Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 156980345

GI number: 156980345

Start: 2150409

End: 2152025

Strand: Reverse

Name: groEL [H]

Synonym: SAHV_2014

Alternate gene names: 156980345

Gene position: 2152025-2150409 (Counterclockwise)

Preceding gene: 156980346

Following gene: 156980342

Centisome position: 74.72

GC content: 37.35

Gene sequence:

>1617_bases
ATGGTTAAACAATTGAAATTCTCTGAAGATGCACGTCAAGCAATGTTACGTGGTGTAGACCAATTAGCAAATGCAGTTAA
AGTAACGATTGGTCCTAAAGGACGTAATGTTGTATTAGATAAAGAGTTTACAGCACCTTTAATTACGAACGATGGTGTAA
CGATTGCTAAAGAAATCGAATTAGAAGATCCATATGAAAATATGGGGGCTAAACTAGTTCAAGAAGTTGCAAATAAGACA
AATGAAATTGCTGGTGACGGTACGACAACTGCAACAGTATTAGCTCAAGCAATGATTCAAGAAGGCTTGAAAAATGTTAC
AAGTGGTGCGAACCCAGTTGGTTTACGTCAAGGTATCGACAAAGCAGTTAAAGTTGCTGTAGAAGCATTACATGAAAATT
CTCAAAAAGTTGAAAATAAAAATGAAATAGCGCAAGTAGGTGCGATTTCAGCAGCAGATGAAGAAATTGGACGTTATATT
TCTGAAGCTATGGAAAAAGTAGGTAACGATGGTGTCATTACAATTGAAGAATCAAATGGACTAAACACTGAACTAGAAGT
GGTTGAAGGTATGCAATTTGATCGTGGTTATCAATCACCATATATGGTTACTGATTCAGATAAAATGGTTGCTGAATTAG
AACGCCCATACATTTTAGTAACAGATAAGAAAATCTCGTCTTTCCAAGATATCTTACCTTTATTAGAACAAGTGGTTCAA
TCTAATCGTCCAATCTTAATTGTAGCTGATGAAGTTGAAGGCGATGCATTAACAAATATCGTGCTAAACCGAATGCGTGG
CACATTTACAGCTGTTGCAGTAAAGGCGCCTGGTTTCGGTGATCGTCGTAAAGCAATGTTAGAAGATTTAGCTATTTTAA
CTGGTGCGCAAGTGATTACTGATGATTTAGGCTTAGATTTAAAAGATGCATCAATTGATATGTTAGGTACTGCAAGTAAA
GTAGAAGTAACTAAAGATAATACCACTGTTGTTGATGGTGACGGTGACGAAAACAGCATTGATGCACGTGTAAGCCAATT
GAAATCTCAAATTGAAGAAACTGAATCTGACTTTGATCGTGAAAAATTACAAGAGCGCTTAGCTAAATTAGCAGGTGGTG
TTGCAGTTATTAAAGTAGGTGCAGCAAGTGAAACAGAGCTTAAAGAACGTAAATTACGTATTGAAGATGCATTAAATTCT
ACACGTGCAGCAGTTGAAGAAGGTATTGTTGCAGGTGGTGGTACTGCATTAGTAAATGTTTACCAAAAAGTAAGTGAAAT
TGAAGCAGAAGGTGACATTGAAACAGGTGTAAATATTGTACTTAAAGCACTAACTGCACCAGTTCGTCAAATTGCTGAAA
ATGCAGGATTAGAAGGTTCTGTTATTGTAGAACGTTTGAAAAACGCAGAGCCGGGTGTTGGTTTTAACGCTGCTACAAAC
GAGTGGGTTAATATGTTAGAAGCAGGTATCGTTGATCCAACTAAAGTAACACGCTCAGCATTACAACATGCTGCAAGTGT
TGCAGCAATGTTCTTAACGACTGAAGCGGTTGTAGCATCAATTCCAGAAAAAAATAATGACCAACCTAACATGGGTGGCA
TGCCGGGAATGATGTAA

Upstream 100 bases:

>100_bases
AGATATTTTAGCGGTAATTGAATAATATAAAATTAAATTCATAGATAAATTGTAAAGAACGAAAATGAAATATGACTAAA
CAAATGGAGGTTTATCATTT

Downstream 100 bases:

>100_bases
AACGACTGTTAAACGCTGATTTTATAAAGTTTGTAATATTGGGTGGTCGTAATTTGGTCATAGAAATTTTAAAATAAATC
TTTTGAGACGTTTTCCATGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Heat shock protein 60; Protein Cpn60 [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKT
NEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYI
SEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQ
SNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASK
VEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNS
TRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATN
EWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM

Sequences:

>Translated_538_residues
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKT
NEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYI
SEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQ
SNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASK
VEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNS
TRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATN
EWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>Mature_538_residues
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKT
NEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYI
SEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQ
SNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASK
VEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNS
TRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATN
EWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=49.4318181818182, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=49.4318181818182, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=57.6271186440678, Blast_Score=614, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=525, Percent_Identity=50.0952380952381, Blast_Score=503, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=49.0384615384615, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17564182, Length=552, Percent_Identity=23.1884057971014, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144674, Length=177, Percent_Identity=31.638418079096, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=522, Percent_Identity=50.7662835249042, Blast_Score=512, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322524, Length=587, Percent_Identity=22.3168654173765, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320058, Length=179, Percent_Identity=25.1396648044693, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322350, Length=538, Percent_Identity=21.3754646840149, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=49.0494296577947, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=49.0494296577947, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI45550936, Length=523, Percent_Identity=46.0803059273423, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550132, Length=523, Percent_Identity=46.0803059273423, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45550935, Length=523, Percent_Identity=46.0803059273423, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17864606, Length=529, Percent_Identity=42.1550094517958, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=34.8571428571429, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=34.8571428571429, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24645179, Length=539, Percent_Identity=21.7068645640074, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57573; Mature: 57573

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEECCCCCCEEECCCCEEEEEEC
LEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGID
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNG
HHHHHHHHHHHCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQ
CCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
SNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVIT
CCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHH
DDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDR
HHCCCCCCCCCCHHCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCH
EKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHH
EWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEECCCCCCEEECCCCEEEEEEC
LEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGID
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNG
HHHHHHHHHHHCCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQ
CCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
SNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVIT
CCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHH
DDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDR
HHCCCCCCCCCCHHCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCH
EKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHH
EWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7916607 [H]