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The map label for this gene is hflC

Identifier: 157163638

GI number: 157163638

Start: 4428036

End: 4429040

Strand: Direct

Name: hflC

Synonym: EcHS_A4417

Alternate gene names: 157163638

Gene position: 4428036-4429040 (Clockwise)

Preceding gene: 157163637

Following gene: 157163639

Centisome position: 95.36

GC content: 53.03

Gene sequence:

>1005_bases
ATGCGTAAGTCAGTTATCGCGATTATCATCATCGTGCTGGTAGTGCTTTACATGTCTGTCTTTGTCGTCAAAGAAGGTGA
GCGCGGTATTACGCTGCGTTTTGGTAAGGTACTGCGTGACGATGACAACAAACCTCTGGTTTATGAGCCGGGTCTGCATT
TCAAGATACCGTTCATTGAAACGGTGAAAATGCTCGACGCACGTATTCAGACCATGGACAACCAGGCCGACCGCTTTGTG
ACCAAAGAGAAGAAAGACCTGATCGTCGACTCTTACATCAAATGGCGCATCAGCGATTTCAGCCGTTACTACCTGGCAAC
GGGTGGTGGCGACATTTCGCAAGCGGAAGTGCTGTTGAAACGTAAGTTCTCTGACCGTCTGCGTTCTGAAATTGGTCGCC
TGGACGTGAAAGACATCGTCACCGATTCCCGTGGTCGTCTGACCCTCGAAGTACGTGACGCGCTGAACTCCGGTTCTGCG
GGTACAGAAGATGAAGTTACTACCCCGGCAGCAGATAACGCCATTGCCGAAGCGGCAGAGCGCGTAACGGCTGAGACGAA
GGGCAAAGTTCCGGTCATCAACCCGAACAGTATGGCGGCGCTGGGTATTGAAGTTGTCGATGTGCGTATCAAGCAGATCA
ACCTGCCGACCGAAGTGTCTGAAGCGATCTACAACCGTATGCGCGCCGAGCGTGAAGCGGTAGCGCGTCGTCACCGTTCA
CAAGGTCAGGAAGAAGCGGAAAAACTGCGCGCGACTGCCGACTATGAAGTGACCAGAACGCTGGCAGAAGCTGAGCGTCA
GGGCCGCATCATGCGTGGTGAAGGCGATGCCGAAGCAGCCAAACTGTTTGCTGATGCATTCAGTAAAGATCCGGACTTCT
ACGCATTCATCCGTAGCCTGCGTGCTTATGAGAACAGCTTCTCTGGCAATCAGGACGTGATGGTCATGAGCCCGGATAGC
GATTTCTTCCGCTACATGAAGACGCCGACTTCCGCAACGCGTTAA

Upstream 100 bases:

>100_bases
GTGGAGCAAGCAACACGTCGTCCACCAGTCAGGGCGATATTATGGACCAACGCCGCGCCAACGCGCAGCGTAACGACTAC
CAGCGTCAGGGGGAATAACG

Downstream 100 bases:

>100_bases
TATAACGACTGCGGTACAGGTCAATAAAGCCACCGCATCCTCAGGGATGTCGGTGGTTTTCTTTTTCTATAAGGATAATG
AATGAATTCGACAATCTGGC

Product: FtsH protease regulator HflC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSA
GTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDS
DFFRYMKTPTSATR

Sequences:

>Translated_334_residues
MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSA
GTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDS
DFFRYMKTPTSATR
>Mature_334_residues
MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSA
GTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDS
DFFRYMKTPTSATR

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily

Homologues:

Organism=Escherichia coli, GI1790617, Length=334, Percent_Identity=100, Blast_Score=676, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HFLC_ECO57 (P0ABC5)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   G86113
- PIR:   G91272
- RefSeq:   NP_290805.1
- RefSeq:   NP_313178.1
- ProteinModelPortal:   P0ABC5
- EnsemblBacteria:   EBESCT00000028782
- EnsemblBacteria:   EBESCT00000056581
- GeneID:   914054
- GeneID:   959948
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5782
- KEGG:   ecs:ECs5151
- GeneTree:   EBGT00050000010263
- HOGENOM:   HBG427952
- OMA:   KIRADAD
- ProtClustDB:   PRK11029
- BioCyc:   ECOL83334:ECS5151-MONOMER
- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972
- PANTHER:   PTHR10264
- SMART:   SM00244
- TIGRFAMs:   TIGR01932

Pfam domain/function: PF01145 Band_7

EC number: 3.4.-.-

Molecular weight: Translated: 37650; Mature: 37650

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19668d20)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIE
CCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHHCCCCCCEEECCCCCEECCHHH
TVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAE
HHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
RVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRS
HHHHHCCCCCEEECCCCCHHHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSL
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHH
RAYENSFSGNQDVMVMSPDSDFFRYMKTPTSATR
HHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCH
>Mature Secondary Structure
MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIE
CCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHHCCCCCCEEECCCCCEECCHHH
TVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAE
HHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
RVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRS
HHHHHCCCCCEEECCCCCHHHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSL
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHH
RAYENSFSGNQDVMVMSPDSDFFRYMKTPTSATR
HHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796