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The map label for this gene is ygcA [C]

Identifier: 15675488

GI number: 15675488

Start: 1326518

End: 1327873

Strand: Reverse

Name: ygcA [C]

Synonym: SPy_1606

Alternate gene names: 15675488

Gene position: 1327873-1326518 (Counterclockwise)

Preceding gene: 15675492

Following gene: 15675487

Centisome position: 71.68

GC content: 42.04

Gene sequence:

>1356_bases
ATGGTCGTAAAGGTTAAACAGAAAATTCCTTTAAAAATTAAGCGAATGGGAATTAACGGTGAGGGGATTGGTTTTTATCA
GAAAACTTTGGTATTTGTCCCTGGTGCTTTAAAGGGAGAAGATATTTTTTGCCAAATCACGGCGGTTAAACGGAATTTTG
CAGAGGCCAAACTGTTAACGGTAAACAAGGCTTCTAAGAATCGTGTCAAACCAGCTTGTTCTGTTTATGAAACTTGTGGT
GGTTGCCAAATCATGCATCTAGCCTATCCTAAACAGCTAGATTTCAAAGATGATGTGATTAGGCAGGCCCTTAAAAAGTT
CAAACCAACTGGCTATGAACAATTTGAGATTAGACCGACTTTAGGAATGAAAAAGCCAGATCACTATCGGGCCAAATTGC
AGTTTCAGCTGCGGTCATTTGGCGGGACGGTCAAGGCTGGTTTATTTTCCCAGGGAAGTCATCGCTTGGTTCCTATTGAC
AATTGCTTGGTACAGGATCAACTAACGCAAGATATTATCAATAAGATTACGCAGTTAGTGGACAAGTACAAGTTGCCCAT
TTACAATGAGCGCAAGATTGCTGGGATTCGGACGATAATGGTTCGTAAGGCACAGGCTAGTGATCAGGTACAGATTATTG
TTGTGAGTAGCAAAGAAGTTAGGTTAGCGAATTTCATTGGCGAATTGACTAAGGCATTTCCTCAGGTTAAAACGGTTGCC
TTGAATAGTAATCGTTCTAAATCGAGTGAGATTTATGGGGACGAAACGGAAATTCTATGGGGACAAGAGGCGATTCATGA
AGAAGTTTTAGACTATGGATTTGCGTTATCACCGAGAGCTTTTTACCAACTTAATCCACAGCAGACAGAAGTTTTGTATG
GTGAGGTGGTGAAGGCCTTGGATGTAGGGAGCAAAGATCATATTATTGATGCCTATTGTGGGGTTGGCTCGATTGGCTTT
GCTTTTGCAGGGAAGGTCAAGTCTGTGCGGGGGATGGATATTATCCCAGAAGCGATTGAAGATGCACAAAAAAATGCCAA
AGCCATGGGCTTTGACAACGCTTACTATGAGGCAGGGAAGGCAGAGGATATTATTTCTAAATGGTATAAACAAGGTTACC
GCGCGGATGCCGTCATTGTGGACCCACCAAGAACTGGTTTAGATGATAAATTATTAAAAACGATTCTTCATTACCAGCCT
AAACAGATGGTTTATGTGTCTTGTAATACCTCCACTTTGGCCCGCGACTTGGTGCAGCTAACAAAGGTTTACGATGTTCA
CTATATCCAAAGTGTAGACATGTTCCCCCATACAGCTAGGACCGAGGCTGTCGTGAAGTTACAAAAACGTGTATGA

Upstream 100 bases:

>100_bases
AAAAATGGTAAAATAGAAGACGAAAATACTGCTAAAAATGTGTTGCTTGTGAATGCTTTTGGTGGTGAGATTAGGATACT
AGAGGAAGTAAGGGGAAGAG

Downstream 100 bases:

>100_bases
TTGAGTGGCAATAACAACTCAAGTTTTATAAGCTCAGGTAATGGGTTTGAGCAATAGCTTGACATAGTAGGGATGTCAAA
AACGGTTTACTAAGCATAGT

Product: putative RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFCQITAVKRNFAEAKLLTVNKASKNRVKPACSVYETCG
GCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPTLGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPID
NCLVQDQLTQDIINKITQLVDKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLANFIGELTKAFPQVKTVA
LNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRAFYQLNPQQTEVLYGEVVKALDVGSKDHIIDAYCGVGSIGF
AFAGKVKSVRGMDIIPEAIEDAQKNAKAMGFDNAYYEAGKAEDIISKWYKQGYRADAVIVDPPRTGLDDKLLKTILHYQP
KQMVYVSCNTSTLARDLVQLTKVYDVHYIQSVDMFPHTARTEAVVKLQKRV

Sequences:

>Translated_451_residues
MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFCQITAVKRNFAEAKLLTVNKASKNRVKPACSVYETCG
GCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPTLGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPID
NCLVQDQLTQDIINKITQLVDKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLANFIGELTKAFPQVKTVA
LNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRAFYQLNPQQTEVLYGEVVKALDVGSKDHIIDAYCGVGSIGF
AFAGKVKSVRGMDIIPEAIEDAQKNAKAMGFDNAYYEAGKAEDIISKWYKQGYRADAVIVDPPRTGLDDKLLKTILHYQP
KQMVYVSCNTSTLARDLVQLTKVYDVHYIQSVDMFPHTARTEAVVKLQKRV
>Mature_451_residues
MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFCQITAVKRNFAEAKLLTVNKASKNRVKPACSVYETCG
GCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPTLGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPID
NCLVQDQLTQDIINKITQLVDKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLANFIGELTKAFPQVKTVA
LNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRAFYQLNPQQTEVLYGEVVKALDVGSKDHIIDAYCGVGSIGF
AFAGKVKSVRGMDIIPEAIEDAQKNAKAMGFDNAYYEAGKAEDIISKWYKQGYRADAVIVDPPRTGLDDKLLKTILHYQP
KQMVYVSCNTSTLARDLVQLTKVYDVHYIQSVDMFPHTARTEAVVKLQKRV

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=214, Percent_Identity=32.2429906542056, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI51173878, Length=214, Percent_Identity=32.2429906542056, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI269784680, Length=204, Percent_Identity=29.9019607843137, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI269784676, Length=204, Percent_Identity=29.9019607843137, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI20149688, Length=204, Percent_Identity=29.9019607843137, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI269784678, Length=204, Percent_Identity=29.9019607843137, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1789148, Length=452, Percent_Identity=25, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787083, Length=390, Percent_Identity=26.4102564102564, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790403, Length=339, Percent_Identity=23.0088495575221, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71997438, Length=165, Percent_Identity=28.4848484848485, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322909, Length=436, Percent_Identity=23.8532110091743, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666579, Length=414, Percent_Identity=26.5700483091787, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 50716; Mature: 50716

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFCQITAVKRNFAEAKLLT
CEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEHHCCCCCEEEEE
VNKASKNRVKPACSVYETCGGCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPT
EECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEC
LGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPIDNCLVQDQLTQDIINKITQLV
CCCCCCCCCEEEEEEEEHHCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
DKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLANFIGELTKAFPQVKTVA
HHHCCCCCCCCCHHHHHEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
LNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRAFYQLNPQQTEVLYGEVVKAL
ECCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DVGSKDHIIDAYCGVGSIGFAFAGKVKSVRGMDIIPEAIEDAQKNAKAMGFDNAYYEAGK
CCCCCCCEEEHHCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHCCCCCHHHCCCC
AEDIISKWYKQGYRADAVIVDPPRTGLDDKLLKTILHYQPKQMVYVSCNTSTLARDLVQL
HHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHH
TKVYDVHYIQSVDMFPHTARTEAVVKLQKRV
HHHHHHHHHEECCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIFCQITAVKRNFAEAKLLT
CEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEHHCCCCCEEEEE
VNKASKNRVKPACSVYETCGGCQIMHLAYPKQLDFKDDVIRQALKKFKPTGYEQFEIRPT
EECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEC
LGMKKPDHYRAKLQFQLRSFGGTVKAGLFSQGSHRLVPIDNCLVQDQLTQDIINKITQLV
CCCCCCCCCEEEEEEEEHHCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
DKYKLPIYNERKIAGIRTIMVRKAQASDQVQIIVVSSKEVRLANFIGELTKAFPQVKTVA
HHHCCCCCCCCCHHHHHEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
LNSNRSKSSEIYGDETEILWGQEAIHEEVLDYGFALSPRAFYQLNPQQTEVLYGEVVKAL
ECCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DVGSKDHIIDAYCGVGSIGFAFAGKVKSVRGMDIIPEAIEDAQKNAKAMGFDNAYYEAGK
CCCCCCCEEEHHCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHCCCCCHHHCCCC
AEDIISKWYKQGYRADAVIVDPPRTGLDDKLLKTILHYQPKQMVYVSCNTSTLARDLVQL
HHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHH
TKVYDVHYIQSVDMFPHTARTEAVVKLQKRV
HHHHHHHHHEECCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12122206; 12799345 [H]