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The map label for this gene is lyx

Identifier: 157163058

GI number: 157163058

Start: 3776387

End: 3777883

Strand: Direct

Name: lyx

Synonym: EcHS_A3784

Alternate gene names: 157163058

Gene position: 3776387-3777883 (Clockwise)

Preceding gene: 157163057

Following gene: 157163059

Centisome position: 81.33

GC content: 57.45

Gene sequence:

>1497_bases
ATGACGCAATACTGGCTGGGGTTAGATTGTGGCGGTAGCTGGCTGAAAGCCGGGCTGTATGACCGCGAAGGCCGGGAGGC
AGGCGTGCAGCGCCTGCCGCTGTGCGCATTAAGCCCGCAGCCAGGCTGGGCAGAGCGCGATATGGCAGAACTGTGGCAAT
GCTGCATGGCTGTCATTCGCGCCCTGCTTACTCATTCTGGTGTTAGCGGGGAACAAATTGTCGGTATCGGCATCTCCGCA
CAGGGAAAGGGCTTGTTTTTGCTGGATAAAAACGACAAACCGCTCGGGAATGCTATTTTGTCCTCGGACCGCCGGGCGAT
GGAAATCGTTCGTCGCTGGCAGGAAGATGGCATCCCGGAAAAACTCTACCCGCTGACCCGACAAACCTTGTGGACCGGGC
ATCCGGTGTCGCTGTTACGCTGGCTGAAAGAGCACGAACCAGAACGCTACGCGCAAATTGGCTGCGTGATGATGACGCAC
GACTACCTGCGCTGGTGTTTAACTGGCGTCAAAGGCTGTGAAGAGAGCAATATTTCCGAGTCCAACCTCTACAACATGAG
TCTTGGGGAATATGACCCGTGCCTCACCGACTGGCTGGGGATCGCTGAAATCAATCACGCCCTGCCGCCTGTTGTCGGAT
CTGCCGAAATCTGCGGGGAGATCACCGCTCAGACAGCCGCCCTGACCGGTCTGAAAGCGGGTACGCCCGTTGTTGGCGGC
CTGTTTGATGTGGTTTCCACCGCACTCTGCGCCGGGATCGAAGACGAATTTACCCTCAATGCGGTGATGGGGACCTGGGC
GGTGACCAGCGGCATAACCCGCGGTTTACGTGACGGTGAAGCGCATCCGTATGTCTATGGTCGCTACGTTAACGATGGTG
AATTTATCGTTCACGAAGCCAGCCCTACCTCTTCCGGCAACCTCGAATGGTTTACCGCACAGTGGGGAGAAATCTCGTTT
GATGAGATCAATCAGGCCGTTGCCAGCTTGCCGAAGGCTGGGGGCGATCTCTTTTTCCTGCCGTTCCTGTACGGCAGCAA
CGCCGGACTCGAGATGACCAGTGGTTTCTACGGGATGCAGGCCATTCACACCCGCGCGCACCTGTTGCAGGCCATCTATG
AAGGGGTGGTGTTCAGCCATATGACCCACCTCAACCGAATGCGCGAACGTTTTACTGATGTTCACACCCTACGCGTCACT
GGCGGCCCGGCGCACTCCGATGTCTGGATGCAAATGCTGGCGGACGTCAGCGGTCTGCGTATCGAGCTGCCGCAGGTGGA
AGAAACCGGCTGCTTTGGTGCGGCCCTTGCCGCCCGCGTCGGCACCGGGGTTTATCACAACTTCAGCGAAGCCCAACGTG
ACTTGCGACACCCGGTGCGCACCCTGCTGCCAGATATGACCGCCCATCAGCTTTACCAAAAAAAATATCAACGTTATCAG
CATCTCATTGCCGCACTTCAGGGCTTTCACGCCCGCATTAAGGAGCACACATTATGA

Upstream 100 bases:

>100_bases
CTTTAGCGACGCACTGGGGAATCAGGTTCGCGACATGTTTGTTAAAGATGTGCCGCAGGGAGCTGATCTGCTGAAAGCCG
TGGATGAGGTGCAATAAACC

Downstream 100 bases:

>100_bases
GCCGACCACTTCTGCAACTGGCCCTCGACCACTCATCACTTGAAGCCGCGCAGCGCGACGTGACGCTGTTAAAAGACAGC
GTCGATATCGTCGAAGCGGG

Product: cryptic L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRALLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISF
DEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQ
HLIAALQGFHARIKEHTL

Sequences:

>Translated_498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRALLTHSGVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISF
DEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQ
HLIAALQGFHARIKEHTL
>Mature_497_residues
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRALLTHSGVSGEQIVGIGISAQ
GKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHD
YLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGGL
FDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISFD
EINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQH
LIAALQGFHARIKEHTL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family

Homologues:

Organism=Homo sapiens, GI88196792, Length=515, Percent_Identity=25.0485436893204, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI164663828, Length=542, Percent_Identity=23.6162361623616, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=100, Blast_Score=1034, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=505, Percent_Identity=25.3465346534653, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789987, Length=492, Percent_Identity=23.9837398373984, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1790361, Length=487, Percent_Identity=24.2299794661191, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24655555, Length=460, Percent_Identity=23.9130434782609, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655560, Length=460, Percent_Identity=23.9130434782609, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655570, Length=460, Percent_Identity=23.9130434782609, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655574, Length=460, Percent_Identity=23.9130434782609, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655565, Length=460, Percent_Identity=23.9130434782609, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24656367, Length=520, Percent_Identity=23.2692307692308, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357867, Length=532, Percent_Identity=22.3684210526316, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656372, Length=167, Percent_Identity=27.5449101796407, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24657106, Length=543, Percent_Identity=23.0202578268877, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24657102, Length=543, Percent_Identity=23.0202578268877, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYXK_ECOLI (P37677)

Other databases:

- EMBL:   U00039
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   S47801
- RefSeq:   AP_004212.1
- RefSeq:   NP_418037.1
- ProteinModelPortal:   P37677
- SMR:   P37677
- STRING:   P37677
- EnsemblBacteria:   EBESCT00000003490
- EnsemblBacteria:   EBESCT00000003491
- EnsemblBacteria:   EBESCT00000015502
- GeneID:   948101
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW3552
- KEGG:   eco:b3580
- EchoBASE:   EB2192
- EcoGene:   EG12284
- eggNOG:   COG1070
- GeneTree:   EBGT00050000009228
- HOGENOM:   HBG299886
- OMA:   YGMQALH
- ProtClustDB:   CLSK870414
- BioCyc:   EcoCyc:LYXK-MONOMER
- BioCyc:   MetaCyc:LYXK-MONOMER
- Genevestigator:   P37677
- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- PANTHER:   PTHR10196

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N

EC number: =2.7.1.53

Molecular weight: Translated: 55156; Mature: 55024

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00933 FGGY_KINASES_1; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
ALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEC
SPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQ
EECCCCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLIAALQGFHARIKEHTL
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
ALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEC
SPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQ
EECCCCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLIAALQGFHARIKEHTL
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871