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The map label for this gene is gabT1 [H]

Identifier: 157160813

GI number: 157160813

Start: 1413003

End: 1414268

Strand: Direct

Name: gabT1 [H]

Synonym: EcHS_A1417

Alternate gene names: 157160813

Gene position: 1413003-1414268 (Clockwise)

Preceding gene: 157160812

Following gene: 157160815

Centisome position: 30.43

GC content: 57.82

Gene sequence:

>1266_bases
ATGAGCAACAATGAATTCCATCAGCGTCGTCTTTCTGCCACCCCGCGCGGGGTTGGCGTGATGTGTAACTTCTTCGCCCA
GTCGGCTGAAAACGCTACGCTGAAGGATGTTGAGGGCAACGAGTACATCGATTTCGCCGCAGGCATTGCGGTGCTGAATA
CCGGGCATCGCCACCCTGATCTGGTCGCGGCGGTGGAGCAGCAACTGCAACAGTTTACCCACACCGCGTATCAGATTGTG
CCGTATGAAAGCTACGTCACCCTGGCGGAGAAAATCAACGCCCTTGCCCCGGTGAGCGGGCAGGCCAAAACCGCGTTCTT
CACTACCGGCGCGGAAGCGGTGGAAAACGCGGTGAAAATGGCTCGCGCCCATACCGGACGACCTGGCGTGATTGCGTTTA
GCGGTGGCTTCCACGGTCGTACATATATGACCATGGCGCTGACCGGAAAAGTTGCGCCGTACAAAATCGGCTTCGGCCCG
TTCCCTGGTTCGGTGTATCACGTACCTTATCCGTCAGATTTACACGGCATTTCAACACAGGACTCCCTCGACGCCATCGA
ACGCTTGTTTAAATCAGACATCGAAGCGAAGCAGGTCGCGGCCATTATTTTCGAACCGGTGCAGGGCGAGGGCGGTTTCA
ACGTTGCGCCAAAAGAGCTGGTTGCCGCCATTCGCCGCCTGTGCGACGAGCACGGTATTGTGATGATTGCCGATGAAGTG
CAAAGCGGCTTTGCGCGTACCGGTAAACTGTTTGCCATGGATCATTACGCCGATAAGCCGGACTTAATGACGATGGCGAA
AAGCCTCGCGGGCGGGATGCCGCTTTCGGGCGTGGTCGGTAACGCGAATATTATGGACGCGCCCGCGCCGGGCGGGTTGG
GTGGCACCTACGCCGGGAACCCGCTGGCGGTGGCTGCCGCGCACGCGGTGCTCAATATTATCGACAAAGAATCACTCTGC
AAACGCGCGAATCAACTGGGCCAGCGTCTCAAAAACACGTTGATTGATGCCAAAGAAAGCGTTCCGGCCATTGCTGCGGT
ACGCGGCCTGGGGTCGATGATTGCGGCAGAGTTTAACGATCCGCAAACGGGCGAGCCGTCAGCGGCGATTGCACAGAAAA
TCCAGCAACGCGCGCTGGCGCAGGGGCTGCTCCTGCTGACCTGTGGCGCATACGGCAACGTGATTCGCTTCCTGTATCCG
CTGACCATCCCGGATGCGCAATTCGATGCGGCAATGAAAATTTTGCAGGATGCGCTGAGCGATTAA

Upstream 100 bases:

>100_bases
CGCGTACCGTTTACCGCGATGGGCGCGGCGTATTACAGCCTGCGCGATCGTCTGGGCGTTTAATTTCCGATTAACAGTGA
AGAGTCAAAAGGTGTGAAAC

Downstream 100 bases:

>100_bases
TAGCCCAACGCAATAATGTCTGATGCGCTGCGCTTATCAGGCCTGCAAACGACGTTGATTATGTATGCCGGATAAAGCAT
TCACGCCGCATCCGGCAAGT

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKMARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
KRANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALSD

Sequences:

>Translated_421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKMARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
KRANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALSD
>Mature_420_residues
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIVP
YESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKMARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPF
PGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEVQ
SGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLCK
RANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPL
TIPDAQFDAAMKILQDALSD

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=32.25, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=32.2981366459627, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI13994255, Length=417, Percent_Identity=30.2158273381295, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI37574042, Length=448, Percent_Identity=28.7946428571429, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI188536080, Length=445, Percent_Identity=28.314606741573, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI38679950, Length=445, Percent_Identity=28.314606741573, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI38679946, Length=445, Percent_Identity=28.314606741573, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=29.8200514138817, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI24119277, Length=392, Percent_Identity=27.5510204081633, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442705, Length=448, Percent_Identity=28.3482142857143, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=99.2874109263658, Blast_Score=858, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=54.6318289786223, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=33.1683168316832, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=34.1772151898734, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=34.9875930521092, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=31.3218390804598, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786991, Length=409, Percent_Identity=28.1173594132029, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=32.6781326781327, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32564660, Length=421, Percent_Identity=31.353919239905, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=29.6037296037296, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=32.2033898305085, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=426, Percent_Identity=25.3521126760563, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=32.7586206896552, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=31.5270935960591, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=334, Percent_Identity=24.5508982035928, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=26.3440860215054, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=31.6831683168317, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=30.3102625298329, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161085790, Length=418, Percent_Identity=29.9043062200957, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=28.3720930232558, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281366494, Length=364, Percent_Identity=27.1978021978022, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24667139, Length=364, Percent_Identity=27.1978021978022, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24667143, Length=364, Percent_Identity=27.1978021978022, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 44719; Mature: 44587

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKM
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCH
DSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCKRANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALS
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C
>Mature Secondary Structure 
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKM
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCH
DSLDAIERLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCKRANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALS
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]