BacMap

Definition	Escherichia coli HS, complete genome.
Accession	NC_009800
Length	4,643,538

Click here to switch to the map view.

The map label for this gene is entA

Identifier: 157160092

GI number: 157160092

Start: 664632

End: 665378

Strand: Direct

Name: entA

Synonym: EcHS_A0647

Alternate gene names: 157160092

Gene position: 664632-665378 (Clockwise)

Preceding gene: 157160091

Following gene: 157160093

Centisome position: 14.31

GC content: 57.97

Gene sequence:

>747_bases
ATGGATTTCAGCGGTAAAAATGTCTGGGTAACCGGCGCAGGTAAAGGTATCGGCTACGCCACGGCGCTGGCGTTTGTTGA
GGCGGGAGCGAAAGTTACAGGTTTTGATCAAGCGTTCACTCAGGAGCAATATCCCTTTGCGACCGAAGTGATGGATGTTG
CCGACGCTGCGCAGGTCGCGCAAGTGTGTCAGCGACTGTTAGCTGAAACGGAGCGACTGGACGCGCTGGTCAATGCGGCG
GGAATTTTACGCATGGGCGCGACCGATCAGCTCAGTAAAGAGGACTGGCAGCAGACTTTTGCGGTTAACGTCGGCGGTGC
GTTTAACCTGTTCCAGCAAACCATGAACCAGTTTCGCCGTCAGCGGGGCGGGGCGATTGTCACTGTGGCGTCCGACGCCG
CGCACACGCCGCGTATTGGCATGAGTGCTTATGGCGCATCGAAAGCGGCGCTGAAAAGCCTGGCGTTGAGCGTCGGGCTG
GAACTGGCGGGTAGCGGCGTGCGCTGTAATGTGGTTTCGCCTGGCTCCACCGACACCGATATGCAACGCACGCTGTGGGT
GAGCGATGACGCCGAAGAACAGCGTATTCGCGGCTTTGGCGAGCAGTTTAAACTCGGCATTCCGCTGGGGAAAATCGCCC
GTCCACAAGAGATCGCCAACACGATTTTGTTCCTCGCCTCTGACCTCGCCAGCCATATTACCCTACAGGATATTGTGGTC
GATGGCGGCTCAACGCTGGGGGCATAA

Upstream 100 bases:

>100_bases
CGCGCTGGCGCAAAGTGCATGGTGATATCGACTTTGTCATGCTGGCGAAAAACCCGACCATCGACGCCTGGTGGAAGCTA
CTCTCCCGCGAGGTGAAATA

Downstream 100 bases:

>100_bases
GCATGATCTGGAAACGCCATTTAACGCTCGACGAACTGAACGCCACCAGCGATAACACAATGGTGGCGCATCTGGGAATT
GTGTATACCCGTCTGGGCGA

Product: 2,3-dihydroxybenzoate-2,3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDALVNAA
GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGL
ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV
DGGSTLGA

Sequences:

>Translated_248_residues
MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDALVNAA
GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGL
ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV
DGGSTLGA
>Mature_248_residues
MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVAQVCQRLLAETERLDALVNAA
GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGL
ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV
DGGSTLGA

Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI66933014, Length=251, Percent_Identity=32.2709163346614, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=30.8880308880309, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=30.3643724696356, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=29.8387096774194, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI40254992, Length=195, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.9610894941634, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI4504505, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI126723750, Length=265, Percent_Identity=26.0377358490566, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=24.609375, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=31.2169312169312, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=24.609375, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=29.8387096774194, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=26.4069264069264, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4503817, Length=236, Percent_Identity=25, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=100, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=36.4, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=31.7829457364341, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788459, Length=197, Percent_Identity=31.4720812182741, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=25.6916996047431, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=31.8897637795276, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=28, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=28.4090909090909, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=27.9527559055118, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI87082160, Length=262, Percent_Identity=27.8625954198473, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=29.5546558704453, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787820, Length=176, Percent_Identity=30.6818181818182, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=32.8, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=34.7169811320755, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=34.9624060150376, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=34.4827586206897, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=34.7328244274809, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=32.4427480916031, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=35.2059925093633, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=34.2205323193916, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=33.2075471698113, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=29.5880149812734, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=32.5757575757576, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=31.4393939393939, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=27.734375, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=29.6992481203008, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30.8, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=30.1587301587302, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=29.811320754717, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=30.2040816326531, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=29.0836653386454, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17508651, Length=194, Percent_Identity=30.4123711340206, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=269, Percent_Identity=29.7397769516729, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=30.3703703703704, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645366, Length=245, Percent_Identity=31.8367346938775, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=30.6818181818182, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=28.0898876404494, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=229, Percent_Identity=30.1310043668122, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193207185, Length=148, Percent_Identity=36.4864864864865, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=205, Percent_Identity=30.7317073170732, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=28.1368821292776, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=28.8659793814433, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=29.4736842105263, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=28.9340101522843, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=219, Percent_Identity=29.2237442922374, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=27.2251308900524, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=256, Percent_Identity=23.046875, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=33.59375, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=33.7349397590361, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=32.9365079365079, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=32.1285140562249, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=32.0158102766798, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=32.4110671936759, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=28.6274509803922, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644337, Length=260, Percent_Identity=32.6923076923077, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=33.1578947368421, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356301, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221331218, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=216, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=236, Percent_Identity=29.2372881355932, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331216, Length=217, Percent_Identity=28.110599078341, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24665247, Length=217, Percent_Identity=28.110599078341, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ENTA_ECOLI (P15047)

Other databases:

- EMBL:   M24148
- EMBL:   M24143
- EMBL:   U82598
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   A91904
- RefSeq:   AP_001243.1
- RefSeq:   NP_415128.1
- PDB:   2FWM
- PDBsum:   2FWM
- ProteinModelPortal:   P15047
- SMR:   P15047
- DIP:   DIP-9511N
- STRING:   P15047
- EnsemblBacteria:   EBESCT00000004749
- EnsemblBacteria:   EBESCT00000014568
- GeneID:   945284
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0588
- KEGG:   eco:b0596
- EchoBASE:   EB0255
- EcoGene:   EG10259
- eggNOG:   COG1028
- GeneTree:   EBGT00050000009180
- HOGENOM:   HBG750976
- OMA:   HASHITL
- ProtClustDB:   PRK08220
- BioCyc:   EcoCyc:ENTA-MONOMER
- BioCyc:   MetaCyc:ENTA-MONOMER
- Genevestigator:   P15047
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR003560
- InterPro:   IPR016040
- InterPro:   IPR020904
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR01397
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: =1.3.1.28

Molecular weight: Translated: 26250; Mature: 26250

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 144-144 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVA
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHH
QVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRR
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHEEEECCCHHHHHHHHHHHHHH
QRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTD
HHCCEEEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
MQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV
HHHEEEECCCHHHHHHHCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
DGGSTLGA
ECCCCCCC
>Mature Secondary Structure
MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVA
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHH
QVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRR
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHEEEECCCHHHHHHHHHHHHHH
QRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTD
HHCCEEEEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
MQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV
HHHEEEECCCHHHHHHHCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
DGGSTLGA
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2521622; 2521621; 9278503