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The map label for this gene is pbp1A [H]

Identifier: 15675521

GI number: 15675521

Start: 1367192

End: 1369357

Strand: Direct

Name: pbp1A [H]

Synonym: SPy_1649

Alternate gene names: 15675521

Gene position: 1367192-1369357 (Clockwise)

Preceding gene: 15675520

Following gene: 15675554

Centisome position: 73.8

GC content: 39.01

Gene sequence:

>2166_bases
GTGATTACAATTAAAAATCCAAAAATCCTTAAGTGGCTAAAGTATGTATTAAGTGCAATTCTTAGCCTTATTATCCTTGT
TATTATTATTGGTGGTCTTTTGTTTACCTTCTACATTAGCAGTGCTCCGAAACTGTCAGAAGCCCAGTTAAAATCAACAA
ACTCTAGCTTGGTTTATGACGGTAATAACAATCTGATTGCTGATTTGGGTTCTGAAAAGCGTGAAAATGTAACAGCTGAT
AGTATCCCTATTAATCTAGTTAATGCTATTACCTCAATTGAAGATAAACGTTTCTTTAACCATCGTGGAGTAGATCTTTA
TCGTATTTTTGGTGCTGCCTTTCATAATCTAACGAGTCAGACCACTCAAGGGGGGTCAACGCTTGATCAGCAACTCATTA
AACTAGCCTATTTTTCTACTAATGAATCTGATCAAACCTTAAAACGTAAGGCTCAAGAAGTTTGGCTTGCTCTTCAAATG
GAGCGAAAATATACTAAACAAGAAATCCTGACTTTTTACATCAACAAAGTATATATGGGTAATGGCAACTATGGTATGCT
GACAGCCGCTAAGTCTTATTATGGCAAGGATCTTAAGGATTTATCTTATGCCCAACTAGCCCTATTGGCTGGAATCCCTC
AAGCTCCTAGTCAATATGATCCTTACCTTCATCCTGAAGCTGCTCAAAATCGCCGTAACGTCGTGTTGCAACAGATGTAC
ATGGAAAAACATCTGACGAAAGCAGAATATGAAACTGCCATCGCAACTCCCGTCGCTGAAGGTCTACAATCACTCCAACA
GCGCTCAACTTATCCAAAATATATGGATAATTATCTAAAACAAGTTATTGAAGAAGTCAAAAAAGAAACGAATAAAGATA
TTTTTACCGCTGGTTTAAAAGTTTATACCAATATTATCCCCGATGCGCAGCAGACTCTTTATAATATTTATCATTCTGGT
GATTATGTTTACTATCCAGACCAAGATTTCCAAGTTGCTTCAACGATTGTTGATGTGACAAATGGTCATGTTATTGCTCA
GCTTGGCGGACGTAATCAAGATGAAAATGTTTCATTTGGGACTAACCAAGCTGTTTTAACTGATCGTGACTGGGGTTCTA
CCATGAAGCCAATCACAGCCTATGCTCCTGCTATTGAATCTGGTGTTTATACTTCTACTGCTCAGTCGACTAATGACTCA
GTCTATTATTGGCCTGGAACCACTACCCAATTGTTTAACTGGGACCTTAGATATAACGGATGGATGACAATCCAAGCTGC
TATTATGCTATCGCGAAATGTCCCAGCAGTCCGAGCACTGGAAGCCGCAGGACTTGACTATGCTCGATCTTTCTTAAGCA
GTTTAGGTATTAACTATCCCGAAATGCACTACTCAAACGCTATCTCAAGTAATAACAGTAGCTCAGATAAAAAATATGGT
GCAAGTAGTGAAAAAATGGCCGCTGCATACGCTGCTTTTGCAAATGGTGGTATTTATCATAAACCAAGGTATGTCAATAA
AGTGGAATTTAGTGATGGTACAAGTAAAACTTTTGATGAAAAAGGAAAACGTGCCATGAAAGAAACCACGGCCTATATGA
TGACAGATATGTTAAAAACTGTTCTCACTTATGGTACAGGTACTGCTGCTGCCATTCCTGGTGTTGCGCAAGCTGGTAAA
ACAGGGACTTCTAACTACACTGATGAGGAACTAGCTAAAATTGGTGAAAAATACGGCCTTTATCCAGATTATGTTGGTAC
ATTAGCGCCAGACGAAAACTTTGTTGGCTTTACTAAGCGCTACGCCATGGCTGTTTGGACAGGTTACAAAAACCGCTTGA
CCCCAGTATACGGATCAAGTCTAGAGATTGCATCTGACGTTTATCGTAGCATGATGACTTACTTAACAAATGGTTACAGT
GAAGATTGGACGATGCCAAATGGTCTTTATCGCAGTGGTGGATTCCTCTACTTAAGCGGAACCTATGCGAGCAACACCGA
CTATACTAATTCGGTTTACAACAATCTTTACAGCAATAACACGACAACAGCTTCTAGCCAAACGACTTCAGATGATACTA
GTAGTAGCAATGATACAAGTAATTCAACCAATACAGACAACAATGGCAGTCATCCATCTACCGATGATAAAAAGACAACT
CATTAA

Upstream 100 bases:

>100_bases
ATGCCCATTGATTATATCAGAAAAAATGGCTTTAAGGTAGCATTTGGAGCCTTTCCACAAGTCCCTTATTTAAACATAAT
TGAACAAAATTTTTTAGGCG

Downstream 100 bases:

>100_bases
TCTCTAACCTCTACTTATTGTCTGTACCTACCTTTTATTACATATCCATTTAGTTACTTTTAATATCTACCTTAAGTGAT
AATCTAAATAAAAAGCGAGT

Product: putative penicillin-binding protein 1a

Products: NA

Alternate protein names: PBP-1A [H]

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MITIKNPKILKWLKYVLSAILSLIILVIIIGGLLFTFYISSAPKLSEAQLKSTNSSLVYDGNNNLIADLGSEKRENVTAD
SIPINLVNAITSIEDKRFFNHRGVDLYRIFGAAFHNLTSQTTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQM
ERKYTKQEILTFYINKVYMGNGNYGMLTAAKSYYGKDLKDLSYAQLALLAGIPQAPSQYDPYLHPEAAQNRRNVVLQQMY
MEKHLTKAEYETAIATPVAEGLQSLQQRSTYPKYMDNYLKQVIEEVKKETNKDIFTAGLKVYTNIIPDAQQTLYNIYHSG
DYVYYPDQDFQVASTIVDVTNGHVIAQLGGRNQDENVSFGTNQAVLTDRDWGSTMKPITAYAPAIESGVYTSTAQSTNDS
VYYWPGTTTQLFNWDLRYNGWMTIQAAIMLSRNVPAVRALEAAGLDYARSFLSSLGINYPEMHYSNAISSNNSSSDKKYG
ASSEKMAAAYAAFANGGIYHKPRYVNKVEFSDGTSKTFDEKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGK
TGTSNYTDEELAKIGEKYGLYPDYVGTLAPDENFVGFTKRYAMAVWTGYKNRLTPVYGSSLEIASDVYRSMMTYLTNGYS
EDWTMPNGLYRSGGFLYLSGTYASNTDYTNSVYNNLYSNNTTTASSQTTSDDTSSSNDTSNSTNTDNNGSHPSTDDKKTT
H

Sequences:

>Translated_721_residues
MITIKNPKILKWLKYVLSAILSLIILVIIIGGLLFTFYISSAPKLSEAQLKSTNSSLVYDGNNNLIADLGSEKRENVTAD
SIPINLVNAITSIEDKRFFNHRGVDLYRIFGAAFHNLTSQTTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQM
ERKYTKQEILTFYINKVYMGNGNYGMLTAAKSYYGKDLKDLSYAQLALLAGIPQAPSQYDPYLHPEAAQNRRNVVLQQMY
MEKHLTKAEYETAIATPVAEGLQSLQQRSTYPKYMDNYLKQVIEEVKKETNKDIFTAGLKVYTNIIPDAQQTLYNIYHSG
DYVYYPDQDFQVASTIVDVTNGHVIAQLGGRNQDENVSFGTNQAVLTDRDWGSTMKPITAYAPAIESGVYTSTAQSTNDS
VYYWPGTTTQLFNWDLRYNGWMTIQAAIMLSRNVPAVRALEAAGLDYARSFLSSLGINYPEMHYSNAISSNNSSSDKKYG
ASSEKMAAAYAAFANGGIYHKPRYVNKVEFSDGTSKTFDEKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGK
TGTSNYTDEELAKIGEKYGLYPDYVGTLAPDENFVGFTKRYAMAVWTGYKNRLTPVYGSSLEIASDVYRSMMTYLTNGYS
EDWTMPNGLYRSGGFLYLSGTYASNTDYTNSVYNNLYSNNTTTASSQTTSDDTSSSNDTSNSTNTDNNGSHPSTDDKKTT
H
>Mature_721_residues
MITIKNPKILKWLKYVLSAILSLIILVIIIGGLLFTFYISSAPKLSEAQLKSTNSSLVYDGNNNLIADLGSEKRENVTAD
SIPINLVNAITSIEDKRFFNHRGVDLYRIFGAAFHNLTSQTTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQM
ERKYTKQEILTFYINKVYMGNGNYGMLTAAKSYYGKDLKDLSYAQLALLAGIPQAPSQYDPYLHPEAAQNRRNVVLQQMY
MEKHLTKAEYETAIATPVAEGLQSLQQRSTYPKYMDNYLKQVIEEVKKETNKDIFTAGLKVYTNIIPDAQQTLYNIYHSG
DYVYYPDQDFQVASTIVDVTNGHVIAQLGGRNQDENVSFGTNQAVLTDRDWGSTMKPITAYAPAIESGVYTSTAQSTNDS
VYYWPGTTTQLFNWDLRYNGWMTIQAAIMLSRNVPAVRALEAAGLDYARSFLSSLGINYPEMHYSNAISSNNSSSDKKYG
ASSEKMAAAYAAFANGGIYHKPRYVNKVEFSDGTSKTFDEKGKRAMKETTAYMMTDMLKTVLTYGTGTAAAIPGVAQAGK
TGTSNYTDEELAKIGEKYGLYPDYVGTLAPDENFVGFTKRYAMAVWTGYKNRLTPVYGSSLEIASDVYRSMMTYLTNGYS
EDWTMPNGLYRSGGFLYLSGTYASNTDYTNSVYNNLYSNNTTTASSQTTSDDTSSSNDTSNSTNTDNNGSHPSTDDKKTT
H

Specific function: Cell wall formation [H]

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=308, Percent_Identity=33.7662337662338, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1788867, Length=611, Percent_Identity=26.8412438625205, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786343, Length=521, Percent_Identity=29.1746641074856, Blast_Score=154, Evalue=3e-38,
Organism=Escherichia coli, GI1789601, Length=219, Percent_Identity=27.8538812785388, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 80208; Mature: 80208

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKNPKILKWLKYVLSAILSLIILVIIIGGLLFTFYISSAPKLSEAQLKSTNSSLVYD
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEE
GNNNLIADLGSEKRENVTADSIPINLVNAITSIEDKRFFNHRGVDLYRIFGAAFHNLTSQ
CCCCEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQMERKYTKQEILTFYINKVYMG
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
NGNYGMLTAAKSYYGKDLKDLSYAQLALLAGIPQAPSQYDPYLHPEAAQNRRNVVLQQMY
CCCEEEEEECHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MEKHLTKAEYETAIATPVAEGLQSLQQRSTYPKYMDNYLKQVIEEVKKETNKDIFTAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VYTNIIPDAQQTLYNIYHSGDYVYYPDQDFQVASTIVDVTNGHVIAQLGGRNQDENVSFG
HHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TNQAVLTDRDWGSTMKPITAYAPAIESGVYTSTAQSTNDSVYYWPGTTTQLFNWDLRYNG
CCCEEEECCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCEEECCCCCCEEEEEEEEECC
WMTIQAAIMLSRNVPAVRALEAAGLDYARSFLSSLGINYPEMHYSNAISSNNSSSDKKYG
EEEEEEEEHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHCC
ASSEKMAAAYAAFANGGIYHKPRYVNKVEFSDGTSKTFDEKGKRAMKETTAYMMTDMLKT
CCHHHHHHHHHHHHCCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLTYGTGTAAAIPGVAQAGKTGTSNYTDEELAKIGEKYGLYPDYVGTLAPDENFVGFTKR
HHHCCCCCHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHH
YAMAVWTGYKNRLTPVYGSSLEIASDVYRSMMTYLTNGYSEDWTMPNGLYRSGGFLYLSG
HHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEC
TYASNTDYTNSVYNNLYSNNTTTASSQTTSDDTSSSNDTSNSTNTDNNGSHPSTDDKKTT
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
H
C
>Mature Secondary Structure
MITIKNPKILKWLKYVLSAILSLIILVIIIGGLLFTFYISSAPKLSEAQLKSTNSSLVYD
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEE
GNNNLIADLGSEKRENVTADSIPINLVNAITSIEDKRFFNHRGVDLYRIFGAAFHNLTSQ
CCCCEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TTQGGSTLDQQLIKLAYFSTNESDQTLKRKAQEVWLALQMERKYTKQEILTFYINKVYMG
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
NGNYGMLTAAKSYYGKDLKDLSYAQLALLAGIPQAPSQYDPYLHPEAAQNRRNVVLQQMY
CCCEEEEEECHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MEKHLTKAEYETAIATPVAEGLQSLQQRSTYPKYMDNYLKQVIEEVKKETNKDIFTAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VYTNIIPDAQQTLYNIYHSGDYVYYPDQDFQVASTIVDVTNGHVIAQLGGRNQDENVSFG
HHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TNQAVLTDRDWGSTMKPITAYAPAIESGVYTSTAQSTNDSVYYWPGTTTQLFNWDLRYNG
CCCEEEECCCCCCCCCCHHHHHHHHHCCCEECCCCCCCCCEEECCCCCCEEEEEEEEECC
WMTIQAAIMLSRNVPAVRALEAAGLDYARSFLSSLGINYPEMHYSNAISSNNSSSDKKYG
EEEEEEEEHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHCC
ASSEKMAAAYAAFANGGIYHKPRYVNKVEFSDGTSKTFDEKGKRAMKETTAYMMTDMLKT
CCHHHHHHHHHHHHCCCCEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLTYGTGTAAAIPGVAQAGKTGTSNYTDEELAKIGEKYGLYPDYVGTLAPDENFVGFTKR
HHHCCCCCHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHH
YAMAVWTGYKNRLTPVYGSSLEIASDVYRSMMTYLTNGYSEDWTMPNGLYRSGGFLYLSG
HHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEC
TYASNTDYTNSVYNNLYSNNTTTASSQTTSDDTSSSNDTSNSTNTDNNGSHPSTDDKKTT
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396576; 11463916 [H]