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The map label for this gene is hutU [H]

Identifier: 15675840

GI number: 15675840

Start: 1732801

End: 1734831

Strand: Direct

Name: hutU [H]

Synonym: SPy_2082

Alternate gene names: 15675840

Gene position: 1732801-1734831 (Clockwise)

Preceding gene: 15675838

Following gene: 15675841

Centisome position: 93.54

GC content: 44.51

Gene sequence:

>2031_bases
ATGTCATTTTACAGTGAAACTGACATAGCTGCCGCTATGACTGTTAAGTTAGACGATGTTTTACCGGAAAAGACTGTGTT
TGAAGAAGGTATCCGAAGAGCACCAGACAGAGGTTTTCGATTGACCCAGGCTCAGACCGAAATCGCCTTGAAAAATGCCC
TACGCTATGTACCTACGAAGTTCCACGAAGAAGTCATTCCAGAATTTTTGGAAGAACTCAAAACCCGTGGCCGTATTTAT
GGCTACCGCTTTAGACCAAAAGACCGCATTTACGGCAAACCCATTGACGAGTACAAGGGAAATTGTACAGCTGCCAAGGC
CATGCAGGTCATGATTGACAATAACTTGAGTTTTGAAATTGCCTTGTACCCTTACGAACTAGTCACATATGGAGAAACTG
GTTCTGTTTGTGCCAACTGGATGCAATATTGTTTGATTAAAAAATACCTAGAAGTCATGACTGATGAACAAACCTTGGTG
GTTGAGTCTGGTCATCCAGTTGGTCTTTTCAAATCCAAACCTGAAGCGCCTCGTGTGATTATTACTAATGGCCTTTTGGT
GGGTGAATACGACAACATGAAAGACTGGGAAATCGCTGAAGAGATGGGTGTCACCAACTATGGTCAAATGACCGCAGGTG
GTTGGATGTATATTGGCCCACAAGGAATCGTTCATGGAACGTTTAATACCCTCTTAAATGCTGGTCGTCTCAAACTTGGA
GTGGCTGATGACGGTGATTTGACCGGTAAACTCTTCATCTCATCTGGTCTAGGAGGCATGAGTGGGGCACAAGGTAAGGC
TGCTGAAATTGCTAAAGCAGTTGCCATTATTGCTGAAGTTGACCAATCTCGGATTAAAACCCGTCATTCTCAAGGCTGGA
TCAGTCAAATTGCCGAAAGCCCTGAAGAAGCTCTGCAATTAGCCCAAAAAGCCATAGATGCTAAGGAGTCCACTTCGATT
GCTTACCATGGTAATATCGTTGATCTTTTAGAGTACGTCAATGACAAGCAGATTCATGTTGATCTTTTGTCTGACCAAAC
CTCTTGTCACAACGTTTATGACGGTGGCTACTGCCCAGTAGGTATTAGCTTTGACGAAAGAACCCGGCTCTTGGCAGAAG
ATAAAGATACCTTCCACCAAATGGTTGATGATACCTTGGCACGGCATTTTGAAGCTATTAAGACGTTAACTGAAAATGGC
ACCTATTTCTTTGACTACGGCAATGCCTTTATGAAGTCTGTTTACGACTCTGGTATTACAGAAATTTCTAAGAATGGTCG
TAACGACAAAGACGGATTTATCTGGCCATCCTATGTGGAAGATATCATGGGACCTATGCTTTTTGACTATGGCTATGGAC
CTTTCCGTTGGGTCTGCTTGAGTGGTAATCACGATGACTTGGTGGCCACTGACAAAGCTGCCATGGAAGCTATCGATCCT
GACCGCCGCTATCAAGACCGTGATAACTACAACTGGATTCGTGATGCTGAGAAAAATCAACTCGTAGTTGGTACCCAAGC
CCGGATCCTTTACCAAGACTGTATCGGTCGTGTGACTATCGCCCTTAAATTTAATGAATTGGTCCGCAAAGGCAAGATTG
GTCCTGTCATGATTGGTCGTGACCACCATGACGTGTCTGGTACCGACTCACCATTTCGTGAAACCTCAAACATTAAAGAC
GGTTCCAATGTGACCTGTGATATGGCGGTGCAATGTTACGCTGGTAACGCTGCGCGTGGTATGAGTTTAGTGGCTCTTCA
TAACGGTGGCGGAACTGGTATTGGTAAAGCCATCAATGGTGGTTTCGGACTTGTTTTAGATGGCAGCGAACGCATTGATG
AGATTATTAAATCTGCTATTGCTTGGGACACCATGGGTGGTGTTGCTCGTCGCAATTGGGCTCGCAATGAGCACGCTATT
GAAACCGCTATTGAGTATAATCGTCTCCATGCAGGTACTGATCACATCACTATCCCATACTTGGCTGATGATGACCTTGT
GACTTCAGCAGTAGATCAATTATTTCACTAA

Upstream 100 bases:

>100_bases
TTTAGACTTTTTTCGCATTTCAAAGCGTGGTTGACTTTTTATAGACTAGACTAAGTTAGACTAATCTCGACAATAAAAAG
GAGTTGAGGAGGAGTTTTCT

Downstream 100 bases:

>100_bases
TAACTGCTAGCTAAAAATGTAAGCGTTATCTAAAGTAGATAACCTATTCCCTTAATGAGTAATTCAATGACATAAAAGGA
GATTAAACATGGCGAAAATT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MSFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTKFHEEVIPEFLEELKTRGRIY
GYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEIALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLV
VESGHPVGLFKSKPEAPRVIITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIKTRHSQGWISQIAESPEEALQLAQKAIDAKESTSI
AYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNVYDGGYCPVGISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENG
TYFFDYGNAFMKSVYDSGITEISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGNHDDLVATDKAAMEAIDP
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGRDHHDVSGTDSPFRETSNIKD
GSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAINGGFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAI
ETAIEYNRLHAGTDHITIPYLADDDLVTSAVDQLFH

Sequences:

>Translated_676_residues
MSFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTKFHEEVIPEFLEELKTRGRIY
GYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEIALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLV
VESGHPVGLFKSKPEAPRVIITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIKTRHSQGWISQIAESPEEALQLAQKAIDAKESTSI
AYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNVYDGGYCPVGISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENG
TYFFDYGNAFMKSVYDSGITEISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGNHDDLVATDKAAMEAIDP
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGRDHHDVSGTDSPFRETSNIKD
GSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAINGGFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAI
ETAIEYNRLHAGTDHITIPYLADDDLVTSAVDQLFH
>Mature_675_residues
SFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTKFHEEVIPEFLEELKTRGRIYG
YRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEIALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLVV
ESGHPVGLFKSKPEAPRVIITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLGV
ADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIKTRHSQGWISQIAESPEEALQLAQKAIDAKESTSIA
YHGNIVDLLEYVNDKQIHVDLLSDQTSCHNVYDGGYCPVGISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENGT
YFFDYGNAFMKSVYDSGITEISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGNHDDLVATDKAAMEAIDPD
RRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGRDHHDVSGTDSPFRETSNIKDG
SNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAINGGFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAIE
TAIEYNRLHAGTDHITIPYLADDDLVTSAVDQLFH

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=668, Percent_Identity=46.2574850299401, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI260306182, Length=728, Percent_Identity=42.1703296703297, Blast_Score=533, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71997891, Length=649, Percent_Identity=46.5331278890601, Blast_Score=588, Evalue=1e-168,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 75192; Mature: 75060

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00024 HEMOPEXIN ; PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTK
CCCCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCHH
FHEEVIPEFLEELKTRGRIYGYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEI
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCHHHHEEEEECCCCEEEE
ALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLVVESGHPVGLFKSKPEAPRVI
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCEEE
ITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
EECCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHCCCCEEEE
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIKTRHSQGWISQIAES
ECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEEALQLAQKAIDAKESTSIAYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNVYDGGYCPV
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEE
GISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENGTYFFDYGNAFMKSVYDSGIT
ECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
EISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGNHDDLVATDKAAMEAIDP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCHHHHHHCCC
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGR
CCCCCCCCCCCHHCCCCCCEEEEECHHHHHHHHHHCEEEEEEEHHHHHHCCCCCCEEECC
DHHDVSGTDSPFRETSNIKDGSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAING
CCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCHHCCC
GFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAIETAIEYNRLHAGTDHITIPY
CEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHEECCCCCEEEEE
LADDDLVTSAVDQLFH
ECCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFYSETDIAAAMTVKLDDVLPEKTVFEEGIRRAPDRGFRLTQAQTEIALKNALRYVPTK
CCCCCCCCEEEEEEEHHHCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCHH
FHEEVIPEFLEELKTRGRIYGYRFRPKDRIYGKPIDEYKGNCTAAKAMQVMIDNNLSFEI
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHCCCCCHHHHEEEEECCCCEEEE
ALYPYELVTYGETGSVCANWMQYCLIKKYLEVMTDEQTLVVESGHPVGLFKSKPEAPRVI
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCEEE
ITNGLLVGEYDNMKDWEIAEEMGVTNYGQMTAGGWMYIGPQGIVHGTFNTLLNAGRLKLG
EECCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHCCCCEEEE
VADDGDLTGKLFISSGLGGMSGAQGKAAEIAKAVAIIAEVDQSRIKTRHSQGWISQIAES
ECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEEALQLAQKAIDAKESTSIAYHGNIVDLLEYVNDKQIHVDLLSDQTSCHNVYDGGYCPV
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEE
GISFDERTRLLAEDKDTFHQMVDDTLARHFEAIKTLTENGTYFFDYGNAFMKSVYDSGIT
ECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
EISKNGRNDKDGFIWPSYVEDIMGPMLFDYGYGPFRWVCLSGNHDDLVATDKAAMEAIDP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCHHHHHHCCC
DRRYQDRDNYNWIRDAEKNQLVVGTQARILYQDCIGRVTIALKFNELVRKGKIGPVMIGR
CCCCCCCCCCCHHCCCCCCEEEEECHHHHHHHHHHCEEEEEEEHHHHHHCCCCCCEEECC
DHHDVSGTDSPFRETSNIKDGSNVTCDMAVQCYAGNAARGMSLVALHNGGGTGIGKAING
CCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCHHCCC
GFGLVLDGSERIDEIIKSAIAWDTMGGVARRNWARNEHAIETAIEYNRLHAGTDHITIPY
CEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHEECCCCCEEEEE
LADDDLVTSAVDQLFH
ECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA