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The map label for this gene is ggt [H]

Identifier: 157162923

GI number: 157162923

Start: 3631339

End: 3633081

Strand: Reverse

Name: ggt [H]

Synonym: EcHS_A3644

Alternate gene names: 157162923

Gene position: 3633081-3631339 (Counterclockwise)

Preceding gene: 157162925

Following gene: 157162918

Centisome position: 78.24

GC content: 55.13

Gene sequence:

>1743_bases
ATGATAAAACCGACGTTTTTACGCCGGGTGGCCATTGCTGCTCTGCTCTCAGGAAGTTGTTTTAGCGCCGCCGCCGCGCC
TCCTGCGCCGCCCGTCTCGTATGGTGTGGAGGAAGATGTCTTCCACCCGGTACGCGCGAAACAGGGAATGGTAGCGTCTG
TGGACGCCACTGCCACTCAGGTGGGGGTGGATATTCTCAAGGAGGGCGGGAATGCCGTTGATGCCGCCGTGGCGGTGGGC
TACGCGCTGGCGGTAACGCATCCGCAGGCAGGGAATCTGGGCGGTGGTGGTTTTATGTTAATCCGCTCGAAAAATGGCAA
TACCACGGCTATCGATTTCCGCGAAATGGCACCCGCCAAAGCGACCCGCGATATGTTCCTCGATGATCAGGGCAACCCGG
ACAGCAAAAAATCACTCACTTCGCATCTGGCTTCCGGCACACCGGGTACGGTAGCAGGTTTCTCGCTGGCGCTGGATAAA
TACGGCACCATGCCGCTGAACAAAGTCGTGCAGCCCGCGTTTAAACTGGCACGCGATGGTTTTATCGTTAACGACGCGCT
GGCTGACGATCTCAAAACCTACGGTAGCGAAGTGTTGCCGAATCACGAAAACAGTAAAGCTATCTTCTGGAAAGAGGGCG
AGCCGCTGAAAAAGGGCGACACGCTGGTGCAGGCGAACCTGGCAAAGAGCCTGGAGATGATTGCTGAAAACGGCCCGGAC
GAATTCTATAAAGGCACGATTGCGGAACAGATCGCCCAGGAGATGCAGAAAAACGGTGGCTTGATCACTAAAGAAGATTT
AGCGGCCTATAAAGCGGTCGAACGCACTCCGATAAGCGGCGATTATCGCGGGTATCAGGTTTACTCCATGCCACCGCCAT
CCTCCGGCGGGATCCATATCGTACAAATCCTCAATATTCTGGAAAACTTCGATATGAAGAAATACGGCTTTGGCAGCGCC
GATGCGATGCAAATCATGGCAGAAGCGGAGAAATACGCCTACGCCGACCGCTCGGAATATCTTGGCGACCCGGATTTTGT
CAAAGTCCCGTGGCAGGCACTGACCAATAAAGCCTATGCCAAATCCATTGCCGATCAAATTGATATCAACAAAGCGAAGC
CGTCCAGTGAGATTCGCCCTGGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTACTCTGTAGTGGATAAAGAC
GGTAACGCGGTGGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGTATTGTCGCGGGCGAGAGCGGTATTCTGCT
TAATAACCAGATGGATGATTTCTCCGCCAAACCGGGCGTACCGAACGTTTACGGGCTGGTGGGCGGTGATGCCAACGCCG
TCGGGCCGAACAAACGCCCGCTGTCGTCGATGTCGCCGACCATTGTGGTGAAAGACGGTAAAACCTGGCTGGTTACCGGT
AGCCCAGGCGGTAGCCGGATCATCACTACAGTGCTGCAAATGGTGGTGAATAGCATCGATTATGGCATGAACGTCGCCGA
AGCGACCAATGCGCCGCGTTTCCACCATCAGTGGTTGCCGGACGAGCTGCGTGTCGAAAAAGGGTTTAGCCCGGATACGC
TCAAGCTGCTGGAAGCAAAAGGTCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGTACACAAAGCATTATGGTTGGGCCG
GACGGTGAGTTGTACGGCGCATCCGACCCGCGCTCGGTGGATGATTTAACGGCGGGGTACTAA

Upstream 100 bases:

>100_bases
ATATCCTTTAAGTTTACTCGCTTCCCGACAAAACGATGATTAATTCAGAGTTATATACCAGGCTTAGCTGGGGTTGCCCC
TTAATCTCTGGAGAATAACG

Downstream 100 bases:

>100_bases
GGTTAGCGGCCCTCTTCGTGGGAAGAGGGCTATTTTGTCAGGGCAAGCCGAAGGTAGCCTTTTTTATTTCGTAATCCTGT
AGATATTCTTCCAGCGGCTT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDK
YGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKD
GNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Sequences:

>Translated_580_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDK
YGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKD
GNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY
>Mature_580_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDK
YGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKD
GNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=31.6698656429942, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=31.047619047619, Blast_Score=235, Evalue=1e-61,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.6939890710383, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=28.4936479128857, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=28.4420289855072, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI153266907, Length=548, Percent_Identity=27.007299270073, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=32.4200913242009, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=30.5936073059361, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=99.8275862068966, Blast_Score=1185, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=573, Percent_Identity=34.3804537521815, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI212646519, Length=573, Percent_Identity=34.3804537521815, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI193208245, Length=561, Percent_Identity=32.7985739750446, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI193208247, Length=561, Percent_Identity=33.1550802139037, Blast_Score=245, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=35.8717434869739, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=30.8797127468582, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.5395033860045, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI72001497, Length=233, Percent_Identity=27.0386266094421, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=232, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=491, Percent_Identity=28.9205702647658, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45551474, Length=516, Percent_Identity=33.1395348837209, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI161077880, Length=516, Percent_Identity=33.1395348837209, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161077878, Length=516, Percent_Identity=33.1395348837209, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642670, Length=516, Percent_Identity=33.1395348837209, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642666, Length=516, Percent_Identity=33.1395348837209, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=31.2977099236641, Blast_Score=235, Evalue=6e-62,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.8880308880309, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=28.6751361161525, Blast_Score=192, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61787; Mature: 61787

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQ
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHHH
VGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAK
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHHCCCH
ATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDG
HHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCCH
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
CCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQ
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHHH
VGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAK
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHHCCCH
ATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDG
HHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCCH
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
CCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]