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The map label for this gene is kdsC [H]

Identifier: 157162682

GI number: 157162682

Start: 3393200

End: 3393766

Strand: Direct

Name: kdsC [H]

Synonym: EcHS_A3391

Alternate gene names: 157162682

Gene position: 3393200-3393766 (Clockwise)

Preceding gene: 157162681

Following gene: 157162683

Centisome position: 73.07

GC content: 52.91

Gene sequence:

>567_bases
ATGAGCAAAGCAGGTGCGTCGCTTGCGACCTGTTACGGCCCTGTCAGCGCCGACGTTATGGCAAAAGCAGAGAACATTCG
TCTGCTGATCCTCGACGTTGATGGCGTACTGTCAGATGGCCTGATTTATATGGGCAATAACGGCGAAGAGCTGAAAGCGT
TCAATGTTCGTGACGGTTATGGCATTCGTTGTGCGCTCACCTCTGATATTGAAGTCGCTATCATTACCGGGCGAAAGGCT
AAACTGGTAGAAGATCGTTGTGCCACATTGGGGATCACTCACTTGTATCAGGGGCAGTCAAACAAACTGATCGCCTTTAG
CGATCTGCTGGAAAAACTGGCGATTGCCCCGGAAAATGTGGCTTATGTCGGCGATGATCTCATCGACTGGCCGGTAATGG
AAAAAGTGGGTTTAAGCGTCGCCGTGGCCGATGCGCATCCACTGTTGATCCCGCGCGCCGATTACGTGACGCGCATTGCT
GGCGGTCGTGGCGCAGTGCGCGAAGTTTGCGACTTATTACTCCTGGCGCAGGGCAAACTGGATGAAGCCAAAGGGCAATC
GATATGA

Upstream 100 bases:

>100_bases
CCTCCGTGATGGTTGCCGATGGCGACCATTTACTCGGTGTGTTACATATGCATGATTTACTGCGTGCAGGCGTAGTGTAA
AGATTCAAGGATAAACAACA

Downstream 100 bases:

>100_bases
GTAAAGCCAGACGTTGGGTTATCATTGTGCTATCACTGGCGGTTCTGGTGATGATCGGCATTAATATGGCCGAAAAAGAC
GATACCGCCCAGGTGGTCGT

Product: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Products: NA

Alternate protein names: KDO 8-P phosphatase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MSKAGASLATCYGPVSADVMAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKA
KLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIA
GGRGAVREVCDLLLLAQGKLDEAKGQSI

Sequences:

>Translated_188_residues
MSKAGASLATCYGPVSADVMAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKA
KLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIA
GGRGAVREVCDLLLLAQGKLDEAKGQSI
>Mature_187_residues
SKAGASLATCYGPVSADVMAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSDIEVAIITGRKAK
LVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAG
GRGAVREVCDLLLLAQGKLDEAKGQSI

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate [H]

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=163, Percent_Identity=29.4478527607362, Blast_Score=77, Evalue=9e-15,
Organism=Escherichia coli, GI2367202, Length=188, Percent_Identity=99.468085106383, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.45 [H]

Molecular weight: Translated: 20015; Mature: 19884

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAGASLATCYGPVSADVMAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGY
CCCCCCCEEEECCCCCHHHEEECCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCC
GIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENV
EEEEEEECCCEEEEEECCCHHHHHHHHHHHCHHHEECCCCCCEEEHHHHHHHHHCCCCCE
AYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKL
EECCCCCCCCCHHHHCCCEEEEECCCCEEEECCHHHEEECCCCCHHHHHHHHHHHCCCCC
DEAKGQSI
CCCCCCCC
>Mature Secondary Structure 
SKAGASLATCYGPVSADVMAKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGY
CCCCCCEEEECCCCCHHHEEECCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCC
GIRCALTSDIEVAIITGRKAKLVEDRCATLGITHLYQGQSNKLIAFSDLLEKLAIAPENV
EEEEEEECCCEEEEEECCCHHHHHHHHHHHCHHHEECCCCCCEEEHHHHHHHHHCCCCCE
AYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTRIAGGRGAVREVCDLLLLAQGKL
EECCCCCCCCCHHHHCCCEEEEECCCCEEEECCHHHEEECCCCCHHHHHHHHHHHCCCCC
DEAKGQSI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]