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The map label for this gene is npr [H]

Identifier: 15675542

GI number: 15675542

Start: 1394433

End: 1395779

Strand: Reverse

Name: npr [H]

Synonym: SPy_1681

Alternate gene names: 15675542

Gene position: 1395779-1394433 (Counterclockwise)

Preceding gene: 15675543

Following gene: 15675541

Centisome position: 75.35

GC content: 41.72

Gene sequence:

>1347_bases
ATGACATTAACGACAAAGACCATACATGTTATCGGGGCATCCTTTGCTGGTCTAGCCTTTGTTGATAAATATAAGGACCT
CAATCCAGATTCCCAAATCATTCTCATTGATAAGGAAAGCTGTCCCAATTATATTCCAAATGGTATCAACCAATTATTCA
GAGGAGACATTCAAGACCTGTCTGATGCTATGTGGGGAAGAGCCTGCCTAGCAGCACAAATAGAGTCTAACCATCGGTTT
ATTCAAGCAGAAGTGTTAGCTATCGAAGCTCCCTCAAACACCTTGCTTCTCAAAGACAGTCAAGGACGAGTTTTTGAAGA
AGGTTATGAAACGCTTGTTTGTGCCATGGGTGCTAGCCCCCAGTCTCATTATATTGAGACGTCACAGACCAACAAAGTTT
TGGTAACCAAATATTATGAAGAAAGCCAAGCTAGTTTAAAACTGATTGAGGCTAGCCAAGAGGTCTTGGTTATTGGTGCC
GGCTTGATTGGCTTAGACCTTGCCTACAGTTTGTCCTTACAAGGCAAACGGGTCAAACTGATTGAAGCAGCCGAACGTCC
AGATTTCTATCAGACTGACGCAGAACTGATAGCCCCTGTAATGGCAGAAATGTCCACTCACCATGTCACCTTTATTAATA
ATAAGCGTGTTACGGCTATTCATGAGATAGAGGGAAAAGTTGTCGCTCATACCGAGCAAGGGGACACCTTCCAAGGTGAT
TTGGCTATTTTAGCCATTAACTTTAGGCCAAATACACACCTTTTGCAAGGACAAGTGGCTTGTGCTCTGGATAAGACCAT
TTTGGTTAATGAAAACTTACAGACCAGCCAGGCTAATATCTATGCCATTGGAGACATGGTTTCATTGCATTTTGGTATAT
TGGGAATGGATTACTATACACCTTTGATTAACCAAGCAATGAAGACAGGTCAGGCTCTGGCTCTGCATTTAGCTGGATAT
CCTATTCCTCCATTACAGACGGTCAAGGTATTAGGAAGTTCTCACTTTGATTATTATCGCGCGAGTGTTGGTGTGACAGA
AGAAGAAGCAGAGCTTTATATGGATACGTGTAGCTATTTGTACCAAAATGGGGATTCTAAAAACCTCTTTTGGCTGAAAT
TAATAGCTAGAAAAACGGATGGGATTTTAATAGGCGCTCAGCTCCTATCCAAAACCAATGCTCTTGTCATCGCCAATCAA
TTAGGTCAGGCTCTGGCTCTGAAAGTTACAGACGCTGACTTAGCATTTCAAGATTTTCTCTTTTTACAAGGTCACAGTGA
TTTGGCTTATCATCTTCATGAAGCTTGTCTCAAATTATTTGAAAAGAGGCTCCGCCATGAAGATTGA

Upstream 100 bases:

>100_bases
TAAAGGGGTTGGCTATCATAGGCCAGCTCCTTTGCATTTTCTTTATAGGATTAGGTAAAACGCTTTCATATCTTAAAAAA
ACTGCTATAATAATACTATT

Downstream 100 bases:

>100_bases
AGACTTAATGGATAAGGAACGAAGGGCCCAATATCGTCTCTTGGTGACCCTTTATCATGCTAAAGAAACGTTAAGGCTAA
AAGACCTAATGAGGCTATCA

Product: NADH peroxidase

Products: NA

Alternate protein names: NPXase; Npx [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDLSDAMWGRACLAAQIESNHRF
IQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASPQSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGA
GLIGLDLAYSLSLQGKRVKLIEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD
LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYTPLINQAMKTGQALALHLAGY
PIPPLQTVKVLGSSHFDYYRASVGVTEEEAELYMDTCSYLYQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQ
LGQALALKVTDADLAFQDFLFLQGHSDLAYHLHEACLKLFEKRLRHED

Sequences:

>Translated_448_residues
MTLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDLSDAMWGRACLAAQIESNHRF
IQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASPQSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGA
GLIGLDLAYSLSLQGKRVKLIEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD
LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYTPLINQAMKTGQALALHLAGY
PIPPLQTVKVLGSSHFDYYRASVGVTEEEAELYMDTCSYLYQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQ
LGQALALKVTDADLAFQDFLFLQGHSDLAYHLHEACLKLFEKRLRHED
>Mature_447_residues
TLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDLSDAMWGRACLAAQIESNHRFI
QAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASPQSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGAG
LIGLDLAYSLSLQGKRVKLIEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGDL
AILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYTPLINQAMKTGQALALHLAGYP
IPPLQTVKVLGSSHFDYYRASVGVTEEEAELYMDTCSYLYQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQL
GQALALKVTDADLAFQDFLFLQGHSDLAYHLHEACLKLFEKRLRHED

Specific function: Peroxidase whose active site is a redox-active cysteine- sulfenic acid [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1789065, Length=336, Percent_Identity=25, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.11.1.1 [H]

Molecular weight: Translated: 49555; Mature: 49424

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDL
CCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHH
SDAMWGRACLAAQIESNHRFIQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASP
HHHHHHHHHHEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCHHHHCHHEEEEEECCCC
QSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGAGLIGLDLAYSLSLQGKRVKL
CCCEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEECCHHHHEEEEEEECCCCEEEE
IEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD
EECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCEEEEEECCCCCEECC
LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYT
EEEEEEEECCCCEEECCEEEEEECCEEEEECCCCCCCCEEEEECCHHHHHHHHCCHHHHH
PLINQAMKTGQALALHLAGYPIPPLQTVKVLGSSHFDYYRASVGVTEEEAELYMDTCSYL
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH
YQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQLGQALALKVTDADLAFQDFL
HHCCCCCCEEEEEEEECCCCCEEEEHHHHCCCCEEEEEECCCCEEEEEEECCCHHHHHEE
FLQGHSDLAYHLHEACLKLFEKRLRHED
EEECCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLTTKTIHVIGASFAGLAFVDKYKDLNPDSQIILIDKESCPNYIPNGINQLFRGDIQDL
CEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHH
SDAMWGRACLAAQIESNHRFIQAEVLAIEAPSNTLLLKDSQGRVFEEGYETLVCAMGASP
HHHHHHHHHHEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCHHHHCHHEEEEEECCCC
QSHYIETSQTNKVLVTKYYEESQASLKLIEASQEVLVIGAGLIGLDLAYSLSLQGKRVKL
CCCEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEECCHHHHEEEEEEECCCCEEEE
IEAAERPDFYQTDAELIAPVMAEMSTHHVTFINNKRVTAIHEIEGKVVAHTEQGDTFQGD
EECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCEEEEEECCCCCEECC
LAILAINFRPNTHLLQGQVACALDKTILVNENLQTSQANIYAIGDMVSLHFGILGMDYYT
EEEEEEEECCCCEEECCEEEEEECCEEEEECCCCCCCCEEEEECCHHHHHHHHCCHHHHH
PLINQAMKTGQALALHLAGYPIPPLQTVKVLGSSHFDYYRASVGVTEEEAELYMDTCSYL
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH
YQNGDSKNLFWLKLIARKTDGILIGAQLLSKTNALVIANQLGQALALKVTDADLAFQDFL
HHCCCCCCEEEEEEEECCCCCEEEEHHHHCCCCEEEEEECCCCEEEEEEECCCHHHHHEE
FLQGHSDLAYHLHEACLKLFEKRLRHED
EEECCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1719212; 12663927; 2501302; 1942054; 8425532; 8756456; 9214307 [H]