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The map label for this gene is xapA [C]

Identifier: 156937891

GI number: 156937891

Start: 985043

End: 985861

Strand: Direct

Name: xapA [C]

Synonym: Igni_1103

Alternate gene names: 156937891

Gene position: 985043-985861 (Clockwise)

Preceding gene: 156937889

Following gene: 156937892

Centisome position: 75.92

GC content: 59.95

Gene sequence:

>819_bases
TTGCCGGCCTTCCCCCCTGAGCCCGGAGAGAGGGTCGAGGTAGCCATAATAGGGGGCTCCGGCCTTTACGACCCCGAAAT
ACTGGAGGGCGTCAAGGAGCTCAAGGTCTACACCCCCTACGGCCCGCCGAGCGACAACATAATAGTAGGCACCCTCAAGG
GTAAGAGGGTAGCCTTCCTGCCCCGCCACGGCAGGGGGCACAAGATACCTCCCCACAAGGTCAACTACCGGGCCAACATA
TGGGCCCTCAAGAGCTTGGGGGCCAAGTGGGTTATATCGGTCTCCGCCGTGGGCAGCTTGAGGGAGGACTACAAGCCCGG
CGACTTCGTAATCCCAGACCAGTTCATAGACATGACCAAAAAGAGGGAGTACACCTTCTTCGACGGGCCCGTGGTCGCCC
ACGTGAGCGTGGCCGAGCCCTTCTGCGAGGACTTGAGGAGGCTCGCGTACGAGACGGCGAAGGAGCTGGGGATAAGGGTC
CACGACAAGGGGACGTACGTTTGCATAGAGGGACCCAGGTTCTCCACGAAGGCGGAGAGCAGGATTTGGAAGGAGGTATT
CAAGGCCGACGTAATAGGGATGACCTTGGTGCCCGAGGTCAACCTCGCTTGCGAGGCGCAGATGTGTTACGCCACCGTAG
CGATGGTGACCGATTACGACGTGTGGGCGGAGAGGCCGGTGACCGCGCAGGAGGTCATAGAAACCATGCAGAGGAACACT
GAGAACGCTAAGAAGCTGTTGTACTCATTGATCCCCAAGTTGCCGGAGGAGCCGGAGAGGTGCAGCTGCTGCAACTCGCT
GGAGACGGCCCTTCTCTAA

Upstream 100 bases:

>100_bases
ACGAACACCATCGCCATCACCCCCGCGCATGGCTATCTTCAAGGGCCTCCGGCCGGACGCACAAAAAGGCTTTGGGCCCC
AGCGAGCCCGGAGCTGAGCC

Downstream 100 bases:

>100_bases
TAAACCCCGTTTCCTAGCCCCGCCAACGGGTCGCGGAGTTGGGAAGGAGGAGGATGACCCTACCCAAGGACGAAGAGAGC
ATGATGAAGATCCAAGAAGA

Product: 5'-methylthioadenosine phosphorylase II

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPAFPPEPGERVEVAIIGGSGLYDPEILEGVKELKVYTPYGPPSDNIIVGTLKGKRVAFLPRHGRGHKIPPHKVNYRANI
WALKSLGAKWVISVSAVGSLREDYKPGDFVIPDQFIDMTKKREYTFFDGPVVAHVSVAEPFCEDLRRLAYETAKELGIRV
HDKGTYVCIEGPRFSTKAESRIWKEVFKADVIGMTLVPEVNLACEAQMCYATVAMVTDYDVWAERPVTAQEVIETMQRNT
ENAKKLLYSLIPKLPEEPERCSCCNSLETALL

Sequences:

>Translated_272_residues
MPAFPPEPGERVEVAIIGGSGLYDPEILEGVKELKVYTPYGPPSDNIIVGTLKGKRVAFLPRHGRGHKIPPHKVNYRANI
WALKSLGAKWVISVSAVGSLREDYKPGDFVIPDQFIDMTKKREYTFFDGPVVAHVSVAEPFCEDLRRLAYETAKELGIRV
HDKGTYVCIEGPRFSTKAESRIWKEVFKADVIGMTLVPEVNLACEAQMCYATVAMVTDYDVWAERPVTAQEVIETMQRNT
ENAKKLLYSLIPKLPEEPERCSCCNSLETALL
>Mature_271_residues
PAFPPEPGERVEVAIIGGSGLYDPEILEGVKELKVYTPYGPPSDNIIVGTLKGKRVAFLPRHGRGHKIPPHKVNYRANIW
ALKSLGAKWVISVSAVGSLREDYKPGDFVIPDQFIDMTKKREYTFFDGPVVAHVSVAEPFCEDLRRLAYETAKELGIRVH
DKGTYVCIEGPRFSTKAESRIWKEVFKADVIGMTLVPEVNLACEAQMCYATVAMVTDYDVWAERPVTAQEVIETMQRNTE
NAKKLLYSLIPKLPEEPERCSCCNSLETALL

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=250, Percent_Identity=53.2, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI71980569, Length=249, Percent_Identity=45.3815261044177, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323045, Length=267, Percent_Identity=40.8239700374532, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20130079, Length=275, Percent_Identity=44.3636363636364, Blast_Score=227, Evalue=8e-60,
Organism=Drosophila melanogaster, GI221459247, Length=253, Percent_Identity=38.7351778656126, Blast_Score=187, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30446; Mature: 30315

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFPPEPGERVEVAIIGGSGLYDPEILEGVKELKVYTPYGPPSDNIIVGTLKGKRVAFL
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCEEECCCCCCCCCEEEEEECCCEEEEE
PRHGRGHKIPPHKVNYRANIWALKSLGAKWVISVSAVGSLREDYKPGDFVIPDQFIDMTK
CCCCCCCCCCCCCCCCEEEEEEHHHCCCEEEEEHHHHHHHHHCCCCCCEECCHHHHHHHH
KREYTFFDGPVVAHVSVAEPFCEDLRRLAYETAKELGIRVHDKGTYVCIEGPRFSTKAES
CCCEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCHHHH
RIWKEVFKADVIGMTLVPEVNLACEAQMCYATVAMVTDYDVWAERPVTAQEVIETMQRNT
HHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCH
ENAKKLLYSLIPKLPEEPERCSCCNSLETALL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAFPPEPGERVEVAIIGGSGLYDPEILEGVKELKVYTPYGPPSDNIIVGTLKGKRVAFL
CCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCEEECCCCCCCCCEEEEEECCCEEEEE
PRHGRGHKIPPHKVNYRANIWALKSLGAKWVISVSAVGSLREDYKPGDFVIPDQFIDMTK
CCCCCCCCCCCCCCCCEEEEEEHHHCCCEEEEEHHHHHHHHHCCCCCCEECCHHHHHHHH
KREYTFFDGPVVAHVSVAEPFCEDLRRLAYETAKELGIRVHDKGTYVCIEGPRFSTKAES
CCCEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCHHHH
RIWKEVFKADVIGMTLVPEVNLACEAQMCYATVAMVTDYDVWAERPVTAQEVIETMQRNT
HHHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCH
ENAKKLLYSLIPKLPEEPERCSCCNSLETALL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]