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The map label for this gene is uxaB

Identifier: 157160993

GI number: 157160993

Start: 1626051

End: 1627502

Strand: Reverse

Name: uxaB

Synonym: EcHS_A1603

Alternate gene names: 157160993

Gene position: 1627502-1626051 (Counterclockwise)

Preceding gene: 157160994

Following gene: 157160992

Centisome position: 35.05

GC content: 51.86

Gene sequence:

>1452_bases
GTGAAAACACTAAATCGTCGCGATTTTCCCGGTGCACAGTATCCAGAACGTATCATTCAGTTTGGTGAAGGTAACTTCCT
GCGCGCCTTTGTTGACTGGCAAATCGATCTCCTGAATGAGCACACCGATCTGAATTCTGGCGTGGTCGTTGTTCGTCCGA
TTGAAACTTCATTCCCGCCGTCACTGAGCACGCAGGATGGTCTGTACACCACCATTATCCGTGGCCTGAATGAGAAGGGG
GAAGCGGTCAGCGACGCGCGTCTGATTCGCTCGGTTAATCGTGAAATCAGCGTCTACAGTGAATACGATGAATTCCTGAA
ACTGGCGCACAACCCGGAAATGCGCTTTGTTTTCTCTAACACCACCGAAGCGGGTATCAGCTACCATGCGGGCGATAAAT
TCGATGACGCGCCAGCGGTAAGCTATCCGGCAAAACTGACCCGTCTGCTGTTCGAACGCTTTAGCCATTTCAACGGTGCG
CTGGATAAAGGTTGGATCATCATTCCGTGTGAGTTGATTGACTACAATGGCGACGCGTTGCGTGAACTGGTGCTGCGCTA
TGCGCAAGAGTGGGCACTGCCAGAAGCATTTATTCAATGGCTGGATCAGGCTAACAGCTTCTGTTCTACGCTGGTGGACC
GTATCGTTACCGGTTATCCGCGCGATGAAGTGGCTAAACTGGAAGAAGAACTGGGTTATCACGATGGTTTTCTCGACACC
GCTGAACACTTTTACCTGTTTGTGATTCAGGGACCGAAATCCTTAGCGACTGAACTGCGTCTGGACAAATATCCGCTCAA
CGTGCTGATTGTTGACGATATTAAACCGTACAAAGAACGCAAAGTGGCAATCCTCAACGGTGCGCACACCGCGCTGGTGC
CGGTGGCGTTCCAGGCAGGGCTGGATACCGTAGGTGAAGCGATGAACGATGCTGAAATTTGCGCATTCGTTGAAAAAGCT
ATCTACGAAGAAATTATTCCGGTACTGGATTTGCCTCGTGATGAACTGGAATCTTTCGCCAGTGCAGTCACCGGGCGTTT
CCGTAACCCGTACATTAAGCATCAGCTGCTGTCTATCGCGCTCAACGGTATGACCAAGTTCCGCACTCGCATCCTGCCGC
AGCTGCTGGCAGGGCAGAAGGCAAAAGGCACACTTCCGGCGCGCCTTACTTTCGCATTAGCGGCATTGATTGCCTTCTAT
CGCGGTGAGCGTAACGGAGAAACATATCCGGTACAGGACGATGCACACTGGCTGGAACGTTATCAGCAACTCTGGAGCCA
GCATCGTGACCGTGTTATCGGCACCCAGGAACTGGTAGCGATTGTTTTGGCAGAAAAAGACCACTGGGAGCAGGACCTGA
CGCAAGTGCCTGGTCTGGTCGAGCAGGTTGCTAATGACCTGGATGCGATTCTTGAAAAAGGGATGCGCGAAGCTGTACGT
CCGTTGTGCTAA

Upstream 100 bases:

>100_bases
CATCAGGAGTTGATCAAAACAGGGGTTCGGCGTATTAAAGTTTGCTAACCTGTCGTACCAATTCAAACAGGTTGTATGAC
TAATCAGAAGGGAACCCATT

Downstream 100 bases:

>100_bases
TAACACCGTTACTTCTGAACCCGGTTTCGACCGGGTTTCTTATTTCACTATATTAGTTACAACATCCTATGTGCCTTTAT
CATTAACAGATGCCACATGC

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKTLNRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLYTTIIRGLNEKG
EAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGA
LDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDT
AEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMNDAEICAFVEKA
IYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKAKGTLPARLTFALAALIAFY
RGERNGETYPVQDDAHWLERYQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVR
PLC

Sequences:

>Translated_483_residues
MKTLNRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLYTTIIRGLNEKG
EAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGA
LDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDT
AEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMNDAEICAFVEKA
IYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKAKGTLPARLTFALAALIAFY
RGERNGETYPVQDDAHWLERYQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVR
PLC
>Mature_483_residues
MKTLNRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLYTTIIRGLNEKG
EAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGA
LDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDT
AEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMNDAEICAFVEKA
IYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKAKGTLPARLTFALAALIAFY
RGERNGETYPVQDDAHWLERYQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVR
PLC

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily

Homologues:

Organism=Escherichia coli, GI48994885, Length=483, Percent_Identity=99.7929606625259, Blast_Score=993, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=368, Percent_Identity=27.1739130434783, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790779, Length=492, Percent_Identity=24.5934959349593, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788497, Length=480, Percent_Identity=22.2916666666667, Blast_Score=95, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324401, Length=430, Percent_Identity=23.0232558139535, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320765, Length=430, Percent_Identity=23.0232558139535, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAB_ECO24 (A7ZLX7)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001462806.1
- ProteinModelPortal:   A7ZLX7
- SMR:   A7ZLX7
- STRING:   A7ZLX7
- EnsemblBacteria:   EBESCT00000020956
- GeneID:   5588308
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_1721
- eggNOG:   COG0246
- GeneTree:   EBGT00050000009063
- HOGENOM:   HBG297101
- OMA:   MTKYRTR
- ProtClustDB:   PRK03643
- BioCyc:   ECOL331111:ECE24377A_1721-MONOMER
- HAMAP:   MF_00670
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.58

Molecular weight: Translated: 54823; Mature: 54823

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLNRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPP
CCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCCC
SLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSN
CCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
TTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGALDKGWIIIPCELIDYNGDAL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHH
RELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHC
AEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAG
CCCEEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCCHHCEEEEECCCCHHHHHHHHHHC
LDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNGMTKFRTRILPQLLAGQKAKGTLPARLTFALAALIAFYRGERNGETYPVQDDAHWLER
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
YQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVR
HHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PLC
CCC
>Mature Secondary Structure
MKTLNRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPP
CCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCCC
SLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSN
CCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
TTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGALDKGWIIIPCELIDYNGDAL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHH
RELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHC
AEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAG
CCCEEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCCHHCEEEEECCCCHHHHHHHHHHC
LDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNGMTKFRTRILPQLLAGQKAKGTLPARLTFALAALIAFYRGERNGETYPVQDDAHWLER
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
YQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVR
HHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PLC
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA