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The map label for this gene is atoS

Identifier: 157161703

GI number: 157161703

Start: 2361025

End: 2362851

Strand: Direct

Name: atoS

Synonym: EcHS_A2360

Alternate gene names: 157161703

Gene position: 2361025-2362851 (Clockwise)

Preceding gene: 157161700

Following gene: 157161704

Centisome position: 50.85

GC content: 48.6

Gene sequence:

>1827_bases
ATGCATTATATGAAGTGGATTTATCCACGCCGCTTACGCAATCAAATGATCCTGATGGCAATCCTGATGGTCATTGTCCC
AACGCTTACTATTGGTTATATCGTAGAAACGGAAGGACGTTCAGCAGTCTTATCTGAAAAAGAGAAAAAACTTTCTGCCG
TGGTCAACCTGCTTAATCAGGCACTAGGCGATCGCTATGATCTCTACATCGACTTACCACGTGAGGAGCGTATCCGCGCA
TTAAATGCAGAACTTGCCCCCATTACCGAAAATATCACTCACGCCTTCCCTGGCATCGGTGCTGGTTATTACAACAAAAT
GCTGGATGCGATAATCACCTACGCGCCTTCAGCGCTATATCAGAATAATGTCGGCGTTACCATTGCCGCAGATCACCCTG
GTCGCGAAGTCATGCGTACAAATACCCCTTTGGTTTATTCAGGCAGGCAGGTGCGCGGCGATATTTTGAATTCAATGCTC
CCCATTGAGCGTAATGGTGAAATCCTCGGCTATATCTGGGCCAATGAATTAACCGAAGATATTCGCCGCCAGGCCTGGAA
AATGGATGTGAGGATTATCATTGTGCTCACCGCCGGTTTGCTGATAAGCCTGCTATTGATTGTCCTTTTCTCCCGTCGCC
TGAGCGCCAATATTGATATCATCACCGATGGCCTCTCGACTCTGGCACAAAATATTCCCACTCGATTACCACAATTGCCC
GGTGAAATGGGGCAAATCAGTCAGAGTGTTAATAACCTCGCCCAGGCACTGCGTGAAACGCGGACACTTAACGATCTGAT
TATTGAAAACGCTGCCGATGGCGTCATTGCCATTGACCGCCAGGGTGATGTAACCACCATGAACCCAGCAGCAGAAGTTA
TCACTGGCTATCAACGCCATGAACTGGTAGGGCAGCCTTACTCCATGTTGTTCGACAATACTCAGTTCTACAGTCCAGTA
CTGGATACGCTGGAACATGGCACCGAACATGTGGCGCTGGAGATCAGTTTTCCAGGTCGTGACCGCACCATTGAACTCAG
TGTCACTACCAGTCGTATTCATAACACGCACGGTGAAATGATAGGTGCTTTGGTGATTTTCTCTGATTTAACTGCCCGCA
AAGAAACCCAGCGCCGCATGGCGCAAGCAGAACGCCTCGCCACACTGGGTGAGCTGATGGCTGGCGTCGCGCATGAAGTA
CGTAATCCGTTAACGGCTATTCGTGGTTATGTACAGATCTTGCGCCAACAAACCAGTGACCCAATACATCAGGAATATCT
GTCCGTAGTACTCAAAGAAATCGATTCAATTAACAAAGTTATTCAGCAATTGCTCGAATTTTCACGTCCACGCCACAGTC
AATGGCAACAAGTCAGCCTCAATGCATTGGTTGAAGAAACTCTGGTACTGGTACAAACCGCCGGCGTACAAGCGCGGGTC
GACTTCATAAGCGAACTGGATAATGAATTAAGCCCGATTAACGCCGATCGTGAACTGCTCAAACAGGTACTACTGAATAT
CCTGATCAATGCCGTCCAGGCTATCAGCGCACGAGGGAAAATTCGCATTCAAACCTGGCAATACAGCGACTCACAACAGG
CCATTTCGATAGAGGACAACGGCTGTGGCATTGATCTCTCGCTGCAAAAAAAGATCTTCGATCCCTTTTTCACCACCAAA
GCCTCAGGAACCGGGCTTGGTCTGGCGTTAAGTCAACGCATCATTAATGCCCATCAGGGTGATATTCGCGTCGCCAGTTT
GCCGGGCTACGGCGCAACCTTCACGCTTATTTTACCGATCAACCCGCAGGGAAATCAGACTGTATGA

Upstream 100 bases:

>100_bases
GCAATGTTCTCTCTTCTCTGGAATATGATACACCGCCGAGAAATCATCACCTTAACCTCTGATAATCGTCATATACCGGA
CAAGACTAGTGGATTTCAGC

Downstream 100 bases:

>100_bases
CTGCTATTAATCGCATCCTTATTGTGGATGATGAAGATAATGTTCGCCGTATGCTAAGCACCGCTTTTGCACTACAAGGA
TTCGAAACACATTGTGCGAA

Product: sensory histidine kinase AtoS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHYMKWIYPRRLRNQMILMAILMVIVPTLTIGYIVETEGRSAVLSEKEKKLSAVVNLLNQALGDRYDLYIDLPREERIRA
LNAELAPITENITHAFPGIGAGYYNKMLDAIITYAPSALYQNNVGVTIAADHPGREVMRTNTPLVYSGRQVRGDILNSML
PIERNGEILGYIWANELTEDIRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLP
GEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPV
LDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEV
RNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARV
DFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTK
ASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQGNQTV

Sequences:

>Translated_608_residues
MHYMKWIYPRRLRNQMILMAILMVIVPTLTIGYIVETEGRSAVLSEKEKKLSAVVNLLNQALGDRYDLYIDLPREERIRA
LNAELAPITENITHAFPGIGAGYYNKMLDAIITYAPSALYQNNVGVTIAADHPGREVMRTNTPLVYSGRQVRGDILNSML
PIERNGEILGYIWANELTEDIRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLP
GEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPV
LDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEV
RNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARV
DFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTK
ASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQGNQTV
>Mature_608_residues
MHYMKWIYPRRLRNQMILMAILMVIVPTLTIGYIVETEGRSAVLSEKEKKLSAVVNLLNQALGDRYDLYIDLPREERIRA
LNAELAPITENITHAFPGIGAGYYNKMLDAIITYAPSALYQNNVGVTIAADHPGREVMRTNTPLVYSGRQVRGDILNSML
PIERNGEILGYIWANELTEDIRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLP
GEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPV
LDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEV
RNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARV
DFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTK
ASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQGNQTV

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

Homologues:

Organism=Escherichia coli, GI1788549, Length=608, Percent_Identity=100, Blast_Score=1236, Evalue=0.0,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=42.1487603305785, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790300, Length=351, Percent_Identity=28.2051282051282, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI145693157, Length=272, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=365, Percent_Identity=23.5616438356164, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI48994928, Length=421, Percent_Identity=25.1781472684086, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=308, Percent_Identity=26.6233766233766, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI87081816, Length=267, Percent_Identity=27.3408239700375, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=218, Percent_Identity=27.5229357798165, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=26.3157894736842, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788713, Length=367, Percent_Identity=23.9782016348774, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=25.7575757575758, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=260, Percent_Identity=26.1538461538462, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=25.3333333333333, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATOS_ECOLI (Q06067)

Other databases:

- EMBL:   L13078
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   A64992
- RefSeq:   AP_002818.1
- RefSeq:   NP_416723.1
- ProteinModelPortal:   Q06067
- SMR:   Q06067
- STRING:   Q06067
- EnsemblBacteria:   EBESCT00000004380
- EnsemblBacteria:   EBESCT00000017103
- GeneID:   949011
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2213
- KEGG:   eco:b2219
- EchoBASE:   EB1618
- EcoGene:   EG11667
- eggNOG:   COG0642
- GeneTree:   EBGT00050000008663
- HOGENOM:   HBG364610
- OMA:   KDSIEQY
- ProtClustDB:   PRK11360
- BioCyc:   EcoCyc:ATOS-MONOMER
- BRENDA:   2.7.13.3
- Genevestigator:   Q06067
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388
- SMART:   SM00091
- TIGRFAMs:   TIGR00229

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 67791; Mature: 67791

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN; PS50113 PAC; PS50112 PAS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x15018c30)-; HASH(0x1617e91c)-; HASH(0x1617e754)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYMKWIYPRRLRNQMILMAILMVIVPTLTIGYIVETEGRSAVLSEKEKKLSAVVNLLNQ
CCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHH
ALGDRYDLYIDLPREERIRALNAELAPITENITHAFPGIGAGYYNKMLDAIITYAPSALY
HCCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH
QNNVGVTIAADHPGREVMRTNTPLVYSGRQVRGDILNSMLPIERNGEILGYIWANELTED
CCCCCEEEECCCCCHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHH
IRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLP
HHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCC
GEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCHHHHHHHCHHHH
ELVGQPYSMLFDNTQFYSPVLDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEM
HHCCCCHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEHHHHHHHHHHH
IGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECC
GCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPI
CCCEEEEHHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEE
NPQGNQTV
CCCCCCCH
>Mature Secondary Structure
MHYMKWIYPRRLRNQMILMAILMVIVPTLTIGYIVETEGRSAVLSEKEKKLSAVVNLLNQ
CCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHH
ALGDRYDLYIDLPREERIRALNAELAPITENITHAFPGIGAGYYNKMLDAIITYAPSALY
HCCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH
QNNVGVTIAADHPGREVMRTNTPLVYSGRQVRGDILNSMLPIERNGEILGYIWANELTED
CCCCCEEEECCCCCHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHH
IRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLP
HHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCC
GEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEECCHHHHHHHCHHHH
ELVGQPYSMLFDNTQFYSPVLDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEM
HHCCCCHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEHHHHHHHHHHH
IGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEECC
GCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPI
CCCEEEEHHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEE
NPQGNQTV
CCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503