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The map label for this gene is pepN

Identifier: 157160454

GI number: 157160454

Start: 1052238

End: 1054850

Strand: Direct

Name: pepN

Synonym: EcHS_A1041

Alternate gene names: 157160454

Gene position: 1052238-1054850 (Clockwise)

Preceding gene: 157160448

Following gene: 157160460

Centisome position: 22.66

GC content: 53.35

Gene sequence:

>2613_bases
ATGACTCAACAGCCACAAGCCAAATACCGTCACGATTATCGTGCGCCGGATTACCAGATTACTGATATTGACTTGACCTT
TGACCTCGACGCGCAAAAGACGGTCGTTACCGCGGTCAGCCAGGCTGTCCGTCATGGTGCATCAGATGCTCCCCTTCGTC
TCAACGGCGAAGACCTCAAACTGGTTTCTGTTCATATTAATGATGAGCCGTGGACCGCCTGGAAAGAAGAAGAGGGCGCA
CTGGTCATCAGTAATTTGCCGGAGCGTTTTACGCTTAAGATCATTAATGAAATAAGCCCGGCGGCGAATACGGCGCTGGA
AGGGCTTTATCAGTCAGGCGATGCGCTTTGCACCCAGTGTGAAGCCGAAGGTTTCCGCCATATTACGTATTATCTCGACC
GCCCGGACGTGCTGGCGCGTTTTACCACCAAAATTATTGCCGATAAAATTAAATATCCCTTCCTGCTTTCCAACGGTAAC
CGCGTTGCGCAAGGCGAACTGGAAAACGGACGCCATTGGGTACAGTGGCAGGACCCGTTCCCGAAACCGTGCTACCTGTT
TGCGCTGGTGGCAGGCGACTTTGATGTACTGCGCGATACCTTTACCACGCGTTCTGGTCGCGAAGTAGCACTGGAGCTGT
ACGTCGATCGCGGCAACCTTGATCGCGCGCCGTGGGCGATGACCTCGCTGAAAAACTCCATGAAATGGGATGAAGAACGC
TTTGGCCTGGAGTATGACCTCGACATCTATATGATCGTCGCGGTGGATTTCTTCAATATGGGCGCAATGGAGAATAAGGG
TCTGAATATCTTTAACTCCAAATATGTGCTGGCCCGCACCGACACCGCCACCGACAAAGATTACCTCGATATTGAACGCG
TTATCGGCCATGAATATTTCCATAACTGGACCGGTAACCGAGTGACCTGCCGCGACTGGTTCCAGCTCAGCCTGAAAGAA
GGTTTAACCGTCTTCCGCGATCAGGAGTTCAGCTCTGACCTTGGTTCCCGCGCAGTTAACCGCATCAATAATGTACGCAC
CATGCGCGGATTGCAGTTTGCAGAAGACGCCAGCCCGATGGCGCACCCGATCCGCCCGGATATGGTCATTGAGATGAACA
ACTTCTACACCCTGACCGTTTACGAGAAGGGCGCGGAAGTGATTCGCATGATCCACACCCTGCTTGGCGAAGAAAACTTC
CAGAAAGGGATGCAGCTTTATTTCGAGCGTCATGATGGTAGTGCAGCGACCTGTGACGACTTTGTGCAGGCGATGGAAGA
TGCGTCGAATGTCGATCTCTCCCATTTCCGCCGTTGGTACAGCCAGTCCGGTACACCGATTGTGACCGTCAAAGACGACT
ACAATCCAGAAACTGAGCAGTACACCCTGACCATCAGCCAGCGCACGCCAGCTACGCCGGATCAGGCAGAAAAACAGCCG
CTGCATATTCCGTTTGCCATCGAACTGTATGATAACGAAGGCAAAGTGATCCCGTTGCAGAAAGGCGGTCATCCGGTGAA
TTCCGTGCTGAACGTCACTCAGGCGGAACAGACCTTTGTTTTTGATAATGTCTACTTCCAGCCGGTGCCTGCGCTGCTGT
GCGAATTCTCTGCGCCAGTGAAACTGGAATATAAGTGGAGCGATCAGCAACTGACCTTCCTGATGCGTCATGCGCGTAAT
GATTTCTCCCGCTGGGATGCGGCGCAAAGTTTGCTGGCAACCTACATCAAGCTGAACGTCGCGCGTCATCAGCAAGGTCA
GCCGCTGTCTCTGCCGGTGCATGTGGCTGATGCTTTCCGCGCGGTACTGCTTGATGAGAAGATTGATCCAGCGCTGGCGG
CAGAAATCCTGACGCTGCCTTCTGTCAATGAAATGGCTGAATTGTTCGATATCATCGACCCGATTGCTATTGCCGAAGTA
CGCGAAGCACTCACTCGTACTCTGGCGACTGAACTGGCGGATGAGCTACTGGCTATTTACAACGCGAATTACCAGAGCGA
GTACCGTGTTGAGCATGAAGATATTGCAAAACGCACTCTGCGTAATGCCTGCCTGCGTTTCCTCGCTTTTGGTGAAACGC
ATCTGGCTGATGTGCTGGTGAGCAAGCAGTTCCACGAAGCAAACAATATGACTGATGCGCTGGCGGCGCTTTCTGCGGCG
GTTGCCGCACAGCTGCCTTGCCGTGACGCGCTGATGCAGGAGTACGACGACAAGTGGCATCAGAACGGTCTGGTGATGGA
TAAATGGTTTATCCTGCAAGCCACCAGCCCGGCGGCGAATGTGCTGGAGACGGTGCGCGGCCTGTTGCAGCATCGCTCAT
TTACCATGAGCAACCCGAACCGTATTCGTTCGTTGATTGGCGCGTTTGCGGGCAGCAATCCGGCAGCGTTCCATGCCGAA
GATGGCAGCGGTTACCTGTTCCTGGTGGAAATGCTTACCGACCTCAACAGCCGTAACCCGCAGGTGGCTTCACGTCTGAT
TGAACCGCTGATTCGCCTGAAACGTTACGATGCCAAACGTCAGGAGAAAATGCGCGCGGCGCTGGAACAGTTGAAAGGGC
TGGAAAATCTCTCTGGCGATCTGTACGAGAAGATAACTAAAGCACTGGCTTGA

Upstream 100 bases:

>100_bases
AGGCGTTTGTACCTGAAAAGATGAAGATTCTGCATAGCGCGATTTACGCAACAGGAATAGACTGAACACCAGACTCTATA
AAAGATGCTAAAGGTTATTT

Downstream 100 bases:

>100_bases
TAAATAACCGAATGGCGGCAATAGCGCCGCCATTCGGGGAATTTACCCCTGTTTTCTCAGGCGAGTTTCAGATTCACCAC
GTTGCATCACCCGTTGCAAC

Product: aminopeptidase N

Products: NA

Alternate protein names: Alpha-aminoacylpeptide hydrolase

Number of amino acids: Translated: 870; Mature: 869

Protein sequence:

>870_residues
MTQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGA
LVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGN
RVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEER
FGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKE
GLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENF
QKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQP
LHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARN
DFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEV
REALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAA
VAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAE
DGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA

Sequences:

>Translated_870_residues
MTQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGA
LVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGN
RVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEER
FGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKE
GLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENF
QKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQP
LHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARN
DFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEV
REALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAA
VAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAE
DGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA
>Mature_869_residues
TQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGAL
VISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNR
VAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERF
GLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEG
LTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQ
KGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPL
HIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARND
FSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVR
EALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAV
AAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAED
GSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA

Specific function: Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation

COG id: COG0308

COG function: function code E; Aminopeptidase N

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M1 family

Homologues:

Organism=Homo sapiens, GI158937236, Length=389, Percent_Identity=26.2210796915167, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI132814467, Length=410, Percent_Identity=27.0731707317073, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI61742777, Length=340, Percent_Identity=25.5882352941176, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI61742775, Length=340, Percent_Identity=25.5882352941176, Blast_Score=106, Evalue=9e-23,
Organism=Homo sapiens, GI194239713, Length=355, Percent_Identity=28.169014084507, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI194306629, Length=395, Percent_Identity=26.3291139240506, Blast_Score=98, Evalue=4e-20,
Organism=Homo sapiens, GI11641261, Length=395, Percent_Identity=26.3291139240506, Blast_Score=98, Evalue=4e-20,
Organism=Homo sapiens, GI310123622, Length=347, Percent_Identity=26.2247838616715, Blast_Score=97, Evalue=8e-20,
Organism=Homo sapiens, GI310133497, Length=345, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI7019561, Length=336, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI94818901, Length=374, Percent_Identity=24.8663101604278, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI94818891, Length=374, Percent_Identity=24.8663101604278, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI4505029, Length=377, Percent_Identity=24.4031830238727, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI157266300, Length=211, Percent_Identity=27.0142180094787, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1787163, Length=870, Percent_Identity=100, Blast_Score=1813, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71989076, Length=475, Percent_Identity=25.4736842105263, Blast_Score=108, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71989071, Length=475, Percent_Identity=25.4736842105263, Blast_Score=108, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17569221, Length=385, Percent_Identity=25.1948051948052, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17569225, Length=289, Percent_Identity=27.3356401384083, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115533276, Length=372, Percent_Identity=25.5376344086022, Blast_Score=93, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI115533278, Length=372, Percent_Identity=25.5376344086022, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI193206928, Length=368, Percent_Identity=25.8152173913043, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193206926, Length=368, Percent_Identity=26.6304347826087, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133903840, Length=378, Percent_Identity=24.3386243386243, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565628, Length=412, Percent_Identity=26.4563106796117, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71990873, Length=327, Percent_Identity=22.9357798165138, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI9755335, Length=345, Percent_Identity=26.0869565217391, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321837, Length=385, Percent_Identity=26.4935064935065, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324283, Length=455, Percent_Identity=23.7362637362637, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24655252, Length=479, Percent_Identity=25.4697286012526, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24655257, Length=479, Percent_Identity=25.4697286012526, Blast_Score=131, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24655274, Length=479, Percent_Identity=25.4697286012526, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24655260, Length=479, Percent_Identity=25.4697286012526, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24655265, Length=479, Percent_Identity=25.4697286012526, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24655268, Length=479, Percent_Identity=25.4697286012526, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24646518, Length=369, Percent_Identity=26.8292682926829, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646516, Length=369, Percent_Identity=26.8292682926829, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646514, Length=349, Percent_Identity=27.2206303724928, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24651025, Length=393, Percent_Identity=27.735368956743, Blast_Score=115, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24651023, Length=393, Percent_Identity=27.735368956743, Blast_Score=115, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24651021, Length=393, Percent_Identity=27.735368956743, Blast_Score=115, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21358341, Length=304, Percent_Identity=27.9605263157895, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221379089, Length=337, Percent_Identity=27.893175074184, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24651016, Length=241, Percent_Identity=28.6307053941909, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648786, Length=371, Percent_Identity=25.8760107816712, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646512, Length=284, Percent_Identity=24.6478873239437, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646510, Length=284, Percent_Identity=24.6478873239437, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550850, Length=378, Percent_Identity=24.8677248677249, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650973, Length=378, Percent_Identity=24.8677248677249, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571901, Length=338, Percent_Identity=23.9644970414201, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161078673, Length=374, Percent_Identity=23.2620320855615, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571792, Length=361, Percent_Identity=24.3767313019391, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330574, Length=224, Percent_Identity=30.8035714285714, Blast_Score=75, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648790, Length=238, Percent_Identity=25.2100840336134, Blast_Score=71, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24584504, Length=211, Percent_Identity=27.0142180094787, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPN_ECOLI (P04825)

Other databases:

- EMBL:   X04020
- EMBL:   X03709
- EMBL:   M15676
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   M15273
- PIR:   C64833
- RefSeq:   AP_001562.1
- RefSeq:   NP_415452.1
- PDB:   2DQ6
- PDB:   2DQM
- PDB:   2HPO
- PDB:   2HPT
- PDB:   2ZXG
- PDB:   3B2P
- PDB:   3B2X
- PDB:   3B34
- PDB:   3B37
- PDB:   3B3B
- PDB:   3KED
- PDBsum:   2DQ6
- PDBsum:   2DQM
- PDBsum:   2HPO
- PDBsum:   2HPT
- PDBsum:   2ZXG
- PDBsum:   3B2P
- PDBsum:   3B2X
- PDBsum:   3B34
- PDBsum:   3B37
- PDBsum:   3B3B
- PDBsum:   3KED
- ProteinModelPortal:   P04825
- SMR:   P04825
- DIP:   DIP-10458N
- MINT:   MINT-1310653
- STRING:   P04825
- MEROPS:   M01.005
- EnsemblBacteria:   EBESCT00000004980
- EnsemblBacteria:   EBESCT00000015837
- GeneID:   947253
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0915
- KEGG:   eco:b0932
- EchoBASE:   EB0690
- EcoGene:   EG10696
- eggNOG:   COG0308
- GeneTree:   EBGT00050000010234
- HOGENOM:   HBG289207
- OMA:   DIFMIVA
- ProtClustDB:   PRK14015
- BioCyc:   EcoCyc:EG10696-MONOMER
- Genevestigator:   P04825
- GO:   GO:0006508
- InterPro:   IPR001930
- InterPro:   IPR014782
- InterPro:   IPR012779
- PANTHER:   PTHR11533:SF8
- PANTHER:   PTHR11533
- PRINTS:   PR00756
- TIGRFAMs:   TIGR02414

Pfam domain/function: PF01433 Peptidase_M1

EC number: =3.4.11.2

Molecular weight: Translated: 98920; Mature: 98789

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 298-298 ACT_SITE 381-381

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLK
CCCCCCCHHCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCEE
LVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQC
EEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHH
EAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPF
HHCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCCCCEEEEECCCC
PKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEER
CCCCEEEEEHHCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHH
FGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYF
CCCEECCCEEEEEEEHHHCCCCCCCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHHH
HNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPM
HCCCCCEEEEHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
AHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDD
CCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHEECCCCCCCHHH
FVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQP
HHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCC
LHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPV
EECEEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCE
KLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFR
EEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHH
AVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIY
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAA
CCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPN
HHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHH
RIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKR
HHHHHHHHHCCCCCCEEEECCCCCCEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHH
QEKMRAALEQLKGLENLSGDLYEKITKALA
HHHHHHHHHHHHCHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
TQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLK
CCCCCCHHCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCCEE
LVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQC
EEEEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHH
EAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPF
HHCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCCCCCEEEEECCCC
PKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEER
CCCCEEEEEHHCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHH
FGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYF
CCCEECCCEEEEEEEHHHCCCCCCCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHHHH
HNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPM
HCCCCCEEEEHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
AHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDD
CCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHEECCCCCCCHHH
FVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQP
HHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCC
LHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPV
EECEEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCE
KLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFR
EEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHH
AVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIY
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAA
CCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPN
HHHCCCHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHH
RIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKR
HHHHHHHHHCCCCCCEEEECCCCCCEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHH
QEKMRAALEQLKGLENLSGDLYEKITKALA
HHHHHHHHHHHHCHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2436977; 3549459; 8905232; 9278503; 3018440; 2869947