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The map label for this gene is hutH

Identifier: 15675846

GI number: 15675846

Start: 1740339

End: 1741880

Strand: Direct

Name: hutH

Synonym: SPy_2089

Alternate gene names: 15675846

Gene position: 1740339-1741880 (Clockwise)

Preceding gene: 15675845

Following gene: 15675847

Centisome position: 93.95

GC content: 45.72

Gene sequence:

>1542_bases
ATGACAAGAGTGATTAATTTAGATGGCGAAAGCCTTACTATCGAAGACGTGATTGCGATTGCTCGCCAAGGCGTAGCCTG
TCACATTGATGATAGTGCTATTGAAGCTGTGAATGCCTCTCGTAAAATTGTTGATGACATTGTCAGTGAAAAACGGGTGG
TTTACGGGGTGACCACCGGTTTTGGATCCCTTTGTAACGTGAGCATCTCACCAGAAGATACAGTTCAACTCCAAGAAAAT
TTGATTCGTACCCATGCTAGTGGATTTGGTGACCCATTGCCAGAAGATGCCGTGAGAGCTATCATGCTGATCCGTATCAA
TTCACTAGTCAAAGGGTATTCTGGTATTCGTCTATCCACCATTGAAAAACTGTTGGAACTGCTCAATAAAGGGGTTCATC
CTTACATTCCTGAAAAAGGGTCTCTAGGGGCTTCAGGAGATTTGGCGCCGCTTGCTCACATGGTGCTTCCTATGCTTGGT
CTAGGGAAAGCTTACTACAAAGGAGAGCTTCTTTCTGGTCAAGAAGCTCTTGATAAAGCTGGTATTGACAAGATTTCTTT
AGCCGCTAAAGAAGGACTCGCCCTTATCAACGGAACAACTGTTCTCACTGCAGTCGGTGCCCTTGCAACCTATGACGCCA
TTCAATTATTGAAACTGTCAGACCTAGCTGGTGCCCTATCCCTTGAAGTGCATAACGGGATTACTAGTCCATTTGAAGAA
AACCTTCACACCATTCGCCCACAAAGCGGCCAGTTGGCAACAGCCCGCAATATCCGAAACCTCCTTGAAGGCAGCCAAAA
CACAACCGTAGCTACTCAATCTCGTGTGCAAGACCCTTACACCTTGCGCTGCATGCCTCAAATTCATGGGGCTAGCAAAG
ACAGTATCGCCTATGTCAAATCCAAAGTTGACATTGAAATCAATTCTGTCACAGATAATCCAATTATCTGTAAAGATGGC
CACGTTATTTCAGGAGGTAACTTCCACGGAGAACCAATGGCACAGCCATTTGACTTCTTAGGCATCGCCATTTCTGAAAT
TGGAAATGTTTCTGAACGCCGCGTGGAACGTTTGGTCAATAGCCAGCTCAGCAAATTGCCATCCTTCCTTGTCAAATACC
CAGGTCTCAATTCAGGCTTTATGATTACCCAGTACGCCTGTGCCTCTCTTGCTTCTGAAAACAAGGTTTTGGCACATCCA
GCCAGTGTGGATTCTATCCCATCTTGTGAGAACCAAGAAGACTTTGTCAGCATGGGCACCACCGCTGCTCGCAAGGCCTT
TGAAATCCTTAAAAATTCTCGCCGCATCGTGGCTACTGAAATCATGGCAGCCTGCCAAGCCCTTGATCTCAAACCTGAAA
ATCATGAACTAGGTAAAGGGACTAAGGTTGCCTACGATCTCTTCCGCAAGGAAGTCAACTTTATCGAACACGATAAACAC
ATCGAAATCTACGATGAACTAAACAAGGCATCAGCAGTCATTGAAGACCCAAGCTTCCTCGAAGCGGTTGAGCAGGCAGT
TGAGTTGAGTATCCAATTTTAG

Upstream 100 bases:

>100_bases
GTTGGTGTCATCATTGCAAGTAGTGTGTACTACCTTATGCACGGACGTAACCACCAAATGGACCAAATGCCCCCTAAGGA
ACAAATCTAGGAGAAAAACT

Downstream 100 bases:

>100_bases
TGAATAAGGTACTTCTTTAACTAGAGGGGCTGTGGCAGAGGTCATGGCCTCTTTAGACTAACTAACCGGGACCAAAAGCA
GACGATTTTATTGCTCTGCT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTRVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQEN
LIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLG
LGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAVGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
NLHTIRPQSGQLATARNIRNLLEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDG
HVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHP
ASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKPENHELGKGTKVAYDLFRKEVNFIEHDKH
IEIYDELNKASAVIEDPSFLEAVEQAVELSIQF

Sequences:

>Translated_513_residues
MTRVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQEN
LIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLG
LGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAVGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
NLHTIRPQSGQLATARNIRNLLEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDG
HVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHP
ASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKPENHELGKGTKVAYDLFRKEVNFIEHDKH
IEIYDELNKASAVIEDPSFLEAVEQAVELSIQF
>Mature_512_residues
TRVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQENL
IRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGL
GKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAVGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEEN
LHTIRPQSGQLATARNIRNLLEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDGH
VISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPA
SVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKPENHELGKGTKVAYDLFRKEVNFIEHDKHI
EIYDELNKASAVIEDPSFLEAVEQAVELSIQF

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=489, Percent_Identity=43.3537832310838, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567831, Length=459, Percent_Identity=45.5337690631808, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_STRP1 (P58083)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_270020.1
- RefSeq:   YP_283140.1
- ProteinModelPortal:   P58083
- SMR:   P58083
- EnsemblBacteria:   EBSTRT00000000320
- EnsemblBacteria:   EBSTRT00000027433
- GeneID:   3571103
- GeneID:   901729
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_2089
- KEGG:   spz:M5005_Spy_1777
- GeneTree:   EBGT00050000028800
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   SPYO160490:SPY2089-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1777-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 55430; Mature: 55299

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTG
CCEEEECCCCEEEHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
FGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLST
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
IEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGELLSGQEALDKA
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHC
GIDKISLAAKEGLALINGTTVLTAVGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
CCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
NLHTIRPQSGQLATARNIRNLLEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVK
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEHHHCCCCCCCHHEEE
SKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVN
EEEEEEEEEECCCCEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
SQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHCH
TAARKAFEILKNSRRIVATEIMAACQALDLKPENHELGKGTKVAYDLFRKEVNFIEHDKH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IEIYDELNKASAVIEDPSFLEAVEQAVELSIQF
EEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTG
CEEEECCCCEEEHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
FGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLST
CCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
IEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGELLSGQEALDKA
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHC
GIDKISLAAKEGLALINGTTVLTAVGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEE
CCCHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHH
NLHTIRPQSGQLATARNIRNLLEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVK
HHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEHHHCCCCCCCHHEEE
SKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVN
EEEEEEEEEECCCCEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
SQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHCH
TAARKAFEILKNSRRIVATEIMAACQALDLKPENHELGKGTKVAYDLFRKEVNFIEHDKH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IEIYDELNKASAVIEDPSFLEAVEQAVELSIQF
EEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296