BacMap

Definition	Escherichia coli HS, complete genome.
Accession	NC_009800
Length	4,643,538

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The map label for this gene is yciK [H]

Identifier: 157160776

GI number: 157160776

Start: 1375411

End: 1376169

Strand: Reverse

Name: yciK [H]

Synonym: EcHS_A1380

Alternate gene names: 157160776

Gene position: 1376169-1375411 (Counterclockwise)

Preceding gene: 157160778

Following gene: 157160775

Centisome position: 29.64

GC content: 52.31

Gene sequence:

>759_bases
ATGCATTACCAGCCAAAACAAGATTTACTCAATGATCGCATTATCCTGGTGACGGGAGCCAGTGATGGTATTGGTCGTGA
AGCCGCGATGACGTATGCACGCTATGGTGCGACAGTGATTCTGTTGGGCCGTAATGAAGAAAAATTACGTCAGGTAGCCA
GCCACATAAACGAAGAAACTGGGCGTCAGCCACAGTGGTTTATTCTCGATTTGCTGACCTGCAGGTCCGAAGATTGCCAA
CAACTGGCACAGCGCATTGCCGTTAATTATCCGCGTCTGGATGGTGTTTTGCATAATGCCGGATTGCTCGGCGATGTTTG
TCCAATGAGCGAACAAAATCCACAGGTCTGGCAGGACGTCATACAGGTCAACGTTAATGCCACCTTTATGCTCACCCAGG
CACTGCTTCCTTTATTACTCAAATCGGACGCCGGTTCACTGGTCTTTACTTCATCAAGCGTTGGACGTCAGGGACGAGCC
AACTGGGGCGCATATGCAGCGTCGAAATTTGCCACCGAAGGGATGATGCAGGTACTGGCCGATGAATATCAGCAGCGCCT
GCGCGTCAACTGCATTAACCCAGGCGGTACGCGCACCGCAATGCGTGCCAGCGCCTTCCCGACCGAAGATCCACAGAAAC
TTAAAACACCCGCTGATATCATGCCGCTCTACCTCTGGCTGATGGGCGATGACAGCCGCCGTAAAACCGGCATGACCTTT
GACGCCCAACCGGGCCGTAAACCAGGAATTTCCCAATGA

Upstream 100 bases:

>100_bases
CGCCCCAGGCTGATTGAAATGCCCTTCTGTTTCAGGCATAAAGCCCCAAAGTCATAAAGTACACTGGCAGCGCGACAGAC
AACGTCGTTGAGGAGTAGCC

Downstream 100 bases:

>100_bases
GTGATGAACGCTACCAACAGCGTCAGCAGCGAGTGAAAGAAAAAGTAGATGCTCGTGTGGCCCAGGCCCAGGATGAACGC
GGTATTATCATCGTCTTTAC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEETGRQPQWFILDLLTCRSEDCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVIQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Sequences:

>Translated_252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEETGRQPQWFILDLLTCRSEDCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVIQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ
>Mature_252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEETGRQPQWFILDLLTCRSEDCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVIQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI142976729, Length=222, Percent_Identity=27.4774774774775, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI20149619, Length=206, Percent_Identity=30.5825242718447, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=26.1904761904762, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4504505, Length=236, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=27.8606965174129, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI5031737, Length=201, Percent_Identity=27.8606965174129, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=29.277566539924, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI40807363, Length=206, Percent_Identity=25.2427184466019, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI66933014, Length=246, Percent_Identity=28.8617886178862, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7657478, Length=222, Percent_Identity=29.2792792792793, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10190704, Length=190, Percent_Identity=25.2631578947368, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7705855, Length=206, Percent_Identity=27.1844660194175, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4557649, Length=188, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI126723191, Length=199, Percent_Identity=26.1306532663317, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=171, Percent_Identity=30.9941520467836, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40548397, Length=195, Percent_Identity=28.7179487179487, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI214010158, Length=195, Percent_Identity=28.7179487179487, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI214010156, Length=195, Percent_Identity=28.7179487179487, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI22758144, Length=195, Percent_Identity=28.7179487179487, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=25.8964143426295, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI31542939, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=27.4725274725275, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=98.8095238095238, Blast_Score=519, Evalue=1e-149,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=27.6859504132231, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=32.6359832635983, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=30.1204819277108, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786701, Length=205, Percent_Identity=30.2439024390244, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787820, Length=224, Percent_Identity=23.2142857142857, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789208, Length=192, Percent_Identity=26.0416666666667, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786812, Length=204, Percent_Identity=25.4901960784314, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=29.6, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=211, Percent_Identity=28.436018957346, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71997402, Length=253, Percent_Identity=26.8774703557312, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=219, Percent_Identity=28.310502283105, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=212, Percent_Identity=27.3584905660377, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=199, Percent_Identity=29.6482412060301, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=204, Percent_Identity=32.3529411764706, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=203, Percent_Identity=26.1083743842365, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=236, Percent_Identity=28.3898305084746, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=29.4736842105263, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560176, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=206, Percent_Identity=28.6407766990291, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=24.6153846153846, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=26.5060240963855, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=191, Percent_Identity=28.2722513089005, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=245, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=216, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=239, Percent_Identity=23.8493723849372, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=182, Percent_Identity=27.4725274725275, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=202, Percent_Identity=27.2277227722772, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=212, Percent_Identity=25.4716981132075, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=207, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=25.3012048192771, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=206, Percent_Identity=26.6990291262136, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=193, Percent_Identity=25.9067357512953, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=213, Percent_Identity=25.3521126760563, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=217, Percent_Identity=26.7281105990783, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=214, Percent_Identity=28.0373831775701, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=214, Percent_Identity=30.8411214953271, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=226, Percent_Identity=28.3185840707965, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=236, Percent_Identity=25.4237288135593, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=196, Percent_Identity=27.0408163265306, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=28.5140562248996, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=32.620320855615, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24640492, Length=182, Percent_Identity=30.2197802197802, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=27.9352226720648, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24643142, Length=205, Percent_Identity=35.1219512195122, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281364892, Length=204, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=29.1866028708134, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=29.1005291005291, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=29.1005291005291, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357041, Length=187, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=27.7992277992278, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584752, Length=230, Percent_Identity=30, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27971; Mature: 27971

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEET
CCCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
GRQPQWFILDLLTCRSEDCQQLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDV
CCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
IQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCHHHCCCCCCCCCHHHHCCCHHHHHEEHEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC
>Mature Secondary Structure
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEET
CCCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
GRQPQWFILDLLTCRSEDCQQLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDV
CCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
IQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCHHHCCCCCCCCCHHHHCCCHHHHHEEHEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]