BacMap

Definition	Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession	NC_002737
Length	1,852,441

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The map label for this gene is scl

Identifier: 15675773

GI number: 15675773

Start: 1651590

End: 1652636

Strand: Reverse

Name: scl

Synonym: SPy_1983

Alternate gene names: NA

Gene position: 1652636-1651590 (Counterclockwise)

Preceding gene: 15675775

Following gene: 15675772

Centisome position: 89.21

GC content: 50.14

Gene sequence:

>1047_bases
ATGTTGACATCAAAGCACCATAATCTCAACAAACTAGTCTGGCGCTACGGGCTAACCTCAGCCGCTGCCGTCCTTCTAGC
CTTTGGAGGCGGGGCAAGCAGCGTTAAGGCTGAGGTTTCTTCTACGACTATGACGTCGAGTCAAAGAGAGTCAAAAATAA
AAGAGATCGAAGAAAGTCTTAAAAAATATCCAGAAGTGTCCAATGAGAAATTTTGGGAAAGAAAGTGGTATGGAACCTAT
TTTAAAGAAGAAGATTTTCAAAAGGAGCTAAAAGATTTTACTGAGAAGAGGCTTAAGGAGATTCTAGATTTAATTGGTAA
ATCTGGAATCAAGGGAGACCGTGGTGAGACTGGTCCTGCTGGCCCAGCCGGACCACAAGGTAAAACTGGTGAGAGGGGCG
CCCAAGGTCCTAAAGGTGACCGCGGTGAGCAAGGAATCCAAGGTAAAGCTGGTGAAAAAGGTGAGCGCGGTGAAAAAGGC
GACAAAGGTGAAACCGGTGAACGCGGTGAAAAAGGCGAAGCTGGAATCCAAGGCCCACAAGGTGAAGCTGGTAAAGATGG
CGCTCCAGGTAAAGATGGAGCTCCAGGCGAAAAGGGTGAAAAAGGTGACCGCGGTGAAACCGGAGCTCAGGGTCCAGTAG
GCCCACAAGGTGAAAAAGGTGAAACGGGCGCCCAAGGCCCAGCAGGCCCACAAGGTGAGGCAGGCAAACCAGGTGAGCAA
GGCCCAGCAGGCCCACAAGGTGAAGCAGGCCAACCAGGCGAAAAAGCTCCAGAAAAGAGCCCAGAAGGCGAAGCAGGCCA
ACCAGGCGAAAAAGCTCCAGAAAAGAGCAAAGAGGTAACTCCAGCTGCAGAAAAACCTGCTGACAAAGAAGCTAACCAAA
CGCCAGAACGCCGCAATGGCAATATGGCTAAGACACCTGTAGCCAACAACCACAGACGTCTACCAGCAACTGGTGAGCAA
GCCAACCCATTCTTTACAGCAGCAGCAGTAGCAGTGATGACAACAGCTGGTGTCCTAGCCGTTACAAAACGCAAAGAAAA
CAACTAA

Upstream 100 bases:

>100_bases
TTTCACACTCTATTATAATACTATTATAAATAATCAGGTCTAGCTACCATGTTATTTTTATCTAAAACACACCATCTAAT
AAAGAAAGAGAGAACAACAT

Downstream 100 bases:

>100_bases
TTCTCTGAATTGAGAGACCTTACTGATAAGCAAACATAATAGAGAGAGCCCCTTGGTTCTCTCTATTTTTGGTCGGGAGC
AGGCCTTTGGTATCATGCTC

Product: collagen-like surface protei

Products: NA

Alternate protein names: IgG-binding protein H [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MLTSKHHNLNKLVWRYGLTSAAAVLLAFGGGASSVKAEVSSTTMTSSQRESKIKEIEESLKKYPEVSNEKFWERKWYGTY
FKEEDFQKELKDFTEKRLKEILDLIGKSGIKGDRGETGPAGPAGPQGKTGERGAQGPKGDRGEQGIQGKAGEKGERGEKG
DKGETGERGEKGEAGIQGPQGEAGKDGAPGKDGAPGEKGEKGDRGETGAQGPVGPQGEKGETGAQGPAGPQGEAGKPGEQ
GPAGPQGEAGQPGEKAPEKSPEGEAGQPGEKAPEKSKEVTPAAEKPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQ
ANPFFTAAAVAVMTTAGVLAVTKRKENN

Sequences:

>Translated_348_residues
MLTSKHHNLNKLVWRYGLTSAAAVLLAFGGGASSVKAEVSSTTMTSSQRESKIKEIEESLKKYPEVSNEKFWERKWYGTY
FKEEDFQKELKDFTEKRLKEILDLIGKSGIKGDRGETGPAGPAGPQGKTGERGAQGPKGDRGEQGIQGKAGEKGERGEKG
DKGETGERGEKGEAGIQGPQGEAGKDGAPGKDGAPGEKGEKGDRGETGAQGPVGPQGEKGETGAQGPAGPQGEAGKPGEQ
GPAGPQGEAGQPGEKAPEKSPEGEAGQPGEKAPEKSKEVTPAAEKPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQ
ANPFFTAAAVAVMTTAGVLAVTKRKENN
>Mature_348_residues
MLTSKHHNLNKLVWRYGLTSAAAVLLAFGGGASSVKAEVSSTTMTSSQRESKIKEIEESLKKYPEVSNEKFWERKWYGTY
FKEEDFQKELKDFTEKRLKEILDLIGKSGIKGDRGETGPAGPAGPQGKTGERGAQGPKGDRGEQGIQGKAGEKGERGEKG
DKGETGERGEKGEAGIQGPQGEAGKDGAPGKDGAPGEKGEKGDRGETGAQGPVGPQGEKGETGAQGPAGPQGEAGKPGEQ
GPAGPQGEAGQPGEKAPEKSPEGEAGQPGEKAPEKSKEVTPAAEKPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQ
ANPFFTAAAVAVMTTAGVLAVTKRKENN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the M protein family [H]

Homologues:

Organism=Homo sapiens, GI4502961, Length=156, Percent_Identity=49.3589743589744, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI115392133, Length=172, Percent_Identity=45.3488372093023, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4502951, Length=134, Percent_Identity=51.4925373134328, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI183583553, Length=204, Percent_Identity=39.7058823529412, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI115527062, Length=187, Percent_Identity=43.8502673796791, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI5803080, Length=170, Percent_Identity=47.0588235294118, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI115527066, Length=187, Percent_Identity=43.8502673796791, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI240255535, Length=209, Percent_Identity=35.8851674641148, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI55743106, Length=209, Percent_Identity=35.8851674641148, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI55743098, Length=209, Percent_Identity=35.8851674641148, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI115527070, Length=187, Percent_Identity=43.8502673796791, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI48762934, Length=208, Percent_Identity=38.9423076923077, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI56847616, Length=171, Percent_Identity=45.0292397660819, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI65301115, Length=247, Percent_Identity=34.8178137651822, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI122937273, Length=326, Percent_Identity=30.3680981595092, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI110735435, Length=133, Percent_Identity=46.6165413533835, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI111118976, Length=179, Percent_Identity=43.5754189944134, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI73486666, Length=198, Percent_Identity=39.8989898989899, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI111118974, Length=179, Percent_Identity=43.5754189944134, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI148536825, Length=157, Percent_Identity=45.859872611465, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI89363017, Length=158, Percent_Identity=44.3037974683544, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI32140760, Length=164, Percent_Identity=41.4634146341463, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI18780273, Length=145, Percent_Identity=44.8275862068966, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI40805823, Length=180, Percent_Identity=38.3333333333333, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI156616290, Length=160, Percent_Identity=41.25, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI111118970, Length=171, Percent_Identity=42.6900584795322, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI111118972, Length=171, Percent_Identity=42.6900584795322, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI111118968, Length=171, Percent_Identity=42.6900584795322, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI154759255, Length=183, Percent_Identity=42.6229508196721, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI87196339, Length=201, Percent_Identity=39.3034825870647, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI11386161, Length=215, Percent_Identity=38.6046511627907, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI119829187, Length=232, Percent_Identity=34.4827586206897, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI73486664, Length=176, Percent_Identity=41.4772727272727, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI38570073, Length=197, Percent_Identity=41.6243654822335, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI47778921, Length=207, Percent_Identity=37.6811594202899, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI98985810, Length=133, Percent_Identity=42.1052631578947, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI38570075, Length=197, Percent_Identity=41.6243654822335, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI98985806, Length=133, Percent_Identity=42.1052631578947, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI299523257, Length=133, Percent_Identity=42.1052631578947, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI116256354, Length=158, Percent_Identity=41.7721518987342, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI299523253, Length=133, Percent_Identity=42.1052631578947, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI119508426, Length=139, Percent_Identity=46.0431654676259, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI110349772, Length=206, Percent_Identity=34.4660194174757, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI291045255, Length=170, Percent_Identity=38.2352941176471, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI61699226, Length=198, Percent_Identity=35.3535353535354, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI18105016, Length=97, Percent_Identity=48.4536082474227, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI100913220, Length=180, Percent_Identity=39.4444444444444, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71992048, Length=187, Percent_Identity=44.3850267379679, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17566918, Length=352, Percent_Identity=28.6931818181818, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25153132, Length=196, Percent_Identity=38.265306122449, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17535735, Length=154, Percent_Identity=44.1558441558442, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17553572, Length=173, Percent_Identity=41.6184971098266, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17569903, Length=137, Percent_Identity=45.2554744525547, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539078, Length=169, Percent_Identity=42.0118343195266, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988210, Length=176, Percent_Identity=40.3409090909091, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506917, Length=289, Percent_Identity=30.1038062283737, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988208, Length=161, Percent_Identity=40.9937888198758, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32566500, Length=128, Percent_Identity=45.3125, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508175, Length=301, Percent_Identity=28.2392026578073, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17557218, Length=125, Percent_Identity=41.6, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI32565355, Length=140, Percent_Identity=43.5714285714286, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507511, Length=174, Percent_Identity=39.0804597701149, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17535685, Length=129, Percent_Identity=46.5116279069767, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532625, Length=179, Percent_Identity=37.9888268156425, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540820, Length=286, Percent_Identity=30.0699300699301, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507107, Length=142, Percent_Identity=43.6619718309859, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17552372, Length=165, Percent_Identity=36.969696969697, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989452, Length=163, Percent_Identity=38.6503067484663, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115532372, Length=276, Percent_Identity=26.8115942028986, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540620, Length=120, Percent_Identity=41.6666666666667, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539040, Length=282, Percent_Identity=32.6241134751773, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540622, Length=120, Percent_Identity=41.6666666666667, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17551704, Length=124, Percent_Identity=45.1612903225806, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17506747, Length=306, Percent_Identity=30.3921568627451, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24581820, Length=285, Percent_Identity=32.280701754386, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581822, Length=285, Percent_Identity=32.280701754386, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581824, Length=285, Percent_Identity=32.280701754386, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221379525, Length=130, Percent_Identity=45.3846153846154, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221379533, Length=130, Percent_Identity=45.3846153846154, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17137252, Length=139, Percent_Identity=44.6043165467626, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45549584, Length=135, Percent_Identity=40.7407407407407, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221379528, Length=189, Percent_Identity=37.037037037037, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005877
- InterPro:   IPR019948
- InterPro:   IPR019950
- InterPro:   IPR019931
- InterPro:   IPR003345
- InterPro:   IPR001899 [H]

Pfam domain/function: PF00746 Gram_pos_anchor; PF02370 M; PF04650 YSIRK_signal [H]

EC number: NA

Molecular weight: Translated: 36260; Mature: 36260

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50847 GRAM_POS_ANCHORING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSKHHNLNKLVWRYGLTSAAAVLLAFGGGASSVKAEVSSTTMTSSQRESKIKEIEESL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYPEVSNEKFWERKWYGTYFKEEDFQKELKDFTEKRLKEILDLIGKSGIKGDRGETGPA
HHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GPAGPQGKTGERGAQGPKGDRGEQGIQGKAGEKGERGEKGDKGETGERGEKGEAGIQGPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GEAGKDGAPGKDGAPGEKGEKGDRGETGAQGPVGPQGEKGETGAQGPAGPQGEAGKPGEQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GPAGPQGEAGQPGEKAPEKSPEGEAGQPGEKAPEKSKEVTPAAEKPADKEANQTPERRNG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHCCCHHHCC
NMAKTPVANNHRRLPATGEQANPFFTAAAVAVMTTAGVLAVTKRKENN
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MLTSKHHNLNKLVWRYGLTSAAAVLLAFGGGASSVKAEVSSTTMTSSQRESKIKEIEESL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYPEVSNEKFWERKWYGTYFKEEDFQKELKDFTEKRLKEILDLIGKSGIKGDRGETGPA
HHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GPAGPQGKTGERGAQGPKGDRGEQGIQGKAGEKGERGEKGDKGETGERGEKGEAGIQGPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GEAGKDGAPGKDGAPGEKGEKGDRGETGAQGPVGPQGEKGETGAQGPAGPQGEAGKPGEQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GPAGPQGEAGQPGEKAPEKSPEGEAGQPGEKAPEKSKEVTPAAEKPADKEANQTPERRNG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHCCCHHHCC
NMAKTPVANNHRRLPATGEQANPFFTAAAVAVMTTAGVLAVTKRKENN
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2332638 [H]