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The map label for this gene is mutL

Identifier: 157368676

GI number: 157368676

Start: 480246

End: 482120

Strand: Direct

Name: mutL

Synonym: Spro_0429

Alternate gene names: 157368676

Gene position: 480246-482120 (Clockwise)

Preceding gene: 157368675

Following gene: 157368677

Centisome position: 8.81

GC content: 57.33

Gene sequence:

>1875_bases
ATGCCCATCCAGGTGTTACCGCCCCAGCTTGCCAACCAGATTGCCGCCGGTGAAGTGGTCGAGCGGCCCGCGTCGGTGGT
CAAGGAATTGGTGGAAAACAGTCTGGATGCCGGGGCGACGCGTATTGATATTGATATCGAGCGTGGTGGCGCCAAGCTGA
TCCGCATTCGTGATAACGGCAGTGGTATTGGCAAGGACGACCTGGCTCTGGCATTGGCTCGTCACGCCACCAGTAAAATC
AGCACGCTCGACGATTTGGAAGCCATTGTCAGCCTCGGCTTTCGCGGCGAGGCGTTGGCCAGCATCAGCTCGGTTTCTCG
CTTAACCCTCACTTCACGTACCGCAGAACAAAACGAAGCCTGGCAGGCTTATGCCGAAGGCCGCGATCAGGCGGTGACGG
TCAAGCCGGCGGCACACCCGATAGGCAGCACGCTGGAAGTGCTGGATCTGTTCTACAACACCCCGGCGCGGCGCAAATTT
ATGCGCACCGAGAAAACCGAATTTGGCCATATCGATGAAGTGGTGCGACGTATTGCACTGGCGCGTTTCGATGTGGCGAT
CAACCTTAGTCACAATGGCAAGCTGATGCGTCAATATCGCGCAGCGAAAGACGAGAGCCAGTATGAGCGCCGTCTGGGCA
GTATTTGCGGCCCGGCCTTTTTGCAGCATGCGCTGAACATCTCCTGGCAGCACGGTGACCTGACCATTCGCGGCTGGGTG
GCCGATCCTGCCGGTGCGCGGCAACTGGGCGAAATGCAGTATTGCTACGTCAACAGCCGCATGATGCGCGATCGTTTGAT
CAATCACGCTATCCGCCAGGCTTATCAGGATCAACTGAAAGACGACCAGCAGCCTGCCTATGTGCTGTATCTCGAGGTAG
ACCCGCATCAGGTGGATGTGAATGTTCACCCGGCCAAGCACGAGGTGCGTTTCCATCAGGCTCGGCTGGTGCACGACTTT
ATCTATCAGGCGGTAACCACCGTGTTGCAGCAGGTCGGCAATGCGCCGCTGCCGTTGACCGATGAAACCGAGCAGCAACC
GACACCGGTCTGGCAGCCGGAAAACCGCGTCGCCGCTGGCGGCAACCATTTTTCGCAGCCTGCACCGCGCCGAGAAACCG
CATCAACCGAGCCTGCCGTCGCGCGTGAACGTGCGCCGCAACCGGCCTATCATTCGGGCAGTGGTTACCAGAAGCGGGAA
GGTGAGCTGTACGGCAAGCTGTTGCAGGCCACGCCAGTGGCTGAGCCACGGCAAGAAGCACCAAAGCAACCGCTGTTTCC
ACCGGTAAAAACCGAGCAGGAAACGCCACTGGCCGGGAGTCAGCACAGTTTCGGCCGTGTGCTGATGATCTACCCGCCGT
GTTATGCGCTGATTGAAAACGGTCAGCAGTTGATGTTGCTTAACCTGCCGGTGGCCGAACGCTGGTTACGTCAGGCGCAA
CTTAATCCTTCGCAAGAAGGCCTGCGGCCACAGCCGCTGCTGATCCCCATCAAGCTGACGTTGAACAAACAAGAGGCGGC
AGCCTGCATACATCATCAGCCGCTATTGGTAACAATGGGGTTGGATCTGCAAGTAGATCACGGGCGTGTGACGTTGCGCG
CAGTACCTTTACCATTACGCCAACAAAATTTACAAAAACTGATACCCGAACTGTTAGGCTATCTGGCCGAGCATCAGGAG
ATGTCGCCCGCGGTATTGGCCACCTGGTTTGCCCGCCATTTAGGTAGCGAACATGAACAGTGGAACACCTCGCAAGCGAT
ACAATTGCTGACCGACGTTGAACGACTTTGCCCGCAGCTGGTCAAATCACCACCCAGCGGACTTTTACAACCTGTTGATT
TACAGGCTGCACTGACAGCACTTAGGCATGATTGA

Upstream 100 bases:

>100_bases
CAGCGATCTGAAACGCGTGAATAAACTGAAGTCGGACGTCGCGCCGCTGGATCGGACGCTGACCATTCCGCAGGCCTAGC
GCCCACATACAGGAGTCAGC

Downstream 100 bases:

>100_bases
AACTGAAATGACACCACGTCCCCCGGCTATCTTTATCATGGGGCCGACCGCCTCGGGCAAAACCGCATTGGCGATCGCGC
TGCGTGAACGCCTGCCTGTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIGKDDLALALARHATSKI
STLDDLEAIVSLGFRGEALASISSVSRLTLTSRTAEQNEAWQAYAEGRDQAVTVKPAAHPIGSTLEVLDLFYNTPARRKF
MRTEKTEFGHIDEVVRRIALARFDVAINLSHNGKLMRQYRAAKDESQYERRLGSICGPAFLQHALNISWQHGDLTIRGWV
ADPAGARQLGEMQYCYVNSRMMRDRLINHAIRQAYQDQLKDDQQPAYVLYLEVDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQAVTTVLQQVGNAPLPLTDETEQQPTPVWQPENRVAAGGNHFSQPAPRRETASTEPAVARERAPQPAYHSGSGYQKRE
GELYGKLLQATPVAEPRQEAPKQPLFPPVKTEQETPLAGSQHSFGRVLMIYPPCYALIENGQQLMLLNLPVAERWLRQAQ
LNPSQEGLRPQPLLIPIKLTLNKQEAAACIHHQPLLVTMGLDLQVDHGRVTLRAVPLPLRQQNLQKLIPELLGYLAEHQE
MSPAVLATWFARHLGSEHEQWNTSQAIQLLTDVERLCPQLVKSPPSGLLQPVDLQAALTALRHD

Sequences:

>Translated_624_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIGKDDLALALARHATSKI
STLDDLEAIVSLGFRGEALASISSVSRLTLTSRTAEQNEAWQAYAEGRDQAVTVKPAAHPIGSTLEVLDLFYNTPARRKF
MRTEKTEFGHIDEVVRRIALARFDVAINLSHNGKLMRQYRAAKDESQYERRLGSICGPAFLQHALNISWQHGDLTIRGWV
ADPAGARQLGEMQYCYVNSRMMRDRLINHAIRQAYQDQLKDDQQPAYVLYLEVDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQAVTTVLQQVGNAPLPLTDETEQQPTPVWQPENRVAAGGNHFSQPAPRRETASTEPAVARERAPQPAYHSGSGYQKRE
GELYGKLLQATPVAEPRQEAPKQPLFPPVKTEQETPLAGSQHSFGRVLMIYPPCYALIENGQQLMLLNLPVAERWLRQAQ
LNPSQEGLRPQPLLIPIKLTLNKQEAAACIHHQPLLVTMGLDLQVDHGRVTLRAVPLPLRQQNLQKLIPELLGYLAEHQE
MSPAVLATWFARHLGSEHEQWNTSQAIQLLTDVERLCPQLVKSPPSGLLQPVDLQAALTALRHD
>Mature_623_residues
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIGKDDLALALARHATSKIS
TLDDLEAIVSLGFRGEALASISSVSRLTLTSRTAEQNEAWQAYAEGRDQAVTVKPAAHPIGSTLEVLDLFYNTPARRKFM
RTEKTEFGHIDEVVRRIALARFDVAINLSHNGKLMRQYRAAKDESQYERRLGSICGPAFLQHALNISWQHGDLTIRGWVA
DPAGARQLGEMQYCYVNSRMMRDRLINHAIRQAYQDQLKDDQQPAYVLYLEVDPHQVDVNVHPAKHEVRFHQARLVHDFI
YQAVTTVLQQVGNAPLPLTDETEQQPTPVWQPENRVAAGGNHFSQPAPRRETASTEPAVARERAPQPAYHSGSGYQKREG
ELYGKLLQATPVAEPRQEAPKQPLFPPVKTEQETPLAGSQHSFGRVLMIYPPCYALIENGQQLMLLNLPVAERWLRQAQL
NPSQEGLRPQPLLIPIKLTLNKQEAAACIHHQPLLVTMGLDLQVDHGRVTLRAVPLPLRQQNLQKLIPELLGYLAEHQEM
SPAVLATWFARHLGSEHEQWNTSQAIQLLTDVERLCPQLVKSPPSGLLQPVDLQAALTALRHD

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=37.5, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI4505911, Length=387, Percent_Identity=28.6821705426357, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI189458898, Length=387, Percent_Identity=28.6821705426357, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI189458896, Length=380, Percent_Identity=28.1578947368421, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4505913, Length=328, Percent_Identity=28.3536585365854, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI310128478, Length=329, Percent_Identity=28.2674772036474, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=32.5688073394495, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI91992162, Length=358, Percent_Identity=24.0223463687151, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI91992160, Length=358, Percent_Identity=24.0223463687151, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310128480, Length=291, Percent_Identity=24.7422680412371, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1790612, Length=629, Percent_Identity=69.3163751987281, Blast_Score=835, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=36.1370716510903, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=27.0348837209302, Blast_Score=132, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=35.6466876971609, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=371, Percent_Identity=26.6846361185984, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=307, Percent_Identity=25.4071661237785, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=361, Percent_Identity=23.5457063711911, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136968, Length=328, Percent_Identity=35.9756097560976, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17136970, Length=190, Percent_Identity=32.6315789473684, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SERP5 (A8G8U7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476665.1
- ProteinModelPortal:   A8G8U7
- STRING:   A8G8U7
- GeneID:   5603683
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0429
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   EGRDQAV
- ProtClustDB:   PRK00095
- BioCyc:   SPRO399741:SPRO_0429-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 69591; Mature: 69460

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIGKDDLALALARHATSKISTLDDLEAIVSLGFRGEALASISSVSRLTLTSRTAEQNEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHHH
WQAYAEGRDQAVTVKPAAHPIGSTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIAL
HHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
ARFDVAINLSHNGKLMRQYRAAKDESQYERRLGSICGPAFLQHALNISWQHGDLTIRGWV
HHEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEEE
ADPAGARQLGEMQYCYVNSRMMRDRLINHAIRQAYQDQLKDDQQPAYVLYLEVDPHQVDV
CCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAVTTVLQQVGNAPLPLTDETEQQPTPVWQPENRVAAG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECC
GNHFSQPAPRRETASTEPAVARERAPQPAYHSGSGYQKREGELYGKLLQATPVAEPRQEA
CCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHC
PKQPLFPPVKTEQETPLAGSQHSFGRVLMIYPPCYALIENGQQLMLLNLPVAERWLRQAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEEECCHHHHHHHHHC
LNPSQEGLRPQPLLIPIKLTLNKQEAAACIHHQPLLVTMGLDLQVDHGRVTLRAVPLPLR
CCCCCCCCCCCCEEEEEEEEECHHHHHHHHCCCCEEEEECCEEEECCCEEEEEECCCCHH
QQNLQKLIPELLGYLAEHQEMSPAVLATWFARHLGSEHEQWNTSQAIQLLTDVERLCPQL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHH
VKSPPSGLLQPVDLQAALTALRHD
HCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIGKDDLALALARHATSKISTLDDLEAIVSLGFRGEALASISSVSRLTLTSRTAEQNEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCHHHHH
WQAYAEGRDQAVTVKPAAHPIGSTLEVLDLFYNTPARRKFMRTEKTEFGHIDEVVRRIAL
HHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
ARFDVAINLSHNGKLMRQYRAAKDESQYERRLGSICGPAFLQHALNISWQHGDLTIRGWV
HHEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEEE
ADPAGARQLGEMQYCYVNSRMMRDRLINHAIRQAYQDQLKDDQQPAYVLYLEVDPHQVDV
CCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQAVTTVLQQVGNAPLPLTDETEQQPTPVWQPENRVAAG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECC
GNHFSQPAPRRETASTEPAVARERAPQPAYHSGSGYQKREGELYGKLLQATPVAEPRQEA
CCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHC
PKQPLFPPVKTEQETPLAGSQHSFGRVLMIYPPCYALIENGQQLMLLNLPVAERWLRQAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEEECCHHHHHHHHHC
LNPSQEGLRPQPLLIPIKLTLNKQEAAACIHHQPLLVTMGLDLQVDHGRVTLRAVPLPLR
CCCCCCCCCCCCEEEEEEEEECHHHHHHHHCCCCEEEEECCEEEECCCEEEEEECCCCHH
QQNLQKLIPELLGYLAEHQEMSPAVLATWFARHLGSEHEQWNTSQAIQLLTDVERLCPQL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHH
VKSPPSGLLQPVDLQAALTALRHD
HCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA