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The map label for this gene is rhtA

Identifier: 157160291

GI number: 157160291

Start: 875813

End: 876700

Strand: Reverse

Name: rhtA

Synonym: EcHS_A0870

Alternate gene names: 157160291

Gene position: 876700-875813 (Counterclockwise)

Preceding gene: 157160293

Following gene: 157160290

Centisome position: 18.88

GC content: 53.49

Gene sequence:

>888_bases
ATGCCTGGTTCATTACGTAAAATGCCGGTCTGGTTACCAATAGTCATATTGCTCGTTGCCATGGCGTCTATTCAGGGTGG
AGCCTCGTTAGCTAAGTCACTTTTTCCTCTGGTGGGCGCACCGGGTGTCACTGCGCTGCGTCTGGCATTAGGAACGCTGA
TCCTCATCGCGTTCTTTAAGCCATGGCGACTGCGCTTTGCCAAAGAGCAACGGTTACCGCTGTTGTTTTACGGCGTTTCG
CTGGGTGGGATGAATTATCTTTTTTATCTTTCTATTCAGACAGTACCGCTGGGTATTGCGGTGGCGCTGGAGTTCACCGG
ACCACTGGCGGTGGCGCTGTTCTCTTCTCGTCGCCCGGTAGATTTCGTCTGGGTTGTGCTGGCGGTTCTTGGTCTGTGGT
TCCTGCTACCGCTGGGGCAAGACGTTTCCCATGTCGATTTAACCGGCTGTGCGCTGGCACTGGGGGCCGGGGCTTGTTGG
GCTATTTACATTTTAAGTGGGCAACGCGCAGGAGCGGAACATGGCCCTGCGACGGTGGCAATTGGTTCGTTGATTGCAGC
GTTAATTTTCGTGCCAATTGGAGCGCTTCAGGCTGGTGAAGCACTCTGGCACTGGTCGGTTATTCCATTGGGTCTGGCTG
TCGCTATTCTCTCGACCGCTCTGCCTTATTCGCTGGAAATGATTGCCCTCACCCGTTTGCCAACACGGACATTTGGTACG
CTGATGAGCATGGAACCGGCGCTGGCTGCCGTTTCCGGGATGATTTTCCTCGGAGAAACACTGACACCCATACAGCTACT
GGCGCTCGGCGCTATCATCGCCGCTTCAATGGGGTCTACGCTGACAGTACGCAAAGAGAGCAAAATAAAAGAATTAGACA
TTAATTAA

Upstream 100 bases:

>100_bases
CAAAACGGGGGAAAATTTTTTCAACAAATGCTCAACCAGCATTGGGTATATCCAGTACACTCCACGCTTTACTTAAGTCT
AGATATTTGTGGGAGAAAGG

Downstream 100 bases:

>100_bases
ATTTACATTTCTGCATGGTTATGCATAACCATGCAGAATTTCTCGCTACTTTTCCTCTACACCGTCTTTATATATCGAAT
TATGCAAAAGCATATTTATT

Product: threonine and homoserine efflux system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MPGSLRKMPVWLPIVILLVAMASIQGGASLAKSLFPLVGAPGVTALRLALGTLILIAFFKPWRLRFAKEQRLPLLFYGVS
LGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPVDFVWVVLAVLGLWFLLPLGQDVSHVDLTGCALALGAGACW
AIYILSGQRAGAEHGPATVAIGSLIAALIFVPIGALQAGEALWHWSVIPLGLAVAILSTALPYSLEMIALTRLPTRTFGT
LMSMEPALAAVSGMIFLGETLTPIQLLALGAIIAASMGSTLTVRKESKIKELDIN

Sequences:

>Translated_295_residues
MPGSLRKMPVWLPIVILLVAMASIQGGASLAKSLFPLVGAPGVTALRLALGTLILIAFFKPWRLRFAKEQRLPLLFYGVS
LGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPVDFVWVVLAVLGLWFLLPLGQDVSHVDLTGCALALGAGACW
AIYILSGQRAGAEHGPATVAIGSLIAALIFVPIGALQAGEALWHWSVIPLGLAVAILSTALPYSLEMIALTRLPTRTFGT
LMSMEPALAAVSGMIFLGETLTPIQLLALGAIIAASMGSTLTVRKESKIKELDIN
>Mature_294_residues
PGSLRKMPVWLPIVILLVAMASIQGGASLAKSLFPLVGAPGVTALRLALGTLILIAFFKPWRLRFAKEQRLPLLFYGVSL
GGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPVDFVWVVLAVLGLWFLLPLGQDVSHVDLTGCALALGAGACWA
IYILSGQRAGAEHGPATVAIGSLIAALIFVPIGALQAGEALWHWSVIPLGLAVAILSTALPYSLEMIALTRLPTRTFGTL
MSMEPALAAVSGMIFLGETLTPIQLLALGAIIAASMGSTLTVRKESKIKELDIN

Specific function: Unknown

COG id: COG5006

COG function: function code R; Predicted permease, DMT superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DUF6 domains

Homologues:

Organism=Escherichia coli, GI1787033, Length=295, Percent_Identity=100, Blast_Score=570, Evalue=1e-164,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RHTA_ECO57 (P0AA69)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C90740
- PIR:   E85590
- RefSeq:   NP_286577.1
- RefSeq:   NP_308918.1
- ProteinModelPortal:   P0AA69
- EnsemblBacteria:   EBESCT00000025212
- EnsemblBacteria:   EBESCT00000057358
- GeneID:   917633
- GeneID:   958056
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z1035
- KEGG:   ecs:ECs0891
- GeneTree:   EBGT00050000011733
- HOGENOM:   HBG352302
- OMA:   SMASLCI
- ProtClustDB:   PRK10532
- BioCyc:   ECOL83334:ECS0891-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000620

Pfam domain/function: PF00892 DUF6

EC number: NA

Molecular weight: Translated: 31169; Mature: 31038

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x4039b280)-; HASH(0x13c083e0)-; HASH(0x12a8cea8)-; HASH(0x137b4cd4)-; HASH(0x13a031b0)-; HASH(0x1383d438)-; HASH(0x136b1498)-; HASH(0x13c92bbc)-; HASH(0x139daff0)-; HASH(0x13349dbc)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGSLRKMPVWLPIVILLVAMASIQGGASLAKSLFPLVGAPGVTALRLALGTLILIAFFK
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
PWRLRFAKEQRLPLLFYGVSLGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPV
HHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEEECEEEEEEEEECCCEEEEHHCCCCCH
DFVWVVLAVLGLWFLLPLGQDVSHVDLTGCALALGAGACWAIYILSGQRAGAEHGPATVA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHH
IGSLIAALIFVPIGALQAGEALWHWSVIPLGLAVAILSTALPYSLEMIALTRLPTRTFGT
HHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHH
LMSMEPALAAVSGMIFLGETLTPIQLLALGAIIAASMGSTLTVRKESKIKELDIN
HHHCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCH
>Mature Secondary Structure 
PGSLRKMPVWLPIVILLVAMASIQGGASLAKSLFPLVGAPGVTALRLALGTLILIAFFK
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
PWRLRFAKEQRLPLLFYGVSLGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRRPV
HHHHHHHHHCCCCEEEEEECCCCCEEEEEEEEEEECEEEEEEEEECCCEEEEHHCCCCCH
DFVWVVLAVLGLWFLLPLGQDVSHVDLTGCALALGAGACWAIYILSGQRAGAEHGPATVA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHH
IGSLIAALIFVPIGALQAGEALWHWSVIPLGLAVAILSTALPYSLEMIALTRLPTRTFGT
HHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHH
LMSMEPALAAVSGMIFLGETLTPIQLLALGAIIAASMGSTLTVRKESKIKELDIN
HHHCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796