent_Identity=40.3361344537815, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24581396, Length=232, Percent_Identity=39.6551724137931, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI20129423, Length=233, Percent_Identity=36.0515021459227, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24639486, Length=196, Percent_Identity=35.2040816326531, Blast_Score=106, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR005936
- InterPro:   IPR011546
- InterPro:   IPR000642 [H]

Pfam domain/function: PF00004 AAA; PF06480 FtsH_ext; PF01434 Peptidase_M41 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 70509; Mature: 70378

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00674 AAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNLILWLVIAVVLMSVFQSFGPSESNGRRVDYSTFMSELTQDQVREARINGREINVTK
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCEEEEEE
KDSNKYTTYIPVNDPKLLDTLLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFM
CCCCCEEEEEECCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAKEEVSELVEYLREPSRFQKL
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHH
GGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
CCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHH
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRP
HHCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
DVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHSRRVPLAPDVDASVLARGTPGFSGAD
CCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHH
LANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
HHHHCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDE
CCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCHH
TARIIDQEVKSLIERNYIRARALLMENMDILHSMKDALMKYETIDAPQIDDLMNRKDVRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
PAGWDDASKGSNSDNGGTPKAPTPVDEPRTPNPGNTMSEQLDK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure 
AKNLILWLVIAVVLMSVFQSFGPSESNGRRVDYSTFMSELTQDQVREARINGREINVTK
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCEEEEEE
KDSNKYTTYIPVNDPKLLDTLLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFM
CCCCCEEEEEECCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAKEEVSELVEYLREPSRFQKL
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHH
GGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
CCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHH
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRP
HHCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
DVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHSRRVPLAPDVDASVLARGTPGFSGAD
CCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHH
LANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
HHHHCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDE
CCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCHH
TARIIDQEVKSLIERNYIRARALLMENMDILHSMKDALMKYETIDAPQIDDLMNRKDVRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
PAGWDDASKGSNSDNGGTPKAPTPVDEPRTPNPGNTMSEQLDK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]