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The map label for this gene is aidB [H]

Identifier: 157368687

GI number: 157368687

Start: 492978

End: 494612

Strand: Direct

Name: aidB [H]

Synonym: Spro_0440

Alternate gene names: 157368687

Gene position: 492978-494612 (Clockwise)

Preceding gene: 157368686

Following gene: 157368688

Centisome position: 9.05

GC content: 60.61

Gene sequence:

>1635_bases
ATGGTCTGGAATACACACACCGTTTTTAATCAGCCGAAGCCGCTCGGGAACAGCAATCTGTTCCTGTCCGATACGGCACT
GCATGAGGCGGTACAGCGCGAGCAAGCCGGTTGGGATGTGGAAGTGCTGGCCTCGTTGGGGCAGCAGTTGGGTACCCAGG
AATCGCTGGAACTGGGGCGATTGGCCAATGCCAACCCGCCGGAGTTATTGCGTTATGATGCCACCGGCCAGCGGTTGGAC
GACGTCCGTTTCCATCCCGCCTGGCATATCCTGATGCAAGGCTTGATCGCTAACCGTGTGCATAACCTGCCGTGGCAGGA
GGATGCCCGTATTGGTTCATTCGTGGCGCGCGCCGCGCGTTTTGTGCTGCATGCTCAGGTCGAAGCCGGCACCCTGTGCC
CGGTGACCATGACCTTTGGCGCTATCCCACTGCTGCAGCGTTCTCTGCCGACAGAATTCCAATCCTGGTTAACGCCACTG
CTATCCGATCGTTACGACGCGCATGTGCTGCCCGGTGGGCAAAAGCGCGGCTTGCTGATTGGCATGGGGATGACCGAAAA
GCAGGGCGGTTCCGACGTATTGAGCAATACCACCACCGCCAGCCCGTTAGCGGCCCGCGGCCCGGGGGAGGCTTACCGGC
TGGTAGGACACAAATGGTTTTTCTCGGTGCCGCAGAGCGATGCGCACCTGGTGCTGGCGCAGGCCGATGGCGGTCTGTCC
TGCTTCTTTCTGCCGCGTATTTTGCCGGACGGCACGCGCAACGCCATACGGCTGGAGCGGTTGAAGGATAAACTGGGTAA
TCGTTCCAACGCCAGCGGAGAGGTTGAGTTTCAGGACGCCAGTGCCTGGCTGGTGGGCGAGGAAGGAGATGGCGTGCGGC
ATATCCTGAAAATGGGTGGCCTGACGCGCTTTGACTGTGCGTTGGGCAGCCAGGGTTTGATGCGGCGCGGGCTATCGGTG
GCGTTATACCACGCTCTGCAGCGGCAGGCGTTCGGCAAACCCTTGATCGAACAACCGATGATGCGTCAGGTGTTGGCACG
GATGGCGCTGCGGCTGGAGGGGCAAACGGCGGCCCTGATGCGCCTGGCGCGAGCCTATGACAGCATCGGCGTCGGGGCGC
CTTTGGAACAGGCGCTGTGTCGGGTGATGACCCCGGCGGCGAAGTTTGAAGTCTGTCGACAGGGCATCCCTTTTATCGGT
GAAGCGATGGAGGCGCTGGGCGGTATCGGCTACTGTGAAGAGAGTGAACTGCCGCGGCTGTACCGTGAAATGCCGGTGAA
CAGCATTTGGGAAGGTTCCGGCAATATCATGTGTCTGGACGTGATGCGAGCCTGGGGGAAGCTGCCGGTGGTACAAGAAG
CCCTGGAGCTTGAATTTGGTGAGGTCAGGGGGCAGAACCGTCACTTTGATCGCCAGTGGCGGCAGTTGCTCCAGTTGATG
CGCAAACCCCAGGAGGAGCAGGGACGGGCAGTCACCGGAGCGTTATTCAATCTGTTCGCCGCGGCGCAGCTTCTGCGCTA
CAGTTCACCGCCGTTAGCGGAAGCCTGGTGCCAAATGATGCTCGATATCCGTGGTGAGCGAACATTACCAGACCGTCTGT
GCGAGACGTTGTTTGCCCGAGCGATGGGAGGCTAG

Upstream 100 bases:

>100_bases
CCTTGTTGCTTTCTCAATTCCCACCCTGTGATCTCACCTGCGGCAGAAATCCCCCTGACGACCATACTTACTCCTGACGC
CTTTATCAGGGAGCAAGCCG

Downstream 100 bases:

>100_bases
GGAAAACAGTAGCGCTACAGCGGGAAAAGCTTTTTAATTCAGCACTTGGCCCGTAAGGGATACTGACCTCTGACCAGGAA
ACATGACATGGATATTCTCA

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MVWNTHTVFNQPKPLGNSNLFLSDTALHEAVQREQAGWDVEVLASLGQQLGTQESLELGRLANANPPELLRYDATGQRLD
DVRFHPAWHILMQGLIANRVHNLPWQEDARIGSFVARAARFVLHAQVEAGTLCPVTMTFGAIPLLQRSLPTEFQSWLTPL
LSDRYDAHVLPGGQKRGLLIGMGMTEKQGGSDVLSNTTTASPLAARGPGEAYRLVGHKWFFSVPQSDAHLVLAQADGGLS
CFFLPRILPDGTRNAIRLERLKDKLGNRSNASGEVEFQDASAWLVGEEGDGVRHILKMGGLTRFDCALGSQGLMRRGLSV
ALYHALQRQAFGKPLIEQPMMRQVLARMALRLEGQTAALMRLARAYDSIGVGAPLEQALCRVMTPAAKFEVCRQGIPFIG
EAMEALGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVMRAWGKLPVVQEALELEFGEVRGQNRHFDRQWRQLLQLM
RKPQEEQGRAVTGALFNLFAAAQLLRYSSPPLAEAWCQMMLDIRGERTLPDRLCETLFARAMGG

Sequences:

>Translated_544_residues
MVWNTHTVFNQPKPLGNSNLFLSDTALHEAVQREQAGWDVEVLASLGQQLGTQESLELGRLANANPPELLRYDATGQRLD
DVRFHPAWHILMQGLIANRVHNLPWQEDARIGSFVARAARFVLHAQVEAGTLCPVTMTFGAIPLLQRSLPTEFQSWLTPL
LSDRYDAHVLPGGQKRGLLIGMGMTEKQGGSDVLSNTTTASPLAARGPGEAYRLVGHKWFFSVPQSDAHLVLAQADGGLS
CFFLPRILPDGTRNAIRLERLKDKLGNRSNASGEVEFQDASAWLVGEEGDGVRHILKMGGLTRFDCALGSQGLMRRGLSV
ALYHALQRQAFGKPLIEQPMMRQVLARMALRLEGQTAALMRLARAYDSIGVGAPLEQALCRVMTPAAKFEVCRQGIPFIG
EAMEALGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVMRAWGKLPVVQEALELEFGEVRGQNRHFDRQWRQLLQLM
RKPQEEQGRAVTGALFNLFAAAQLLRYSSPPLAEAWCQMMLDIRGERTLPDRLCETLFARAMGG
>Mature_544_residues
MVWNTHTVFNQPKPLGNSNLFLSDTALHEAVQREQAGWDVEVLASLGQQLGTQESLELGRLANANPPELLRYDATGQRLD
DVRFHPAWHILMQGLIANRVHNLPWQEDARIGSFVARAARFVLHAQVEAGTLCPVTMTFGAIPLLQRSLPTEFQSWLTPL
LSDRYDAHVLPGGQKRGLLIGMGMTEKQGGSDVLSNTTTASPLAARGPGEAYRLVGHKWFFSVPQSDAHLVLAQADGGLS
CFFLPRILPDGTRNAIRLERLKDKLGNRSNASGEVEFQDASAWLVGEEGDGVRHILKMGGLTRFDCALGSQGLMRRGLSV
ALYHALQRQAFGKPLIEQPMMRQVLARMALRLEGQTAALMRLARAYDSIGVGAPLEQALCRVMTPAAKFEVCRQGIPFIG
EAMEALGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVMRAWGKLPVVQEALELEFGEVRGQNRHFDRQWRQLLQLM
RKPQEEQGRAVTGALFNLFAAAQLLRYSSPPLAEAWCQMMLDIRGERTLPDRLCETLFARAMGG

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=318, Percent_Identity=27.3584905660377, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI4557231, Length=282, Percent_Identity=26.9503546099291, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI187960098, Length=282, Percent_Identity=26.9503546099291, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI226958412, Length=275, Percent_Identity=26.9090909090909, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI226958414, Length=275, Percent_Identity=26.9090909090909, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI7656849, Length=271, Percent_Identity=26.1992619926199, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI76496475, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4557235, Length=272, Percent_Identity=26.8382352941176, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87082384, Length=545, Percent_Identity=71.0091743119266, Blast_Score=781, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=330, Percent_Identity=26.3636363636364, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081958, Length=264, Percent_Identity=28.030303030303, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI86563383, Length=434, Percent_Identity=32.258064516129, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI86563381, Length=434, Percent_Identity=32.258064516129, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=275, Percent_Identity=28.7272727272727, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=266, Percent_Identity=23.6842105263158, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=270, Percent_Identity=27.037037037037, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506239, Length=269, Percent_Identity=23.0483271375465, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71985184, Length=340, Percent_Identity=24.4117647058824, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356377, Length=319, Percent_Identity=24.7648902821317, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646207, Length=277, Percent_Identity=24.5487364620939, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363737, Length=298, Percent_Identity=23.8255033557047, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355753, Length=267, Percent_Identity=28.0898876404494, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 60287; Mature: 60287

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWNTHTVFNQPKPLGNSNLFLSDTALHEAVQREQAGWDVEVLASLGQQLGTQESLELGR
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
LANANPPELLRYDATGQRLDDVRFHPAWHILMQGLIANRVHNLPWQEDARIGSFVARAAR
CCCCCCHHHEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FVLHAQVEAGTLCPVTMTFGAIPLLQRSLPTEFQSWLTPLLSDRYDAHVLPGGQKRGLLI
HHHHEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCCEEE
GMGMTEKQGGSDVLSNTTTASPLAARGPGEAYRLVGHKWFFSVPQSDAHLVLAQADGGLS
ECCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCEEEEEECCCCEE
CFFLPRILPDGTRNAIRLERLKDKLGNRSNASGEVEFQDASAWLVGEEGDGVRHILKMGG
EEEHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHCC
LTRFDCALGSQGLMRRGLSVALYHALQRQAFGKPLIEQPMMRQVLARMALRLEGQTAALM
CCEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
RLARAYDSIGVGAPLEQALCRVMTPAAKFEVCRQGIPFIGEAMEALGGIGYCEESELPRL
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHH
YREMPVNSIWEGSGNIMCLDVMRAWGKLPVVQEALELEFGEVRGQNRHFDRQWRQLLQLM
HHHCCCCCEECCCCCEEEHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RKPQEEQGRAVTGALFNLFAAAQLLRYSSPPLAEAWCQMMLDIRGERTLPDRLCETLFAR
HCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AMGG
HCCC
>Mature Secondary Structure
MVWNTHTVFNQPKPLGNSNLFLSDTALHEAVQREQAGWDVEVLASLGQQLGTQESLELGR
CCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
LANANPPELLRYDATGQRLDDVRFHPAWHILMQGLIANRVHNLPWQEDARIGSFVARAAR
CCCCCCHHHEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
FVLHAQVEAGTLCPVTMTFGAIPLLQRSLPTEFQSWLTPLLSDRYDAHVLPGGQKRGLLI
HHHHEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCCEEE
GMGMTEKQGGSDVLSNTTTASPLAARGPGEAYRLVGHKWFFSVPQSDAHLVLAQADGGLS
ECCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCEEEEEECCCCEE
CFFLPRILPDGTRNAIRLERLKDKLGNRSNASGEVEFQDASAWLVGEEGDGVRHILKMGG
EEEHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHCC
LTRFDCALGSQGLMRRGLSVALYHALQRQAFGKPLIEQPMMRQVLARMALRLEGQTAALM
CCEEHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
RLARAYDSIGVGAPLEQALCRVMTPAAKFEVCRQGIPFIGEAMEALGGIGYCEESELPRL
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHH
YREMPVNSIWEGSGNIMCLDVMRAWGKLPVVQEALELEFGEVRGQNRHFDRQWRQLLQLM
HHHCCCCCEECCCCCEEEHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RKPQEEQGRAVTGALFNLFAAAQLLRYSSPPLAEAWCQMMLDIRGERTLPDRLCETLFAR
HCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AMGG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]