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The map label for this gene is yjcE [H]

Identifier: 157163535

GI number: 157163535

Start: 4311745

End: 4313394

Strand: Direct

Name: yjcE [H]

Synonym: EcHS_A4308

Alternate gene names: 157163535

Gene position: 4311745-4313394 (Clockwise)

Preceding gene: 157163534

Following gene: 157163540

Centisome position: 92.85

GC content: 55.94

Gene sequence:

>1650_bases
ATGGAAATCTTCTTCACCATACTGATAATGACCCTCGTGGTCTCGCTGTCCGGGGTGGTCACTCGTGTCATGCCCTTTCA
GATCCCGCTTCCGCTTATGCAAATCGCCATCGGTGCGCTACTGGCGTGGCCGACGTTTGGTTTGCATGTGGAGTTTGATC
CTGAACTCTTTTTAGTCTTGTTTATCCCGCCGTTGCTGTTCGCTGATGGCTGGAAAACGCCGACCCGTGAATTTCTCGAA
CATGGTCGAGAGATTTTTGGCCTCGCGCTGGCGCTGGTGGTGGTCACCGTGGTCGGCATTGGCTTCCTTATTTACTGGGT
GGTGCCGGGCATTCCGCTGATCCCCGCCTTTGCGCTGGCGGCAGTGCTTTCTCCGACCGATGCTGTGGCGCTCTCCGGGA
TTGTTGGCGAAGGGCGCATCCCGAAAAAAATCATGGGTATTTTGCAGGGCGAAGCGTTGATGAATGACGCCTCCGGCCTG
GTGTCGTTGAAGTTTGCCGTGGCAGTGGCGATGGGGACGATGATCTTCACCGTTGGCGGTGCGACGGTCGAATTTATGAA
AGTAGCCATTGGCGGTATTCTCGCCGGCTTTGTGGTGAGCTGGCTGTATGGTCGCTCGCTGCGATTCCTCAGCCGCTGGG
GCGGTGATGAACCCGCGACGCAGATCGTTCTGCTGTTCTTGCTGCCATTCGCTTCTTATCTGATTGCCGAACATATTGGC
GTTTCCGGCATCCTCGCTGCGGTTGCCGCCGGGATGACCATCACCCGCTCCGGTGTGATGCGCCGTGCGCCGCTGGCAAT
GCGCCTGCGCGCAAACAGCACCTGGGCGATGCTGGAATTTGTCTTTAACGGCATGGTGTTCCTGCTGTTAGGTCTGCAGC
TGCCGGGTATTCTGGAGACGTCGCTGATGGCGGCAGAAATCGACCCTAACGTCGAAATCTGGATGCTGTTTACCGATATT
ATTCTGATATATGCGGCGCTGATGCTGGTCCGTTTCGGCTGGCTGTGGACGATGAAAAAGTTCAGCAACCGCTTCCTGAA
GAAGAAGCCGATGGAGTTTGGTTCGTGGACCACACGAGAAATCCTGATCGCGTCTTTCGCCGGGGTGCGTGGGGCGATCA
CTCTGGCCGGTGTGCTCTCTATCCCGCTGCTCTTGCCGGATGGTAACGTCTTCCCGGCGCGCTATGAGCTGGTGTTCCTG
GCGGCTGGCGTCATTCTCTTCTCGCTGTTTGTCGGCGTGGTGATGTTGCCTATTCTGCTACAACACATTGAAGTCGCGGA
CCATTCGCAACAATTGAAAGAAGAACGTATTGCGCGAGCGGCAACGGCAGAAGTGGCGATTGTGGCGATCCAGAAAATGG
AGGAGCGTCTGGCGGCGGATACCGAAGAGAATATCGATAACCAGCTGCTTACGGAGGTCAGTTCTCGCGTCATTGGTAAC
CTGCGTCGTCGCGCCGATGGACGTAACGACGTTGAAAGTTCCGTGCAGGAAGAGAACCTTGAGCGTCGCTTCCGTCTGGC
GGCATTGCGTTCTGAACGTGCTGAACTGTACCACCTGCGCGCCACGCGGGAGATCAGCAACGAAACGCTGCAAAAATTAC
TGCACGATCTCGATTTGCTTGAAGCGTTGCTAATTGAGGAAAATCAGTAA

Upstream 100 bases:

>100_bases
CTCCGCACATTGTGTGAGCTTTTGCGATATTCTGAAAAAATGAGAATTCAGGCATAACGTCTTTCTCAGATCATAAAAAA
ACATCGCAAACAGGGAACGC

Downstream 100 bases:

>100_bases
GCCGAAAGCGACGTAACCAGGCCCGAGGTAATCTGAAAAAGGTGCAATCTTTTGCACCTTTAACAGGTTAGCTCGGGCTA
ACATTCATGATTCTAAAACA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MEIFFTILIMTLVVSLSGVVTRVMPFQIPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVVVTVVGIGFLIYWVVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMIFTVGGATVEFMKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILETSLMAAEIDPNVEIWMLFTDI
ILIYAALMLVRFGWLWTMKKFSNRFLKKKPMEFGSWTTREILIASFAGVRGAITLAGVLSIPLLLPDGNVFPARYELVFL
AAGVILFSLFVGVVMLPILLQHIEVADHSQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDNQLLTEVSSRVIGN
LRRRADGRNDVESSVQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLLEALLIEENQ

Sequences:

>Translated_549_residues
MEIFFTILIMTLVVSLSGVVTRVMPFQIPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVVVTVVGIGFLIYWVVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMIFTVGGATVEFMKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILETSLMAAEIDPNVEIWMLFTDI
ILIYAALMLVRFGWLWTMKKFSNRFLKKKPMEFGSWTTREILIASFAGVRGAITLAGVLSIPLLLPDGNVFPARYELVFL
AAGVILFSLFVGVVMLPILLQHIEVADHSQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDNQLLTEVSSRVIGN
LRRRADGRNDVESSVQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLLEALLIEENQ
>Mature_549_residues
MEIFFTILIMTLVVSLSGVVTRVMPFQIPLPLMQIAIGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVVVTVVGIGFLIYWVVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMIFTVGGATVEFMKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILETSLMAAEIDPNVEIWMLFTDI
ILIYAALMLVRFGWLWTMKKFSNRFLKKKPMEFGSWTTREILIASFAGVRGAITLAGVLSIPLLLPDGNVFPARYELVFL
AAGVILFSLFVGVVMLPILLQHIEVADHSQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDNQLLTEVSSRVIGN
LRRRADGRNDVESSVQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLLEALLIEENQ

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=462, Percent_Identity=24.8917748917749, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI148727259, Length=458, Percent_Identity=23.5807860262009, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI14211919, Length=343, Percent_Identity=23.9067055393586, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194239733, Length=500, Percent_Identity=24, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI27734935, Length=258, Percent_Identity=23.6434108527132, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI294997330, Length=269, Percent_Identity=22.6765799256506, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI41872703, Length=409, Percent_Identity=22.0048899755501, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI110227626, Length=269, Percent_Identity=22.6765799256506, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI5454070, Length=292, Percent_Identity=21.5753424657534, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790501, Length=549, Percent_Identity=99.8178506375228, Blast_Score=1081, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71980847, Length=401, Percent_Identity=25.6857855361596, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25150332, Length=383, Percent_Identity=24.2819843342037, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71990932, Length=405, Percent_Identity=23.7037037037037, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71990924, Length=405, Percent_Identity=23.4567901234568, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999817, Length=456, Percent_Identity=22.5877192982456, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71999819, Length=456, Percent_Identity=22.5877192982456, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=254, Percent_Identity=20.8661417322835, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=254, Percent_Identity=20.8661417322835, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999821, Length=401, Percent_Identity=23.1920199501247, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147678, Length=403, Percent_Identity=22.8287841191067, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71987559, Length=408, Percent_Identity=21.8137254901961, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71987545, Length=404, Percent_Identity=22.5247524752475, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=372, Percent_Identity=22.5806451612903, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510734, Length=403, Percent_Identity=23.3250620347395, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221510738, Length=403, Percent_Identity=23.3250620347395, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281364513, Length=453, Percent_Identity=20.7505518763797, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473222, Length=453, Percent_Identity=20.7505518763797, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510732, Length=403, Percent_Identity=23.3250620347395, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221473215, Length=455, Percent_Identity=20.6593406593407, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510736, Length=403, Percent_Identity=23.3250620347395, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585580, Length=403, Percent_Identity=23.3250620347395, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585578, Length=403, Percent_Identity=23.3250620347395, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221510740, Length=403, Percent_Identity=23.3250620347395, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221473212, Length=467, Percent_Identity=20.1284796573876, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 60525; Mature: 60525

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFFTILIMTLVVSLSGVVTRVMPFQIPLPLMQIAIGALLAWPTFGLHVEFDPELFLVL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEHHH
FIPPLLFADGWKTPTREFLEHGREIFGLALALVVVTVVGIGFLIYWVVPGIPLIPAFALA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGLVSLKFAVAVAMGTMIFTVGG
HHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
ATVEFMKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILET
HHHHHHHHHHCCHHHHCCHHHCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
SLMAAEIDPNVEIWMLFTDIILIYAALMLVRFGWLWTMKKFSNRFLKKKPMEFGSWTTRE
HHHHEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
ILIASFAGVRGAITLAGVLSIPLLLPDGNVFPARYELVFLAAGVILFSLFVGVVMLPILL
HHHHHHHCHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHIEVADHSQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDNQLLTEVSSRVIGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHH
LRRRADGRNDVESSVQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALLIEENQ
HHHHHCCCC
>Mature Secondary Structure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HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]