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The map label for this gene is argD [H]

Identifier: 157162836

GI number: 157162836

Start: 3533303

End: 3534523

Strand: Reverse

Name: argD [H]

Synonym: EcHS_A3556

Alternate gene names: 157162836

Gene position: 3534523-3533303 (Counterclockwise)

Preceding gene: 157162837

Following gene: 157162833

Centisome position: 76.12

GC content: 53.73

Gene sequence:

>1221_bases
ATGGCAATTGAACAAACAGCAATTACACGCGCGACTTTCGATGAAGTGATCCTGCCGATTTATGCACCGGCAGAGTTTAT
TCCGGTAAAAGGTCAGGGCAGCCGAATCTGGGATCAGCAAGGCAAGGAGTATGTCGATTTCGCGGGTGGCATTGCAGTTA
CGGCGTTGGGCCATTGCCATCCTGCGCTGGTGAACGCGTTAAAAACCCAGGGCGAAACTCTGTGGCATATCAGTAACGTT
TTCACCAATGAACCGGCGCTGCGTCTTGGGCATAAACTGATTGAGGCGACGTTTGCCGAACGCGTGGTGTTTATGAACTC
CGGCACGGAAGCTAACGAAACCGCCTTTAAACTGGCACGCCATTACGCCTGTGTGCGTCATAGCCCGTTCAAAACCAAAA
TTATTGCCTTCCATAAAGCTTTTCATGGTCGCTCGCTGTTTACCGTTTCGGTGGGTGGGCAGCCAAAATATTCCGACGGC
TTTGGGTCAAAACCGGCAGACATCATCCACGTTCCCTTTAACGATCTCCACGCAGTGAAAGCGGTGATGGATGATCACAC
CTGTGCAGTGGTGGTTGAGCCGATCCAAGGCGAGGGCGGTGTGACGGCAGCGACGCCAGAGTTTTTGCAGGGCTTGCGTG
AGTTGTGCGATCAACATCAGGCATTATTGGTGTTTGATGAAGTACAGTGCGGGATGGGGCGGACTGGCGATTTGTTTGCT
TACATGCACTACGGCGTGACGCCGGATATTCTGACTTCTGCGAAAGCGTTAGGCGGCGGCTTCCCGATTAGCGCCATGCT
GACCACGGCGGAAATTGCTTCTGCGTTTCATCCTGGTTCTCACGGTTCCACCTACGGCGGTAATCCTCTGGCCTGTGCAG
TAGCGGGCGCGGCGTTTGATATCATTAATACCCCTGAAGTGCTGGAAGGCATTCAGGCGAAACGCCAGCGTTTTGTTGAC
CATTTGCAGAAGATCGATCAGCAGTACGATGTGTTTAGCGATATTCGCGGTATGGGGCTGTTAATTGGCGCGGAGCTGAA
ACCACAGTACAAAGGTCAGGCGCGTGATTTCCTGTATGCGGGCGCAGAGGCTGGCGTAATGGTGCTGAATGCCGGACCGG
ATGTGATGCGTTTTGCACCGTCGCTGGTGGTGGAAGATGCGGATATCGATGAAGGGATGCAACGTTTCGCCCACGCGGTG
GCGAAGGTGGTTGGGGCGTAA

Upstream 100 bases:

>100_bases
TTCCTGCATCGCTGATTTCTGATTGCCATTCAGTGATTTTTTATGCATATTTTGTGATTATAATTTCAAATTTATTTATG
CGTAACAGGGTGATCATGAG

Downstream 100 bases:

>100_bases
ATAAGACGCATCAGGCAAAAGATGTCGGATGCGGCGTGAATGCCTTATCCGATGGTTTAGCCTGCATTACGCCTTCGAAT
CCCGCAACTTGCGACTCAGC

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT; DapATase; Succinyldiaminopimelate transferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGHKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHKAFHGRSLFTVSVGGQPKYSDG
FGSKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAV
AKVVGA

Sequences:

>Translated_406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGHKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHKAFHGRSLFTVSVGGQPKYSDG
FGSKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAV
AKVVGA
>Mature_405_residues
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVF
TNEPALRLGHKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHKAFHGRSLFTVSVGGQPKYSDGF
GSKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAY
MHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDH
LQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVA
KVVGA

Specific function: Involved in both the arginine and lysine biosynthetic pathways [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=378, Percent_Identity=36.7724867724868, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI284507298, Length=294, Percent_Identity=38.4353741496599, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=28.9411764705882, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI37574042, Length=404, Percent_Identity=30.1980198019802, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI226442709, Length=377, Percent_Identity=30.5039787798408, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI226442705, Length=404, Percent_Identity=28.960396039604, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI24119277, Length=396, Percent_Identity=26.5151515151515, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI188536080, Length=418, Percent_Identity=23.444976076555, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679950, Length=418, Percent_Identity=23.444976076555, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI38679946, Length=418, Percent_Identity=23.444976076555, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=99.0147783251232, Blast_Score=827, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=59.9496221662469, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI1789016, Length=407, Percent_Identity=35.3808353808354, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=32.9207920792079, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI145693181, Length=330, Percent_Identity=36.3636363636364, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=31.8611987381703, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1786991, Length=414, Percent_Identity=28.9855072463768, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=35.7333333333333, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=28.175519630485, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=253, Percent_Identity=37.5494071146245, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=28.3333333333333, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=26.4840182648402, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=31.0975609756098, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=37.8787878787879, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=32.0099255583127, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=29.2993630573248, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=24.5977011494253, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357415, Length=377, Percent_Identity=34.2175066312997, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=27.6995305164319, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI161085790, Length=421, Percent_Identity=27.5534441805226, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=29.6912114014252, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI281366494, Length=431, Percent_Identity=22.5058004640371, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24667139, Length=431, Percent_Identity=22.5058004640371, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24667143, Length=431, Percent_Identity=22.5058004640371, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11; =2.6.1.17 [H]

Molecular weight: Translated: 43724; Mature: 43593

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGHKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHKAFHGRSLFTVSVGGQPKYSDGFGSKPADIIHVPFNDLHAVK
HHHHHHCCCCHHHHEEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGHKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHKAFHGRSLFTVSVGGQPKYSDGFGSKPADIIHVPFNDLHAVK
HHHHHHCCCCHHHHEEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]