| Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
|---|---|
| Accession | NC_002737 |
| Length | 1,852,441 |
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The map label for this gene is relA [H]
Identifier: 15675772
GI number: 15675772
Start: 1649119
End: 1651350
Strand: Reverse
Name: relA [H]
Synonym: SPy_1981
Alternate gene names: 15675772
Gene position: 1651350-1649119 (Counterclockwise)
Preceding gene: 15675773
Following gene: 15675771
Centisome position: 89.14
GC content: 44.31
Gene sequence:
>2232_bases ATGAGGAACGAAATGGCAAAAATAATGAACGTAACAGGAGAAGAAGTCATTGCCTTAGCGGCCACCTATATGACCAAGGC TGATGTGGCTTTTGTGGCAAAGGCTTTAGCATATGCAACAGCGGCCCATTTCTACCAAGTGAGAAAGTCAGGCGAACCCT ATATCGTCCATCCGATTCAGGTGGCGGGGATTCTGGCTGATTTGCATCTGGATGCTGTGACAGTTGCTTGTGGCTTTTTA CATGATGTCGTAGAAGATACGGATATTACCTTAGATGAGATCGAAGCAGACTTTGGCCATGATGCTCGTGATATCGTTGA TGGTGTCACCAAGTTAGGTGAAGTTGAGTACAAATCTCATGAGGAGCAACTCGCCGAAAACCATCGCAAAATGCTGATGG CTATGTCCAAAGATATTCGCGTGATTTTGGTGAAATTGGCTGACCGCCTGCATAATATGCGCACCCTCAAACATTTGCGC AAGGACAAACAAGAGCGCATTTCGCGCGAAACCATGGAAATCTATGCCCCCTTGGCGCATCGTTTGGGGATTAGTCGCAT CAAATGGGAACTAGAAGATTTGGCTTTTCGTTACCTCAATGAAACCGAATTTTACAAAATTTCCCATATGATGAAAGAAA AACGTCGCGAGCGTGAAGCTTTGGTAGAGGCTATTGTCAGTAAGGTCAAAACCTATACGACACAACAAGGGTTGTTTGGA GATGTGTATGGCCGACCAAAACACATTTATTCGATTTATCGGAAAATGCGGGACAAAAAGAAACGATTCGATCAGATTTT TGATCTGATTGCCATTCGTTGTGTCATGGAAACGCAAAGCGATGTCTATGCTATGGTTGGCTATATTCATGAGCTTTGGC GTCCCATGCCAGGCCGCTTCAAGGATTATATTGCAGCTCCTAAAGCTAATGGCTACCAGTCTATTCATACCACCGTGTAT GGGCCAAAAGGACCTATTGAGATTCAAATCAGAACTAAGGACATGCATCAAGTGGCTGAGTACGGGGTTGCTGCTCACTG GGCTTATAAAAAAGGCGTGCGTGGTAAGGTCAATCAAGCTGAGCAAGCCGTTGGCATGAACTGGATCAAAGAGCTGGTAG AATTGCAAGATGCCTCAAATGGCGATGCAGTGGACTTTGTGGATTCGGTCAAAGAAGACATTTTTTCTGAACGGATTTAT GTCTTTACACCGACAGGGGCCGTTCAGGAGTTACCAAAAGAATCAGGTCCTATTGATTTTGCTTATGCGATCCATACGCA AATCGGTGAAAAAGCAACAGGTGCCAAAGTCAATGGACGTATGGTTCCTCTCACTGCCAAGTTAAAAACAGGAGATGTGG TTGAAATCATCACCAATGCCAATTCCTTTGGCCCTAGTCGAGACTGGGTAAAACTGGTCAAAACCAATAAGGCTCGCAAC AAAATTCGTCAGTTCTTTAAAAATCAAGACAAGGAATTGTCAGTGAATAAAGGCCGTGATTTGTTGGTGTCTTATTTTCA AGAGCAGGGCTACGTTGCCAATAAATACCTTGACAAAAAACGCATTGAAGCCATCCTTCCAAAAGTCAGTGTGAAGAGCG AAGAATCACTCTATGCAGCCGTTGGGTTTGGTGACATTAGTCCTATCAGTGTCTTTAACAAGTTAACCGAAAAAGAGCGC CGTGAAGAAGAAAGGGCCAAGGCTAAAGCAGAAGCTGAAGAATTGGTTAAGGGCGGTGAGGTCAAACACGAAAACAAAGA TGTGCTCAAGGTTCGCAGTGAAAATGGAGTCATTATCCAAGGAGCATCAGGCCTCTTGATGCGGATTGCCAAGTGTTGTA ATCCTGTACCTGGTGATCCTATTGACGGCTACATTACCAAAGGGCGTGGCATTGCGATTCACAGATCGGACTGTCATAAC ATTAAGAGTCAAGATGGCTACCAAGAACGCTTGATTGAGGTCGAGTGGGATTTGGACAATTCGAGTAAAGATTATCAGGC TGAAATTGATATCTATGGGCTCAATCGTAGTGGTCTGCTTAATGATGTGCTCCAAATTTTATCAAACTCAACCAAGAGCA TATCGACAGTCAATGCTCAGCCGACCAAGGACATGAAGTTTGCTAATATTCACGTGAGCTTTGGCATTCCAAATCTGACG CATCTGACCACTGTTGTCGAAAAAATCAAGGCAGTTCCAGATGTTTATAGCGTGAAGCGGACCAATGGCTAA
Upstream 100 bases:
>100_bases TAACCGTTTTCTAAGAAAAGGTCACACTAAGCGCTTTCTTAGCAGATTCTGCCTTTTGCTTTTGTGTGTAAAGTGTTAAA ATAGGGAAAAGAAATGCTAG
Downstream 100 bases:
>100_bases GAAAGGATAAAAACATGAAACTTGTCTTGCAACGGGTCAAAGAGGCCTCTGTTTCTATTGATGGGAAAATTGCTGGCGCT ATTAATCAAGGGTTGTTGTT
Product: (p)ppGpp synthetase
Products: NA
Alternate protein names: GTP pyrophosphokinase; (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; Stringent response-like protein; ppGpp synthase I; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase [H]
Number of amino acids: Translated: 743; Mature: 743
Protein sequence:
>743_residues MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFL HDVVEDTDITLDEIEADFGHDARDIVDGVTKLGEVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLR KDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFG DVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVY GPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIY VFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARN KIRQFFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKER REEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHN IKSQDGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLT HLTTVVEKIKAVPDVYSVKRTNG
Sequences:
>Translated_743_residues MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFL HDVVEDTDITLDEIEADFGHDARDIVDGVTKLGEVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLR KDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFG DVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVY GPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIY VFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARN KIRQFFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKER REEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHN IKSQDGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLT HLTTVVEKIKAVPDVYSVKRTNG >Mature_743_residues MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFL HDVVEDTDITLDEIEADFGHDARDIVDGVTKLGEVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLR KDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFG DVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVY GPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIY VFTPTGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARN KIRQFFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKER REEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHN IKSQDGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLT HLTTVVEKIKAVPDVYSVKRTNG
Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp wh
COG id: COG0317
COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HD domain [H]
Homologues:
Organism=Homo sapiens, GI38348360, Length=139, Percent_Identity=39.568345323741, Blast_Score=71, Evalue=4e-12, Organism=Escherichia coli, GI1790082, Length=729, Percent_Identity=39.917695473251, Blast_Score=548, Evalue=1e-157, Organism=Escherichia coli, GI1789147, Length=698, Percent_Identity=36.2464183381089, Blast_Score=471, Evalue=1e-134, Organism=Caenorhabditis elegans, GI25143118, Length=137, Percent_Identity=37.956204379562, Blast_Score=70, Evalue=3e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR012675 - InterPro: IPR003607 - InterPro: IPR007685 - InterPro: IPR004811 - InterPro: IPR004095 - InterPro: IPR012676 [H]
Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]
EC number: =2.7.6.5; =3.1.7.2 [H]
Molecular weight: Translated: 84063; Mature: 84063
Theoretical pI: Translated: 8.81; Mature: 8.81
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQ CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH VAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGHDARDIVDGVTKLGEVEYKSH HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHH EEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQERISRETMEIYAPLAH HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFG HCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC DVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRF CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH KDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQA HHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHCHHHHHHHHCCCCCCCCHH EQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTPTGAVQELPKESGPIDF HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCCCEE AYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARN EEEEHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH KIRQFFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAA HHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEE VGFGDISPISVFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQ ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEE GASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQERLIEVEWDLDN CCCHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCHHCCCCCCCCHHHCEEEEEECCCC SSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLT CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEEEECCCCHH HLTTVVEKIKAVPDVYSVKRTNG HHHHHHHHHHHCCCHHHHCCCCC >Mature Secondary Structure MRNEMAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQ CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH VAGILADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGHDARDIVDGVTKLGEVEYKSH HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHH EEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQERISRETMEIYAPLAH HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFG HCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC DVYGRPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRF CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH KDYIAAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQA HHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHCHHHHHHHHCCCCCCCCHH EQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTPTGAVQELPKESGPIDF HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCCCEE AYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARN EEEEHHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH KIRQFFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAA HHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEE VGFGDISPISVFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQ ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEE GASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQERLIEVEWDLDN CCCHHHHHHHHHCCCCCCCCCCCEEECCCCEEEECCHHCCCCCCCCHHHCEEEEEECCCC SSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLT CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEEEECCCCHH HLTTVVEKIKAVPDVYSVKRTNG HHHHHHHHHHHCCCHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8232196 [H]