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The map label for this gene is pepE [H]

Identifier: 157368506

GI number: 157368506

Start: 285991

End: 286716

Strand: Direct

Name: pepE [H]

Synonym: Spro_0257

Alternate gene names: 157368506

Gene position: 285991-286716 (Clockwise)

Preceding gene: 157368504

Following gene: 157368507

Centisome position: 5.25

GC content: 56.75

Gene sequence:

>726_bases
ATGGAGTTATTTCTGTTGAGCAACGGCAAACTGTCCGGTGAGAGTGAACTGCTGGGCTATGCCAAGAGCCATCTGTTGGC
GATGATCGCCCGCCGTGGCATCACATCCGCCGTCTTTATCCCCTATGCCATGATCCGTAGTGATTACGATCAGCGCGCGC
AGGAACTGGCGCAAACTCTGGGCATCAAGGTCACCAGCATTCACCATGCCGAGTCCCCAGCTGCGGCGATTGAACAGGCG
GAATGTATCCTGGTCAGCGGCGGCAATACCTGGATGCTGAACCAAATGCTGCATGAGAAGGGCCTGATTGTTCCGATCCA
GCGGGCTGTTCGTGAACGTAGCGTCCCCTATGTTGGCTGGAGCGCCGGTTGTAACGTGGCTACGCCAAGTATCCGTACCA
CCAATGATATGCCGGTACGCAACAGCGTAGTGTTGCCGGCGTTGAGCCTGTTCCCGGTGCAGATTAACCCGCATTACATT
GACGCCCATATCAGTGGCCACATGGGCGAAACCCGTGATGAGCGCCTGGCGGAATTCTGTGCAGTCAATCCGAGCGAATC
TGTAGTGGCGCTGCGCGAGGGCAGTCTGTTGCACGTTGAGGGCAATGACTTGCGTTATTTCAGTGCCAGAGACCAAGGCT
TCAAGGTGTTCCGCCACGGCGTAGAGACCCAAGAGTATCAGGATACGCAGGCATTACGCCCGCTGGTGCCGTTCACGTGC
CACTGA

Upstream 100 bases:

>100_bases
GGGTATAACAGAGGGCTAAAAATTTGCTACCGTCGCAGTATGCCTTGGGGCGCTGTCGCCTGATGTGACGGTATTCATCG
TTTTTGATTGAGGGGGAGAA

Downstream 100 bases:

>100_bases
GTGCCGGTAAGGTCTTTACCGGTGTTTAACAAAAGTGCAGCAACAACCGTGAAGAGGGCTTATAATGCCCTTCTCACTGG
CCGTTATAATGATCAGCATG

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MELFLLSNGKLSGESELLGYAKSHLLAMIARRGITSAVFIPYAMIRSDYDQRAQELAQTLGIKVTSIHHAESPAAAIEQA
ECILVSGGNTWMLNQMLHEKGLIVPIQRAVRERSVPYVGWSAGCNVATPSIRTTNDMPVRNSVVLPALSLFPVQINPHYI
DAHISGHMGETRDERLAEFCAVNPSESVVALREGSLLHVEGNDLRYFSARDQGFKVFRHGVETQEYQDTQALRPLVPFTC
H

Sequences:

>Translated_241_residues
MELFLLSNGKLSGESELLGYAKSHLLAMIARRGITSAVFIPYAMIRSDYDQRAQELAQTLGIKVTSIHHAESPAAAIEQA
ECILVSGGNTWMLNQMLHEKGLIVPIQRAVRERSVPYVGWSAGCNVATPSIRTTNDMPVRNSVVLPALSLFPVQINPHYI
DAHISGHMGETRDERLAEFCAVNPSESVVALREGSLLHVEGNDLRYFSARDQGFKVFRHGVETQEYQDTQALRPLVPFTC
H
>Mature_241_residues
MELFLLSNGKLSGESELLGYAKSHLLAMIARRGITSAVFIPYAMIRSDYDQRAQELAQTLGIKVTSIHHAESPAAAIEQA
ECILVSGGNTWMLNQMLHEKGLIVPIQRAVRERSVPYVGWSAGCNVATPSIRTTNDMPVRNSVVLPALSLFPVQINPHYI
DAHISGHMGETRDERLAEFCAVNPSESVVALREGSLLHVEGNDLRYFSARDQGFKVFRHGVETQEYQDTQALRPLVPFTC
H

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=204, Percent_Identity=45.0980392156863, Blast_Score=170, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24641669, Length=224, Percent_Identity=39.2857142857143, Blast_Score=140, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 26697; Mature: 26697

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFLLSNGKLSGESELLGYAKSHLLAMIARRGITSAVFIPYAMIRSDYDQRAQELAQTL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
GIKVTSIHHAESPAAAIEQAECILVSGGNTWMLNQMLHEKGLIVPIQRAVRERSVPYVGW
CEEEEEEECCCCCHHHHCCCCEEEEECCCEEHHHHHHHHCCCEEEHHHHHHHCCCCEEEE
SAGCNVATPSIRTTNDMPVRNSVVLPALSLFPVQINPHYIDAHISGHMGETRDERLAEFC
CCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCEEEEEEECCCCCCCHHHHHHHHH
AVNPSESVVALREGSLLHVEGNDLRYFSARDQGFKVFRHGVETQEYQDTQALRPLVPFTC
CCCCCCCEEEEECCCEEEEECCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCC
H
C
>Mature Secondary Structure
MELFLLSNGKLSGESELLGYAKSHLLAMIARRGITSAVFIPYAMIRSDYDQRAQELAQTL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
GIKVTSIHHAESPAAAIEQAECILVSGGNTWMLNQMLHEKGLIVPIQRAVRERSVPYVGW
CEEEEEEECCCCCHHHHCCCCEEEEECCCEEHHHHHHHHCCCEEEHHHHHHHCCCCEEEE
SAGCNVATPSIRTTNDMPVRNSVVLPALSLFPVQINPHYIDAHISGHMGETRDERLAEFC
CCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCEEEEEEECCCCCCCHHHHHHHHH
AVNPSESVVALREGSLLHVEGNDLRYFSARDQGFKVFRHGVETQEYQDTQALRPLVPFTC
CCCCCCCEEEEECCCEEEEECCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA