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The map label for this gene is pepQ

Identifier: 157368512

GI number: 157368512

Start: 294135

End: 295466

Strand: Direct

Name: pepQ

Synonym: Spro_0263

Alternate gene names: 157368512

Gene position: 294135-295466 (Clockwise)

Preceding gene: 157368511

Following gene: 157368513

Centisome position: 5.4

GC content: 54.58

Gene sequence:

>1332_bases
ATGGAAACGCTGGCTTCTTTGTATAACGACCACCTGGCAGAACTGCAAAAACGGGCGCGTGAAGTGTTAACGCGCAACAA
ACTGGATGCGTTGCTGATTCACTCTGGGGAACTGCAACGGATATTCCAGGACGACCGTAGCTACCCGTTCAAAGTGAACG
CGCACTTTAAGGCCTGGGTGCCAGTCACCTCGGTACCCAACTGCTGGCTGTGGGTGGATGGCGTTAACAAACCGAAGCTG
TGGTTCTATTCGCCGGTCGATTACTGGCATAGCGTTGAGCCACTGCCGGAGAGTTTCTGGACCAGGTCCGTTGAACTGAT
GCCGCTGGCCAATGCTGATGATATCGCGCAGCAGCTTCCTGCCCAGCGTGAGCGTGTGGGCTATATCGGTTATGCGCAGC
AACGTGCCCGCGATCTCGGGATCCTGGCAGAAAACGTCAACCCGAAAGCGGTATTGAATTACCTCGATTTTCATCGCTCT
ATCAAAACGGGCTACGAGCTGGCCTGCATGCGCGAAGCGCAGAAAACTGCTGTTATGGGGCACCGTGCCGCTCATGAGGC
CTTCCTGTCCGGCATGAGTGAGTTTGATATCAACCAGGCTTACCTCACCGCCACGGGGCATCGCGACACCGATGTACCTT
ATGACAATATTGTTGCGCTGAATGAGCATGCGTCGGTGCTGCATTACACCACGCTGGATCATCAGCCTCCGTCCGAAATG
CTAAGCTTCCTGCTTGACGCCGGTGCCGAATATAACGGTTACGCCGCCGACCTGACTCGCACCTATGCTGGCCAGAGCGG
CAGTGATTTCGCGCAGCTGATAAAAGATCTTAACGGTGAACAACTGGCACTGATGGATACCATCAAAGCCGGTGTGCGTT
ACACCGATTACCATGTGCAAATGCATCAACGCGTCGCCAAATTGCTCAAGAGTCACAAGCTGGTGACCGGCATCAGTGAA
GAGGCCATGGTTGAGCAGGGGCTGACCACGCCATTCCTGCCACACGGTCTGGGCCATCCGCTAGGTTTGCAGGTGCATGA
CTCTGCCGGCTTTATGCAAGATGAACAGGGCACCCATCTGGCCGCCCCTTCCAAATACCCGTACCTGCGCTGCACCCGCA
TGTTGCAGCCTGGCATGGTGTTAACCATTGAGCCCGGCATGTATTTTATTGATTCCTTGTTGGCACCATGGCGCAGCGGC
GAATTCAGTCAACATTTTGCCTGGGATCGCATCGATGCGCTGAAACCTTATGGTGGTATCCGTATTGAAGACAATATCGT
GATCCACGAAAAGCGTATCGAGAACATGACGCGCGATCTGAACCTGGCCTGA

Upstream 100 bases:

>100_bases
TGCGAACCGCTCCGCATGCCAGAGCTGATGGGGTTGGTGCACCTGAACGGTGTGCTAAGATGACTCATTCCGTTCTAATG
GTATGTATAAGGGTATTGTG

Downstream 100 bases:

>100_bases
TGCAGCCTTACCCGATCCCGGCAGGCCCCGTCAGTGTCAGCGAAGAAATAAAGAAGAGCCGTTTCATCACCCTGCTGGCA
CCGACCAGTGGGGTTGATGT

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
METLASLYNDHLAELQKRAREVLTRNKLDALLIHSGELQRIFQDDRSYPFKVNAHFKAWVPVTSVPNCWLWVDGVNKPKL
WFYSPVDYWHSVEPLPESFWTRSVELMPLANADDIAQQLPAQRERVGYIGYAQQRARDLGILAENVNPKAVLNYLDFHRS
IKTGYELACMREAQKTAVMGHRAAHEAFLSGMSEFDINQAYLTATGHRDTDVPYDNIVALNEHASVLHYTTLDHQPPSEM
LSFLLDAGAEYNGYAADLTRTYAGQSGSDFAQLIKDLNGEQLALMDTIKAGVRYTDYHVQMHQRVAKLLKSHKLVTGISE
EAMVEQGLTTPFLPHGLGHPLGLQVHDSAGFMQDEQGTHLAAPSKYPYLRCTRMLQPGMVLTIEPGMYFIDSLLAPWRSG
EFSQHFAWDRIDALKPYGGIRIEDNIVIHEKRIENMTRDLNLA

Sequences:

>Translated_443_residues
METLASLYNDHLAELQKRAREVLTRNKLDALLIHSGELQRIFQDDRSYPFKVNAHFKAWVPVTSVPNCWLWVDGVNKPKL
WFYSPVDYWHSVEPLPESFWTRSVELMPLANADDIAQQLPAQRERVGYIGYAQQRARDLGILAENVNPKAVLNYLDFHRS
IKTGYELACMREAQKTAVMGHRAAHEAFLSGMSEFDINQAYLTATGHRDTDVPYDNIVALNEHASVLHYTTLDHQPPSEM
LSFLLDAGAEYNGYAADLTRTYAGQSGSDFAQLIKDLNGEQLALMDTIKAGVRYTDYHVQMHQRVAKLLKSHKLVTGISE
EAMVEQGLTTPFLPHGLGHPLGLQVHDSAGFMQDEQGTHLAAPSKYPYLRCTRMLQPGMVLTIEPGMYFIDSLLAPWRSG
EFSQHFAWDRIDALKPYGGIRIEDNIVIHEKRIENMTRDLNLA
>Mature_443_residues
METLASLYNDHLAELQKRAREVLTRNKLDALLIHSGELQRIFQDDRSYPFKVNAHFKAWVPVTSVPNCWLWVDGVNKPKL
WFYSPVDYWHSVEPLPESFWTRSVELMPLANADDIAQQLPAQRERVGYIGYAQQRARDLGILAENVNPKAVLNYLDFHRS
IKTGYELACMREAQKTAVMGHRAAHEAFLSGMSEFDINQAYLTATGHRDTDVPYDNIVALNEHASVLHYTTLDHQPPSEM
LSFLLDAGAEYNGYAADLTRTYAGQSGSDFAQLIKDLNGEQLALMDTIKAGVRYTDYHVQMHQRVAKLLKSHKLVTGISE
EAMVEQGLTTPFLPHGLGHPLGLQVHDSAGFMQDEQGTHLAAPSKYPYLRCTRMLQPGMVLTIEPGMYFIDSLLAPWRSG
EFSQHFAWDRIDALKPYGGIRIEDNIVIHEKRIENMTRDLNLA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily

Homologues:

Organism=Homo sapiens, GI149589008, Length=464, Percent_Identity=26.9396551724138, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI260593665, Length=294, Percent_Identity=31.2925170068027, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI260593663, Length=306, Percent_Identity=29.7385620915033, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI11559925, Length=285, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=73.5891647855531, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=283, Percent_Identity=31.095406360424, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788728, Length=294, Percent_Identity=26.8707482993197, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508215, Length=293, Percent_Identity=34.4709897610922, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321118, Length=294, Percent_Identity=30.952380952381, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=282, Percent_Identity=28.3687943262411, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357079, Length=458, Percent_Identity=26.6375545851528, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPQ_SERP5 (A8G8D3)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476501.1
- STRING:   A8G8D3
- MEROPS:   M24.003
- GeneID:   5606615
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0263
- eggNOG:   COG0006
- HOGENOM:   HBG296884
- OMA:   PYGNIVA
- ProtClustDB:   PRK13607
- BioCyc:   SPRO399741:SPRO_0263-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01279
- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.13.9

Molecular weight: Translated: 50239; Mature: 50239

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLASLYNDHLAELQKRAREVLTRNKLDALLIHSGELQRIFQDDRSYPFKVNAHFKAWV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCEEEECCEEEEE
PVTSVPNCWLWVDGVNKPKLWFYSPVDYWHSVEPLPESFWTRSVELMPLANADDIAQQLP
ECCCCCCCEEEECCCCCCCEEEECCHHHHCCCCCCCHHHHCCCEEEEECCCHHHHHHHCC
AQRERVGYIGYAQQRARDLGILAENVNPKAVLNYLDFHRSIKTGYELACMREAQKTAVMG
HHHHHCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
HRAAHEAFLSGMSEFDINQAYLTATGHRDTDVPYDNIVALNEHASVLHYTTLDHQPPSEM
HHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHH
LSFLLDAGAEYNGYAADLTRTYAGQSGSDFAQLIKDLNGEQLALMDTIKAGVRYTDYHVQ
HHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCEEEHHHHH
MHQRVAKLLKSHKLVTGISEEAMVEQGLTTPFLPHGLGHPLGLQVHDSAGFMQDEQGTHL
HHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEE
AAPSKYPYLRCTRMLQPGMVLTIEPGMYFIDSLLAPWRSGEFSQHFAWDRIDALKPYGGI
CCCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCE
RIEDNIVIHEKRIENMTRDLNLA
EEECCEEEEHHHHHHHHHHCCCC
>Mature Secondary Structure
METLASLYNDHLAELQKRAREVLTRNKLDALLIHSGELQRIFQDDRSYPFKVNAHFKAWV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCCEEEECCEEEEE
PVTSVPNCWLWVDGVNKPKLWFYSPVDYWHSVEPLPESFWTRSVELMPLANADDIAQQLP
ECCCCCCCEEEECCCCCCCEEEECCHHHHCCCCCCCHHHHCCCEEEEECCCHHHHHHHCC
AQRERVGYIGYAQQRARDLGILAENVNPKAVLNYLDFHRSIKTGYELACMREAQKTAVMG
HHHHHCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
HRAAHEAFLSGMSEFDINQAYLTATGHRDTDVPYDNIVALNEHASVLHYTTLDHQPPSEM
HHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHH
LSFLLDAGAEYNGYAADLTRTYAGQSGSDFAQLIKDLNGEQLALMDTIKAGVRYTDYHVQ
HHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCEEEHHHHH
MHQRVAKLLKSHKLVTGISEEAMVEQGLTTPFLPHGLGHPLGLQVHDSAGFMQDEQGTHL
HHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEE
AAPSKYPYLRCTRMLQPGMVLTIEPGMYFIDSLLAPWRSGEFSQHFAWDRIDALKPYGGI
CCCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCE
RIEDNIVIHEKRIENMTRDLNLA
EEECCEEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA