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The map label for this gene is pncB [H]

Identifier: 15675524

GI number: 15675524

Start: 1372172

End: 1373626

Strand: Reverse

Name: pncB [H]

Synonym: SPy_1653

Alternate gene names: 15675524

Gene position: 1373626-1372172 (Counterclockwise)

Preceding gene: 15675525

Following gene: 15675523

Centisome position: 74.15

GC content: 40.34

Gene sequence:

>1455_bases
ATGTATAAAGATGATAGTTTAACTCTCCATACTGATTTGTATCAGATTAATATGATGCAAGTTTATTTTGAGCAGGGCAT
TCATAATCGTCATGCGGTGTTTGAAGTCTATTTCCGCAAGGAACCTTTTAACAATGGTTATGCTGTTTTTGCCGGTTTAC
AGCGCATGGTGGAGTACCTAGAGCAATTTCAATTTTCAGAAACAGATTTGGCTTACCTTGAAGAACTGGGTTATCCAGAA
AACTTTTTGACCTACCTTAAAGAGTTACGATTAGAATTGACCATCCGTTCAGCTAAAGAAGGAGATTTGGTTTTTGCTAA
TGAGCCGATTGTGCAAGTAGAAGGCCCTCTAGGTCAGTGTCAGTTGGTCGAAACAGCTCTTTTAAACATTGTTAACTTCC
AGACCTTGATTGCTACAAAGGCTGCTCGTATTCGTTCTGTGATTGAGGATGAACCCCTTTTGGAATTTGGCACCCGTCGT
GCACAGGAACTAGATGCTGCGATTTGGGGAACCCGCGCAGCGATGATTGGTGGAGCAGATGCAACAAGTAATGTGAGAGC
AGGTAAACGCTTTGATATCCCTGTTTCAGGTACGCATGCTCATGCTTTAGTGCAAGCCTATGGTAATGATTATGATGCTT
TCATGGCTTATGCTAAGACCCATAAAGATTGTGTATTTCTTGTTGACACCTATGATACACTTAAAGTAGGTGTGCCAACA
GCTATCCGAGTAGCCAAAGAAATGGGTGACAAGATTAATTTTCTAGGTGTTCGATTGGACTCTGGTGACTTGGCTTACCT
CTCAAAAACAGTCCGTCAGCAGTTAGACGACGCTGGTTTTACCGAGGCTAAGATCTATGCTTCTAATGACCTCGATGAAA
ATACCATCCTCAACTTAAAAATGCAAAAGGCCAAAATTGATGTTTGGGGTGTTGGGACCAAACTGATCACAGCCTATGAT
CAGCCTGCCTTAGGTGCTGTTTATAAGATTGTCTCTATTGAGCAAGAAGATGGCAGCATGCGTGATACGATCAAATTATC
AAATAATGCAGAAAAAGTATCCACACCAGGTAAAAAACAAGTTTGGCGCATCACCAGTCGTGAAAAAGGCAAATCAGAAG
GCGACTATATCACGTTTACTGATATTAATGTTAATGAATTAACTGAGATTGAGATGTTCCATCCGACCTATACCTATATT
AAGAAAACCGTTAAAGAATTTGATGCAATTCCTCTCTTAGTTGATATTTTTGTCAAGGGAGAATTAGTTTACCAGCTACC
GACCTTAGCTGAAATCAAGGCTTATGCTAAAAAAGAATTTGACAAGCTTTGGGATGAATACAAGCGTGTCTTAAATCCTC
AAGACTACCCAGTAGACTTAGCCCGTGATGTGTGGCAAAACAAGATGGCCTTAATTGATAACATTCGCAAAGATGCTTAT
GGAAAGAGTGAATGA

Upstream 100 bases:

>100_bases
TTTTACTTTAGCGATAACTCAAGTTATTTCTAAACCCTAGCCAAAGAGTCTTTTTTAAAATATGTTATAATAGTAACAAT
AATTCAAAGGAGTCCCCTTT

Downstream 100 bases:

>100_bases
CATGACACTACAAGAAGAGATAATTCGACAATTAGGCGTCAAGGCTAGCATTGACCCACAAGAAGAAATTCGGAAAGCCG
TTGATTTTTTAAAAGCTTAT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYLEQFQFSETDLAYLEELGYPE
NFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRR
AQELDAAIWGTRAAMIGGADATSNVRAGKRFDIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYI
KKTVKEFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
GKSE

Sequences:

>Translated_484_residues
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYLEQFQFSETDLAYLEELGYPE
NFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRR
AQELDAAIWGTRAAMIGGADATSNVRAGKRFDIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYI
KKTVKEFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
GKSE
>Mature_484_residues
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYLEQFQFSETDLAYLEELGYPE
NFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRR
AQELDAAIWGTRAAMIGGADATSNVRAGKRFDIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYI
KKTVKEFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
GKSE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=527, Percent_Identity=30.9297912713473, Blast_Score=239, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71997952, Length=534, Percent_Identity=35.5805243445693, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71997947, Length=534, Percent_Identity=35.5805243445693, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71997955, Length=217, Percent_Identity=44.7004608294931, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24581587, Length=517, Percent_Identity=34.2359767891683, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=42.2330097087379, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=42.2330097087379, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=42.2330097087379, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=42.2330097087379, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=42.2330097087379, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55041; Mature: 55041

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYL
CCCCCCEEEEECCEEHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH
EQFQFSETDLAYLEELGYPENFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQC
HHHCCCCCHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCCEEEECCCEEEECCCCCCH
QLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRRAQELDAAIWGTRAAMIGGAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHEECCCC
ATSNVRAGKRFDIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
CCCCCCCCCEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCH
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLK
HHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEE
MQKAKIDVWGVGTKLITAYDQPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQ
EEEEEEEEEECCCEEEEECCCCHHHHHEEEEEEECCCCCCEEEEEECCCCHHCCCCCHHH
VWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYIKKTVKEFDAIPLLVDIFVKG
EEEECCCCCCCCCCCEEEEEECCHHHCEEEEEECCHHHHHHHHHHHHCCCCEEEEHEECC
ELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GKSE
CCCC
>Mature Secondary Structure
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYL
CCCCCCEEEEECCEEHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH
EQFQFSETDLAYLEELGYPENFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQC
HHHCCCCCHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCCEEEECCCEEEECCCCCCH
QLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRRAQELDAAIWGTRAAMIGGAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHEECCCC
ATSNVRAGKRFDIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
CCCCCCCCCEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCH
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLK
HHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEE
MQKAKIDVWGVGTKLITAYDQPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQ
EEEEEEEEEECCCEEEEECCCCHHHHHEEEEEEECCCCCCEEEEEECCCCHHCCCCCHHH
VWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYIKKTVKEFDAIPLLVDIFVKG
EEEECCCCCCCCCCCEEEEEECCHHHCEEEEEECCHHHHHHHHHHHHCCCCEEEEHEECC
ELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GKSE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]