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The map label for this gene is ydgK [H]

Identifier: 157368511

GI number: 157368511

Start: 292821

End: 294017

Strand: Direct

Name: ydgK [H]

Synonym: Spro_0262

Alternate gene names: 157368511

Gene position: 292821-294017 (Clockwise)

Preceding gene: 157368508

Following gene: 157368512

Centisome position: 5.37

GC content: 56.98

Gene sequence:

>1197_bases
ATGAGTAAAGCGGTATGTGTAAAACACAGTGGTTTCTGGAGTATTCCCGCCAGAACCATGACGCTGGCTTGTCTGCTGGT
GTTTATGGCGCAGATGGCGACGACGGTGTATTTGCCTTCATTACCGACGGTGATGCAGGAACTGGCAATGACGCGCCGCG
CCACCGAGCTTTCTATATCGATATTCGTGATAGGAGCCGCCTTGCCGGTGTTGTTCTGGGGGGCTGCGGCCGATCGTTTT
GGCCGTCGCCTGCCGCTGACATTGTCTCTGGCGTTGTTTATCAGTTGCAGTGCTCTGCTGGCATTTTGCAGTAACGGTAC
TCAGTTATTAGTGCTGCGGGCACTGCAGGGGGTTGCCGCCGGTGGTGCTGCAATCATCGCGCGCATTATTGTTCGTGATA
ACTGGAGTGGTGACGAGCTGGCAAGGCGCCTTTCGGTGCTGTCGATAGCCTTTATCGCCGCGTTGGGCGGTGGGCAGTTT
ATCGGTGGGCTGCTCAGTCAGTATTCGCACTGGCAAATGGGTTTTGTGGTGATGGGGCTGACCGGGCTGGCGATATGGTT
ACTGATGCTGACGTTGCCACTGGAAGCGGGCCGCGGAGCAGGCAGGCGGCCGGCCATGGCGGCAACCTATTGGCACATTC
TGCGTCGTCCGGGGTTCTTCTGGCCGGCAGTTGTCGGCGGATTGGGGTTTGCTACCACCGTCACTCTGCAGGAAGTGAGT
CCGTTTATCATGCAGCAGGGGTTTGGCCTGAACGTTACCGCCTTTGGGGCTCTGGGGCTGGTGATCGGCGTGGCTTACTT
TACTGGAGCAATGACGGTAAACCGGACGGTTGCGCGCTTTGGCGGTAAGCGGCTGATGCAGGCGGGGACGAGTATCGTCG
CCGTTGCCACTGCTGCGATAATGGTGCTGTGGTGGAGCGGTGTACTGGTGGGGCTTTCCGGTATGACAGTCTTCATCGCT
TTGTATTGTTTGACGATTTTTGGCCAGGCGGTGTTGTTTCCCAATAGCATGGCGATGGCGGTCAGCGATGTTAAACAGCA
GGGCGCCTACGCCATGGCGTTATGTGGCTTTCTGCAACAGTGTCTGGCAGGCATAGCTGCAGCCGGTGCGGTTCTACTCG
AACATCATGGCCTGTGGGCGGCTGCTATCGCGTTGCTTGGTCTGATCGCCTGGTTAATTGTTAAGCTAAGGATGTAA

Upstream 100 bases:

>100_bases
TTAAAACGAAGTTATATTTTATGCTTTATGGTGATTTGTCGGCGTGTAAAAGCACTCATACACTTGCCAGAGCAGAGCGC
TGCCCACGCAGAGGTGTGAA

Downstream 100 bases:

>100_bases
CGACGTTTACAGCGATTTGCGAACCGCTCCGCATGCCAGAGCTGATGGGGTTGGTGCACCTGAACGGTGTGCTAAGATGA
CTCATTCCGTTCTAATGGTA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSKAVCVKHSGFWSIPARTMTLACLLVFMAQMATTVYLPSLPTVMQELAMTRRATELSISIFVIGAALPVLFWGAAADRF
GRRLPLTLSLALFISCSALLAFCSNGTQLLVLRALQGVAAGGAAIIARIIVRDNWSGDELARRLSVLSIAFIAALGGGQF
IGGLLSQYSHWQMGFVVMGLTGLAIWLLMLTLPLEAGRGAGRRPAMAATYWHILRRPGFFWPAVVGGLGFATTVTLQEVS
PFIMQQGFGLNVTAFGALGLVIGVAYFTGAMTVNRTVARFGGKRLMQAGTSIVAVATAAIMVLWWSGVLVGLSGMTVFIA
LYCLTIFGQAVLFPNSMAMAVSDVKQQGAYAMALCGFLQQCLAGIAAAGAVLLEHHGLWAAAIALLGLIAWLIVKLRM

Sequences:

>Translated_398_residues
MSKAVCVKHSGFWSIPARTMTLACLLVFMAQMATTVYLPSLPTVMQELAMTRRATELSISIFVIGAALPVLFWGAAADRF
GRRLPLTLSLALFISCSALLAFCSNGTQLLVLRALQGVAAGGAAIIARIIVRDNWSGDELARRLSVLSIAFIAALGGGQF
IGGLLSQYSHWQMGFVVMGLTGLAIWLLMLTLPLEAGRGAGRRPAMAATYWHILRRPGFFWPAVVGGLGFATTVTLQEVS
PFIMQQGFGLNVTAFGALGLVIGVAYFTGAMTVNRTVARFGGKRLMQAGTSIVAVATAAIMVLWWSGVLVGLSGMTVFIA
LYCLTIFGQAVLFPNSMAMAVSDVKQQGAYAMALCGFLQQCLAGIAAAGAVLLEHHGLWAAAIALLGLIAWLIVKLRM
>Mature_397_residues
SKAVCVKHSGFWSIPARTMTLACLLVFMAQMATTVYLPSLPTVMQELAMTRRATELSISIFVIGAALPVLFWGAAADRFG
RRLPLTLSLALFISCSALLAFCSNGTQLLVLRALQGVAAGGAAIIARIIVRDNWSGDELARRLSVLSIAFIAALGGGQFI
GGLLSQYSHWQMGFVVMGLTGLAIWLLMLTLPLEAGRGAGRRPAMAATYWHILRRPGFFWPAVVGGLGFATTVTLQEVSP
FIMQQGFGLNVTAFGALGLVIGVAYFTGAMTVNRTVARFGGKRLMQAGTSIVAVATAAIMVLWWSGVLVGLSGMTVFIAL
YCLTIFGQAVLFPNSMAMAVSDVKQQGAYAMALCGFLQQCLAGIAAAGAVLLEHHGLWAAAIALLGLIAWLIVKLRM

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=368, Percent_Identity=23.9130434782609, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994889, Length=328, Percent_Identity=23.1707317073171, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790146, Length=231, Percent_Identity=27.7056277056277, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082312, Length=355, Percent_Identity=24.5070422535211, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42182; Mature: 42051

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAVCVKHSGFWSIPARTMTLACLLVFMAQMATTVYLPSLPTVMQELAMTRRATELSIS
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEH
IFVIGAALPVLFWGAAADRFGRRLPLTLSLALFISCSALLAFCSNGTQLLVLRALQGVAA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
GGAAIIARIIVRDNWSGDELARRLSVLSIAFIAALGGGQFIGGLLSQYSHWQMGFVVMGL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
TGLAIWLLMLTLPLEAGRGAGRRPAMAATYWHILRRPGFFWPAVVGGLGFATTVTLQEVS
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHH
PFIMQQGFGLNVTAFGALGLVIGVAYFTGAMTVNRTVARFGGKRLMQAGTSIVAVATAAI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MVLWWSGVLVGLSGMTVFIALYCLTIFGQAVLFPNSMAMAVSDVKQQGAYAMALCGFLQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
CLAGIAAAGAVLLEHHGLWAAAIALLGLIAWLIVKLRM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKAVCVKHSGFWSIPARTMTLACLLVFMAQMATTVYLPSLPTVMQELAMTRRATELSIS
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEH
IFVIGAALPVLFWGAAADRFGRRLPLTLSLALFISCSALLAFCSNGTQLLVLRALQGVAA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
GGAAIIARIIVRDNWSGDELARRLSVLSIAFIAALGGGQFIGGLLSQYSHWQMGFVVMGL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
TGLAIWLLMLTLPLEAGRGAGRRPAMAATYWHILRRPGFFWPAVVGGLGFATTVTLQEVS
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHH
PFIMQQGFGLNVTAFGALGLVIGVAYFTGAMTVNRTVARFGGKRLMQAGTSIVAVATAAI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MVLWWSGVLVGLSGMTVFIALYCLTIFGQAVLFPNSMAMAVSDVKQQGAYAMALCGFLQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
CLAGIAAAGAVLLEHHGLWAAAIALLGLIAWLIVKLRM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]